Advanced Search (OLGA)

Gene: Bckdha (branched chain keto acid dehydrogenase E1 subunit alpha) Rattus norvegicus

Analyze

Symbol:

Bckdha

Name:

branched chain keto acid dehydrogenase E1 subunit alpha

RGD ID:

2196

Description:

Predicted to enable metal ion binding activity and oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor. Predicted to contribute to branched-chain 2-oxo acid dehydrogenase activity. Involved in response to cAMP; response to glucocorticoid; and response to nutrient. Predicted to be located in mitochondrion. Predicted to be part of branched-chain alpha-ketoacid dehydrogenase complex. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human BCKDHA (branched chain keto acid dehydrogenase E1 subunit alpha); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; BCKDA; BCKDE1A; BCKDH E1-alpha; Branched chain alpha-ketoacid dehydrogenase subunit E1 alpha; branched chain keto acid dehydrogenase subunit E1, alpha polypeptide; branched chain ketoacid dehydrogenase E1, alpha polypeptide; branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; E1a

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	90,266,731 - 90,295,521 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	90,261,629 - 90,295,749 (-)	Ensembl				GRCr8
mRatBN7.2	1	81,138,946 - 81,167,765 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	81,138,947 - 81,167,862 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	86,531,142 - 86,559,905 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	95,083,063 - 95,111,555 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	88,286,937 - 88,315,700 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	82,423,291 - 82,452,094 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	82,423,277 - 82,452,281 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	83,684,796 - 83,713,671 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	80,837,906 - 80,866,672 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	75,579,300 - 75,595,435 (-)	NCBI		Celera
RGSC_v3.1	1	80,916,017 - 80,944,767 (-)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Diabetes Mellitus (IEP)

genetic disease (ISO)

intellectual disability (ISO)

maple syrup urine disease (ISO)

maple syrup urine disease type IA (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2,4-trimethylbenzene (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrabromodibenzodioxine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amiodarone (EXP)

amitrole (EXP)

ammonium chloride (EXP)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (EXP,ISO)

clotrimazole (EXP)

copper atom (EXP)

copper(0) (EXP)

coumarin (ISO)

dioxygen (ISO)

FR900359 (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

ivermectin (ISO)

ketamine (EXP)

methapyrilene (EXP)

N-nitrosomorpholine (EXP)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

phenylephrine (EXP)

pirinixic acid (EXP,ISO)

propiconazole (EXP)

quercetin (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (EXP)

streptozocin (ISO)

sulforaphane (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (EXP)

thioacetamide (EXP)

topotecan (ISO)

triadimefon (EXP)

trichloroethene (EXP)

tunicamycin (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA (ISO,ISS)

branched-chain amino acid catabolic process (IBA,ISO,ISS)

response to cAMP (IEP)

response to glucocorticoid (IEP)

response to nutrient (IEP)

Cellular Component

branched-chain alpha-ketoacid dehydrogenase complex (IBA,ISO,ISS)

mitochondrial matrix (IEA,ISS)

mitochondrion (ISO)

Molecular Function

branched-chain 2-oxo acid dehydrogenase activity (IEA,ISO,ISS)

metal ion binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (IEA)

protein binding (ISO)

protein-containing complex binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway (ISO)

3-hydroxyisobutyric aciduria pathway (ISO)

3-methylcrotonyl CoA carboxylase 1 deficiency pathway (ISO)

3-methylglutaconic aciduria type 1 pathway (ISO)

3-methylglutaconic aciduria type 3 pathway (ISO)

isobutyryl-CoA dehydrogenase deficiency pathway (ISO)

isovaleric acidemia pathway (ISO)

malonic aciduria pathway (ISO)

maple syrup urine disease pathway (ISO)

methylmalonate semialdehyde dehydrogenase deficiency pathway (ISO)

methylmalonic acidemia pathway (ISO)

methylmalonic aciduria, cobalamin-related pathway (ISO)

propanoate metabolic pathway (ISO)

propionic acidemia pathway (ISO)

