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Gene: Btg3 (BTG anti-proliferation factor 3) Rattus norvegicus

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Symbol:

Btg3

Name:

BTG anti-proliferation factor 3

RGD ID:

2226

Description:

Involved in response to oxidative stress. Predicted to be active in cytoplasm and nucleus. Orthologous to human BTG3 (BTG anti-proliferation factor 3); PARTICIPATES IN RNA degradation pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

B-cell translocation gene 3; BTG family, member 3; LOC360251; rBTG3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BTG3 (BTG anti-proliferation factor 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Btg3 (BTG anti-proliferation factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Btg3 (BTG anti-proliferation factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BTG3 (BTG anti-proliferation factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BTG3 (BTG anti-proliferation factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Btg3 (BTG anti-proliferation factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BTG3 (BTG anti-proliferation factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BTG3 (BTG anti-proliferation factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Btg3 (BTG anti-proliferation factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Btg3 (BTG anti-proliferation factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	BTG3 (BTG anti-proliferation factor 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Btg3 (BTG anti-proliferation factor 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	btg3 (B-cell translocation gene 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	btg3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	30,517,068 - 30,532,981 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	30,517,072 - 30,533,082 (-)	Ensembl				GRCr8
mRatBN7.2	11	17,030,156 - 17,046,069 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	17,030,160 - 17,046,170 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	25,668,320 - 25,684,227 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	18,398,339 - 18,414,241 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	17,559,086 - 17,574,992 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	16,873,642 - 16,889,100 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	16,873,646 - 16,889,201 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	20,528,289 - 20,543,935 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	17,241,627 - 17,257,740 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	17,021,018 - 17,036,611 (-)	NCBI		Celera
RGSC_v3.1	11	17,241,630 - 17,257,740	NCBI
Cytogenetic Map	11	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cholestasis (ISO)

juvenile rheumatoid arthritis (ISO)

renal cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(S)-colchicine (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

adenine (ISO)

aflatoxin B1 (EXP,ISO)

amitrole (EXP)

ammonium chloride (EXP)

antimycin A (ISO)

Aroclor 1254 (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlordecone (ISO)

chlorpromazine (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

deguelin (ISO)

diazinon (EXP)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dichloroacetic acid (ISO)

dicrotophos (ISO)

dieldrin (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

etoposide (ISO)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

hydrogen peroxide (ISO)

hydroxyurea (ISO)

iron dichloride (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

mercury dichloride (EXP)

metacetamol (ISO)

methidathion (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

methylseleninic acid (ISO)

mitomycin C (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nickel dichloride (EXP)

okadaic acid (ISO)

p-chloromercuribenzoic acid (ISO)

paclitaxel (ISO)

paracetamol (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phenylephrine (EXP)

phenylmercury acetate (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

succimer (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tetrachloromethane (EXP)

theophylline (ISO)

thimerosal (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

Triptolide (ISO)

troglitazone (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cell population proliferation (NAS)

negative regulation of mitotic cell cycle (ISO)

response to oxidative stress (IEP)

Cellular Component

cytoplasm (IBA,IEA,ISO)

nucleus (IBA)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Expression of rat BTG(3) gene, Rbtg3, is regulated by redox changes.	Seo MS, etal., Gene 1999 Nov 15;240(1):165-73.
10.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:9632145	PMID:12477932	PMID:16434477	PMID:19359386	PMID:23770100

Genomics

Comparative Map Data

Btg3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	30,517,068 - 30,532,981 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	30,517,072 - 30,533,082 (-)	Ensembl				GRCr8
mRatBN7.2	11	17,030,156 - 17,046,069 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	17,030,160 - 17,046,170 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	25,668,320 - 25,684,227 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	18,398,339 - 18,414,241 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	17,559,086 - 17,574,992 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	16,873,642 - 16,889,100 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	16,873,646 - 16,889,201 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	20,528,289 - 20,543,935 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	17,241,627 - 17,257,740 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	17,021,018 - 17,036,611 (-)	NCBI		Celera
RGSC_v3.1	11	17,241,630 - 17,257,740	NCBI
Cytogenetic Map	11	q11	NCBI

BTG3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	17,593,653 - 17,612,901 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	17,593,650 - 17,613,014 (-)	Ensembl			hg38	GRCh38
GRCh37	21	18,965,971 - 18,985,219 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	17,887,842 - 17,907,033 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	17,887,842 - 17,907,033	NCBI
Celera	21	4,140,718 - 4,160,017 (-)	NCBI		Celera
Cytogenetic Map	21	q21.1	NCBI
HuRef	21	4,351,708 - 4,371,005 (-)	NCBI		HuRef
CHM1_1	21	18,526,539 - 18,545,830 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	21	15,948,673 - 15,970,578 (-)	NCBI		T2T-CHM13v2.0

