Comp (cartilage oligomeric matrix protein)

Gene: Comp (cartilage oligomeric matrix protein) Rattus norvegicus

Analyze

Symbol:

Comp

Name:

cartilage oligomeric matrix protein

RGD ID:

2378

Description:

Enables fibronectin binding activity and vitamin D binding activity. An extracellular matrix structural constituent. Predicted to be involved in cartilage homeostasis; negative regulation of apoptotic process; and protein homooligomerization. Predicted to act upstream of or within several processes, including BMP signaling pathway; cartilage development; and vasculature development. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in carpal tunnel syndrome 2; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein); PARTICIPATES IN cell-extracellular matrix signaling pathway; malaria pathway; phagocytosis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	COMP (cartilage oligomeric matrix protein)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Comp (cartilage oligomeric matrix protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	COMP (cartilage oligomeric matrix protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	COMP (cartilage oligomeric matrix protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Comp (cartilage oligomeric matrix protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	COMP (cartilage oligomeric matrix protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	COMP (cartilage oligomeric matrix protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Comp (cartilage oligomeric matrix protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Comp (cartilage oligomeric matrix protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	COMP (cartilage oligomeric matrix protein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	comp (cartilage oligomeric matrix protein)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Tsp	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	comp	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	19,081,172 - 19,089,548 (-)	NCBI		GRCr8
mRatBN7.2	16	19,047,206 - 19,055,584 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	19,047,207 - 19,055,845 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	19,086,958 - 19,095,161 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,219,417 - 20,227,820 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	19,139,921 - 19,148,124 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,798,437 - 20,807,070 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,798,437 - 20,807,070 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,647,382 - 20,657,932 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	16	19,237,609 - 19,245,998 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

carpal tunnel syndrome 2 (ISO)

connective tissue disease (ISO)

genetic disease (ISO)

Joint Instability (ISO)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ISO)

multiple epiphyseal dysplasia (ISO,ISS)

multiple epiphyseal dysplasia 1 (ISO)

osteoarthritis (ISO)

Osteoarthritis, Hip (ISO)

osteochondrodysplasia (ISO)

progressive myoclonus epilepsy 8 (ISO)

pseudoachondroplasia (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

aluminium oxide (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bleomycin A2 (ISO)

butanal (ISO)

calcitriol (ISO)

chlorpyrifos (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diethyl malate (ISO)

dimethylarsinic acid (EXP)

endosulfan (EXP)

furan (EXP)

gentamycin (EXP)

ivermectin (ISO)

microcystin-LR (ISO)

mifepristone (EXP)

mono(2-ethylhexyl) phthalate (ISO)

monosodium L-glutamate (ISO)

paracetamol (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA,ISO)

artery morphogenesis (IEA,ISO)

blood coagulation (ISO)

BMP signaling pathway (IEA,ISO)

bone growth (ISO)

bone mineralization (IEA,ISO)

bone morphogenesis (ISO)

cartilage development (ISO)

cartilage homeostasis (IEA,ISO,ISS)

cell adhesion (IEA)

cellular senescence (IEA,ISO)

chondrocyte development (IEA,ISO)

chondrocyte proliferation (IEA,ISO)

collagen fibril organization (IEA,ISO)

endochondral bone growth (ISO)

growth plate cartilage development (IEA,ISO)

limb development (IEA,ISO)

multicellular organism growth (IEA,ISO)

muscle cell development (ISO)

musculoskeletal movement (IEA,ISO)

negative regulation of apoptotic process (IEA,ISO)

negative regulation of hemostasis (IEA,ISO)

neuromuscular process (ISO)

ossification (ISO)

platelet aggregation (IEA,ISO)

positive regulation of chondrocyte proliferation (IEA,ISO)

protein homooligomerization (IEA,ISO,ISS)

protein processing (IEA,ISO)

protein secretion (IEA,ISO)

regulation of bone mineralization (IEA,ISO)

regulation of gene expression (IEA,ISO)

response to unfolded protein (IEA,ISO)

skeletal system development (ISO)

skin development (IEA,ISO)

tendon development (IEA,ISO)

vascular associated smooth muscle cell development (IEA,ISO)

vascular associated smooth muscle contraction (IEA,ISO)

