Apoc1 (apolipoprotein C1) - Rat Genome Database

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Gene: Apoc1 (apolipoprotein C1) Rattus norvegicus
Analyze
Symbol: Apoc1
Name: apolipoprotein C1
RGD ID: 2134
Description: Predicted to enable fatty acid binding activity and phospholipase inhibitor activity. Involved in regulation of lipid transport. Part of high-density lipoprotein particle and very-low-density lipoprotein particle. Human ortholog(s) of this gene implicated in Alzheimer's disease and obesity. Orthologous to human APOC1 (apolipoprotein C1); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALPCI; apo-CI; Apo-CIB; apoC-I; ApoC-IB; apolipoprotein C-I; liver regeneration-related protein LRRG04; LRRG04; NEWGENE_2134
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,475,018 - 88,479,052 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,474,663 - 88,478,155 (-)EnsemblGRCr8
mRatBN7.2179,347,057 - 79,350,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,346,136 - 79,350,375 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,741,974 - 84,745,241 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,293,309 - 93,296,592 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,497,080 - 86,500,347 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,606,638 - 80,609,921 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,606,638 - 80,609,921 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,872,116 - 81,875,399 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,996,677 - 78,999,960 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,806,255 - 73,809,538 (-)NCBICelera
RGSC_v3.1179,074,789 - 79,077,986 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-ephedrine  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
belinostat  (ISO)
Benoxacor  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
capsaicin  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dicyclanil  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
indometacin  (EXP,ISO)
isotretinoin  (ISO)
lithocholic acid  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
nickel atom  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
tributylstannane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. APOE and APOC1 genetic polymorphisms in age-associated memory impairment. Bartres-Faz D, etal., Neurogenetics. 2001 Oct;3(4):215-9.
2. Serum apolipoproteins C-I and C-III are reduced in stomach cancer patients: results from MALDI-based peptidome and immuno-based clinical assays. Cohen M, etal., PLoS One. 2011 Jan 18;6(1):e14540. doi: 10.1371/journal.pone.0014540.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Very low-density lipoprotein-apoprotein CI is increased in diabetic nephropathy: comparison with apoprotein CIII. Hirano T, etal., Kidney Int. 2003 Jun;63(6):2171-7.
6. Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3. Jong MC, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):472-84.
7. Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1. Jong MC, etal., Diabetes. 2001 Dec;50(12):2779-85.
8. Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease. Ki CS, etal., Neurosci Lett. 2002 Feb 15;319(2):75-8.
9. Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes. Masson D, etal., J Lipid Res. 2006 Feb;47(2):356-65. Epub 2005 Nov 10.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Abnormal composition of apoproteins C-I, C-II, and C-III in plasma and very-low-density lipoproteins of non-insulin-dependent diabetic Chinese. Pan XR, etal., Clin Chem. 1986 Oct;32(10):1914-20.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Stromal responses to carcinomas of the pancreas: juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtype. Ricci F, etal., Cancer Biol Ther. 2005 Mar;4(3):302-7. Epub 2005 Mar 23.
17. Two coding regions closely linked to the rat apolipoprotein E gene: nucleotide sequences of rat apolipoprotein C-I and ECL cDNA. Shen P and Howlett GJ, Arch Biochem Biophys 1992 Sep;297(2):345-53.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus-related hepatocellular carcinoma. Wang X, etal., J Cell Biochem. 2019 Oct;120(10):18246-18265. doi: 10.1002/jcb.29131. Epub 2019 Jun 18.