Btg3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	78,156,748 - 78,174,069 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	78,129,525 - 78,174,080 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	78,359,860 - 78,377,181 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	78,332,637 - 78,377,192 (-)	Ensembl			mm10	GRCm38
MGSCv37	16	78,360,105 - 78,377,030 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	78,907,197 - 78,925,757 (-)	NCBI		MGSCv36	mm8
MGSCv36	16	78,242,452 - 78,259,377 (-)	NCBI		MGSCv36	mm8
Celera	16	78,582,660 - 78,596,171 (-)	NCBI		Celera
Cytogenetic Map	16	C3.1	NCBI
cM Map	16	45.36	NCBI

Btg3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	18,927,211 - 18,941,424 (-)	Ensembl
ChiLan1.0	NW_004955407	18,927,211 - 18,939,576 (-)	NCBI	ChiLan1.0	ChiLan1.0

BTG3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	14,087,460 - 14,106,734 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	8,910,870 - 8,934,623 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	4,327,813 - 4,347,053 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	17,693,067 - 17,712,280 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	17,693,067 - 17,712,280 (-)	Ensembl			panPan2	panpan1.1

BTG3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	14,079,228 - 14,117,347 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	14,079,652 - 14,095,265 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	14,099,386 - 14,137,273 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	14,113,682 - 14,151,419 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	14,114,112 - 14,129,537 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	14,116,127 - 14,153,978 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	14,121,622 - 14,159,558 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	14,520,447 - 14,558,189 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Btg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	15,112,560 - 15,126,270 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936505	10,032,237 - 10,046,047 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936505	10,032,333 - 10,046,008 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BTG3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	182,208,958 - 182,227,971 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	182,209,850 - 182,228,626 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	192,359,371 - 192,377,343 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BTG3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	74,986,522 - 75,005,834 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	74,990,327 - 75,006,412 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	78,986,586 - 79,005,893 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Btg3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	5,953,305 - 5,976,331 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	5,954,812 - 5,975,899 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Btg3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	63,701,579 - 63,717,622 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Btg3
68 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	322
Count of miRNA genes:	216
Interacting mature miRNAs:	249
Transcripts:	ENSRNOT00000002121
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	22524746	82951192	Rat
2290451	Scl58	Serum cholesterol level QTL 58	3.48		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	11	26318031	55806125	Rat
1598842	Glom10	Glomerulus QTL 10	3.4		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	3818154	48818154	Rat
1600394	Edcs1	Endometrial carcinoma susceptibility QTL1	2.9	0.04	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	11	12823152	57823152	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	10806125	55806125	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	29958996	57754989	Rat
631510	Spl2	Serum phospholipid level QTL 2	4.1		blood phospholipid amount (VT:0006084)	serum phospholipid level (CMO:0001171)	11	27556685	72556685	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	91	59	6	355	191	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF087037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC127498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002121 ⟹ ENSRNOP00000002121

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	30,517,072 - 30,533,082 (-)	Ensembl
mRatBN7.2 Ensembl	11	17,030,160 - 17,046,170 (-)	Ensembl
Rnor_6.0 Ensembl	11	16,873,646 - 16,889,201 (-)	Ensembl

RefSeq Acc Id:

NM_019290 ⟹ NP_062163

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	30,517,068 - 30,532,981 (-)	NCBI
mRatBN7.2	11	17,030,156 - 17,046,069 (-)	NCBI
Rnor_6.0	11	16,873,642 - 16,889,100 (-)	NCBI
Rnor_5.0	11	20,528,289 - 20,543,935 (-)	NCBI
RGSC_v3.4	11	17,241,627 - 17,257,740 (-)	RGD
Celera	11	17,021,018 - 17,036,611 (-)	RGD

Sequence:

show sequence

GGCACGAGGGCGAGGGTGCAGCCCCGGAGCGGCGGCGGGGCAAAATGAAAAACGAAATTGCTGC
TGTTGTCTTCTTTTTCACAAGGCTGGTTCGAAAGCATGATAAGTTGAAAAAAGAAGCAGTTGAG
AGGTTTGCTGAGAAATTGACTCAAATACTTCAAGAGAAATACAAAAATCACTGGTATCCAGAAA
AACCCTCAAAAGGACAAGCCTACAGATGCATTCGTGTCAATAAGTTTCAGAGAGTTGATCCCGA
CGTCCTGAAAGCCTGTGAGGACAGCTGCATCCTGTACAGTGACCTGGGCTTGCCAAAGGAGCTT
ACACTCTGGGTGGATCCGTGTGAGGTGTGCTGCCGGTATGGAAAGAAAAACAATGCATTCATTG
TTGCCAGCTTTGAAAATGAGGATGAGAACAAGGATGAGATCTCCAAGAAAGTTAGCAGGGCTCT
TGATAAGGTGACCTCTGATTATCATTCAGGGTCCTCCTCCTCAGATGAAGACACAAGCAAGGAA
GTAGAAGTGAAACCGAGTGCAGTGGCTACAACGCCAAGCCCCGTGTACCAGATTTCAGAACTGA
TATTCCCACCTCTTCCAATGTGGCACCCTTTGCCCAGAAAAAAGCCAGGAATGTACCGAGGGGG
TGGCCATCAGAGTCACTACCCTCCTCCTGTTCCATTTGCTTATCCAAGTCCAGGAAGGAAGAAT
AAAGCGTTCCGCCCAATTCCAGTGACATGGGTACCTCCTCCTGGAATGCATTGTGATCGGAATC
ACTGGATTAATCCTCACATGTTAGCACCTCACTAGTTCATTTGGATTGGGCGGATGTCATTTTG
ATAGAAAGGAAGAAATACCTTCTTAGATACTTAAGAGTTTCACAACTTGTAGTGAAGTCAGATG
GACAAAACCATCAGGCTTATTTTTATAGAAAAGCTATTGAGATAATCTTTCTTAAAGTATATAT
ATATATGCACTTTAGATATATTGATATAGTTTGAGAAACTTTATTAAAGTTAGTCAAGTGCCTG
AGTTTTTAATATTGGACTTGAGTATTTATATATTGTGCATTGACTCTGTTGGATACAAAACACT
GTAGGAGGGCGATATGTTTTAGCACCTTTGAGCATTTACTTTATGGAGAATATGTAAGTTATTT
ATACAGAAGGACATTTATTTTATGTCACATAGAAGAATTGTGTGAAATCATGTAGTTGCAAATA
AAAAGTAGTTTGAGGCGTGAAAAAAAAAAAAAAAAAAAAAAAA

