Psg19 (pregnancy specific glycoprotein 19) - Rat Genome Database

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Gene: Psg19 (pregnancy specific glycoprotein 19) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Psg19 (Ensembl: LOC102557319)
Name: pregnancy specific glycoprotein 19 (Ensembl:carcinoembryonic antigen-related cell adhesion molecule 3-like)
RGD ID: 2334
Description: Involved in female pregnancy. Predicted to be active in external side of plasma membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Carcinoembryonic antigen gene family (CGM3); Cea3; CEAC; CGM3; MGC114333; pregnancy-specific glycoprotein (rnCGM3); RATCEAC
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,549,234 - 87,559,500 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl187,549,234 - 87,559,500 (-)EnsemblGRCr8
mRatBN7.2178,421,183 - 78,431,449 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,421,183 - 78,431,449 (-)EnsemblmRatBN7.2
Rnor_6.0179,680,194 - 79,690,460 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,680,194 - 79,708,835 (-)Ensemblrn6Rnor6.0
Rnor_5.0180,936,820 - 80,947,086 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,124,961 - 78,135,217 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera172,888,830 - 72,899,096 (-)NCBICelera
RGSC_v3.1178,203,071 - 78,213,328 (-)NCBI
RH 3.4 Map1790.6RGD
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Characterization of two promoters of a rat pregnancy-specific glycoprotein gene. Chen H, etal., Biochemistry 1994 Aug 16;33(32):9615-26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of a carcinoembryonic antigen gene family in the rat. Analysis of the N-terminal domains reveals immunoglobulin-like, hypervariable regions. Kodelja V, etal., J Biol Chem 1989 Apr 25;264(12):6906-12.
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Psg19
62 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:90
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000057986, ENSRNOT00000057988
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
D1Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,449,047 - 78,449,238 (+)MAPPERmRatBN7.2
mRatBN7.2178,430,471 - 78,430,669 (+)MAPPERmRatBN7.2
Rnor_6.0179,689,483 - 79,689,680NCBIRnor6.0
Rnor_6.0179,707,865 - 79,708,055NCBIRnor6.0
Rnor_5.0180,970,158 - 80,970,349NCBIRnor5.0
Rnor_5.0180,946,110 - 80,946,306NCBIRnor5.0
Rnor_5.0180,946,109 - 80,946,306NCBIRnor5.0
RGSC_v3.4178,134,240 - 78,134,437UniSTSRGSC3.4
RGSC_v3.4178,153,048 - 78,153,238UniSTSRGSC3.4
RGSC_v3.4178,134,239 - 78,134,437RGDRGSC3.4
RGSC_v3.4178,153,047 - 78,153,238RGDRGSC3.4
Celera172,898,119 - 72,898,316UniSTS
Celera172,916,167 - 72,916,357UniSTS
RGSC_v3.1178,231,158 - 78,231,349RGD
RH 3.4 Map1788.3RGD
RH 3.4 Map1788.3UniSTS
RH 2.0 Map1519.4RGD
Cytogenetic Map1q21UniSTS
D1Arb36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,430,424 - 78,430,754 (+)MAPPERmRatBN7.2
Rnor_6.0179,689,436 - 79,689,765NCBIRnor6.0
Rnor_5.0180,946,064 - 80,946,391UniSTSRnor5.0
RGSC_v3.4178,134,193 - 78,134,522UniSTSRGSC3.4
RGSC_v3.4178,153,000 - 78,153,323RGDRGSC3.4
