Calcrl (calcitonin receptor like receptor)

Gene: Calcrl (calcitonin receptor like receptor) Rattus norvegicus

Analyze

Symbol:

Calcrl

Name:

calcitonin receptor like receptor

RGD ID:

2255

Description:

Predicted to enable adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in negative regulation of smooth muscle contraction. Is active in neuronal dense core vesicle and synaptic vesicle. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (calcitonin receptor like receptor); INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

calcitonin gene-related peptide type 1 receptor; calcitonin receptor-like; calcitonin receptor-like receptor; CGRP type 1 receptor; CLR; Crlr; RATCRLR; RNCLR

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CALCRL (calcitonin receptor like receptor)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):	Calcrl (calcitonin receptor-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Calcrl (calcitonin receptor like receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CALCRL (calcitonin receptor like receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CALCRL (calcitonin receptor like receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Calcrl (calcitonin receptor like receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CALCRL (calcitonin receptor like receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CALCRL (calcitonin receptor like receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Calcrl (calcitonin receptor like receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CALCR (calcitonin receptor)	HGNC	OrthoDB
Homo sapiens (human):	APBB1IP (amyloid beta precursor protein binding family B member 1 interacting protein)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CALCRL (calcitonin receptor like receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Calcrl (calcitonin receptor-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	calcrla (calcitonin receptor-like a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	calcrlb (calcitonin receptor-like b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Dh31-R	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pdfr-1	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	hec	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	calcrl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	89,835,071 - 89,932,616 (-)	NCBI		GRCr8
mRatBN7.2	3	69,428,348 - 69,525,910 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	69,430,120 - 69,525,910 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	72,811,179 - 72,908,073 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	81,409,834 - 81,506,738 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	79,163,302 - 79,260,027 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	71,747,938 - 71,845,487 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	71,747,956 - 71,845,232 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	78,269,326 - 78,366,557 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	67,553,022 - 67,646,877 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	67,449,393 - 67,543,249 (-)	NCBI
Celera	3	68,788,591 - 68,882,607 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

brain infarction (IEP)

COVID-19 (ISO)

genetic disease (ISO)

Lymphatic Malformation 8 (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (EXP)

1,2-dichloroethane (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

calciol (EXP)

CGP 52608 (ISO)

chlordecone (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

cobalt atom (ISO)

cobalt dichloride (ISO)

colforsin daropate hydrochloride (ISO)

cyclosporin A (ISO)

DDT (EXP)

dimethylarsinic acid (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

eugenol (ISO)

iron dichloride (ISO)

isoprenaline (EXP)

leflunomide (ISO)

miconazole (ISO)

nickel sulfate (ISO)

nicotine (EXP)

nitric oxide (EXP)

orphenadrine (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phenylephrine (EXP)

pirinixic acid (ISO)

progesterone (EXP)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IBA,IEA,ISO,NAS)

adrenomedullin receptor signaling pathway (IEA,ISO,NAS)

angiogenesis (IBA,IEA,ISO)

calcitonin gene-related peptide receptor signaling pathway (IEA,ISO)

calcium ion transport (IEA,ISO)

cell population proliferation (ISO)

cell surface receptor signaling pathway (IEA)

cellular response to sucrose stimulus (IEA,ISO)

heart development (IEA,ISO)

negative regulation of smooth muscle contraction (IMP)

positive regulation of cell population proliferation (ISO)

positive regulation of vascular associated smooth muscle cell proliferation (IEA,ISO)

protein transport (IEA,ISO)

receptor internalization (IEA,ISO)

smooth muscle cell proliferation (ISO)

vascular associated smooth muscle cell proliferation (IEA,ISO)

Cellular Component

adrenomedullin receptor complex (IEA,ISO,ISS)

CGRP receptor complex (IEA,ISO)

cytoplasm (ISO)

endoplasmic reticulum (IEA,ISO)

endosome (IEA,ISO)

lysosome (IEA,ISO)

neuronal dense core vesicle (IDA)

plasma membrane (IBA,ISO)

synaptic vesicle (IDA)

