Actg1l1 (actin, gamma 1 like 1) - Rat Genome Database

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Gene: Actg1l1 (actin, gamma 1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Actg1l1
Name: actin, gamma 1 like 1
RGD ID: 2320108
Description: A structural constituent of postsynaptic actin cytoskeleton. Involved in response to calcium ion and response to mechanical stimulus. Is active in postsynaptic actin cytoskeleton and presynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 2 and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTG1 (actin gamma 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin, cytoplasmic 2; actin, gamma 1 propeptide-like; actin-1; LOC100361457
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8393,434,045 - 93,435,969 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl393,434,045 - 93,474,629 (+)EnsemblGRCr8
mRatBN7.2372,977,767 - 72,979,691 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,619,737 - 105,624,232 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl372,977,773 - 72,979,693 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl372,977,767 - 72,979,694 (-)EnsemblmRatBN7.2
Rnor_6.0375,643,053 - 75,644,978 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0382,359,486 - 82,361,393 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4371,261,736 - 71,263,201 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera372,258,396 - 72,270,791 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Presbycusis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. beta-Actin is confined to structures having high capacity of remodelling in developing and adult rat cerebellum. Micheva KD, etal., Eur J Neurosci. 1998 Dec;10(12):3785-98.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8476030   PMID:22926577   PMID:23580065   PMID:24780915  


Genomics

Variants

.
Variants in Actg1l1
17 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
PMC138261P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
PMC156330P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1951,258,498 - 51,259,502UniSTS
Celera1213,454,501 - 13,455,354UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map18p12UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map10q32.3UniSTS
PMC201106P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map18p12UniSTS
PMC22644P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
PMC302066P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
PMC97568P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
RH128697  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
PMC156124P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map18p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 61 134 57 60 41 86 41 298 168 11 125 71 73 19 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000079310   ⟹   ENSRNOP00000072273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl372,977,767 - 72,979,694 (-)Ensembl
Rnor_6.0 Ensembl375,643,054 - 75,644,954 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl372,977,773 - 72,979,693 (+)Ensembl
RefSeq Acc Id: NM_001409346   ⟹   NP_001396275
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8393,434,045 - 93,435,969 (+)NCBI
mRatBN7.2372,977,767 - 72,979,691 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001396275 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000096406.1
  ENSRNOP00000109636
Ensembl Acc Id: ENSRNOP00000072273   ⟸   ENSRNOT00000079310
RefSeq Acc Id: NP_001396275   ⟸   NM_001409346
- UniProtKB: P63259 (UniProtKB/Swiss-Prot),   A6HLC1 (UniProtKB/TrEMBL),   A0A8L2QLX4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63259-F1-model_v2 AlphaFold P63259 1-375 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692198
Promoter ID:EPDNEW_R2719
Type:multiple initiation site
Name:LOC100361457_1
Description:actin, gamma 1 propeptide-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0375,643,057 - 75,643,117EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2320108 AgrOrtholog
BioCyc Gene G2FUF-48969 BioCyc
Ensembl Genes ENSRNOG00000036701 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000053452 Ensembl, ENTREZGENE
  ENSRNOG00000069875 Ensembl
Ensembl Transcript ENSRNOT00000099821.2 UniProtKB/TrEMBL
  ENSRNOT00000102734 ENTREZGENE
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  Actin, Chain A, domain 2 UniProtKB/TrEMBL
InterPro Actin UniProtKB/TrEMBL
  Actin_CS UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
NCBI Gene 100361457 ENTREZGENE
PANTHER PTHR11937 UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PhenoGen Actg1l1 PhenoGen
PROSITE ACTINS_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036701 RatGTEx
  ENSRNOG00000053452 RatGTEx
  ENSRNOG00000069875 RatGTEx
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A8I6AQR0_RAT UniProtKB/TrEMBL
  A0A8L2QLX4 ENTREZGENE
  A6HLC1 ENTREZGENE
  P63259 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Actg1l1  actin, gamma 1 like 1  LOC100361457  actin, gamma 1 propeptide-like  Symbol and Name Changed 1299863 APPROVED
2010-05-05 LOC100361457  actin, gamma 1 propeptide-like      Symbol and Name status set to provisional 70820 PROVISIONAL