RGSC_v3.4178,134,192 - 78,134,522RGDRGSC3.4
Celera172,898,072 - 72,898,401UniSTS
RGSC_v3.1178,231,111 - 78,231,434RGD
SHRSP x BN Map140.2499UniSTS
SHRSP x BN Map140.2499RGD
FHH x ACI Map140.1RGD
Cytogenetic Map1q21UniSTS
D1Mgh5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8187,558,587 - 87,558,729 (+)Marker Load Pipeline
mRatBN7.2178,430,536 - 78,430,678 (+)MAPPERmRatBN7.2
Rnor_6.0179,689,548 - 79,689,689NCBIRnor6.0
Rnor_5.0180,946,174 - 80,946,315UniSTSRnor5.0
RGSC_v3.4178,134,304 - 78,134,446RGDRGSC3.4
RGSC_v3.4178,134,305 - 78,134,446UniSTSRGSC3.4
Celera172,898,184 - 72,898,325UniSTS
RGSC_v3.1178,212,415 - 78,212,557RGD
RH 3.4 Map1791.5RGD
RH 3.4 Map1791.5UniSTS
RH 2.0 Map1501.0RGD
SHRSP x BN Map140.2499RGD
FHH x ACI Map140.1RGD
Cytogenetic Map1q21UniSTS
D1Got78  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8187,574,078 - 87,574,288 (+)Marker Load Pipeline
mRatBN7.2178,446,028 - 78,446,238 (+)MAPPERmRatBN7.2
Rnor_6.0179,704,846 - 79,705,055NCBIRnor6.0
Rnor_5.0180,965,515 - 80,965,724UniSTSRnor5.0
RGSC_v3.4178,150,029 - 78,150,238UniSTSRGSC3.4
RGSC_v3.4178,150,028 - 78,150,238RGDRGSC3.4
Celera172,913,148 - 72,913,357UniSTS
RGSC_v3.1178,228,140 - 78,228,349RGD
RH 3.4 Map1791.5RGD
RH 3.4 Map1791.5UniSTS
RH 2.0 Map1500.5RGD
Cytogenetic Map1q21UniSTS
RH94690  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,421,624 - 78,421,824 (+)MAPPERmRatBN7.2
Rnor_6.0179,680,636 - 79,680,835NCBIRnor6.0
Rnor_5.0180,937,262 - 80,937,461UniSTSRnor5.0
RGSC_v3.4178,125,393 - 78,125,592UniSTSRGSC3.4
Celera172,889,272 - 72,889,471UniSTS
RH 3.4 Map1790.6UniSTS
Cytogenetic Map1q21UniSTS
RH94691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,449,862 - 78,449,971 (+)MAPPERmRatBN7.2
mRatBN7.2178,431,293 - 78,431,402 (+)MAPPERmRatBN7.2
Rnor_6.0179,708,680 - 79,708,788NCBIRnor6.0
Rnor_6.0179,690,305 - 79,690,413NCBIRnor6.0
Rnor_5.0180,970,974 - 80,971,082UniSTSRnor5.0
Rnor_5.0180,946,931 - 80,947,039UniSTSRnor5.0
RGSC_v3.4178,135,062 - 78,135,170UniSTSRGSC3.4
RGSC_v3.4178,153,863 - 78,153,971UniSTSRGSC3.4
Celera172,916,982 - 72,917,090UniSTS
Celera172,898,941 - 72,899,049UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map1q21UniSTS
AI059471  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,438,522 - 78,438,711 (+)MAPPERmRatBN7.2
Rnor_6.0179,697,340 - 79,697,528NCBIRnor6.0
Rnor_5.0180,959,447 - 80,959,635UniSTSRnor5.0
RGSC_v3.4178,142,523 - 78,142,711UniSTSRGSC3.4
Celera172,905,642 - 72,905,830UniSTS
RH 3.4 Map1793.5UniSTS
Cytogenetic Map1q21UniSTS
RH140305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,439,939 - 78,440,147 (+)MAPPERmRatBN7.2
Rnor_6.0179,698,757 - 79,698,964NCBIRnor6.0
Rnor_5.0180,960,864 - 80,961,071UniSTSRnor5.0
RGSC_v3.4178,143,940 - 78,144,147UniSTSRGSC3.4
Celera172,907,059 - 72,907,266UniSTS
RH 3.4 Map1789.3UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map1q21UniSTS
RH141744  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,421,297 - 78,421,509 (+)MAPPERmRatBN7.2
Rnor_6.0179,680,309 - 79,680,520NCBIRnor6.0
Rnor_5.0180,936,935 - 80,937,146UniSTSRnor5.0