Additional References at PubMed
PMID:182536   PMID:1917954   PMID:2302419   PMID:2771655   PMID:4020294   PMID:7848292   PMID:10978346   PMID:11162594   PMID:12477932   PMID:15576844   PMID:17339654   PMID:23376485  


Genomics

Comparative Map Data
Apoc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,475,018 - 88,479,052 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,474,663 - 88,478,155 (-)EnsemblGRCr8
mRatBN7.2179,347,057 - 79,350,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,346,136 - 79,350,375 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,741,974 - 84,745,241 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,293,309 - 93,296,592 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,497,080 - 86,500,347 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,606,638 - 80,609,921 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,606,638 - 80,609,921 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,872,116 - 81,875,399 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,996,677 - 78,999,960 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,806,255 - 73,809,538 (-)NCBICelera
RGSC_v3.1179,074,789 - 79,077,986 (-)NCBI
Cytogenetic Map1q21NCBI
APOC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,914,325 - 44,919,346 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,913,133 - 44,920,054 (+)Ensemblhg38GRCh38
GRCh371945,417,582 - 45,422,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,109,761 - 50,114,446 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341950,109,760 - 50,114,446NCBI
Celera1942,222,238 - 42,226,929 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,848,690 - 41,853,227 (+)NCBIHuRef
CHM1_11945,420,643 - 45,425,333 (+)NCBICHM1_1
T2T-CHM13v2.01947,739,017 - 47,744,046 (+)NCBIT2T-CHM13v2.0
Apoc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,423,405 - 19,426,584 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,423,406 - 19,426,585 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,689,480 - 19,692,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,689,481 - 19,692,660 (-)Ensemblmm10GRCm38
MGSCv37720,274,830 - 20,278,007 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36718,848,007 - 18,851,095 (-)NCBIMGSCv36mm8
Celera717,095,563 - 17,098,741 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555552,005,962 - 2,007,239 (+)NCBIChiLan1.0ChiLan1.0
LOC100994952
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,084,361 - 51,104,382 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,956,135 - 52,961,814 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,862,168 - 41,878,231 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,468,337 - 50,480,967 (+)NCBIPanPan1.1PanPan1.1panPan2
APOC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,520,177 - 110,522,563 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,520,198 - 110,631,412 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1110,001,120 - 110,003,506 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01111,049,949 - 111,052,329 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,049,970 - 111,194,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,724,595 - 110,726,986 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,360,068 - 110,362,462 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,228,866 - 111,231,250 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apoc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,171,122 - 17,173,636 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,519,248 - 1,520,102 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236677216,928 - 11,782 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,758,696 - 1,760,611 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249071,758,671 - 1,760,611 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Apoc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12170,923,673 - 170,927,490 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Apoc1
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:59
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000046169
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 59 150 100 99 68 39 68 6 258 122 4 136 44 85 31 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY327505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000046169   ⟹   ENSRNOP00000040585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,475,026 - 88,478,155 (-)Ensembl
mRatBN7.2 Ensembl179,347,053 - 79,350,340 (-)Ensembl
