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Gene: Atp4a (ATPase H+/K+ transporting subunit alpha) Rattus norvegicus

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Symbol:

Atp4a

Name:

ATPase H+/K+ transporting subunit alpha

RGD ID:

2177

Description:

Predicted to enable P-type potassium transmembrane transporter activity and metal ion binding activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to act upstream of or within pH reduction; regulation of proton transport; and response to xenobiotic stimulus. Located in apical plasma membrane. Orthologous to human ATP4A (ATPase H+/K+ transporting subunit alpha); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esomeprazole pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ATPase H+/K+ transporting alpha subunit; ATPase H+K+-transporting alpha / (gastric HK-ATPase catalytic subunit); ATPase, H+,K+-transporting, alpha / (gastric H,K-ATPase catalytic subunit); ATPase, H+/K+ exchanging, alpha polypeptide; ATPase, H+/K+ transporting, alpha polypeptide; gastric H(+)/K(+) ATPase subunit alpha; gastric H,K-ATPase catalytic subunit; H+,K+-ATPase alpha subunit; Hka; HKATPC; hydrogen/potassium-exchanging ATPase 4A; potassium-transporting ATPase alpha chain 1; proton pump; RATHKATPC

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ATP4A (ATPase H+/K+ transporting subunit alpha)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Atp4a (ATPase, H+/K+ exchanging, gastric, alpha polypeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Atp4a (ATPase H+/K+ transporting subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ATP4A (ATPase H+/K+ transporting subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ATP4A (ATPase H+/K+ transporting subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Atp4a (ATPase H+/K+ transporting subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ATP4A (ATPase H+/K+ transporting subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ATP4A (ATPase H+/K+ transporting subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Atp4a (ATPase H+/K+ transporting subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Atp4a (ATPase H+/K+ transporting subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Atp4a (ATPase, H+/K+ exchanging, gastric, alpha polypeptide)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ATP4A (ATPase H+/K+ transporting subunit alpha)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Atpalpha	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	catp-2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	catp-3	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	atp4a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	atp4a	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	95,089,122 - 95,102,277 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	95,089,122 - 95,102,277 (+)	Ensembl				GRCr8
mRatBN7.2	1	85,961,607 - 85,974,972 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,961,708 - 85,974,844 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	91,377,251 - 91,390,049 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,843,427 - 99,856,225 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,135,546 - 93,148,344 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,162,700 - 89,175,504 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,162,639 - 89,175,811 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	90,317,629 - 90,330,433 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	85,756,388 - 85,769,192 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	80,333,302 - 80,346,109 (+)	NCBI		Celera
RGSC_v3.1	5	2,286,438 - 2,286,714 (+)	NCBI
RH 2.0 Map	1	561.1	RGD
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

stomach cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bexarotene (EXP)

bisphenol A (EXP)

butanal (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

copper atom (EXP)

copper(0) (EXP)

ethylparaben (ISO)

furan (EXP)

gentamycin (EXP)

glycidol (EXP)

graphite (EXP)

lipopolysaccharide (EXP)

N-methyl-4-phenylpyridinium (ISO)

paracetamol (EXP,ISO)

Pentagastrin (EXP)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

potassium dichromate (ISO)

pravastatin (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

sodium arsenite (ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment or maintenance of transmembrane electrochemical gradient (IEA)

gastric acid secretion (TAS)

intracellular potassium ion homeostasis (IBA)

intracellular sodium ion homeostasis (IBA)

monoatomic ion transport (IEA)

pH reduction (ISO)

potassium ion import across plasma membrane (IBA)

potassium ion transmembrane transport (IEA,ISO)

potassium ion transport (IEA)

proton transmembrane transport (IBA,IEA)

regulation of proton transport (ISO)

response to xenobiotic stimulus (ISO)

sodium ion export across plasma membrane (IBA)

Cellular Component

apical plasma membrane (IDA,IEA)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

potassium:proton exchanging ATPase complex (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

magnesium ion binding (IEA,ISO,ISS)

metal ion binding (IEA)

nucleotide binding (IEA)