RGSC_v3.4178,125,066 - 78,125,277UniSTSRGSC3.4
Celera172,888,945 - 72,889,156UniSTS
RH 3.4 Map1791.5UniSTS
Cytogenetic Map1q21UniSTS
AI547520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,444,740 - 78,444,939 (+)MAPPERmRatBN7.2
Rnor_6.0179,703,558 - 79,703,756NCBIRnor6.0
Rnor_5.0180,964,227 - 80,964,425UniSTSRnor5.0
RGSC_v3.4178,148,741 - 78,148,939UniSTSRGSC3.4
Celera172,911,860 - 72,912,058UniSTS
RH 3.4 Map1793.5UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 10 10 45 34 36 18 18 18 79 38 37 13 36 18

Sequence


RefSeq Acc Id: NM_001270654   ⟹   NP_001257583
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,549,234 - 87,559,500 (-)NCBI
mRatBN7.2178,421,183 - 78,431,449 (-)NCBI
Rnor_6.0179,680,194 - 79,690,460 (-)NCBI
Rnor_5.0180,936,820 - 80,947,086 (-)NCBI
Celera172,888,830 - 72,899,096 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019126   ⟹   NP_061999
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,549,234 - 87,559,500 (-)NCBI
mRatBN7.2178,421,183 - 78,431,449 (-)NCBI
Rnor_6.0179,680,194 - 79,690,460 (-)NCBI
Rnor_5.0180,936,820 - 80,947,086 (-)NCBI
RGSC_v3.4178,124,961 - 78,135,217 (-)RGD
Celera172,888,830 - 72,899,096 (-)NCBI
Sequence:
RefSeq Acc Id: NP_061999   ⟸   NM_019126
- Peptide Label: precursor
- UniProtKB: G3V9P5 (UniProtKB/TrEMBL),   A6J8H4 (UniProtKB/TrEMBL),   Q62664 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257583   ⟸   NM_001270654
- Peptide Label: isoform 2 precursor
- UniProtKB: Q4V8L4 (UniProtKB/TrEMBL),   D4A4A3 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9P5-F1-model_v2 AlphaFold G3V9P5 1-475 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2334 AgrOrtholog
BioCyc Gene G2FUF-60558 BioCyc
Ensembl Genes ENSRNOG00000038101 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057986 ENTREZGENE
  ENSRNOT00000057986.6 UniProtKB/TrEMBL
  ENSRNOT00000057988 ENTREZGENE
  ENSRNOT00000057988.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7462517 IMAGE-MGC_LOAD
InterPro CEA_cell_adhesion UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:24256 UniProtKB/TrEMBL
MGC_CLONE MGC:114333 IMAGE-MGC_LOAD
NCBI Gene 24256 ENTREZGENE
PANTHER CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1 UniProtKB/TrEMBL
  CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 UniProtKB/TrEMBL
  PREGNANCY SPECIFIC BETA-1-GLYCOPROTEIN 18-RELATED UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Psg19 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038101 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A6J8H4 ENTREZGENE, UniProtKB/TrEMBL
  D4A4A3 ENTREZGENE
  G3V9P5 ENTREZGENE, UniProtKB/TrEMBL
  Q4V8L4 ENTREZGENE, UniProtKB/TrEMBL
  Q62664 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D4A4A3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Psg19  pregnancy specific glycoprotein 19  Cgm3  Carcinoembryonic antigen gene family (CGM3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cgm3  Carcinoembryonic antigen gene family (CGM3)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression placental glycoprotein expressed during pregnancy 1298757