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Gene: Ptmal5 (prothymosin alpha like 5) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Ptmal5

Name:

prothymosin alpha like 5

RGD ID:

2323611

Description:

Orthologous to human PTMA (prothymosin alpha).

Type:

pseudo (Ensembl: protein-coding)

RefSeq Status:

INFERRED

Previously known as:

hypothetical protein LOC100359583; LOC100359583; prothymosin alpha; prothymosin-alpha

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Alliance orthologs ³				less info ...
Mus musculus (house mouse):	Ptma (prothymosin alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Ptma (prothymosin alpha)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PTMA (prothymosin alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	PTMA (prothymosin alpha)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ptmab (prothymosin alpha b)	Alliance	DIOPT (OrthoFinder\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	ptmaa (prothymosin alpha a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	ptmaa (prothymosin alpha a)	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ptma	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,453,151 - 86,454,460 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	86,453,334 - 86,454,481 (-)	Ensembl				GRCr8
mRatBN7.2	13	83,920,723 - 83,922,032 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,921,044 - 83,922,040 (-)	Ensembl				mRatBN7.2
Rnor_6.0	13	89,873,071 - 89,874,033 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,873,243 - 89,874,008 (-)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	9	93,545,396 - 93,549,436 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	94,500,396 - 94,501,354 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	87,418,455 - 87,418,972 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	83,551,507 - 83,552,469 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

nucleus (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription.	Karetsou Z, etal., EMBO Rep. 2002 Apr;3(4):361-6. Epub 2002 Mar 15.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2226321	PMID:25002582

Genomics

Variants

Variants in Ptmal5
6 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

AU049413

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	83,923,276 - 83,923,462 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	89,875,273 - 89,875,456	NCBI	Rnor6.0
Rnor_5.0	13	94,502,598 - 94,502,781	UniSTS	Rnor5.0
RGSC_v3.4	13	87,420,218 - 87,420,401	UniSTS	RGSC3.4
Celera	13	83,553,709 - 83,553,892	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
18	22	98	226	182	180	118	50	118	12	436	194	186	90	120	62

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_081583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003751278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003752676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M60664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025093 ⟹ ENSRNOP00000025093

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	87,176,252 - 87,180,333 (+)	Ensembl
Rnor_6.0 Ensembl	9	93,545,396 - 93,549,436 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000051368 ⟹ ENSRNOP00000059708

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	83,921,044 - 83,922,040 (-)	Ensembl
Rnor_6.0 Ensembl	13	89,873,243 - 89,874,008 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094457 ⟹ ENSRNOP00000095675

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	87,176,230 - 87,180,333 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102204 ⟹ ENSRNOP00000086906

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	87,177,984 - 87,180,312 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108532 ⟹ ENSRNOP00000082211

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	87,177,945 - 87,180,312 (+)	Ensembl

RefSeq Acc Id:

XM_003751278 ⟹ XP_003751326

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	83,921,073 - 83,922,040 (-)	NCBI
Rnor_6.0	13	89,873,071 - 89,874,033 (-)	NCBI
Rnor_5.0	13	94,500,396 - 94,501,354 (-)	NCBI

Sequence:

show sequence

CCCCCCCCACTGGCTGCTCCGAAAAGCCATCTTTGCATTGTTCCCGGGTCGTGCTCCGCGCTCA
CTGCAGCCACCTTCGCCGCCCACCGTCTCCTCCAACGCGGACTCCGGCAGCTTTCTCGCCAGAG
TCCTCGAAACTCCACTAATTCCTTACGCGTAGCATCAGACCACCGGCGTGCCCCACCATGTCAG
ACGCGGCAGTGGACACCAGCTCCGAGATCACCACCAAGGACTTGAAGGAGAAGAAGGAAGTTGT
GGAGGAGGCAGAGAATGGAAGAGACGCACCTGCCAATGGGAACGCTCAAAATGAGGAAAATGGG
GAGCAGGAGGCTGACAATGAGGTAGATGAAGAAGAGGAAGAAGGTGGGGAGGAAGAGGAGGAGG
AAGAAGAAGGTGATGGTGAGGAAGAAGATGGAGATGAAGATGAGGAAGCTGAGGCTCCTACGGG
CAAGCGGGTAGCTGAGGATGATGAGGATGATGATGTTGAGACCAAGAAGCAGAAGAAGACTGAT
GAGGATGACTAGACAGCAAAAGGAAAAGCTAACCTTACGCACCGTGACCTATTCACCCTCCACT
TCCCGTCTCAGAATTTAAACGTGGTCACCTTCGAGTAGAGAAGCAGGCCCCCGCCCGCCCACTG
CGGGCAGTGCCACCCACACATGACATGCGCTCTTCACCACCCCACCAAAACCACAACATGAATT
GGCAACATGGGAGGAGAAAAGAACCAGAACTTCCCAGGCCCTGCTTTTTTTCTTAAAAATACTT
TAAAAGGAAAATTTGTTTGTATTTTTTTATTTACATTTTATATTTTTGTACATATTGTTAGGGG
TCAGCCATTTTTAATGATAACGGGTGACCAAACCAGCCTTCAGAGCGTTTTCTGTCCTACTTCA
GACTTTACTTGTGGTGTGACCATGTTCATTATACTCTCAAAGGAGAAAAAAAACCTTGTAAAAA
AAA

hide sequence

Protein Sequences


GenBank Protein	AAA41941	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000086906.2
	ENSRNOP00000095675.1

RefSeq Acc Id:	XP_003751326 ⟸ XM_003751278
- Sequence:	show sequence MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAQNEENGEQEADNEVDEEEEEGGEEE EEEEEGDGEEEDGDEDEEAEAPTGKRVAEDDEDDDVETKKQKKTDEDD hide sequence

Ensembl Acc Id:

ENSRNOP00000059708 ⟸ ENSRNOT00000051368

Ensembl Acc Id:

ENSRNOP00000025093 ⟸ ENSRNOT00000025093

Ensembl Acc Id:

ENSRNOP00000086906 ⟸ ENSRNOT00000102204

Ensembl Acc Id:

ENSRNOP00000082211 ⟸ ENSRNOT00000108532

Ensembl Acc Id:

ENSRNOP00000095675 ⟸ ENSRNOT00000094457

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P06302-F1-model_v2	AlphaFold	P06302	1-112	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699015

Promoter ID:

EPDNEW_R9534

Type:

multiple initiation site

Name:

Ptma_1

Description:

prothymosin alpha

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	89,874,025 - 89,874,085	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2323611	AgrOrtholog
BioCyc Gene	G2FUF-17365	BioCyc
Ensembl Genes	ENSRNOG00000018584	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000025731	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000094457.2	UniProtKB/TrEMBL
	ENSRNOT00000102204.2	UniProtKB/TrEMBL
InterPro	Pro/parathymosin	UniProtKB/TrEMBL
NCBI Gene	100359583	ENTREZGENE
PANTHER	PROTHYMOSIN ALPHA	UniProtKB/TrEMBL
	PTHR22745	UniProtKB/TrEMBL
Pfam	Prothymosin	UniProtKB/TrEMBL
PhenoGen	Ptmal5	PhenoGen
RatGTEx	ENSRNOG00000018584	RatGTEx
	ENSRNOG00000025731	RatGTEx
UniProt	A0A8I6AP82_RAT	UniProtKB/TrEMBL
	A0A8I6GFG4_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-10-13	Ptmal5	prothymosin alpha like 5	Ptmal1	prothymosin alpha like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2023-09-19	Ptmal1	prothymosin alpha like 1	LOC100359583	hypothetical protein LOC100359583	Symbol and Name Changed	1299863	APPROVED
2010-05-06	LOC100359583	hypothetical protein LOC100359583			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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