P-type potassium transmembrane transporter activity (IEA)

P-type potassium:proton transporter activity (IBA,IEA,ISO,TAS)

P-type sodium:potassium-exchanging transporter activity (IBA)

potassium ion binding (ISO,ISS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cimetidine pharmacodynamics pathway (ISO)

esomeprazole pharmacodynamics pathway (ISO)

esomeprazole pharmacokinetics pathway (ISO)

famotidine pharmacodynamics pathway (ISO)

lansoprazole pharmacodynamics pathway (ISO)

lansoprazole pharmacokinetics pathway (ISO)

nizatidine pharmacodynamics pathway (ISO)

omeprazole pharmacodynamics pathway (ISO)

omeprazole pharmacokinetics pathway (ISO)

oxidative phosphorylation pathway (IEA)

pantoprazole pharmacodynamics pathway (ISO)

pantoprazole pharmacokinetics pathway (ISO)

pirenzepine pharmacodynamics pathway (ISO)

rabeprazole pharmacodynamics pathway (ISO)

rabeprazole pharmacokinetics pathway (ISO)

ranitidine pharmacodynamics pathway (ISO)

roxatidine acetate pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion.	Barone S, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3462-70. Epub 2007 Sep 5.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Identification and Analysis of Key Genes Driving Gastric Cancer Through Bioinformatics.	Liu Z, etal., Genet Test Mol Biomarkers. 2021 Jan;25(1):1-11. doi: 10.1089/gtmb.2020.0126.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes.	Newman PR, etal., DNA Cell Biol 1990 Dec;9(10):749-62.
8.	Control region and gastric specific transcription of the rat H+,K(+)-ATPase alpha subunit gene.	Oshiman K, etal., FEBS Lett 1991 Apr 9;281(1-2):250-4.
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Molecular cloning of the rat stomach (H+ + K+)-ATPase.	Shull GE and Lingrel JB, J Biol Chem 1986 Dec 25;261(36):16788-91.
15.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:1324928	PMID:7762614	PMID:7840253	PMID:15743908	PMID:22664934

Genomics

Comparative Map Data

Atp4a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	95,089,122 - 95,102,277 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	95,089,122 - 95,102,277 (+)	Ensembl				GRCr8
mRatBN7.2	1	85,961,607 - 85,974,972 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,961,708 - 85,974,844 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	91,377,251 - 91,390,049 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,843,427 - 99,856,225 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,135,546 - 93,148,344 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,162,700 - 89,175,504 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,162,639 - 89,175,811 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	90,317,629 - 90,330,433 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	85,756,388 - 85,769,192 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	80,333,302 - 80,346,109 (+)	NCBI		Celera
RGSC_v3.1	5	2,286,438 - 2,286,714 (+)	NCBI
RH 2.0 Map	1	561.1	RGD
Cytogenetic Map	1	q21	NCBI

ATP4A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	35,550,031 - 35,563,658 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	35,550,031 - 35,563,658 (-)	Ensembl			hg38	GRCh38
GRCh37	19	36,040,933 - 36,054,560 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,732,935 - 40,746,400 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	40,732,934 - 40,746,400	NCBI
Celera	19	32,754,548 - 32,768,023 (-)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	32,546,540 - 32,560,013 (-)	NCBI		HuRef
CHM1_1	19	36,042,661 - 36,056,126 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	38,094,977 - 38,108,614 (-)	NCBI		T2T-CHM13v2.0

Atp4a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,411,634 - 30,424,959 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,411,634 - 30,424,959 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	30,712,209 - 30,725,534 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,712,209 - 30,725,534 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	31,497,251 - 31,510,553 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,421,112 - 30,433,944 (+)	NCBI		MGSCv36	mm8
Celera	7	25,294,279 - 25,307,645 (+)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	19.2	NCBI

Atp4a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	4,778,295 - 4,842,366 (-)	Ensembl
ChiLan1.0	NW_004955468	4,778,327 - 4,844,498 (-)	NCBI	ChiLan1.0	ChiLan1.0

