Cel (carboxyl ester lipase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Cel (carboxyl ester lipase) Rattus norvegicus
Analyze
Symbol: Cel
Name: carboxyl ester lipase
RGD ID: 2331
Description: Enables carboxylic ester hydrolase activity and glycosphingolipid binding activity. Predicted to be involved in ceramide catabolic process; intestinal cholesterol absorption; and pancreatic juice secretion. Located in extracellular space and zymogen granule. Part of protein-containing complex. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase); PARTICIPATES IN glycerolipid metabolic pathway; steroid biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bal; bile salt-activated lipase; bile salt-stimulated lipase; Bssl; cholesterol esterase; pancreatic lysophospholipase; sterol esterase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,281,518 - 32,289,019 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl332,281,518 - 32,289,019 (-)EnsemblGRCr8
mRatBN7.2311,883,532 - 11,891,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,883,532 - 11,891,035 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx314,955,824 - 14,963,304 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0323,540,779 - 23,548,259 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0321,795,231 - 21,802,711 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.037,134,021 - 7,141,522 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,134,021 - 7,141,522 (-)Ensemblrn6Rnor6.0
Rnor_5.0312,485,038 - 12,492,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.437,541,127 - 7,549,245 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera36,664,206 - 6,672,217 (-)NCBICelera
RGSC_v3.137,541,429 - 7,549,545 (-)NCBI
Cytogenetic Map3p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenyl acetate  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
cyclophosphamide  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dihydroxyacetone  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
ferroheme b  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
heme b  (EXP)
hydralazine  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
isotretinoin  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-N-nitrosourea  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
orlistat  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
taurocholic acid  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The combinatorial extension method reveals a sphingolipid binding domain on pancreatic bile salt-dependent lipase: role in secretion. Aubert-Jousset E, etal., Structure. 2004 Aug;12(8):1437-47.
2. Participation of GRP94-related protein in secretion of pancreatic bile salt-dependent lipase and in its internalization by the intestinal epithelium. Bruneau N, etal., J Cell Sci. 1998 Sep;111 ( Pt 17):2665-79.
3. Pancreatic bile-salt-dependent lipase activity in serum of diabetic patients: is there a relationship with glycation? Caillol N, etal., Clin Sci (Lond). 1998 Feb;94(2):181-8.
4. Identity of a cytosolic neutral cholesterol esterase in rat liver with the bile salt stimulated cholesterol esterase in pancreas. Camulli ED, etal., Biochim Biophys Acta. 1989 Sep 25;1005(2):177-82.
5. Site-specific mutagenesis of an essential histidine residue in pancreatic cholesterol esterase. DiPersio LP, etal., J Biol Chem 1991 Mar 5;266(7):4033-6.
6. Decrease in contents of pancreatic carboxyl ester lipase, phospholipase A2, and lingual lipase in rats with streptozotocin-induced diabetes. Duan RD and Sternby B, Scand J Gastroenterol. 1993 Mar;28(3):256-60.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning. Han JH, etal., Biochemistry 1987 Mar 24;26(6):1617-25.
10. Size of the catalytically active unit of rat hepatic carboxylester lipase in the presence and absence of bile salt. Harrison EH, etal., Biochim Biophys Acta. 1997 Aug 16;1347(2-3):177-82.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Molecular cloning and expression of cDNA for rat pancreatic cholesterol esterase. Kissel JA, etal., Biochim Biophys Acta 1989 Nov 28;1006(2):227-36.
13. Impairment of bile salt-dependent lipase secretion in AR4-2J rat pancreatic cells induces its degradation by the proteasome. Le Petit-Thevenin J, etal., Biochim Biophys Acta. 2001 Feb 26;1530(2-3):184-98.
14. Importance of arginines 63 and 423 in modulating the bile salt-dependent and bile salt-independent hydrolytic activities of rat carboxyl ester lipase. Liang Y, etal., J Biol Chem. 2000 Aug 4;275(31):24040-6.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Circulating antibodies against an exocrine pancreatic enzyme in type 1 diabetes. Panicot L, etal., Diabetes. 1999 Dec;48(12):2316-23.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase. Raeder H, etal., Diabetes. 2007 Feb;56(2):444-9.
21. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Raeder H, etal., Nat Genet. 2006 Jan;38(1):54-62. Epub 2005 Dec 20.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:1854805   PMID:2069957   PMID:2211595   PMID:9160047   PMID:11733511   PMID:12031288   PMID:15265857   PMID:16502470   PMID:17805199   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Cel
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,281,518 - 32,289,019 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl332,281,518 - 32,289,019 (-)EnsemblGRCr8
mRatBN7.2311,883,532 - 11,891,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,883,532 - 11,891,035 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx314,955,824 - 14,963,304 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0323,540,779 - 23,548,259 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0321,795,231 - 21,802,711 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.037,134,021 - 7,141,522 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,134,021 - 7,141,522 (-)Ensemblrn6Rnor6.0
Rnor_5.0312,485,038 - 12,492,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.437,541,127 - 7,549,245 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera36,664,206 - 6,672,217 (-)NCBICelera
RGSC_v3.137,541,429 - 7,549,545 (-)NCBI
Cytogenetic Map3p12NCBI
CEL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,061,981 - 133,071,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,061,981 - 133,071,861 (+)Ensemblhg38GRCh38
GRCh379135,937,368 - 135,947,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,927,186 - 134,937,069 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349132,966,918 - 132,976,801NCBI
Celera9106,479,095 - 106,504,472 (+)NCBICelera
Cytogenetic Map9q34.13NCBI
HuRef9105,431,068 - 105,440,909 (+)NCBIHuRef
CHM1_19136,087,941 - 136,097,924 (+)NCBICHM1_1
T2T-CHM13v2.09145,276,137 - 145,285,985 (+)NCBIT2T-CHM13v2.0
Cel
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39228,445,831 - 28,453,415 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl228,445,807 - 28,453,415 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38228,555,819 - 28,563,403 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,555,795 - 28,563,403 (-)Ensemblmm10GRCm38
MGSCv37228,411,339 - 28,418,882 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36228,377,828 - 28,385,371 (-)NCBIMGSCv36mm8
Celera228,259,995 - 28,267,538 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.38NCBI
Cel
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555132,324,025 - 2,382,877 (+)NCBIChiLan1.0ChiLan1.0
CEL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,284,217 - 6,298,052 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan196,287,257 - 6,297,627 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,180,310 - 104,191,434 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19132,809,606 - 132,821,010 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9132,810,986 - 132,821,010 (+)EnsemblpanPan2panpan1.1
CEL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,337,205 - 51,345,284 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl951,337,187 - 51,362,422 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha950,600,407 - 50,608,486 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0952,230,487 - 52,238,498 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl952,230,540 - 52,255,656 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1951,009,024 - 51,017,035 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0951,333,616 - 51,341,559 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0951,412,863 - 51,420,943 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cel
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,691,971 - 199,702,102 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648719,463,182 - 19,469,900 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648719,463,219 - 19,472,029 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,763,003 - 272,770,170 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11272,763,203 - 272,770,259 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,719,658 - 306,726,753 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CEL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,053,817 - 5,077,487 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl125,066,882 - 5,077,227 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607910,574,982 - 10,585,407 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cel