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Protein Sequences


Protein RefSeqs	NP_062163	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC34894	(Get FASTA)	NCBI Sequence Viewer
	AAI27499	(Get FASTA)	NCBI Sequence Viewer
	EDM10601	(Get FASTA)	NCBI Sequence Viewer
	EDM10602	(Get FASTA)	NCBI Sequence Viewer
	EDM10603	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002121
GenBank Protein	O88677	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062163 ⟸ NM_019290

- UniProtKB:

O88677 (UniProtKB/Swiss-Prot), A0JPM2 (UniProtKB/TrEMBL), A6JL38 (UniProtKB/TrEMBL), F7FB02 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTQILQEKYKNHWYPEKPSKGQAYRCIRVNK
FQRVDPDVLKACEDSCILYSDLGLPKELTLWVDPCEVCCRYGKKNNAFIVASFENEDENKDEIS
KKVSRALDKVTSDYHSGSSSSDEDTSKEVEVKPSAVATTPSPVYQISELIFPPLPMWHPLPRKK
PGMYRGGGHQSHYPPPVPFAYPSPGRKNKAFRPIPVTWVPPPGMHCDRNHWINPHMLAPH

hide sequence

Ensembl Acc Id:

ENSRNOP00000002121 ⟸ ENSRNOT00000002121

Protein Domains

Anti-proliferative protein

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88677-F1-model_v2	AlphaFold	O88677	1-252	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698008

Promoter ID:

EPDNEW_R8533

Type:

initiation region

Name:

Btg3_1

Description:

BTG anti-proliferation factor 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	16,889,212 - 16,889,272	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2226	AgrOrtholog
BioCyc Gene	G2FUF-22138	BioCyc
Ensembl Genes	ENSRNOG00000001555	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000002121	ENTREZGENE
Gene3D-CATH	3.90.640.90	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:8371953	IMAGE-MGC_LOAD
InterPro	Anti_prolifrtn	UniProtKB/Swiss-Prot
	BTG	UniProtKB/Swiss-Prot
	BTG-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:54230	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156659	IMAGE-MGC_LOAD
NCBI Gene	54230	ENTREZGENE
PANTHER	PROTEIN BTG3	UniProtKB/Swiss-Prot
	PTHR22978	UniProtKB/Swiss-Prot
Pfam	BTG	UniProtKB/Swiss-Prot
PhenoGen	Btg3	PhenoGen
PRINTS	ANTIPRLFBTG1	UniProtKB/Swiss-Prot
PROSITE	BTG_1	UniProtKB/Swiss-Prot
	BTG_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001555	RatGTEx
SMART	btg1	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF160696	UniProtKB/Swiss-Prot
TIGR	TC218958
UniProt	A0JPM2	ENTREZGENE
	A6JL36_RAT	UniProtKB/TrEMBL
	A6JL37_RAT	UniProtKB/TrEMBL
	A6JL38	ENTREZGENE, UniProtKB/TrEMBL
	BTG3_RAT	UniProtKB/Swiss-Prot
	F7FB02	ENTREZGENE, UniProtKB/TrEMBL
	O88677	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-13	Btg3	BTG anti-proliferation factor 3	Btg3	BTG family, member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-02-04	Btg3	BTG family, member 3	Btg3	B-cell translocation gene 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-04-06	Btg3	B-cell translocation gene 3	Btg3_predicted	B-cell translocation gene 3 (predicted)	Data merged from RGD:1308486	737654	APPROVED
2005-01-12	Btg3_predicted	B-cell translocation gene 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-06-10	Btg3	B-cell translocation gene 3			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed highly in brain but low expression seen in lung, kidney, thymus and spleen	69783
gene_regulation	induced by 12-O-tetradecanoylphorbol-13-acetate and regulated by redox changes	69783

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)