Calcrl (calcitonin receptor like receptor) - Rat Genome Database

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Gene: Calcrl (calcitonin receptor like receptor) Rattus norvegicus
Analyze
Symbol: Calcrl
Name: calcitonin receptor like receptor
RGD ID: 2255
Description: Predicted to enable adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in negative regulation of smooth muscle contraction. Is active in neuronal dense core vesicle and synaptic vesicle. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (calcitonin receptor like receptor); INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcitonin gene-related peptide type 1 receptor; calcitonin receptor-like; calcitonin receptor-like receptor; CGRP type 1 receptor; CLR; Crlr; RATCRLR; RNCLR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,835,071 - 89,932,616 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl389,835,077 - 89,887,350 (-)EnsemblGRCr8
mRatBN7.2369,428,348 - 69,525,910 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,430,120 - 69,525,910 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx372,811,179 - 72,908,073 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,409,834 - 81,506,738 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,163,302 - 79,260,027 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,747,938 - 71,845,487 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,747,956 - 71,845,232 (-)Ensemblrn6Rnor6.0
Rnor_5.0378,269,326 - 78,366,557 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4367,553,022 - 67,646,877 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera368,788,591 - 68,882,607 (-)NCBICelera
RGSC_v3.1367,449,393 - 67,543,249 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
eugenol  (ISO)
iron dichloride  (ISO)
isoprenaline  (EXP)
leflunomide  (ISO)
miconazole  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nitric oxide  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs? Barwell J, etal., Br J Pharmacol. 2012 May;166(1):51-65. doi: 10.1111/j.1476-5381.2011.01525.x.
2. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
3. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Chang CP, etal., Neuron 1993 Dec;11(6):1187-95.
4. THE ROLE OF CALCITONIN RECEPTOR-LIKE RECEPTOR IN COLONIC MOTILITY AND INFLAMMATION. Clifton MS, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar 15;.
5. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors. Marvizón JC, etal., Neuroscience. 2007 Aug 10;148(1):250-65. doi: 10.1016/j.neuroscience.2007.05.036. Epub 2007 Jul 5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. A new calcitonin-receptor-like sequence in rat pulmonary blood vessels. Njuki F, etal., Clin Sci (Lond) 1993 Oct;85(4):385-8.
12. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Qing X, etal., Am J Physiol Lung Cell Mol Physiol 2001 Mar;280(3):L547-54.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Antiapoptotic effect of calcitonin gene-related peptide on oxidative stress-induced injury in H9c2 cardiomyocytes via the RAMP1/CRLR complex. Sueur S, etal., J Mol Cell Cardiol. 2005 Dec;39(6):955-63. Epub 2005 Oct 19.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats. Yoshihara F, etal., Hypertension 2001 Feb;37(2):216-22.