valine, leucine and isoleucine degradation pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of gene expression of branched-chain keto acid dehydrogenase complex in primary cultured hepatocytes by dexamethasone and a cAMP analog.	Chicco AG, etal., J Biol Chem. 1994 Jul 29;269(30):19427-34.
2.	Molecular basis of maple syrup urine disease: novel mutations at the E1 alpha locus that impair E1(alpha 2 beta 2) assembly or decrease steady-state E1 alpha mRNA levels of branched-chain alpha-keto acid dehydrogenase complex.	Chuang JL, etal., Am J Hum Genet 1994 Aug;55(2):297-304.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Posttranscriptional alterations in protein masses of hepatic branched-chain keto acid dehydrogenase and its associated kinase in diabetes.	Lombardo YB, etal., Proc Assoc Am Physicians. 1998 Jan-Feb;110(1):40-9.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	Purification of branched chain alpha-ketoacid dehydrogenase complex from rat liver.	Shimomura Y, etal., Anal Biochem. 1987 May 15;163(1):74-8.
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17.	Molecular cloning of a cDNA for the E1 alpha subunit of rat liver branched chain alpha-ketoacid dehydrogenase.	Zhang B, etal., J Biol Chem 1987 Nov 5;262(31):15220-4.
18.	Molecular defects in the E1 alpha subunit of the branched-chain alpha-ketoacid dehydrogenase complex that cause maple syrup urine disease.	Zhang B, etal., Mol Biol Med 1991 Feb;8(1):39-47.
19.	Effect of dietary protein on the liver content and subunit composition of the branched-chain alpha-ketoacid dehydrogenase complex.	Zhao Y, etal., Arch Biochem Biophys. 1994 Feb 1;308(2):446-53.

Additional References at PubMed

PMID:7883996	PMID:12477932	PMID:14651853	PMID:16396499	PMID:18614015	PMID:20833797	PMID:24625528	PMID:25193403	PMID:26035971	PMID:26316108	PMID:29476059	PMID:34800366
PMID:36802195

Genomics

Comparative Map Data

Bckdha
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	90,266,731 - 90,295,521 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	90,261,629 - 90,295,749 (-)	Ensembl				GRCr8
mRatBN7.2	1	81,138,946 - 81,167,765 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	81,138,947 - 81,167,862 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	86,531,142 - 86,559,905 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	95,083,063 - 95,111,555 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	88,286,937 - 88,315,700 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	82,423,291 - 82,452,094 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	82,423,277 - 82,452,281 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	83,684,796 - 83,713,671 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	80,837,906 - 80,866,672 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	75,579,300 - 75,595,435 (-)	NCBI		Celera
RGSC_v3.1	1	80,916,017 - 80,944,767 (-)	NCBI
Cytogenetic Map	1	q21	NCBI

BCKDHA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	41,397,818 - 41,425,002 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	41,397,793 - 41,425,005 (+)	Ensembl			hg38	GRCh38
GRCh37	19	41,903,723 - 41,930,907 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	46,595,544 - 46,622,750 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	46,595,543 - 46,622,749	NCBI
Celera	19	38,703,549 - 38,730,745 (+)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	38,335,417 - 38,362,686 (+)	NCBI		HuRef
CHM1_1	19	41,903,371 - 41,930,595 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	44,219,041 - 44,246,226 (+)	NCBI		T2T-CHM13v2.0

Bckdha
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	25,329,371 - 25,358,178 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	25,329,371 - 25,358,406 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	25,629,852 - 25,658,782 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	25,629,946 - 25,658,981 (-)	Ensembl			mm10	GRCm38
MGSCv37	7	26,414,871 - 26,443,780 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	25,338,706 - 25,367,498 (-)	NCBI		MGSCv36	mm8
Celera	7	20,238,873 - 20,267,674 (-)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	13.94	NCBI

Bckdha
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955555	333,642 - 358,799 (+)	Ensembl
ChiLan1.0	NW_004955555	334,253 - 357,417 (+)	NCBI	ChiLan1.0	ChiLan1.0

BCKDHA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	47,608,205 - 47,635,733 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	49,477,013 - 49,504,623 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	38,391,618 - 38,418,826 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	46,898,024 - 46,925,171 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	46,898,024 - 46,925,171 (+)	Ensembl			panPan2	panpan1.1