Molecular Function

adrenomedullin binding (IEA,ISO)

adrenomedullin receptor activity (IBA,IEA,ISO)

calcitonin gene-related peptide receptor activity (IBA,IEA,ISO)

calcitonin receptor activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?	Barwell J, etal., Br J Pharmacol. 2012 May;166(1):51-65. doi: 10.1111/j.1476-5381.2011.01525.x.
2.	Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke.	Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
3.	Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain.	Chang CP, etal., Neuron 1993 Dec;11(6):1187-95.
4.	THE ROLE OF CALCITONIN RECEPTOR-LIKE RECEPTOR IN COLONIC MOTILITY AND INFLAMMATION.	Clifton MS, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar 15;.
5.	Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure.	Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors.	Marvizón JC, etal., Neuroscience. 2007 Aug 10;148(1):250-65. doi: 10.1016/j.neuroscience.2007.05.036. Epub 2007 Jul 5.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	A new calcitonin-receptor-like sequence in rat pulmonary blood vessels.	Njuki F, etal., Clin Sci (Lond) 1993 Oct;85(4):385-8.
12.	mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung.	Qing X, etal., Am J Physiol Lung Cell Mol Physiol 2001 Mar;280(3):L547-54.
13.	GOA pipeline	RGD automated data pipeline
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Antiapoptotic effect of calcitonin gene-related peptide on oxidative stress-induced injury in H9c2 cardiomyocytes via the RAMP1/CRLR complex.	Sueur S, etal., J Mol Cell Cardiol. 2005 Dec;39(6):955-63. Epub 2005 Oct 19.
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17.	Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats.	Yoshihara F, etal., Hypertension 2001 Feb;37(2):216-22.

Additional References at PubMed

PMID:8582325	PMID:9620797	PMID:10882736	PMID:11556887	PMID:11847213	PMID:12538603	PMID:12801991	PMID:12837925	PMID:14642779	PMID:15193773	PMID:15315911	PMID:15643132
PMID:15680493	PMID:16537897	PMID:16713642	PMID:17301036	PMID:17310067	PMID:17660394	PMID:18039931	PMID:18434369	PMID:18655130	PMID:19041918	PMID:20074556	PMID:20596610
PMID:21034462	PMID:21040789	PMID:21111722	PMID:22102369	PMID:22208649	PMID:22233274	PMID:23570731	PMID:24177018	PMID:25061099	PMID:26927337	PMID:27338549	PMID:29087309

Genomics

Comparative Map Data

Calcrl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	89,835,071 - 89,932,616 (-)	NCBI		GRCr8
mRatBN7.2	3	69,428,348 - 69,525,910 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	69,430,120 - 69,525,910 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	72,811,179 - 72,908,073 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	81,409,834 - 81,506,738 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	79,163,302 - 79,260,027 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	71,747,938 - 71,845,487 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	71,747,956 - 71,845,232 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	78,269,326 - 78,366,557 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	67,553,022 - 67,646,877 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	67,449,393 - 67,543,249 (-)	NCBI
Celera	3	68,788,591 - 68,882,607 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

CALCRL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	187,341,964 - 187,448,252 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	187,341,964 - 187,448,460 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	188,206,691 - 188,312,979 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	187,916,091 - 188,021,266 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	188,035,337 - 188,138,484	NCBI
Celera	2	181,804,216 - 181,909,138 (-)	NCBI		Celera
Cytogenetic Map	2	q32.1	NCBI
HuRef	2	180,066,508 - 180,172,591 (-)	NCBI		HuRef
CHM1_1	2	188,212,632 - 188,318,691 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	187,831,183 - 187,937,204 (-)	NCBI		T2T-CHM13v2.0

Calcrl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	84,160,970 - 84,255,786 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	84,160,970 - 84,255,755 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	84,330,626 - 84,425,405 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	84,330,626 - 84,425,411 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	84,170,783 - 84,265,423 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	84,131,465 - 84,177,826 (-)	NCBI		MGSCv36	mm8
Celera	2	85,934,298 - 86,033,453 (-)	NCBI		Celera
Cytogenetic Map	2	D	NCBI
cM Map	2	49.38	NCBI