Additional References at PubMed
PMID:8582325   PMID:9620797   PMID:10882736   PMID:11556887   PMID:11847213   PMID:12538603   PMID:12801991   PMID:12837925   PMID:14642779   PMID:15193773   PMID:15315911   PMID:15643132  
PMID:15680493   PMID:16537897   PMID:16713642   PMID:17301036   PMID:17310067   PMID:17660394   PMID:18039931   PMID:18434369   PMID:18655130   PMID:19041918   PMID:20074556   PMID:20596610  
PMID:21034462   PMID:21040789   PMID:21111722   PMID:22102369   PMID:22208649   PMID:22233274   PMID:23570731   PMID:24177018   PMID:25061099   PMID:26927337   PMID:27338549   PMID:29087309  


Genomics

Comparative Map Data
Calcrl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,835,071 - 89,932,616 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl389,835,077 - 89,887,350 (-)EnsemblGRCr8
mRatBN7.2369,428,348 - 69,525,910 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,430,120 - 69,525,910 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx372,811,179 - 72,908,073 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,409,834 - 81,506,738 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,163,302 - 79,260,027 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,747,938 - 71,845,487 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,747,956 - 71,845,232 (-)Ensemblrn6Rnor6.0
Rnor_5.0378,269,326 - 78,366,557 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4367,553,022 - 67,646,877 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera368,788,591 - 68,882,607 (-)NCBICelera
RGSC_v3.1367,449,393 - 67,543,249 (-)NCBI
Cytogenetic Map3q24NCBI
CALCRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382187,341,964 - 187,448,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2187,341,946 - 187,448,506 (-)Ensemblhg38GRCh38
GRCh372188,206,691 - 188,312,979 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,916,091 - 188,021,266 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342188,035,337 - 188,138,484NCBI
Celera2181,804,216 - 181,909,138 (-)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2180,066,508 - 180,172,591 (-)NCBIHuRef
CHM1_12188,212,632 - 188,318,691 (-)NCBICHM1_1
T2T-CHM13v2.02187,831,183 - 187,937,204 (-)NCBIT2T-CHM13v2.0
Calcrl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,160,970 - 84,255,786 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,160,970 - 84,255,755 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38284,330,626 - 84,425,405 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,330,626 - 84,425,411 (-)Ensemblmm10GRCm38
MGSCv37284,170,783 - 84,265,423 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36284,131,465 - 84,177,826 (-)NCBIMGSCv36mm8
Celera285,934,298 - 86,033,453 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.38NCBI
Calcrl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540311,080,874 - 11,118,494 (+)Ensembl
ChiLan1.0NW_00495540311,016,753 - 11,118,494 (+)NCBIChiLan1.0ChiLan1.0
CALCRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21390,010,005 - 90,113,723 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B90,025,544 - 90,128,696 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B74,622,892 - 74,728,067 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B192,422,283 - 192,525,916 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B192,422,283 - 192,463,064 (-)EnsemblpanPan2panpan1.1
CALCRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13629,342,869 - 29,442,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3629,345,236 - 29,442,732 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3629,242,232 - 29,342,195 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03629,565,888 - 29,666,202 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3629,565,658 - 29,666,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13629,628,014 - 29,728,166 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03629,561,790 - 29,663,178 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03629,731,680 - 29,831,875 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Calcrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303146,545,711 - 146,646,302 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650610,249,687 - 10,292,424 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650610,191,789 - 10,292,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALCRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1592,233,841 - 92,332,386 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11592,233,264 - 92,332,459 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215102,426,205 - 102,522,564 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CALCRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11072,884,271 - 72,986,916 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1072,887,139 - 72,925,198 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040126,514,636 - 126,617,444 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Calcrl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248992,487,225 - 2,594,780 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248992,487,261 - 2,593,304 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Calcrl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1561,737,771 - 61,782,949 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Calcrl