Cellular Component

collagen-containing extracellular matrix (IBA,IDA,IEA)

extracellular region (IEA,ISO,ISS)

extracellular space (IEA,ISO)

protein-containing complex (IEA,ISO)

Molecular Function

BMP binding (IEA,ISO)

calcium ion binding (IEA,ISO)

collagen binding (IEA,ISO)

extracellular matrix structural constituent (IDA)

fibronectin binding (IDA)

heparan sulfate proteoglycan binding (IEA,ISO)

heparin binding (IEA,ISO)

integrin binding (IEA,ISO)

protease binding (IEA,ISO)

protein binding (IPI,ISO)

proteoglycan binding (ISO)

vitamin D binding (IMP)

Molecular Pathway Annotations Click to see Annotation Detail View

cell-extracellular matrix signaling pathway (IEA)

malaria pathway (IEA)

phagocytosis pathway (IEA)

transforming growth factor-beta superfamily mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene.	Briggs MD, etal., Nat Genet. 1995 Jul;10(3):330-6.
2.	Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin.	Di Cesare PE, etal., Matrix Biol 2002 Aug;21(5):461-70.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia.	Hecht JT, etal., Nat Genet. 1995 Jul;10(3):325-9.
6.	Localization and distribution of cartilage oligomeric matrix protein in the rat intervertebral disc.	Ishii Y, etal., Spine. 2006 Jun 15;31(14):1539-46.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins.	Oldberg A, etal., J Biol Chem 1992 Nov 5;267(31):22346-50.
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3).	Ozbek S, etal., EMBO J 2002 Nov 15;21(22):5960-8.
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17.	Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin.	Wang L, etal., Circ Res. 2010 Feb 19;106(3):514-25. doi: 10.1161/CIRCRESAHA.109.202762. Epub 2009 Dec 17.

Additional References at PubMed

PMID:8864111	PMID:10852928	PMID:11084047	PMID:15579310	PMID:15749701	PMID:16542502	PMID:16611630	PMID:17307734	PMID:17588949	PMID:17588960	PMID:17882701	PMID:17993464
PMID:18191556	PMID:18467703	PMID:18485748	PMID:19681593	PMID:19808781	PMID:20138147	PMID:20551380	PMID:21350216	PMID:22006726	PMID:22154936	PMID:23376485	PMID:23533145
PMID:23850469	PMID:23951406	PMID:24006456	PMID:24312420	PMID:25446117	PMID:26045608	PMID:26746240	PMID:27068509	PMID:27151399	PMID:27498005	PMID:28860005	PMID:29030641
PMID:29867124	PMID:34395611	PMID:35468843

Genomics

Comparative Map Data

Comp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	19,081,172 - 19,089,548 (-)	NCBI		GRCr8
mRatBN7.2	16	19,047,206 - 19,055,584 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	19,047,207 - 19,055,845 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	19,086,958 - 19,095,161 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,219,417 - 20,227,820 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	19,139,921 - 19,148,124 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,798,437 - 20,807,070 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,798,437 - 20,807,070 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,647,382 - 20,657,932 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	16	19,237,609 - 19,245,998 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

COMP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	18,782,773 - 18,791,305 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	18,782,773 - 18,791,305 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	18,893,583 - 18,902,114 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,754,583 - 18,763,114 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	18,754,583 - 18,763,114	NCBI
Celera	19	18,798,378 - 18,806,909 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	18,458,025 - 18,466,569 (-)	NCBI		HuRef
CHM1_1	19	18,893,587 - 18,902,107 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	18,918,369 - 18,926,902 (-)	NCBI		T2T-CHM13v2.0