ATP4A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	41,562,807 - 41,577,373 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	43,546,280 - 43,560,837 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	32,496,614 - 32,510,649 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	41,233,630 - 41,246,893 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	41,234,052 - 41,248,628 (-)	Ensembl			panPan2	panpan1.1

ATP4A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	117,103,937 - 117,116,779 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	117,103,620 - 117,116,778 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,507,704 - 116,519,874 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	117,705,000 - 117,716,940 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	117,604,904 - 117,716,954 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	117,267,860 - 117,280,034 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	116,893,656 - 116,905,826 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	117,949,139 - 117,961,076 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Atp4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	10,831,472 - 10,843,738 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	802,170 - 814,056 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	802,170 - 815,023 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP4A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	44,984,233 - 44,997,552 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	44,984,014 - 45,057,796 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,444,521 - 40,454,205 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP4A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,475,352 - 30,489,500 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,475,764 - 30,489,080 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	8,269,571 - 8,283,253 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp4a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	8,033,020 - 8,060,292 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	8,046,638 - 8,059,359 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Atp4a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	165,291,205 - 165,303,726 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Atp4a
20 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	50
Count of miRNA genes:	42
Interacting mature miRNAs:	49
Transcripts:	ENSRNOT00000028508
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	92963855	109494029	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat

Markers in Region

D1Bda8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	85,974,512 - 85,974,817 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	89,175,480 - 89,175,784	NCBI	Rnor6.0
Rnor_5.0	1	90,330,409 - 90,330,713	UniSTS	Rnor5.0
RGSC_v3.4	1	85,769,168 - 85,769,472	UniSTS	RGSC3.4
Celera	1	80,346,085 - 80,346,389	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
14	9	61	133	66	65	34	63	34	6	261	148	3	115	58	84	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L11569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M63963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X61933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X61934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X61935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028508 ⟹ ENSRNOP00000028508

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,089,122 - 95,102,277 (+)	Ensembl
mRatBN7.2 Ensembl	1	85,961,733 - 85,974,844 (+)	Ensembl
Rnor_6.0 Ensembl	1	89,162,639 - 89,175,811 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107494 ⟹ ENSRNOP00000083096

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,089,128 - 95,102,264 (+)	Ensembl
mRatBN7.2 Ensembl	1	85,961,708 - 85,974,844 (+)	Ensembl

RefSeq Acc Id:

NM_012509 ⟹ NP_036641

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	95,089,122 - 95,102,277 (+)	NCBI
mRatBN7.2	1	85,961,702 - 85,974,857 (+)	NCBI
Rnor_6.0	1	89,162,700 - 89,175,504 (+)	NCBI
Rnor_5.0	1	90,317,629 - 90,330,433 (+)	NCBI
RGSC_v3.4	1	85,756,388 - 85,769,192 (+)	RGD
Celera	1	80,333,302 - 80,346,109 (+)	RGD

Sequence:

show sequence

ATGGGGAAGGCAGAGAATTATGAATTGTACTCAGTGGAACTGGGGACTGGCCCTGGTGGGAACA
TGGCTGCCAAGATGAGCAAGAAGAAGGCGGGAGGCGGGGGAGGCAAGAAGAAGGAGAAGCTAGA
GAACATGAAGAAGGAGATGGAGATGAACGACCACCAGTTGTCAGTGTCTGAGCTGGAGCAGAAG
TACCAGACCAGTGCCACCAAGGGCCTGAAGGCGAGTCTGGCAGCTGAGCTGCTGCTGAGGGATG
GGCCCAATGCACTCCGGCCACCTCGGGGCACCCCTGAGTACGTGAAGTTCGCCCGGCAGCTGGC
AGGCGGTCTGCAGTGCCTCATGTGGGTGGCTGCAGCCATCTGCCTCATTGCCTTTGCGATTCAG
GCCAGCGAGGGAGACCTGACCACTGATGACAATTTGTACCTGGCGTTGGCACTCATTGCTGTGG
TTGTGGTCACTGGCTGTTTTGGCTACTACCAGGAGTTCAAGAGCACAAATATCATCGCCAGCTT
CAAGAATCTTGTACCCCAGCAAGCCACAGTGATCCGAGACGGGGATAAGTTCCAGATCAACGCG
GATCAGCTTGTGGTGGGCGACCTGGTAGAGATGAAAGGCGGGGACCGCGTCCCAGCAGACATCC
GAATTCTGTCAGCCCAGGGCTGCAAGGTGGACAACTCCTCGCTTACTGGAGAGTCTGAACCGCA
GACCCGCTCACCTGAGTGTACACACGAGAGTCCCCTTGAGACCCGCAACATCGCCTTCTTCTCC
ACCATGTGTCTGGAGGGCACGGCGCAGGGCTTGGTGGTGAGCACCGGTGATCGCACCATCATTG
GACGCATCGCCTCTCTGGCTTCGGGTGTGGAAAACGAGAAGACTCCTATCGCGATCGAGATCGA
ACATTTTGTGGACATCATTGCTGGCCTGGCCATCCTCTTCGGTGCCACATTCTTTGTGGTGGCC
ATGTGTATCGGCTATACCTTCCTTCGGGCCATGGTCTTCTTCATGGCCATTGTGGTAGCCTATG
TGCCTGAGGGGCTGCTGGCTACTGTCACGGTCTGCCTGTCACTGACAGCAAAGAGGCTGGCCAG
TAAAAACTGTGTGGTCAAAAATCTGGAAGCAGTGGAGACCCTGGGTTCCACGTCAGTCATCTGC
TCAGACAAGACAGGAACTCTTACTCAGAACCGCATGACGGTGTCTCATCTATGGTTTGACAACC
ATATCCACACGGCGGACACCACAGAAGACCAGTCAGGGCAAACGTTCGACCAATCGTCGGAGAC
CTGGCGGGCGCTGTGCCGCGTGCTCACCCTGTGCAACCGCGCTGCCTTCAAGTCTGGCCAGGAC
GCCGTGCCAGTGCCCAAGCGCATCGTGATCGGAGACGCATCTGAGACTGCGCTGCTCAAGTTCT
CGGAGTTGACGTTGGGCAACGCCATGGGTTATCGGGACCGCTTCCCCAAAGTTTGCGAGATCCC
CTTCAACTCCACCAACAAGTTTCAGCTGTCCATTCACACTCTGGAGGATCCGCGCGACCCCCGG
CACTTGCTGGTGATGAAGGGCGCCCCAGAGCGCGTGCTGGAGCGTTGCAGCTCCATCCTCATCA
AGGGCCAGGAGCTGCCCCTGGACGAGCAATGGCGTGAGGCCTTCCAGACAGCCTACCTTAGCCT
GGGAGGCCTAGGCGAACGCGTTCTTGGTTTCTGCCAGCTCTACCTGAATGAGAAGGACTACCCG
CCTGGCTACACCTTTGATGTGGAGGCCATGAACTTTCCAAGTAGTGGCCTCTGCTTTGCGGGAC