BCKDHA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	112,579,345 - 112,599,163 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	111,983,522 - 112,003,339 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	113,177,443 - 113,197,277 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	113,175,101 - 113,213,830 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	112,738,731 - 112,758,552 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	112,371,075 - 112,390,893 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	113,364,328 - 113,384,163 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Bckdha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	15,371,915 - 15,389,480 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	3,799,955 - 3,819,851 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936661	3,799,998 - 3,817,560 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BCKDHA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	49,381,967 - 49,398,743 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	49,381,995 - 49,398,745 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	45,273,884 - 45,290,452 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BCKDHA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	35,717,679 - 35,747,245 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	35,717,694 - 35,751,098 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	13,954,030 - 13,983,378 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bckdha
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624907	203,992 - 228,488 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624907	203,819 - 225,334 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Bckdha
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	169,135,943 - 169,164,035 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Bckdha
205 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	78
Count of miRNA genes:	69
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000027995
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	46302615	91302615	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	46302615	91302615	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	46302615	91302615	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	46302615	91302615	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	51909206	91302615	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	46302615	91302615	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	46302615	91302615	Rat

Markers in Region

D1Rat97

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	81,169,450 - 81,169,607 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	82,453,792 - 82,453,948	NCBI	Rnor6.0
Rnor_5.0	1	83,715,300 - 83,715,456	UniSTS	Rnor5.0
RGSC_v3.4	1	80,868,407 - 80,868,564	RGD	RGSC3.4
RGSC_v3.4	1	80,868,408 - 80,868,564	UniSTS	RGSC3.4
Celera	1	75,609,187 - 75,609,343	UniSTS
RGSC_v3.1	1	80,946,519 - 80,946,675	RGD
RH 3.4 Map	1	825.5	UniSTS
RH 3.4 Map	1	825.5	RGD
RH 2.0 Map	1	500.3	RGD
FHH x ACI Map	1	42.3299	RGD
Cytogenetic Map	1	q21	UniSTS

D1Bda6

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	81,139,043 - 81,139,261 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	82,423,389 - 82,423,606	NCBI	Rnor6.0
Rnor_5.0	1	83,684,894 - 83,685,111	UniSTS	Rnor5.0
RGSC_v3.4	1	80,838,004 - 80,838,221	UniSTS	RGSC3.4
Celera	1	75,579,398 - 75,579,615	UniSTS
Cytogenetic Map	1	q21	UniSTS

BE119497

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	81,166,774 - 81,166,968 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	82,451,116 - 82,451,309	NCBI	Rnor6.0
Rnor_5.0	1	83,712,624 - 83,712,817	UniSTS	Rnor5.0
RGSC_v3.4	1	80,865,731 - 80,865,924	UniSTS	RGSC3.4
Celera	1	75,607,191 - 75,607,385	UniSTS
RH 3.4 Map	1	827.2	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC134759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC161819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB579195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J02827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027995 ⟹ ENSRNOP00000027995

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	90,266,732 - 90,295,749 (-)	Ensembl
mRatBN7.2 Ensembl	1	81,138,947 - 81,167,862 (-)	Ensembl
Rnor_6.0 Ensembl	1	82,423,277 - 82,452,281 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095163 ⟹ ENSRNOP00000087713

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	90,266,732 - 90,287,265 (-)	Ensembl
mRatBN7.2 Ensembl	1	81,138,947 - 81,151,280 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139513 ⟹ ENSRNOP00000105536

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	90,261,629 - 90,295,634 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151777 ⟹ ENSRNOP00000109641

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	90,265,123 - 90,295,749 (-)	Ensembl

RefSeq Acc Id:

NM_012782 ⟹ NP_036914

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	90,266,731 - 90,295,497 (-)	NCBI
mRatBN7.2	1	81,138,946 - 81,167,716 (-)	NCBI
Rnor_6.0	1	82,423,291 - 82,452,057 (-)	NCBI
Rnor_5.0	1	83,684,796 - 83,713,671 (-)	NCBI
RGSC_v3.4	1	80,837,906 - 80,866,672 (-)	RGD
Celera	1	75,579,300 - 75,595,435 (-)	RGD

Sequence:

show sequence

GATGGCGGTAGCGATGTCCGCGGCCAAGATCTGGAGGCCGAGCCGTGGCCTGCGCCAGGCTGCC
CTCTTGCTGTTGGGGCGACCTGGGGCTCGGGGCTTGGCTAGATTCCACCCCAGCAGGCAGCAGC
AACAGCAGTTCCCATCCCTGGATGACAAGCCCCAGTTCCCAGGGGCCTCTGCAGAGTTTGTAGA
CAAGCTTGAGTTCATCCAGCCCAATGTCATCTCCGGCATCCCCATCTACCGCGTCATGGACCGA
CAGGGCCAGATCATCAACCCCAGTGAAGATCCCCACCTGCCCCAGGAGGAGGTCCTGAAGTTGT
ACAGGAGCATGACGCTGCTCAACACCATGGACCGCATTCTCTATGAGTCCCAGCGACAGGGCCG
GATCTCCTTCTACATGACCAACTATGGCGAGGAGGGGACACATGTGGGGAGTGCCGCTGCCCTG
GAGCGAACGGACCTGGTGTTTGGCCAGTACCGGGAGGCAGGTGTGCTCATGTACCGGGACTACC
CGCTGGAGCTGTTCATGGCCCAGTGCTACGGCAACGTGAGTGACCCAGGCAAGGGACGCCAGAT
GCCCGTTCACTACGGCTGCAAGGAGCGTCACTTCGTCACCATTTCCTCTCCACTGGCTACGCAG
ATCCCTCAGGCGGTAGGGGCAGCCTATGCTGCCAAGCGGGCCAATGCCAATCAGATCGTGATCT
GTTACTTTGGCGAGGGGGCAGCCAGTGAAGGGGATGCCCACGCCGGTTTCAATTTTGCTGCCAC
CTTGGAGTGTCCTATCATCTTCTTCTGCCGGAACAATGGCTATGCCATCTCCACACCAACCTCT
GAGCAGTACCGTGGGGATGGCATAGCGGCTCGGGGCCCTGGGTATGGCATCATGTCAATCCGTG
TGGACGGCAACGATGTGTTTGCGGTGTACAATGCCACTAAGGAGGCCCGACGGCGGGCTGTGGC
TGAGAACCAGCCCTTCCTCATTGAGGCCATGACCTACAGGATCGGGCACCACAGCACCAGTGAC
GACAGCTCTGCGTACCGTTCGGTGGATGAGGTCAATTACTGGGACAAGCAGGACCACCCGATCT
CGAGACTGAGGCAGTACCTGCTGAACCAGGGTTGGTGGGATGAGGAACAGGAGAAGGCCTGGCG
GAAGCAGTCACGAAAGAAGGTGATGGAGGCCTTTGAACAGGCTGAGCGGAAGCTAAAGCCCAAC
CCAAGCCTCCTCTTCTCCGATGTGTACCAGGAGATGCCTGCCCAGCTGCGCAGGCAGCAGGAGT
CCCTGGCTCGGCACCTGCAGACCTACGGGGAGCACTACCCCCTGGACCACTTTGACAAGTGAGG
CCCTAACCACCACAAGGTGGTCCTGCTCTGAGTGGAGCTGGGGGGCGGCAGGACGCTGCCCCCC
GCTGCTAACCAGTGCTGCTGACGTGCTGAGCAGCCAGTGTGGCACGCACTGCGGCTCCCCCAGG
CTACTTCACTGGGGCACCACATTTGCAGCCATTGCTGCAGCTCCATCACTCCCTTCACCTGTTA
CAGTGCCTTTTAGGGGTGGGGAGGAACCAGGGCCAGGGCAGACCCTTTGGGCAGGGTGGCCCTG
GATTTGCTCAGAGAAATAGCTGATTGGCAGAGTAAGTAAACCACAGCTCTGCCTTTGAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017588814 ⟹ XP_017444303

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	90,266,731 - 90,295,514 (-)	NCBI
mRatBN7.2	1	81,138,946 - 81,167,752 (-)	NCBI
Rnor_6.0	1	82,423,291 - 82,452,094 (-)	NCBI

Sequence:

show sequence

TCTATCTCCTGAGAAAGGAGGAGTGGTTACTAGCCAAGATGGCGGTAGCGATGTCCGCGGCCAA
GATCTGGAGGCCGAGCCGTGGCCTGCGCCAGGCTGCCCTCTTGCTGTTGGGGCGACCTGGGGCT
CGGGGCTTGGCTAGATTCCTGCCCCAGGAGGAGGTCCTGAAGTTGTACAGGAGCATGACGCTGC
TCAACACCATGGACCGCATTCTCTATGAGTCCCAGCGACAGGGCCGGATCTCCTTCTACATGAC
CAACTATGGCGAGGAGGGGACACATGTGGGGAGTGCCGCTGCCCTGGAGCGAACGGACCTGGTG
TTTGGCCAGTACCGGGAGGCAGGTGTGCTCATGTACCGGGACTACCCGCTGGAGCTGTTCATGG
CCCAGTGCTACGGCAACGTGAGTGACCCAGGCAAGGGACGCCAGATGCCCGTTCACTACGGCTG
CAAGGAGCGTCACTTCGTCACCATTTCCTCTCCACTGGCTACGCAGATCCCTCAGGCGGTAGGG
GCAGCCTATGCTGCCAAGCGGGCCAATGCCAATCAGATCGTGATCTGTTACTTTGGCGAGGGGG
CAGCCAGTGAAGGGGATGCCCACGCCGGTTTCAATTTTGCTGCCACCTTGGAGTGTCCTATCAT
CTTCTTCTGCCGGAACAATGGCTATGCCATCTCCACACCAACCTCTGAGCAGTACCGTGGGGAT
GGCATAGCGGCTCGGGGCCCTGGGTATGGCATCATGTCAATCCGTGTGGACGGCAACGATGTGT
TTGCGGTGTACAATGCCACTAAGGAGGCCCGACGGCGGGCTGTGGCTGAGAACCAGCCCTTCCT
CATTGAGGCCATGACCTACAGGATCGGGCACCACAGCACCAGTGACGACAGCTCTGCGTACCGT
TCGGTGGATGAGGTCAATTACTGGGACAAGCAGGACCACCCGATCTCGAGACTGAGGCAGTACC
TGCTGAACCAGGGTTGGTGGGATGAGGAACAGGAGAAGGCCTGGCGGAAGCAGTCACGAAAGAA
GGTGATGGAGGCCTTTGAACAGGCTGAGCGGAAGCTAAAGCCCAACCCAAGCCTCCTCTTCTCC
GATGTGTACCAGGAGATGCCTGCCCAGCTGCGCAGGCAGCAGGAGTCCCTGGCTCGGCACCTGC
AGACCTACGGGGAGCACTACCCCCTGGACCACTTTGACAAGTGAGGCCCTAACCACCACAAGGT
GGTCCTGCTCTGAGTGGAGCTGGGGGGCGGCAGGACGCTGCCCCCCGCTGCTAACCAGTGCTGC
TGACGTGCTGAGCAGCCAGTGTGGCACGCACTGCGGCTCCCCCAGGCTACTTCACTGGGGCACC
ACATTTGCAGCCATTGCTGCAGCTCCATCACTCCCTTCACCTGTTACAGTGCCTTTTAGGGGTG
GGGAGGAACCAGGGCCAGGGCAGACCCTTTGGGCAGGGTGGCCCTGGATTTGCTCAGAGAAATA
GCTGATTGGCAGAGTAAGTAAACCACAGCTCTGCCTTTGA

hide sequence

RefSeq Acc Id:

XM_039101525 ⟹ XP_038957453

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	90,266,731 - 90,295,521 (-)	NCBI
mRatBN7.2	1	81,138,946 - 81,167,765 (-)	NCBI

RefSeq Acc Id:

XM_063281522 ⟹ XP_063137592

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	90,266,731 - 90,295,511 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_036914	(Get FASTA)	NCBI Sequence Viewer
	XP_017444303	(Get FASTA)	NCBI Sequence Viewer
	XP_038957453	(Get FASTA)	NCBI Sequence Viewer
	XP_063137592	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40811	(Get FASTA)	NCBI Sequence Viewer
	AAH89915	(Get FASTA)	NCBI Sequence Viewer
	AAI61819	(Get FASTA)	NCBI Sequence Viewer
	EDM08010	(Get FASTA)	NCBI Sequence Viewer
	EDM08011	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000109641
GenBank Protein	P11960	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036914 ⟸ NM_012782

- UniProtKB:

P11960 (UniProtKB/Swiss-Prot), B1WBN3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVAMSAAKIWRPSRGLRQAALLLLGRPGARGLARFHPSRQQQQQFPSLDDKPQFPGASAEFVD
KLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEEVLKLYRSMTLLNTMDRILYESQRQGR
ISFYMTNYGEEGTHVGSAAALERTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDPGKGRQM
PVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANQIVICYFGEGAASEGDAHAGFNFAAT
LECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVA
ENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEKAWR
KQSRKKVMEAFEQAERKLKPNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYPLDHFDK

hide sequence

RefSeq Acc Id:	XP_017444303 ⟸ XM_017588814
- Peptide Label:	isoform X1
- UniProtKB:	A6J973 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVAMSAAKIWRPSRGLRQAALLLLGRPGARGLARFLPQEEVLKLYRSMTLLNTMDRILYESQR QGRISFYMTNYGEEGTHVGSAAALERTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDPGKG RQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANQIVICYFGEGAASEGDAHAGFNF AATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRR AVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEK AWRKQSRKKVMEAFEQAERKLKPNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYPLDHFD K hide sequence