Comp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	70,826,186 - 70,834,721 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	70,826,208 - 70,834,716 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	70,373,548 - 70,382,066 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,373,558 - 70,382,066 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	72,897,447 - 72,905,965 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	73,302,547 - 73,311,055 (+)	NCBI		MGSCv36	mm8
Celera	8	72,929,973 - 72,938,489 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.15	NCBI

COMP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	23,643,332 - 23,652,510 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	22,651,519 - 22,661,150 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	18,222,270 - 18,230,936 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	19,229,420 - 19,238,053 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	19,229,562 - 19,238,008 (-)	Ensembl	panpan1.1		panPan2

COMP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,306,813 - 44,314,575 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	44,306,859 - 44,314,625 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,221,457 - 44,229,145 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	44,793,007 - 44,800,779 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	44,793,063 - 44,800,711 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	44,030,270 - 44,038,042 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	44,440,677 - 44,448,355 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	44,715,955 - 44,723,648 (+)	NCBI		UU_Cfam_GSD_1.0

Comp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	202,995,236 - 203,002,126 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	2,544,389 - 2,551,164 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	2,544,389 - 2,551,155 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COMP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	59,061,426 - 59,069,564 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	59,061,409 - 59,068,951 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	58,815,756 - 58,823,293 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COMP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	17,246,617 - 17,255,561 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	17,246,762 - 17,255,126 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	2,070,833 - 2,079,420 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Comp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,871,002 - 1,877,369 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,870,975 - 1,877,434 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Comp
44 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	126
Count of miRNA genes:	100
Interacting mature miRNAs:	107
Transcripts:	ENSRNOT00000072536
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	15726433	21034895	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	19004435	75226532	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									2		7
Low	3	20	9	1		1	7	10	22		15	11	7
Below cutoff		19	42	34	19	34	1	1	46	32	19		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X72914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000072536 ⟹ ENSRNOP00000067037

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	19,047,207 - 19,055,584 (-)	Ensembl
Rnor_6.0 Ensembl	16	20,798,437 - 20,807,070 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083281 ⟹ ENSRNOP00000070348

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	20,798,570 - 20,800,646 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	19,047,207 - 19,054,228 (-)	Ensembl
Rnor_6.0 Ensembl	16	20,803,585 - 20,805,482 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000120265 ⟹ ENSRNOP00000095935

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	19,047,207 - 19,055,845 (-)	Ensembl

RefSeq Acc Id:

NM_012834 ⟹ NP_036966

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	19,081,172 - 19,089,548 (-)	NCBI
mRatBN7.2	16	19,047,206 - 19,055,584 (-)	NCBI
Rnor_6.0	16	20,798,437 - 20,807,070 (-)	NCBI
Rnor_5.0	16	20,647,382 - 20,657,932 (-)	NCBI
Celera	16	19,237,609 - 19,245,998 (-)	RGD

Sequence:

show sequence

GTCGACATGAGCCCCACTGCCTGCGTTCTAGTGCTCGCCCTGGCTGCCTTGCGGGCTACCGGCC
AGGGCCAGATCCCGCTGGGTGGAGACCTAGCCCCACAGATGCTTCGAGAACTCCAGGAGACTAA
TGCGGCGCTGCAAGACGTGAGAGAGCTCTTGCGACACAGGGTCAAGGAGATCACCTTCCTGAAG
AATACGGTGATGGAATGTGACGCTTGCGGAATGCAGCCCGCACGCACCCCCGGTCTGAGCGTGC
GGCCAGTCGCGCTCTGCGCACCCGGCTCCTGCTTCCCTGGCGTAGTCTGCACGGAGACAGCTAC
CGGCGCGCGCTGCGGCCCCTGCCCTCCGGGCTACACCGGCAACGGCTCGCACTGCACCGACGTT
AATGAGTGCAACGCTCACCCCTGTTTCCCGCGCGTGCGGTGCATCAATACCAGCCCTGGCTTTC
ACTGCGAAGCCTGTCCCCCTGGGTTCAGCGGGCCCACCCACGAGGGTGTGGGGCTGACCTTCGC
CAAGACCAACAAACAAGTTTGCACAGATATTAATGAGTGTGAGACCGGGCAGCACAATTGCGTT
CCCAACTCCGTGTGCGTCAACACCCGGGGCTCCTTCCAGTGCGGTCCCTGCCAGCCCGGCTTCG
TGGGCGACCAGAGGTCAGGCTGCCAGCGGCGTGGGCAACACTTCTGCCCCGACGGGTCACCCAG
CCCGTGCCATGAGAAAGCAGACTGTATTTTGGAGCGCGACGGCTCAAGGTCCTGCGTGTGTGCG
GTCGGCTGGGCCGGCAACGGGCTCCTGTGCGGACGCGACACAGACCTGGACGGTTTCCCGGACG
AGAAGCTTCGCTGCTCAGAGCGCCAGTGCCGCAAGGACAACTGCGTGACGGTGCCCAATTCAGG
GCAGGAGGATGTGGACCGGGACCGCATTGGAGATGCTTGTGACCCGGATGCGGACGGGGATGGA
GTCCCTAATGAGCAAGACAATTGCCCGCTGGTTCGAAACCCAGACCAGCGCAACTCCGATAAAG
ACAAGTGGGGAGATGCCTGCGACAACTGCCGGTCCCAGAAGAATGATGACCAGAAAGATACAGA
CCGGGATGGCCAGGGCGATGCCTGCGACGACGACATAGATGGCGATCGAATCCGAAATGTAGCT
GACAACTGTCCCCGGGTGCCCAACTTTGACCAGAGTGACAGCGATGGTGATGGTGTTGGGGATG
CCTGTGACAATTGTCCCCAGAAAGACAACCCGGACCAGAGGGACGTGGACCACGACTTTGTGGG
TGATGCCTGTGACAGTGACCAAGACCAGGACGGGGATGGACACCAAGACTCCCGGGACAACTGC
CCCACAGTGCCCAACAGTGCCCAGCAGGACTCAGACCATGATGGCAAGGGTGATGCCTGTGATG
ATGACGACGACAATGACGGAGTCCCTGACAGCCGGGACAATTGCCGCTTGGTGCCCAACCCGGG
CCAAGAGGACAATGACCGGGATGGCGTGGGTGACGCTTGTCAGGGTGACTTCGATGCTGACAAG
GTTATAGACAAGATCGATGTGTGCCCCGAGAACGCCGAGGTCACTCTCACCGACTTCAGGGCCT
TCCAAACAGTTGTGCTGGACCCCGAGGGTGATGCGCAGATCGACCCCAACTGGGTGGTGCTCAA
TCAGGGAATGGAGATCGTTCAGACCATGAACAGTGACCCTGGCCTGGCTGTGGGTTACACGGCA
TTCAACGGTGTAGATTTTGAGGGAACGTTCCATGTAAACACCGCCACCGATGATGACTACGCTG
GCTTCATCTTCGGCTATCAAGACAGCTCAAGTTTCTATGTGGTCATGTGGAAACAGATGGAGCA
GACGTACTGGCAGGCCAATCCTTTCCGGGCAGTGGCTGAACCAGGGATTCAGCTCAAGGCTGTC
AAGTCCTCTACAGGTCCCGGGGAACAGCTCCGAAATGCGTTGTGGCACACGGGGGACACAGCAT
CCCAGGTGCGGCTGCTGTGGAAGGATCCTCGAAATGTGGGCTGGAAGGATAAGACATCCTACCG
CTGGTTCCTGCAGCACCGGCCTCAAGTCGGCTACATCAGGGTGCGGTTCTATGAGGGTCCTGAG
CTAGTAGCTGACAGCAACGTGGTGCTGGACACAGCTATGCGTGGTGGCCGCCTGGGTGTCTTCT
GCTTCTCCCAAGAGAATATCATCTGGGCTAACCTGCGCTACCGTTGCAATGATACAATCCCTGA
GGACTATGAGCGTCACCGGCTGCGGAGGGCCTAGGGACCCTAAGAGGGGCCCCGCTGACCGATG
GACTGCGGTAGCATCGGCCACAGGTGTCTGGGGGGGGGGGTCTGGCATCTTTCTGAAGGGATGT
CTGGCCTGGGGAGGAAAGGCAAATAAAGAATGTATGTGGGGGAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006252822 ⟹ XP_006252884