Calcrl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	11,080,874 - 11,118,494 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	11,016,753 - 11,118,494 (+)	NCBI	ChiLan1.0	ChiLan1.0

CALCRL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	90,010,005 - 90,113,723 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	90,025,544 - 90,128,696 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	74,622,892 - 74,728,067 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	192,422,283 - 192,525,916 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	192,422,283 - 192,463,064 (-)	Ensembl	panpan1.1		panPan2

CALCRL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	29,342,869 - 29,442,977 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	29,345,236 - 29,442,732 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	29,242,232 - 29,342,195 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	29,565,888 - 29,666,202 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	29,565,658 - 29,666,020 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	29,628,014 - 29,728,166 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	29,561,790 - 29,663,178 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	29,731,680 - 29,831,875 (-)	NCBI		UU_Cfam_GSD_1.0

Calcrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	146,545,711 - 146,646,302 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936506	10,249,687 - 10,292,424 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936506	10,191,789 - 10,292,355 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CALCRL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	92,233,841 - 92,332,386 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	92,233,264 - 92,332,459 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	102,426,205 - 102,522,564 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CALCRL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	72,884,271 - 72,986,916 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	72,887,139 - 72,925,198 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	126,514,636 - 126,617,444 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Calcrl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624899	2,487,225 - 2,594,780 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624899	2,487,261 - 2,593,304 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Calcrl
483 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	141
Count of miRNA genes:	105
Interacting mature miRNAs:	125
Transcripts:	ENSRNOT00000006462
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat
2302055	Pia30	Pristane induced arthritis QTL 30	3.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	3	27936919	72936919	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	28249687	73249687	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	28249687	73249687	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	28249687	73249687	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	28249687	73249687	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	28249687	73249687	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	28468571	73468571	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	28468571	73468571	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
11565451	Bw177	Body weight QTL 177		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	3	31426403	70668733	Rat
11565452	Kidm57	Kidney mass QTL 57		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	31426403	70668733	Rat
12879866	Cm94	Cardiac mass QTL 94		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	31426403	70668733	Rat
12879867	Cm95	Cardiac mass QTL 95		0.047	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	31426403	70668733	Rat
12879868	Am6	Aortic mass QTL 6		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	31426403	70668733	Rat
2301400	Cm68	Cardiac mass QTL 68		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	31426403	70668733	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	61134348	89115068	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat

Markers in Region

D3Wox15

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	69,430,219 - 69,430,414 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	71,749,798 - 71,749,992	NCBI	Rnor6.0
Rnor_5.0	3	78,271,111 - 78,271,305	UniSTS	Rnor5.0
RGSC_v3.4	3	67,552,320 - 67,552,514	UniSTS	RGSC3.4
Celera	3	68,787,875 - 68,788,083	UniSTS
Cytogenetic Map	3	q24	UniSTS

UniSTS:488324

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	69,517,643 - 69,518,316 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	71,837,227 - 71,837,899	NCBI	Rnor6.0
Rnor_5.0	3	78,358,296 - 78,358,968	UniSTS	Rnor5.0
RGSC_v3.4	3	67,638,872 - 67,639,544	UniSTS	RGSC3.4
Celera	3	68,874,596 - 68,875,268	UniSTS
Cytogenetic Map	3	q24	UniSTS
Cytogenetic Map	6	q16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	32	30	22	16	22	6	6	18	29	32	11	6
Low	1	11	27	19	3	19	2	5	56	6	7		2
Below cutoff											2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L27487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X70658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000078645 ⟹ ENSRNOP00000074452

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	69,430,120 - 69,525,910 (-)	Ensembl
Rnor_6.0 Ensembl	3	71,750,500 - 71,845,232 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000088170 ⟹ ENSRNOP00000070720

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	69,430,120 - 69,473,780 (-)	Ensembl
Rnor_6.0 Ensembl	3	71,747,956 - 71,798,531 (-)	Ensembl

RefSeq Acc Id:

NM_012717 ⟹ NP_036849

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	89,835,071 - 89,932,616 (-)	NCBI
mRatBN7.2	3	69,428,350 - 69,525,910 (-)	NCBI
Rnor_6.0	3	71,750,500 - 71,845,232 (-)	NCBI
Rnor_5.0	3	78,269,326 - 78,366,557 (-)	NCBI
RGSC_v3.4	3	67,553,022 - 67,646,877 (-)	RGD
Celera	3	68,788,591 - 68,882,607 (-)	RGD

Sequence:

show sequence

GGGAACTCTTTTCTACTATCTCAGAAAATCAAATTCCCTCCTGAGACTATTCACACAGAATTTC
CTTAGGAGCCGTGCGGGGCCCTATGATGATACACCAACATCTTGTGCTACCAACTGTCAAAACT
TTGGATGGTCTAACACTCAGGTCATGACCCTTGTAATTAAGAAATTCTCGAAGACAATATTGAG
CATGATTCAGGAGAAAATGTGATTTGAGTCTGGAGACAATTGTGCATGTATATCTTTTCTTAAG
ATCTTAAAAAGAAAGAGAAAACAAATCCAGGGTTGTCGGTCACTGATTGATAGAAGAGAAAACA
ATATTCAGACGATTGCTTATGATTGACAAGAGCAGCTGCGGCCGCTACCCAGCTTGAACATATC
GCACACTTCAGTTGGACTCTAATGATGGATAAAAAGTGTACACTATGTTTTCTGTTTCTCTTGC
TTCTTAATATGGCTCTCATCGCAGCAGAGTCGGAAGAAGGCGCGAACCAAACAGACTTGGGAGT
CACTAGGAACAAGATCATGACGGCTCAGTATGAATGTTACCAAAAGATCATGCAGGATCCCATT
CAACAAGGAGAAGGCCTTTACTGCAACAGAACCTGGGACGGATGGCTATGCTGGAATGACGTTG
CAGCAGGAACCGAGTCAATGCAGTACTGCCCTGATTACTTTCAAGATTTTGATCCTTCAGAGAA
GGTTACAAAGATCTGTGACCAAGATGGAAACTGGTTCAGACATCCAGATAGTAACAGGACATGG
ACAAACTACACCTTGTGTAACAACAGCACGCATGAGAAAGTGAAGACAGCACTGAATTTGTTCT
ACCTAACTATAATTGGACATGGATTATCTATTGCCTCTCTGATCATCTCACTCATCATATTTTT
TTATTTCAAGAGCCTAAGTTGCCAACGGATTACATTGCATAAAAACCTGTTCTTTTCATTTGTT
TGTAATTCGATTGTGACAATCATTCACCTCACGGCAGTGGCCAATAACCAGGCCTTAGTGGCCA
CAAATCCTGTGAGCTGCAAGGTGTCCCAGTTCATTCATCTTTACCTGATGGGCTGTAACTACTT
TTGGATGCTCTGTGAAGGCATTTACCTGCACACACTCATTGTGGTGGCTGTGTTTGCAGAGAAG
CAGCACTTGATGTGGTATTATTTTCTTGGCTGGGGGTTTCCTCTGCTTCCTGCCTGCATCCATG
CCATCGCCAGAAGCTTGTATTACAATGACAACTGCTGGATCAGCTCAGACACTCATCTCCTCTA
CATCATCCATGGTCCCATTTGTGCTGCTTTACTGGTAAATCTCTTTTTCCTATTAAATATTGTA
CGTGTTCTCATCACCAAGTTGAAAGTTACACACCAAGCAGAATCCAATCTCTACATGAAAGCTG
TAAGAGCCACTCTCATCTTGGTACCACTACTTGGCATTGAATTTGTGCTTTTTCCATGGCGGCC
TGAAGGAAAGGTTGCTGAGGAGGTGTATGACTATGTCATGCACATTCTCATGCACTATCAGGGT
CTTTTGGTGTCTACAATTTTCTGCTTCTTTAACGGAGAGGTTCAAGCAATTCTGAGAAGAAATT
GGAACCAGTATAAAATCCAATTTGGCAATGGCTTTTCCCACTCTGATGCTCTCCGCAGCGCATC
CTATACGGTGTCAACAATCAGCGATGTGCAGGGGTACAGCCACGACTGCCCCACTGAACACTTA
AATGGAAAAAGCATCCAGGATATTGAAAATGTTGCCTTAAAACCAGAAAAAATGTATGATCTAG
TGATGTGAAAATACAGAAATCTCACTTGTTTTGTGTCACTTGAACCTATGATTTTATAGTCGGA
AGATTTAATAGCAAATGGGTTTCTTGAATACCATGAAGAAAGCCCTCAAATGAAATGAGAATTG
TGTGGATAAATGTTTAACGACCCTCTCTCTATGGGGGAGAAAAGCCTCAATTTTTATTGTTGGC
CAGTAAATACTCCTACCATAGCTGATTTCAAGTTACCAACCTGACATCACCGAATGTGGAATTG
GAAAGAAAATAAGCACAATCAACTCTTGGGAGCTGACATGCGTCGTC