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v158,113,183 - 8,120,587 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cel
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:42
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000014572
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
D3Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2311,884,712 - 11,884,828 (+)MAPPERmRatBN7.2
Rnor_6.037,135,202 - 7,135,317NCBIRnor6.0
Rnor_5.0312,486,219 - 12,486,334UniSTSRnor5.0
RGSC_v3.437,542,305 - 7,542,420UniSTSRGSC3.4
RGSC_v3.437,542,304 - 7,542,420RGDRGSC3.4
Celera36,666,010 - 6,666,125UniSTS
RGSC_v3.137,542,604 - 7,542,720RGD
RH 3.4 Map321.8RGD
RH 3.4 Map321.8UniSTS
Cytogenetic Map3p12UniSTS
D3Arb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8332,287,733 - 32,288,067 (+)Marker Load Pipeline
Rnor_6.037,140,238 - 7,140,570NCBIRnor6.0
Rnor_5.0312,491,255 - 12,491,693UniSTSRnor5.0
RGSC_v3.437,547,341 - 7,548,297UniSTSRGSC3.4
Celera36,671,047 - 6,671,265UniSTS
RH 3.4 Map321.9RGD
RH 3.4 Map321.9UniSTS
SHRSP x BN Map32.2899RGD
SHRSP x BN Map32.2899UniSTS
Cytogenetic Map3p12UniSTS
RH132776  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8332,283,352 - 32,283,672 (+)Marker Load Pipeline
mRatBN7.2311,885,366 - 11,885,686 (+)MAPPERmRatBN7.2
Rnor_6.037,135,856 - 7,136,175NCBIRnor6.0
Rnor_5.0312,486,873 - 12,487,192UniSTSRnor5.0
RGSC_v3.437,542,959 - 7,543,278UniSTSRGSC3.4
Celera36,666,664 - 6,666,984UniSTS
RH 3.4 Map321.8UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 11 61 156 90 89 58 85 58 6 333 178 10 134 76 89 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014572   ⟹   ENSRNOP00000014572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl332,281,518 - 32,289,019 (-)Ensembl
mRatBN7.2 Ensembl311,883,532 - 11,891,035 (-)Ensembl
Rnor_6.0 Ensembl37,134,021 - 7,141,522 (-)Ensembl
RefSeq Acc Id: NM_016997   ⟹   NP_058693
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,281,518 - 32,289,019 (-)NCBI
mRatBN7.2311,883,532 - 11,891,035 (-)NCBI
Rnor_6.037,134,021 - 7,141,522 (-)NCBI
Rnor_5.0312,485,038 - 12,492,645 (-)NCBI
RGSC_v3.437,541,127 - 7,549,245 (-)RGD
Celera36,664,206 - 6,672,217 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058693 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41540 (Get FASTA)   NCBI Sequence Viewer  
  AAB46376 (Get FASTA)   NCBI Sequence Viewer  
  CAA34189 (Get FASTA)   NCBI Sequence Viewer  
  CAA80460 (Get FASTA)   NCBI Sequence Viewer  
  EDL93407 (Get FASTA)   NCBI Sequence Viewer  
  EDL93408 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014572
GenBank Protein P07882 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058693   ⟸   NM_016997
- Peptide Label: precursor
- UniProtKB: P14722 (UniProtKB/Swiss-Prot),   P07882 (UniProtKB/Swiss-Prot),   G3V7G2 (UniProtKB/TrEMBL),   A6JTP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014572   ⟸   ENSRNOT00000014572
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07882-F1-model_v2 AlphaFold P07882 1-612 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691934
Promoter ID:EPDNEW_R2459
Type:multiple initiation site
Name:Cel_1
Description:carboxyl ester lipase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.037,141,522 - 7,141,582EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2331 AgrOrtholog
BioCyc Gene G2FUF-50278 BioCyc
Ensembl Genes ENSRNOG00000010406 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014572 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Neuroligin/BSAL UniProtKB/Swiss-Prot
NCBI Gene 24254 ENTREZGENE
PANTHER NEUROLIGIN UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Cel PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010406 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A6JTN9_RAT UniProtKB/TrEMBL
  A6JTP0 ENTREZGENE, UniProtKB/TrEMBL
  CEL_RAT UniProtKB/Swiss-Prot
  G3V7G2 ENTREZGENE, UniProtKB/TrEMBL
  P07882 ENTREZGENE
  P14722 ENTREZGENE
UniProt Secondary P14722 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cel  Carboxyl ester lipase      Symbol and Name status set to approved 70586 APPROVED