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	19,081,172 - 19,088,208 (-)	NCBI
mRatBN7.2	16	19,047,206 - 19,053,818 (-)	NCBI
Rnor_6.0	16	20,798,437 - 20,805,681 (-)	NCBI
Rnor_5.0	16	20,647,382 - 20,657,932 (-)	NCBI

Sequence:

show sequence

GGGCTCCCCACACCCCCGCCGTCCTGTTCCTACCCGGGCCGACCCCACCACAAATTCCCTCCAT
CCAGACGACGTCCCCCTCATCCACTGAGGGTATTCTCCTGGAGCAGCCCCTCGCAGCCCGGGAC
TCCAACCCAGAAGACCTCACGTCTAGCAGGGGGGCCCCACCCAGCTCAACTCCATCACTATATC
AGACGCACGCTCTGACCACGCCTTTTGCCCATATCGACGCCCACTCCAACGACCCTTTGGACGC
CGGGGGTGGCTCTCTCCAGCCCTTCCCCTCACCACTGGGGCTTGCTCGCCCGGACCACGTGTCT
GCTTTGGAGAGTCGCCCTCGACGGGGTGATCGCTGCCGTGCTTGCAGGTCCAGGCGGCCACTTC
CTCCCTCGGCTGGGGATGCCCGCCCCCCAAGTTCATTTTCTCATCCCTAAGAGGTCACAACTCC
ATGCCCATGAAGGCAAAGTCGTCAGCGACCCTCGGGTTCTTTATCCCGTGTGGCACCGTACTTC
AAGAGCTGGCTGATGGCTCTTAAGCGCCCTGAAATGCAGAGGCTTGCCAATCCCTTTGAGTTCG
AGGCCAGCCTGGTATACATGTGCAACGCTCACCCCTGTTTCCCGCGCGTGCGGTGCATCAATAC
CAGCCCTGGCTTTCACTGCGAAGCCTGTCCCCCTGGGTTCAGCGGGCCCACCCACGAGGGTGTG
GGGCTGACCTTCGCCAAGACCAACAAACAAGTTTGCACAGATATTAATGAGTGTGAGACCGGGC
AGCACAATTGCGTTCCCAACTCCGTGTGCGTCAACACCCGGGGCTCCTTCCAGTGCGGTCCCTG
CCAGCCCGGCTTCGTGGGCGACCAGAGGTCAGGCTGCCAGCGGCGTGGGCAACACTTCTGCCCC
GACGGGTCACCCAGCCCGTGCCATGAGAAAGCAGACTGTATTTTGGAGCGCGACGGCTCAAGGT
CCTGCGTGTGTGCGGTCGGCTGGGCCGGCAACGGGCTCCTGTGCGGACGCGACACAGACCTGGA
CGGTTTCCCGGACGAGAAGCTTCGCTGCTCAGAGCGCCAGTGCCGCAAGGACAACTGCGTGACG
GTGCCCAATTCAGGGCAGGAGGATGTGGACCGGGACGGCATTGGAGATGCTTGTGACCCGGATG
CGGACGGGGATGGAGTCCCTAATGAGCAAGACAATTGCCCGCTGGTTCGAAACCCAGACCAGCG
CAACTCGGATAAAGACAAGTGGGGAGATGCCTGCGACAACTGCCGGTCCCAGAAGAATGATGAC
CAGAAAGATACAGACCGGGATGGCCAGGGCGATGCCTGCGACGACGACATAGATGGCGATCGAA
TCCGAAATGTAGCTGACAACTGTCCCCGGGTGCCCAACTTTGACCAGAGTGACAGCGATGGTGA
TGGTGTTGGGGATGCCTGTGACAATTGTCCCCAGAAAGACAACCCGGACCAGAGGGACGTGGAC
CACGACTTTGTGGGTGATGCCTGTGACAGTGACCAAGACCAGGACGGGGATGGACACCAAGACT
CCCGGGACAACTGCCCCACAGTACCCAACAGTGCCCAGCAGGACTCAGACCATGATGGCAAGGG
TGATGCCTGTGATGATGACGACGACAATGACGGAGTCCCTGACAGCCGGGACAATTGCCGCTTG
GTGCCCAACCCGGGCCAAGAGGACAATGACCGGGATGGCGTGGGTGACGCTTGTCAGGGTGACT
TCGATGCTGACAAGGTTATAGACAAGATCGATGTGTGCCCCGAGAACGCCGAGGTCACTCTCAC
CGACTTCAGGGCCTTCCAAACAGTTGTGCTGGACCCCGAGGGTGATGCGCAGATCGACCCCAAC