hide sequence

RefSeq Acc Id:

XM_006234439 ⟹ XP_006234501

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	89,835,144 - 89,932,507 (-)	NCBI
mRatBN7.2	3	69,428,348 - 69,525,798 (-)	NCBI
Rnor_6.0	3	71,747,938 - 71,845,402 (-)	NCBI
Rnor_5.0	3	78,269,326 - 78,366,557 (-)	NCBI

Sequence:

show sequence

ATGTTTCCCTTCTGCTGCTGATCGCTTACAATCTGACAACACTCCCCATCTACCCAGAACAAGC
CCTCTCTTCGCAGCGGTGCACTTCTGCTTTAGGACCGGCGGGCTCTGTTGCCTGGACCTCACGC
TGCCTGCAGCAAAGCTTTTTGACTCTTCCACACCTCTTCTCCGGGAACTCTTTTCTACTATCTC
AGAAAATCAAATTCCCTCCTGAGACTATTCACACAGAATTTCCTTAGGAGCCGTGCGGGGTCAT
GACCCTTGTAATTAAGAAATTCTCGAAGACAATATTGAGCATGATTCAGGAGAAAATGTGATTT
GAGTCTGGAGACAATTGTGCATGTATATTTTTCTTAAGATCTTAAAAAGAAAGAGAAAACAAAT
CCAGGGTTGTCGGTCACTGATTGATAGAAGAGAAAACAATATTCAGACGATTGCTTATGATTGA
CAAGAGCAGCTGCGGCCGCTACCCAGCTTGAACATATCGCACACTTCAGTTGGACTCTAATGAT
GGATAAAAAGTGTACACTATGTTTTCTGTTTCTCTTGCTTCTTAATATGGCTCTCATCGCAGCA
GAGTCGGAAGAAGGCGCGAACCAAACAGACTTGGGAGTCACTAGGAACAAGATCATGACGGCTC
AGTATGAATGTTACCAAAAGATCATGCAGGATCCCATTCAACAAGGAGAAGGCCTTTACTGCAA
CAGAACCTGGGACGGATGGCTATGCTGGAATGACGTTGCAGCAGGAACCGAGTCAATGCAGTAC
TGCCCTGATTACTTTCAAGATTTTGATCCTTCAGAGAAGGTTACAAAGATCTGTGACCAAGATG
GAAACTGGTTCAGACATCCAGATAGTAACAGGACATGGACAAACTACACCTTGTGTAACAACAG
CACGCATGAGAAAGTGAAGACAGCACTGAATTTGTTCTACCTAACTATAATTGGACATGGATTA
TCTATTGCCTCTCTGATCATCTCACTCATCATATTTTTTTATTTCAAGAGCCTAAGTTGCCAAC
GGATTACATTGCATAAAAACCTGTTCTTTTCATTTGTTTGTAATTCGATTGTGACAATCATTCA
CCTCACGGCAGTGGCCAATAACCAGGCCTTAGTGGCCACAAATCCTGTGAGCTGCAAGGTGTCC
CAGTTCATTCATCTTTACCTGATGGGCTGTAACTACTTTTGGATGCTCTGTGAAGGCATTTACC
TGCACACACTCATTGTGGTGGCTGTGTTTGCAGAGAAGCAGCACTTGATGTGGTATTATTTTCT
TGGCTGGGGGTTTCCTCTGCTTCCTGCCTGCATCCATGCCATCGCCAGAAGCTTGTATTACAAT
GACAACTGCTGGATCAGCTCAGACACTCATCTCCTCTACATCATCCATGGTCCCATTTGTGCTG
CTTTACTGGTAAATCTCTTTTTCCTATTAAATATTGTACGTGTTCTCATCACCAAGTTGAAAGT
TACACACCAAGCAGAATCCAATCTCTACATGAAAGCTGTAAGAGCCACTCTCATCTTGGTACCA
CTACTTGGCATTGAATTTGTGCTTTTTCCATGGCGGCCTGAAGGAAAGGTTGCTGAGGAGGTGT
ATGACTATGTCATGCACATTCTCATGCACTATCAGGGTCTTTTGGTGTCTACAATTTTCTGCTT
CTTTAACGGAGAGGTTCAAGCAATTCTGAGAAGAAATTGGAACCAGTATAAAATCCAATTTGGC