TTGTATCCATGATTGACCCTCCCCGGGCCACCGTTCCAGATGCTGTGCTCAAATGCCGTACGGC
AGGCATCCGGGTGATCATGGTGACTGGTGACCATCCCATCACAGCCAAGGCCATTGCAGCCAGT
GTGGGGATCATCTCGGAAGGCAGCGAGACAGTGGAAGACATCGCCGCCCGCCTCCGAATGCCTG
TAGACCAGGTTAATAAGAAGGATGCCCGGGCCTGTGTGATCAATGGCATGCAGTTGAAGGACAT
GGACCCATCTGAGCTGGTGGAGGCGCTGCGCACCCACCCTGAGATGGTGTTTGCTCGAACCAGT
CCTCAGCAGAAGCTGGTGATTGTGGAGAGCTGTCAGCGACTGGGTGCCATTGTGGCTGTAACAG
GGGATGGTGTGAATGACTCCCCAGCCCTGAAGAAGGCTGACATTGGTGTAGCCATGGGCATTGC
TGGCTCCGATGCTGCTAAAAATGCTGCTGACATGATCTTGCTGGATGACAACTTCGCTTCCATT
GTGACGGGCGTGGAGCAGGGCCGACTGATCTTTGACAACCTGAAGAAATCCATCGCCTATACAC
TGACCAAGAACATTCCAGAACTGACACCCTACCTTATCTATATCACTGTCAGTGTGCCCCTACC
CCTTGGGTGTATCACCATTCTCTTCATAGAACTCTGCACAGATATCTTTCCATCTGTGTCCCTG
GCATATGAAAAGGCCGAGAGTGACATCATGCACCTGCGCCCACGGAACCCCAGGCGGGACCGGT
TGGTCAATGAACCCCTGGCTGCTTATTCCTATTTTCAGATTGGTGCCATTCAGTCATTTGCCGG
CTTTGCTGACTACTTCACGGCCATGGCCCAGGAGGGCTGGTTCCCTCTGCTGTGTGTGGGGCTG
CGACCACAATGGGAGGACCACCATCTACAAGATCTTCAAGACAGCTACGGCCAGGAATGGACAT
TTGGTCAGCGTCTGTACCAGCAGTACACCTGTTACACCGTGTTCTTCATCAGCATCGAGATGTG
CCAGATCGCTGATGTCCTCATCCGCAAGACACGCCGCCTCTCCGCTTTCCAGCAGGGATTCTTC
AGGAACAGGATCCTGGTGATCGCCATCGTGTTTCAGGTCTGCATTGGCTGCTTCCTGTGCTACT
GCCCAGGGATGCCCAACATCTTCAACTTCATGCCCATCCGGTTCCAGTGGTGGCTGGTCCCCAT
GCCCTTTGGCCTTCTCATCTTTGTCTATGATGAGATCCGGAAACTTGGAGTTCGCTGTTGCCCA
GGGAGCTGGTGGGACCAGGAACTCTACTATTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_036641	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41331	(Get FASTA)	NCBI Sequence Viewer
	AAA72354	(Get FASTA)	NCBI Sequence Viewer
	CAA43937	(Get FASTA)	NCBI Sequence Viewer
	CAA43938	(Get FASTA)	NCBI Sequence Viewer
	CAA43939	(Get FASTA)	NCBI Sequence Viewer
	EDM07724	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028508
GenBank Protein	P09626	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036641 ⟸ NM_012509

