Cort (cortistatin) - Rat Genome Database

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Gene: Cort (cortistatin) Rattus norvegicus
Analyze
Symbol: Cort
Name: cortistatin
RGD ID: 2383
Description: Enables neuropeptide hormone activity. Involved in neuropeptide signaling pathway and regulation of circadian sleep/wake cycle, sleep. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of brain infarction. Orthologous to human CORT (cortistatin); INTERACTS WITH (S)-nicotine; 2,4,6-trinitrobenzenesulfonic acid; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Preprocortistatin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,843,682 - 164,845,796 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.25159,560,591 - 159,562,032 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx5162,277,300 - 162,278,741 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,098,034 - 164,099,461 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,054,406 - 164,055,833 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,942,780 - 165,944,221 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05169,592,961 - 169,594,402 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45166,198,987 - 166,200,428 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5157,831,542 - 157,832,983 (-)NCBICelera
RGSC_v3.15166,209,174 - 166,210,616 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
2. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. de Lecea L, etal., Nature 1996 May 16;381(6579):242-5.
3. Growth hormone-inhibiting activity of cortistatin in the rat. Deghenghi R, etal., J Endocrinol Invest 2001 Dec;24(11):RC31-3.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9125122   PMID:12915402   PMID:17481746   PMID:17686045   PMID:23619555   PMID:27480534   PMID:28636167   PMID:29436118  


Genomics

Comparative Map Data
Cort
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,843,682 - 164,845,796 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.25159,560,591 - 159,562,032 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx5162,277,300 - 162,278,741 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,098,034 - 164,099,461 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,054,406 - 164,055,833 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,942,780 - 165,944,221 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05169,592,961 - 169,594,402 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45166,198,987 - 166,200,428 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5157,831,542 - 157,832,983 (-)NCBICelera
RGSC_v3.15166,209,174 - 166,210,616 (-)NCBI
Cytogenetic Map5q36NCBI
CORT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38110,450,031 - 10,451,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl110,450,031 - 10,451,998 (+)Ensemblhg38GRCh38
GRCh37110,510,088 - 10,512,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36110,432,558 - 10,434,546 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34110,444,236 - 10,446,223NCBI
Celera19,621,375 - 9,623,363 (+)NCBICelera
Cytogenetic Map1p36.22ENTREZGENE
HuRef19,663,393 - 9,665,676 (+)NCBIHuRef
CHM1_1110,497,518 - 10,499,802 (+)NCBICHM1_1
T2T-CHM13v2.019,993,648 - 9,995,614 (+)NCBIT2T-CHM13v2.0
Cort
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,209,491 - 149,211,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4149,209,491 - 149,211,220 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384149,125,034 - 149,126,763 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,125,034 - 149,126,763 (-)Ensemblmm10GRCm38
MGSCv374148,499,300 - 148,500,850 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364147,968,991 - 147,970,541 (-)NCBIMGSCv36mm8
MGSCv364144,510,109 - 144,511,659 (-)NCBIMGSCv36mm8
Celera4151,391,300 - 151,392,845 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.89NCBI
Cort
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554863,152,810 - 3,154,205 (-)Ensembl
ChiLan1.0NW_0049554863,152,745 - 3,154,956 (-)NCBIChiLan1.0ChiLan1.0
CORT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21217,775,202 - 217,777,221 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11216,421,119 - 216,422,961 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019,210,186 - 9,212,201 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1110,435,120 - 10,436,977 (+)NCBIPanPan1.1PanPan1.1panPan2
Cort
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505833,801,913 - 33,804,110 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366234,287,175 - 4,289,347 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CORT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl670,716,386 - 70,718,032 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1670,716,630 - 70,717,980 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2664,649,453 - 64,650,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Cort
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1111,648,545 - 11,650,207 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cort
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:491
Count of miRNA genes:241
Interacting mature miRNAs:279
Transcripts:ENSRNOT00000018609, ENSRNOT00000030302, ENSRNOT00000041937, ENSRNOT00000042768, ENSRNOT00000067514, ENSRNOT00000072014, ENSRNOT00000074436
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
BI274598  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25159,560,821 - 159,560,930 (+)MAPPERmRatBN7.2
Rnor_6.05165,943,011 - 165,943,119NCBIRnor6.0
Rnor_5.05169,593,192 - 169,593,300UniSTSRnor5.0
RGSC_v3.45166,199,218 - 166,199,326UniSTSRGSC3.4
Celera5157,831,773 - 157,831,881UniSTS
RH 3.4 Map51106.3UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
4 1 6 25 36 57 43 2 27 10 18 11 11

Sequence


RefSeq Acc Id: NM_012835   ⟹   NP_036967
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,843,683 - 164,845,124 (-)NCBI
mRatBN7.25159,560,591 - 159,562,032 (-)NCBI
Rnor_6.05165,942,780 - 165,944,221 (-)NCBI
Rnor_5.05169,592,961 - 169,594,402 (-)NCBI
RGSC_v3.45166,198,987 - 166,200,428 (-)RGD
Celera5157,831,542 - 157,832,983 (-)RGD
Sequence:
RefSeq Acc Id: XM_063287180   ⟹   XP_063143250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,843,682 - 164,845,796 (-)NCBI
Protein Sequences
Protein RefSeqs NP_036967 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143250 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52585 (Get FASTA)   NCBI Sequence Viewer  
  EDL81150 (Get FASTA)   NCBI Sequence Viewer  
  Q62949 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036967   ⟸   NM_012835
- Peptide Label: preproprotein
- UniProtKB: Q62949 (UniProtKB/Swiss-Prot),   A6IU99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063143250   ⟸   XM_063287180
- Peptide Label: isoform X1
Protein Domains
Somatostatin/Cortistatin C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62949-F1-model_v2 AlphaFold Q62949 1-112 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2383 AgrOrtholog
BioCyc Gene G2FUF-39143 BioCyc
InterPro Somatostatin UniProtKB/Swiss-Prot
  Somatostatin/Cortistatin_C UniProtKB/Swiss-Prot
KEGG Report rno:25305 UniProtKB/Swiss-Prot
NCBI Gene 25305 ENTREZGENE
PANTHER CORTISTATIN UniProtKB/Swiss-Prot
  SOMATOSTATIN UniProtKB/Swiss-Prot
Pfam Somatostatin UniProtKB/Swiss-Prot
PhenoGen Cort PhenoGen
PIRSF Somatostatin UniProtKB/Swiss-Prot
TIGR TC238992
UniProt A6IU99 ENTREZGENE, UniProtKB/TrEMBL
  CORT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-07-23 Cort  cortistatin      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Cort  Preprocortistatin      Name withdrawn 67952 WITHDRAWN