AATGGCTTTTCCCACTCTGATGCTCTCCGCAGCGCATCCTATACGGTGTCAACAATCAGCGATG
TGCAGGGGTACAGCCACGACTGCCCCACTGAACACTTAAATGGAAAAAGCATCCAGGATATTGA
AAATGTTGCCTTAAAACCAGAAAAAATGTATGATCTAGTGATGTGAAAATACAGAAATCTCACT
TGTTTTGTGTCACTTGAACCTATGATTTTATAGTCGGAAGATTTAATAGCAAATGGGTTTCTTG
AATACCATGAAGAAAGCCCTCAAATGAAATGAGAATTGTGTGGATAAATGTTTAACAACCCTCT
CTCTATGGGGGAGAAAAGCCTCAATTTTTATTGTTGGCCAGTAAATACTCCTACCATAGCTGAT
TTCAAGTTACCAACCTGACATCACCGAATGTGGAATTGGAAAGAAAATAAGCACAATCAACTCT
TGGGAGCTGACATGCGTCGTCAAACCTGCACAACACCGCATGCTCTCACAGATGGACCTGTGCA
CACTCACACCCGCACTGACCAGAACTCTGCTCCTCTGTCTGAGAAGATCTTGCTCAGTCTTACA
GACATGAAAGGAAAGTTTGGTTTTTGTTATAAAACTCCTCATCCTTTGTCATTTGATGGTAGTG
AACGGTTTGTCCAGAAACACTTTAACCCTCTTTATAACTTCTCCTGTAGACGAGACAGAGTTTG
CTATCTCTGTCACCTCGTGTTCCTTTCTTTAAGAAAAGCAACTGAGCAGAATTCCCATGGGCTT
CTCAGTTGCTGCTACATATGGTTGTATCCTGTGGCATATCCATTCTGAATCACTAGGGAGACGT
ATTGATAGAAGCTACAAACACTTTGTCAGCTACCTTTTTGCCCTCTAAATCTTGCTGCAGGAGT
AGGAGGAAATCAGTCTTCCTGAATCTGTAAATAGAAACTTTGGCCTTTCCATTTCTACTGTGTA
GATAAGTGATCAACCATTTTATATGAAGGGAATCAATGAAGGATTTATTTTTATCTTGGGAATC
TGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGATTGTTGTACAAATGA
AACTGTAAGTACTCTGTCATTTTATTTTATTGTTTCAAATCAAAACACAACCTAAGTAACTGTT
TTAAAGCAGATGGATAATGCAACTTTATATGCGACTAGGTGTCTGATACTGTGTCTGGGCTGAT
TTATTTTATAGAAAAAATGGAGTACTGAATTCTATATTTGGTAAATATTTTAAGGACAAACAGA
TACCAGCATCAGAAGTTTGAGAACTCAAAACAAACCCCCAGAAATATCAATGATAAGATGTGAA
ATATTTATTTTAAAATGCAAAGTCATACTTTTACAAGCACGTTATCTTTGGAGTGCTGACATAT
TGCCTCTTCCAATCGGATGATGATTCACTCAAATTCAGAAATTATGAACAACTACTGTAAGAAG
TGCTAATCTGCTACAATTGTGTATTTTAACTCACTAAACTATAGTTTTACTGACTTTTACTAAA
GGAAGATATATGGCTTTGAAAAAGGCCCAGGTTATTTCTCTTATGAACCACAGAGGAATTGTCT
CTATATAATATACACTGTTTCAGTATTTCAGTAGACTACTGTGGGTGATAATACAACCATGGGA
AGACTCGAACTTACCACTGAGGATGAAATGTCAGATGTTTAGGTAATAATTAAATTAAAGTAGA
AGAAAGTTTCGCTTGTAAGTTAAAGTGACATTTTAAATGGATTTAGTTTTTCTAATATTGCTTT
GTCTGGACTTTCTGAAGAACCAGATTGACTTCAGTTGGTAAAAGTCAGTTTGGGGACAGTCACA
TGAATCCATGTTTTTTGAAGTGTGTCCATCAGCCTACAGTGCATGAAAGGCATGACTCAGTCCT
CCCTCATTGTGTCTTAAACTACAATAGATAGTAAATTCAGAAGTTGTTCGAAACTGTCAAGGAA
AATAATTCAAATTATCAAGCACTGATGTATTAGATGATCTGGCAGACATTATTTGTAATTTATC
TATACAGACCAAGGTGTCACTAAGTTACTTTCAGCATTGAAAAGGAGCTCATGCTTTTCTGAAC