TGGGTGGTGCTCAATCAGGGAATGGAGATCGTTCAGACCATGAACAGTGACCCTGGCCTGGCTG
TGGGTTACACGGCATTCAACGGTGTAGATTTTGAGGGAACGTTCCATGTAAACACCGCCACCGA
TGATGACTACGCTGGCTTCATCTTCGGCTATCAAGACAGCTCAAGTTTCTATGTGGTCATGTGG
AAACAGATGGAGCAGACGTACTGGCAGGCCAATCCTTTCCGGGCAGTGGCTGAACCAGGGATTC
AGCTCAAGGCTGTCAAGTCCTCTACAGGTCCCGGGGAACAGCTCCGAAATGCGTTGTGGCACAC
GGGGGACACAGCATCCCAGGTGCGGCTGCTGTGGAAGGATCCTCGAAATGTGGGCTGGAAGGAT
AAGACATCCTACCGCTGGTTCCTGCAGCACCGGCCTCAAGTCGGCTACATCAGGGTGCGGTTCT
ATGAGGGTCCTGAGCTAGTAGCTGACAGCAACGTGGTGCTGGACACAGCTATGCGTGGTGGCCG
CCTGGGTGTCTTCTGCTTCTCCCAAGAGAATATCATCTGGGCTAACCTGCGCTACCGTTGCAAT
GATACAATCCCTGAGGACTATGAGCGTCACCGGCTGCGGAGGGCCTAGGGACCCTAAGAGGGGC
CCCGCTGACCGATGGACTGCGGTAGCATCGGCCACAGGTGTCTGGGGGGGGGGGGTCTGGCATC
TTTCTGAAGGGATGTCTGGCCTGGGGAGGAAAGGCAAATAAAGAATGTATGTGGGGGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036966	(Get FASTA)	NCBI Sequence Viewer
	XP_006252884	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA51419	(Get FASTA)	NCBI Sequence Viewer
	EDL90681	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000067037
	ENSRNOP00000067037.1
	ENSRNOP00000089337
	ENSRNOP00000089337.1
	ENSRNOP00000095935.1
GenBank Protein	P35444	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036966 ⟸ NM_012834
- Peptide Label:	precursor
- UniProtKB:	P35444 (UniProtKB/Swiss-Prot), M0RBU0 (UniProtKB/TrEMBL), A6KA56 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSPTACVLVLALAALRATGQGQIPLGGDLAPQMLRELQETNAALQDVRELLRHRVKEITFLKNT VMECDACGMQPARTPGLSVRPVALCAPGSCFPGVVCTETATGARCGPCPPGYTGNGSHCTDVNE CNAHPCFPRVRCINTSPGFHCEACPPGFSGPTHEGVGLTFAKTNKQVCTDINECETGQHNCVPN SVCVNTRGSFQCGPCQPGFVGDQRSGCQRRGQHFCPDGSPSPCHEKADCILERDGSRSCVCAVG WAGNGLLCGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQEDVDRDRIGDACDPDADGDGVP NEQDNCPLVRNPDQRNSDKDKWGDACDNCRSQKNDDQKDTDRDGQGDACDDDIDGDRIRNVADN CPRVPNFDQSDSDGDGVGDACDNCPQKDNPDQRDVDHDFVGDACDSDQDQDGDGHQDSRDNCPT VPNSAQQDSDHDGKGDACDDDDDNDGVPDSRDNCRLVPNPGQEDNDRDGVGDACQGDFDADKVI DKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFN GVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKS STGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELV ADSNVVLDTAMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYERHRLRRA hide sequence