- UniProtKB:

F1LRK1 (UniProtKB/TrEMBL), A6JA10 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGKAENYELYSVELGTGPGGNMAAKMSKKKAGGGGGKKKEKLENMKKEMEMNDHQLSVSELEQK
YQTSATKGLKASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQ
ASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINA
DQLVVGDLVEMKGGDRVPADIRILSAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFS
TMCLEGTAQGLVVSTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFVVA
MCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVIC
SDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQD
AVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPR
HLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYP
PGYTFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAAS
VGIISEGSETVEDIAARLRMPVDQVNKKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTS
PQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASI
VTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSL
AYEKAESDIMHLRPRNPRRDRLVNEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGL
RPQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFF
RNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCP
GSWWDQELYY

hide sequence

Ensembl Acc Id:

ENSRNOP00000028508 ⟸ ENSRNOT00000028508

Ensembl Acc Id:

ENSRNOP00000083096 ⟸ ENSRNOT00000107494

Protein Domains

Cation-transporting P-type ATPase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P09626-F1-model_v2	AlphaFold	P09626	1-1033	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689928

Promoter ID:

EPDNEW_R452

Type:

single initiation site

Name:

Atp4a_1

Description:

ATPase H+/K+ transporting alpha subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	89,162,669 - 89,162,729	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2177	AgrOrtholog
BioCyc Gene	G2FUF-60082	BioCyc
Ensembl Genes	ENSRNOG00000020985	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000028508	ENTREZGENE
Gene3D-CATH	3.40.1110.10	UniProtKB/Swiss-Prot
	3.40.50.1000	UniProtKB/Swiss-Prot
	Calcium-transporting ATPase, cytoplasmic transduction domain A	UniProtKB/Swiss-Prot
	Calcium-transporting ATPase, transmembrane domain	UniProtKB/Swiss-Prot
InterPro	ATPase_P-typ_cation-transptr_C	UniProtKB/Swiss-Prot
	ATPase_P-typ_cation-transptr_N	UniProtKB/Swiss-Prot
	ATPase_P-typ_cyto_dom_N	UniProtKB/Swiss-Prot
	ATPase_P-typ_H/K-transp_N	UniProtKB/Swiss-Prot
	ATPase_P-typ_P_site	UniProtKB/Swiss-Prot
	ATPase_P-typ_TM_dom_sf	UniProtKB/Swiss-Prot
	ATPase_P-typ_transduc_dom_A_sf	UniProtKB/Swiss-Prot
	Cation_transp_ATPase_P-type	UniProtKB/Swiss-Prot
	HAD-like_sf	UniProtKB/Swiss-Prot
	HAD_sf	UniProtKB/Swiss-Prot
	P-type_ATPase_IIC	UniProtKB/Swiss-Prot
	P_typ_ATPase	UniProtKB/Swiss-Prot
	P_typ_ATPase_HD_dom	UniProtKB/Swiss-Prot
NCBI Gene	24216	ENTREZGENE
PANTHER	POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1	UniProtKB/Swiss-Prot
	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA	UniProtKB/Swiss-Prot
Pfam	Cation_ATPase	UniProtKB/Swiss-Prot
	Cation_ATPase_C	UniProtKB/Swiss-Prot
	Cation_ATPase_N	UniProtKB/Swiss-Prot
	E1-E2_ATPase	UniProtKB/Swiss-Prot
	H-K_ATPase_N	UniProtKB/Swiss-Prot
	Hydrolase	UniProtKB/Swiss-Prot
PhenoGen	Atp4a	PhenoGen
PRINTS	CATATPASE	UniProtKB/Swiss-Prot
	NAKATPASE	UniProtKB/Swiss-Prot
PROSITE	ATPASE_E1_E2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000020985	RatGTEx
SMART	Cation_ATPase_N	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56784	UniProtKB/Swiss-Prot
	SSF81653	UniProtKB/Swiss-Prot
	SSF81660	UniProtKB/Swiss-Prot
	SSF81665	UniProtKB/Swiss-Prot
TIGR	TC233041
UniProt	A0A8I5ZYI7_RAT	UniProtKB/TrEMBL
	A6JA10	ENTREZGENE, UniProtKB/TrEMBL
	ATP4A_RAT	UniProtKB/Swiss-Prot
	F1LRK1	ENTREZGENE, UniProtKB/TrEMBL
	P09626	ENTREZGENE
UniProt Secondary	P70511	UniProtKB/Swiss-Prot
	P97892	UniProtKB/Swiss-Prot
	Q63253	UniProtKB/Swiss-Prot
	Q6LD86	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-03	Atp4a	ATPase H+/K+ transporting subunit alpha	Atp4a	ATPase H+/K+ transporting alpha subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-17	Atp4a	ATPase H+/K+ transporting alpha subunit	Atp4a	ATPase, H+/K+ exchanging, alpha polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Atp4a	ATPase, H+/K+ exchanging, alpha polypeptide		ATPase, H+/K+ transporting, alpha polypeptide	Name updated	1299863	APPROVED
2002-11-06	Atp4a	ATPase, H+/K+ transporting, alpha polypeptide		ATPase, H+,K+-transporting, alpha / (gastric H,K-ATPase catalytic subunit)	Name updated	625702	APPROVED
2002-06-10	Atp4a	ATPase, H+,K+-transporting, alpha / (gastric H,K-ATPase catalytic subunit)			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	gene was transcribed only in gastric mucosa	631780
gene_function	subunit of ATP dependent pump that catalyzes the exchange of H+ and K+	631722
gene_process	involved in secretion of acid into the stomach	631722
gene_transcript	may have response elements for Ca2+ and cAMP	631781

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)