TTTCAACTGCCTAAACCGTGCAAGCCTTCCTTTTAATACGTTCAAACTTTAGCTGGCTATTATT
CAAAGGCGTGTCTTCGTATCTTCTCTGACAGTGTTCATGTAAATTCTGCATTCTTCCAAACTGT
CAAGTTTGAACAGCAAATGATAGCACAGAATGCCGAATTACCAGAGGACATATTCAAAAGTTAT
TGTAATTTTAAATTTTATTATTCTTTTACCGTATTGAGCAGAGCTGAGATTTCTCTACTGCCAA
TATCTACTGTGGTGTCAACCATGCCATAGAGGTCTGAGATTAGTCAGTATTAGTTTTGTAATAA
TATTTTTGAAGCTAAATTTCTCTAAAGCTGAAGTGCCAATTAAAATATTTCTACTTTGCTTGTA
GGAAAAAAAACCTGAAATTTTTGAAAGAAAACTTCTCTGGTGCCTAAAAACTAACTTGGGGGAA
TTTTTAGCATTTAAAAGTTGGATTTGTCATTTTTAGAAGTGACTTATGTATGTTTTTGTTAATA
AGTCGTCCATCCTGGAGTTTAGTGTTTGTTCAAATATAACAAACTATGTAGAGTTTACTAGTAC
TCACAGTGTTACACTTACTGTTTAGATATTTTAATGTGAATCTATTTTAATTTTCTTTGTGTTT
TAATTTGCTCATAGAAACATCTGTAAATGTTCTGGTCACTTAAAAGAACTCATGTTGTATCGAC
TTAAAATCTTTATTTAGGTTTTATGAGAATATTAAAATTGTAAGTTAACATTCACTTTCACTCA
TCTTCCCTGGAGTACAGAGTGATTGAATTTCTCACAAAATTCTTGCAGCAATTAAAGAAATACT
TTGCAAAATAAATGGCGATGTCTTTATTCCTCTCTTTAAAGACTTTAATAAACTAGTAAGTGAA
TTTAATAAATGAATTAAAAAAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036849	(Get FASTA)	NCBI Sequence Viewer
	XP_006234501	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA49997	(Get FASTA)	NCBI Sequence Viewer
	EDL79299	(Get FASTA)	NCBI Sequence Viewer
	EDL79300	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070720
	ENSRNOP00000070720.2
	ENSRNOP00000074452
	ENSRNOP00000074452.1
	ENSRNOP00055030502
	ENSRNOP00060013601
	ENSRNOP00065029528
GenBank Protein	Q63118	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036849 ⟸ NM_012717
- Peptide Label:	precursor
- UniProtKB:	A0A8L2R2X9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMDKKCTLCFLFLLLLNMALIAAESEEGANQTDLGVTRNKIMTAQYECYQKIMQDPIQQGEGLY CNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRTWTNYTLCN NSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFVCNSIVTI IHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYY FLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKL KVTHQAESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHYQGLLVSTIF CFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDVQGYSHDCPTEHLNGKSIQD IENVALKPEKMYDLVM hide sequence

RefSeq Acc Id:	XP_006234501 ⟸ XM_006234439
- Peptide Label:	isoform X1
- UniProtKB:	Q63118 (UniProtKB/Swiss-Prot), A6HMP9 (UniProtKB/TrEMBL), A0A8L2R2X9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMDKKCTLCFLFLLLLNMALIAAESEEGANQTDLGVTRNKIMTAQYECYQKIMQDPIQQGEGLY CNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRTWTNYTLCN NSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFVCNSIVTI IHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYY FLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKL KVTHQAESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHYQGLLVSTIF CFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDVQGYSHDCPTEHLNGKSIQD IENVALKPEKMYDLVM hide sequence

RefSeq Acc Id:

ENSRNOP00000074452 ⟸ ENSRNOT00000078645

RefSeq Acc Id:

ENSRNOP00000070720 ⟸ ENSRNOT00000088170

Protein Domains

G-protein coupled receptors family 2 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63118-F1-model_v2	AlphaFold	Q63118	1-464	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2255	AgrOrtholog
BioCyc Gene	G2FUF-49183	BioCyc
Ensembl Genes	ENSRNOG00000054695	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055021800	UniProtKB/Swiss-Prot
	ENSRNOG00060010321	UniProtKB/Swiss-Prot
	ENSRNOG00065021521	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000078645	ENTREZGENE
	ENSRNOT00000078645.2	UniProtKB/Swiss-Prot
	ENSRNOT00000088170.2	UniProtKB/TrEMBL
	ENSRNOT00055037418	UniProtKB/Swiss-Prot
	ENSRNOT00060017511	UniProtKB/Swiss-Prot
	ENSRNOT00065036689	UniProtKB/Swiss-Prot
Gene3D-CATH	4.10.1240.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GCPR_2_calcitonin_rcpt_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_CGRP1_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_extracell_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_extracellular_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_secretin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_secretin-like_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25029	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	25029	ENTREZGENE
PANTHER	CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDF RECEPTOR-LIKE PROTEIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Calcrl	PhenoGen
PRINTS	CGRPRECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CTRFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCRSECRETIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000054695	RatGTEx
	ENSRNOG00055021800	RatGTEx
	ENSRNOG00060010321	RatGTEx
	ENSRNOG00065021521	RatGTEx
SMART	HormR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF111418	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC230639
UniProt	A0A8L2R2X9	ENTREZGENE, UniProtKB/TrEMBL
	A6HMP9	ENTREZGENE, UniProtKB/TrEMBL
	CALRL_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-12-13	Calcrl	calcitonin receptor like receptor	Calcrl	calcitonin receptor-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Calcrl	calcitonin receptor-like	Calcrl	calcitonin receptor-like receptor	Name updated	629478	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	may play a role in chronic heart failure	625420
gene_expression	expressed in lung	68902
gene_expression	expressed in atria and ventricles of the heart	625420
gene_function	acts as either a calcitonin gene-related peptide receptor or an adrenomedullin receptor	68718
gene_function	acts as either a calcitonin gene-related peptide receptor or an adrenomedullin receptor	68902
gene_process	may play a role in vascular tone maintenance	68686
gene_regulation	induced by several growth factors including colony stimulating factor-1, epidermal growth factor, and Ang II	68718

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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