RefSeq Acc Id:	XP_006252884 ⟸ XM_006252822
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A7Z1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALKRPEMQRLANPFEFEASLVYMCNAHPCFPRVRCINTSPGFHCEACPPGFSGPTHEGVGLTF AKTNKQVCTDINECETGQHNCVPNSVCVNTRGSFQCGPCQPGFVGDQRSGCQRRGQHFCPDGSP SPCHEKADCILERDGSRSCVCAVGWAGNGLLCGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNS GQEDVDRDGIGDACDPDADGDGVPNEQDNCPLVRNPDQRNSDKDKWGDACDNCRSQKNDDQKDT DRDGQGDACDDDIDGDRIRNVADNCPRVPNFDQSDSDGDGVGDACDNCPQKDNPDQRDVDHDFV GDACDSDQDQDGDGHQDSRDNCPTVPNSAQQDSDHDGKGDACDDDDDNDGVPDSRDNCRLVPNP GQEDNDRDGVGDACQGDFDADKVIDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVL NQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQME QTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSY RWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTAMRGGRLGVFCFSQENIIWANLRYRCNDTIP EDYERHRLRRA hide sequence

RefSeq Acc Id:

ENSRNOP00000067037 ⟸ ENSRNOT00000072536

RefSeq Acc Id:

ENSRNOP00000070348 ⟸ ENSRNOT00000083281

RefSeq Acc Id:

ENSRNOP00000095935 ⟸ ENSRNOT00000120265

Protein Domains

EGF-like TSP C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P35444-F1-model_v2	AlphaFold	P35444	1-755	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700034

Promoter ID:

EPDNEW_R10557

Type:

single initiation site

Name:

Comp_1

Description:

cartilage oligomeric matrix protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	20,807,085 - 20,807,145	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2378	AgrOrtholog
BioCyc Gene	G2FUF-11776	BioCyc
Ensembl Genes	ENSRNOG00000048472	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000072536	ENTREZGENE
	ENSRNOT00000072536.3	UniProtKB/TrEMBL
	ENSRNOT00000092334.2	UniProtKB/TrEMBL
	ENSRNOT00000120265.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.120.200	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4.10.1080.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ConA-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thbs/COMP_coiled-coil	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thrombospondin_3-like_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thrombospondin_3_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thrombospondin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP-5_cc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP/COMP_coiled-coil_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP_type-3_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25304	UniProtKB/Swiss-Prot
NCBI Gene	25304	ENTREZGENE
PANTHER	PTHR10199:SF88	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	THROMBOSPONDIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	COMP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Comp	PhenoGen
PROSITE	EGF_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP_CTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000048472	RatGTEx
SMART	EGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Assembly domain of cartilage oligomeric matrix protein	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF/Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF103647	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49899	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57184	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC218086
UniProt	A0A8I6A7Z1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AP06_RAT	UniProtKB/TrEMBL
	A6KA56	ENTREZGENE, UniProtKB/TrEMBL
	COMP_RAT	UniProtKB/Swiss-Prot
	M0RBU0	ENTREZGENE, UniProtKB/TrEMBL
	P35444	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Comp	Cartilage oligomeric matrix protein			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_homology	homologous to carboxy-terminal half of thrombospondin	1298776
gene_physical_interaction	interacts with fibronectin in extracellular matrix	1298778
gene_process	may play a role in extracellular matrix molecular interactions and in extracellular matrix assembly	1298778
gene_protein	755 amino acids; calculated molecular weight of 82,700 Da	1298776
gene_protein	homopolymer composed of five disulfide-linked subunits	1298776

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)