513 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:105
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000006462
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
D3Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8389,836,940 - 89,837,135 (+)Marker Load Pipeline
mRatBN7.2369,430,219 - 69,430,414 (+)MAPPERmRatBN7.2
Rnor_6.0371,749,798 - 71,749,992NCBIRnor6.0
Rnor_5.0378,271,111 - 78,271,305UniSTSRnor5.0
RGSC_v3.4367,552,320 - 67,552,514UniSTSRGSC3.4
Celera368,787,875 - 68,788,083UniSTS
Cytogenetic Map3q24UniSTS
UniSTS:488324  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2369,517,643 - 69,518,316 (+)MAPPERmRatBN7.2
Rnor_6.0371,837,227 - 71,837,899NCBIRnor6.0
Rnor_5.0378,358,296 - 78,358,968UniSTSRnor5.0
RGSC_v3.4367,638,872 - 67,639,544UniSTSRGSC3.4
Celera368,874,596 - 68,875,268UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map6q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 355 192 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078645   ⟹   ENSRNOP00000074452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl389,835,077 - 89,887,350 (-)Ensembl
mRatBN7.2 Ensembl369,430,120 - 69,525,910 (-)Ensembl
Rnor_6.0 Ensembl371,750,500 - 71,845,232 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088170   ⟹   ENSRNOP00000070720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl389,835,077 - 89,880,492 (-)Ensembl
mRatBN7.2 Ensembl369,430,120 - 69,473,780 (-)Ensembl
Rnor_6.0 Ensembl371,747,956 - 71,798,531 (-)Ensembl
RefSeq Acc Id: NM_012717   ⟹   NP_036849
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,835,071 - 89,932,616 (-)NCBI
mRatBN7.2369,428,350 - 69,525,910 (-)NCBI
Rnor_6.0371,750,500 - 71,845,232 (-)NCBI
Rnor_5.0378,269,326 - 78,366,557 (-)NCBI
RGSC_v3.4367,553,022 - 67,646,877 (-)RGD
Celera368,788,591 - 68,882,607 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234439   ⟹   XP_006234501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,835,144 - 89,932,507 (-)NCBI
mRatBN7.2369,428,348 - 69,525,798 (-)NCBI
Rnor_6.0371,747,938 - 71,845,402 (-)NCBI
Rnor_5.0378,269,326 - 78,366,557 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036849 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234501 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA49997 (Get FASTA)   NCBI Sequence Viewer  
  EDL79299 (Get FASTA)   NCBI Sequence Viewer  
  EDL79300 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074452
  ENSRNOP00000074452.1
GenBank Protein Q63118 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036849   ⟸   NM_012717
- Peptide Label: precursor
- UniProtKB: A0A8L2R2X9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234501   ⟸   XM_006234439
- Peptide Label: isoform X1
- UniProtKB: Q63118 (UniProtKB/Swiss-Prot),   A6HMP9 (UniProtKB/TrEMBL),   A0A8L2R2X9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074452   ⟸   ENSRNOT00000078645
Ensembl Acc Id: ENSRNOP00000070720   ⟸   ENSRNOT00000088170
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63118-F1-model_v2 AlphaFold Q63118 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2255 AgrOrtholog
BioCyc Gene G2FUF-49183 BioCyc
Ensembl Genes ENSRNOG00000054695 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078645 ENTREZGENE
  ENSRNOT00000078645.2 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GCPR_2_calcitonin_rcpt_fam UniProtKB/Swiss-Prot
  GPCR_2 UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
  GPCR_2_CGRP1_rcpt UniProtKB/Swiss-Prot
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot
  GPCR_2_secretin-like UniProtKB/Swiss-Prot
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot
KEGG Report rno:25029 UniProtKB/Swiss-Prot
NCBI Gene 25029 ENTREZGENE
PANTHER CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR UniProtKB/Swiss-Prot
  PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam 7tm_2 UniProtKB/Swiss-Prot
  HRM UniProtKB/Swiss-Prot
PhenoGen Calcrl PhenoGen
PRINTS CGRPRECEPTOR UniProtKB/Swiss-Prot
  CTRFAMILY UniProtKB/Swiss-Prot
  GPCRSECRETIN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054695 RatGTEx
SMART HormR UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
  SSF111418 UniProtKB/Swiss-Prot
TIGR TC230639
UniProt A0A8L2R2X9 ENTREZGENE, UniProtKB/TrEMBL
  A6HMP9 ENTREZGENE, UniProtKB/TrEMBL
  CALRL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-12-13 Calcrl  calcitonin receptor like receptor  Calcrl  calcitonin receptor-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Calcrl  calcitonin receptor-like  Calcrl  calcitonin receptor-like receptor  Name updated 629478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in chronic heart failure 625420
gene_expression expressed in lung 68902
gene_expression expressed in atria and ventricles of the heart 625420
gene_function acts as either a calcitonin gene-related peptide receptor or an adrenomedullin receptor 68718
gene_function acts as either a calcitonin gene-related peptide receptor or an adrenomedullin receptor 68902
gene_process may play a role in vascular tone maintenance 68686
gene_regulation induced by several growth factors including colony stimulating factor-1, epidermal growth factor, and Ang II 68718