Rnor_6.0 Ensembl180,606,638 - 80,609,921 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091647   ⟹   ENSRNOP00000068542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl180,606,640 - 80,609,836 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115465   ⟹   ENSRNOP00000081499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,346,136 - 79,350,375 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162861   ⟹   ENSRNOP00000100847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,474,663 - 88,478,155 (-)Ensembl
RefSeq Acc Id: NM_001109996   ⟹   NP_001103466
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,475,022 - 88,478,305 (-)NCBI
mRatBN7.2179,347,057 - 79,350,340 (-)NCBI
Rnor_6.0180,606,638 - 80,609,921 (-)NCBI
Rnor_5.0181,872,116 - 81,875,399 (-)NCBI
RGSC_v3.4178,996,677 - 78,999,960 (-)RGD
Celera173,806,255 - 73,809,538 (-)RGD
Sequence:
RefSeq Acc Id: NM_012824   ⟹   NP_036956
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,475,022 - 88,478,220 (-)NCBI
mRatBN7.2179,347,057 - 79,350,255 (-)NCBI
Rnor_6.0180,606,638 - 80,609,921 (-)NCBI
Rnor_5.0181,872,116 - 81,875,399 (-)NCBI
RGSC_v3.4178,996,677 - 78,999,960 (-)RGD
Celera173,806,255 - 73,809,538 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281630   ⟹   XP_063137700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,475,018 - 88,478,958 (-)NCBI
RefSeq Acc Id: XM_063281631   ⟹   XP_063137701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,475,018 - 88,479,052 (-)NCBI
RefSeq Acc Id: XM_063281632   ⟹   XP_063137702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,475,018 - 88,478,858 (-)NCBI
RefSeq Acc Id: NP_036956   ⟸   NM_012824
- Peptide Label: precursor
- UniProtKB: Q53ZD8 (UniProtKB/Swiss-Prot),   P19939 (UniProtKB/Swiss-Prot),   A6J8R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103466   ⟸   NM_001109996
- Peptide Label: precursor
- UniProtKB: Q53ZD8 (UniProtKB/Swiss-Prot),   P19939 (UniProtKB/Swiss-Prot),   A6J8R3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068542   ⟸   ENSRNOT00000091647
Ensembl Acc Id: ENSRNOP00000040585   ⟸   ENSRNOT00000046169
Ensembl Acc Id: ENSRNOP00000081499   ⟸   ENSRNOT00000115465
RefSeq Acc Id: XP_063137701   ⟸   XM_063281631
- Peptide Label: isoform X1
- UniProtKB: Q53ZD8 (UniProtKB/Swiss-Prot),   P19939 (UniProtKB/Swiss-Prot),   A6J8R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137700   ⟸   XM_063281630
- Peptide Label: isoform X1
- UniProtKB: Q53ZD8 (UniProtKB/Swiss-Prot),   P19939 (UniProtKB/Swiss-Prot),   A6J8R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137702   ⟸   XM_063281632
- Peptide Label: isoform X1
- UniProtKB: Q53ZD8 (UniProtKB/Swiss-Prot),   P19939 (UniProtKB/Swiss-Prot),   A6J8R3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100847   ⟸   ENSRNOT00000162861

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19939-F1-model_v2 AlphaFold P19939 1-88 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689779
Promoter ID:EPDNEW_R303
Type:multiple initiation site
Name:Apoc1_1
Description:apolipoprotein C1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,609,921 - 80,609,981EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2134 AgrOrtholog
BioCyc Gene G2FUF-60489 BioCyc
Ensembl Genes ENSRNOG00000018426 Ensembl
Gene3D-CATH 4.10.260.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7372566 IMAGE-MGC_LOAD
InterPro ApoC-1_sf UniProtKB/Swiss-Prot
  ApoC-I UniProtKB/Swiss-Prot
KEGG Report rno:25292 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112622 IMAGE-MGC_LOAD
NCBI Gene 25292 ENTREZGENE
PANTHER APOLIPOPROTEIN C-I UniProtKB/Swiss-Prot
  PTHR16565 UniProtKB/Swiss-Prot
Pfam ApoC-I UniProtKB/Swiss-Prot
PhenoGen Apoc1 PhenoGen
RatGTEx ENSRNOG00000018426 RatGTEx
TIGR TC209704
UniProt A0A8L2ULG0_RAT UniProtKB/TrEMBL
  A0ABK0LCK2_RAT UniProtKB/TrEMBL
  A6J8R2_RAT UniProtKB/TrEMBL
  A6J8R3 ENTREZGENE, UniProtKB/TrEMBL
  APOC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q53ZD8 ENTREZGENE
UniProt Secondary Q53ZD8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Apoc1  apolipoprotein C1  NEWGENE_2134  apolipoprotein C1  Data merged from RGD:11432420 737654 PROVISIONAL
2016-08-02 NEWGENE_2134  apolipoprotein C1      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-05-04 Apoc1  apolipoprotein C1  Apoc1  apolipoprotein C-I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Apoc1  apolipoprotein C-I    Apolipoprotein C1  Name updated 629478 APPROVED
2002-06-10 Apoc1  Apolipoprotein C1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 70608
gene_mapping maps 4.5 kb downstream of the Apoe gene 70608
gene_protein mature protein contains histidine and lacks valine 70608