Ensembl Acc Id:

ENSRNOP00000027995 ⟸ ENSRNOT00000027995

RefSeq Acc Id:	XP_038957453 ⟸ XM_039101525
- Peptide Label:	isoform X2
- UniProtKB:	P11960 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000087713 ⟸ ENSRNOT00000095163

RefSeq Acc Id:	XP_063137592 ⟸ XM_063281522
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000109641 ⟸ ENSRNOT00000151777

Ensembl Acc Id:

ENSRNOP00000105536 ⟸ ENSRNOT00000139513

Protein Domains

Dehydrogenase E1 component

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P11960-F1-model_v2	AlphaFold	P11960	1-441	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2196	AgrOrtholog
BioCyc Gene	G2FUF-60375	BioCyc
BioCyc Pathway	ILEUDEG-PWY [L-isoleucine degradation I]	BioCyc
	LEU-DEG2-PWY [L-leucine degradation I]	BioCyc
	PWY-5046 [2-oxoisovalerate decarboxylation to isobutanoyl-CoA]	BioCyc
	PWY-5130 [2-oxobutanoate degradation I]	BioCyc
	PWY66-428 [L-threonine degradation V]	BioCyc
	VALDEG-PWY [L-valine degradation I]	BioCyc
BioCyc Pathway Image	ILEUDEG-PWY	BioCyc
	LEU-DEG2-PWY	BioCyc
	PWY-5046	BioCyc
	PWY-5130	BioCyc
	PWY66-428	BioCyc
	VALDEG-PWY	BioCyc
Ensembl Genes	ENSRNOG00000020607	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000151777	ENTREZGENE
Gene3D-CATH	3.40.50.970	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7305384	IMAGE-MGC_LOAD
	IMAGE:9099948	IMAGE-MGC_LOAD
InterPro	Alpha-ketoacid_DH_E1_comp	UniProtKB/Swiss-Prot
	DH_E1	UniProtKB/Swiss-Prot
	THDP-binding	UniProtKB/Swiss-Prot
KEGG Report	rno:25244	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109190	IMAGE-MGC_LOAD
	MGC:187269	IMAGE-MGC_LOAD
NCBI Gene	25244	ENTREZGENE
PANTHER	2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	PTHR43380:SF1	UniProtKB/Swiss-Prot
Pfam	E1_dh	UniProtKB/Swiss-Prot
PhenoGen	Bckdha	PhenoGen
RatGTEx	ENSRNOG00000020607	RatGTEx
Superfamily-SCOP	SSF52518	UniProtKB/Swiss-Prot
TIGR	TC218941
UniProt	A0A8I6GGA5_RAT	UniProtKB/TrEMBL
	A0ABK0LFS2_RAT	UniProtKB/TrEMBL
	A0ABK0LL10_RAT	UniProtKB/TrEMBL
	A6J973	ENTREZGENE, UniProtKB/TrEMBL
	A6J974_RAT	UniProtKB/TrEMBL
	B1WBN3	ENTREZGENE, UniProtKB/TrEMBL
	F7EV94_RAT	UniProtKB/TrEMBL
	ODBA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5EB89_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-05-09	Bckdha	branched chain keto acid dehydrogenase E1 subunit alpha	Bckdha	branched chain ketoacid dehydrogenase E1, alpha polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Bckdha	branched chain ketoacid dehydrogenase E1, alpha polypeptide		branched chain keto acid dehydrogenase subunit E1, alpha polypeptide	Name updated	1299863	APPROVED
2003-04-09	Bckdha	branched chain keto acid dehydrogenase subunit E1, alpha polypeptide		Branched chain alpha-ketoacid dehydrogenase subunit E1 alpha	Name updated	629478	APPROVED
2002-06-10	Bckdha	Branched chain alpha-ketoacid dehydrogenase subunit E1 alpha			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in liver and muscle	631719
gene_function	dehydrogenase	631719
gene_protein	18.0 kb	631719

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways