Acadl (acyl-CoA dehydrogenase, long chain) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Acadl (acyl-CoA dehydrogenase, long chain) Rattus norvegicus
Analyze
Symbol: Acadl
Name: acyl-CoA dehydrogenase, long chain
RGD ID: 2011
Description: Enables flavin adenine dinucleotide binding activity; long-chain fatty acyl-CoA dehydrogenase activity; and protein homodimerization activity. Involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase and long-chain fatty acid catabolic process. Located in mitochondrial matrix and mitochondrial membrane. Orthologous to human ACADL (acyl-CoA dehydrogenase long chain); PARTICIPATES IN fatty acid beta degradation pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; carnitine palmitoyltransferase I deficiency pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acetyl-Coenzyme A dehydrogenase, long-chain; ACOADA; Acyl Coenzyme A dehydrogenase long chain; Acyl Coenzyme A dehydrogenase, long chain; acyl-Coenzyme A dehydrogenase, long-chain; LCAD; LCAD long chain acyl-CoA dehydrogenase; LCAD, long chain acyl-CoA dehydrogenase; long-chain acyl-CoA dehydrogenase; long-chain specific acyl-CoA dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8975,783,689 - 75,822,077 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl975,783,689 - 75,822,164 (-)EnsemblGRCr8
mRatBN7.2968,333,981 - 68,372,149 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl968,333,980 - 68,372,220 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx976,823,956 - 76,861,404 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0981,952,887 - 81,990,335 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0980,351,815 - 80,389,588 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0973,833,368 - 73,871,857 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl973,833,388 - 73,871,888 (-)Ensemblrn6Rnor6.0
Rnor_5.0973,434,371 - 73,472,895 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4965,613,130 - 65,651,775 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera965,813,263 - 65,851,320 (-)NCBICelera
RGSC_v3.1965,760,111 - 65,798,754 (-)NCBI
RH 3.4 Map9612.99RGD
Cytogenetic Map9q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
Alisol B  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brequinar  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorotoluron  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
Di-n-hexyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
glucose  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lipoic acid  (EXP)
meldonium  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
mitochondrial matrix  (IDA,IEA)
mitochondrial membrane  (IDA)
mitochondrion  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Acyl-CoA dehydrogenases. A mechanistic overview. Ghisla S and Thorpe C, Eur J Biochem. 2004 Feb;271(3):494-508.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation. Guerra C, etal., J Clin Invest. 1998 Nov 1;102(9):1724-31. doi: 10.1172/JCI4532.
5. Biosynthesis of four rat liver mitochondrial acyl-CoA dehydrogenases: in vitro synthesis, import into mitochondria, and processing of their precursors in a cell-free system and in cultured cells. Ikeda Y, etal., Arch Biochem Biophys. 1987 Feb 1;252(2):662-74.
6. Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme. Ikeda Y, etal., J Biol Chem. 1985 Jan 25;260(2):1311-25.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family. Matsubara Y, etal., J Biol Chem 1989 Sep 25;264(27):16321-31.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Cloning of a cDNA for short/branched chain acyl-Coenzyme A dehydrogenase from rat and characterization of its tissue expression and substrate specificity. Willard J, etal., Arch Biochem Biophys 1996 Jul 1;331(1):127-33.
Additional References at PubMed
PMID:8268228   PMID:9861014   PMID:14651853   PMID:15489334   PMID:15639194   PMID:18614015   PMID:21151927   PMID:23106098   PMID:26316108   PMID:26767982  


Genomics

Comparative Map Data
Acadl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8975,783,689 - 75,822,077 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl975,783,689 - 75,822,164 (-)EnsemblGRCr8
mRatBN7.2968,333,981 - 68,372,149 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl968,333,980 - 68,372,220 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx976,823,956 - 76,861,404 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0981,952,887 - 81,990,335 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0980,351,815 - 80,389,588 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0973,833,368 - 73,871,857 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl973,833,388 - 73,871,888 (-)Ensemblrn6Rnor6.0
Rnor_5.0973,434,371 - 73,472,895 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4965,613,130 - 65,651,775 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera965,813,263 - 65,851,320 (-)NCBICelera
RGSC_v3.1965,760,111 - 65,798,754 (-)NCBI
RH 3.4 Map9612.99RGD
Cytogenetic Map9q32NCBI
ACADL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382210,187,923 - 210,225,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2210,187,126 - 210,225,447 (-)Ensemblhg38GRCh38
GRCh372211,052,647 - 211,090,171 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362210,760,959 - 210,798,392 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342210,878,223 - 210,915,653NCBI
Celera2204,820,713 - 204,858,229 (-)NCBICelera
Cytogenetic Map2q34ENTREZGENE
HuRef2202,897,948 - 202,935,464 (-)NCBIHuRef
CHM1_12211,058,802 - 211,096,307 (-)NCBICHM1_1
T2T-CHM13v2.02210,668,601 - 210,706,298 (-)NCBIT2T-CHM13v2.0
Acadl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39166,869,998 - 66,902,468 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl166,869,998 - 66,902,436 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38166,830,839 - 66,863,309 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl166,830,839 - 66,863,277 (-)Ensemblmm10GRCm38
MGSCv37166,877,427 - 66,909,841 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36166,764,061 - 66,796,475 (-)NCBIMGSCv36mm8
Celera167,346,353 - 67,377,247 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map133.64NCBI
Acadl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554575,266,033 - 5,300,056 (+)Ensembl
ChiLan1.0NW_0049554575,266,032 - 5,300,632 (+)NCBIChiLan1.0ChiLan1.0
ACADL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213112,810,225 - 112,849,103 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B112,824,820 - 112,864,084 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B97,445,421 - 97,483,514 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B215,847,775 - 215,885,524 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B215,847,775 - 215,885,524 (-)EnsemblpanPan2panpan1.1
ACADL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13718,028,244 - 18,073,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3718,017,087 - 18,073,862 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3718,906,886 - 18,954,457 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03717,964,225 - 18,011,748 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3717,968,220 - 18,011,731 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13717,917,084 - 17,964,271 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03717,879,408 - 17,926,609 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03717,894,240 - 17,941,487 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acadl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303166,499,563 - 166,529,186 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493684566,241 - 96,249 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493684566,674 - 96,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACADL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15112,933,506 - 112,969,577 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115112,935,631 - 112,969,381 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215124,759,345 - 124,793,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACADL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11095,886,502 - 95,925,928 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1095,887,465 - 95,925,578 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040103,432,787 - 103,482,132 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acadl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247656,018,534 - 6,050,736 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acadl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14139,995,245 - 140,033,002 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acadl
249 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000017686
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
AW530440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2968,371,430 - 68,371,643 (+)MAPPERmRatBN7.2
Rnor_6.0973,871,139 - 73,871,351NCBIRnor6.0
Rnor_5.0973,434,877 - 73,435,089UniSTSRnor5.0
RGSC_v3.4965,651,057 - 65,651,269UniSTSRGSC3.4
Celera965,850,602 - 65,850,814UniSTS
RH 3.4 Map9597.4UniSTS
Cytogenetic Map9q32UniSTS
RH142293  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0973,465,420 - 73,467,333NCBIRnor5.0
RGSC_v3.4965,618,692 - 65,620,274UniSTSRGSC3.4
Celera965,818,825 - 65,820,407UniSTS
RH 3.4 Map9612.99UniSTS
Cytogenetic Map9q32UniSTS
ACADL  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2968,362,611 - 68,362,737 (+)MAPPERmRatBN7.2
Rnor_6.0973,862,321 - 73,862,446NCBIRnor6.0
Rnor_5.0973,443,782 - 73,443,907UniSTSRnor5.0
RGSC_v3.4965,642,239 - 65,642,364UniSTSRGSC3.4
Celera965,841,784 - 65,841,909UniSTS
Cytogenetic Map9q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017686   ⟹   ENSRNOP00000017686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl975,783,689 - 75,822,164 (-)Ensembl
mRatBN7.2 Ensembl968,333,983 - 68,372,220 (-)Ensembl
Rnor_6.0 Ensembl973,833,388 - 73,871,888 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118459   ⟹   ENSRNOP00000097339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl975,783,689 - 75,817,314 (-)Ensembl
mRatBN7.2 Ensembl968,333,980 - 68,367,608 (-)Ensembl
RefSeq Acc Id: NM_012819   ⟹   NP_036951
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8975,783,689 - 75,821,854 (-)NCBI
mRatBN7.2968,333,981 - 68,372,149 (-)NCBI
Rnor_6.0973,833,368 - 73,871,857 (-)NCBI
Rnor_5.0973,434,371 - 73,472,895 (+)NCBI
RGSC_v3.4965,613,130 - 65,651,775 (-)RGD
Celera965,813,263 - 65,851,320 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266668   ⟹   XP_063122738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8975,790,793 - 75,822,077 (-)NCBI
RefSeq Acc Id: NP_036951   ⟸   NM_012819
- Peptide Label: precursor
- UniProtKB: P15650 (UniProtKB/Swiss-Prot),   A6KFD6 (UniProtKB/TrEMBL),   A0A8I6GMH0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017686   ⟸   ENSRNOT00000017686
Ensembl Acc Id: ENSRNOP00000097339   ⟸   ENSRNOT00000118459
RefSeq Acc Id: XP_063122738   ⟸   XM_063266668
- Peptide Label: isoform X1
Protein Domains
Acyl-CoA dehydrogenase/oxidase C-terminal   Acyl-CoA dehydrogenase/oxidase N-terminal   Acyl-CoA oxidase/dehydrogenase middle

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15650-F1-model_v2 AlphaFold P15650 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696724
Promoter ID:EPDNEW_R7249
Type:initiation region
Name:Acadl_1
Description:acyl-CoA dehydrogenase, long chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0973,871,908 - 73,871,968EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2011 AgrOrtholog
BioCyc Gene G2FUF-27289 BioCyc
Ensembl Genes ENSRNOG00000012966 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017686 ENTREZGENE
  ENSRNOT00000017686.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot
  2.40.110.10 UniProtKB/Swiss-Prot
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599828 IMAGE-MGC_LOAD
InterPro Acyl-CoA_dehydrogenase UniProtKB/Swiss-Prot
  Acyl-CoA_DH_CS UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot
  AcylCo_DH-like_C UniProtKB/Swiss-Prot
  AcylCo_DH/oxidase_C UniProtKB/Swiss-Prot
  AcylCoA_DH/ox_N UniProtKB/Swiss-Prot
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot
  LCAD UniProtKB/Swiss-Prot
KEGG Report rno:25287 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72554 IMAGE-MGC_LOAD
NCBI Gene 25287 ENTREZGENE
PANTHER LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
Pfam Acyl-CoA_dh_1 UniProtKB/Swiss-Prot
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot
  Acyl-CoA_dh_N UniProtKB/Swiss-Prot
PhenoGen Acadl PhenoGen
PROSITE ACYL_COA_DH_1 UniProtKB/Swiss-Prot
  ACYL_COA_DH_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012966 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot
  SSF56645 UniProtKB/Swiss-Prot
TIGR TC203790
UniProt A0A8I6GMH0 ENTREZGENE, UniProtKB/TrEMBL
  A6KFD6 ENTREZGENE, UniProtKB/TrEMBL
  A6KFD7_RAT UniProtKB/TrEMBL
  ACADL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Acadl  acyl-CoA dehydrogenase, long chain  Acadl  acyl-Coenzyme A dehydrogenase, long-chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Acadl  acyl-Coenzyme A dehydrogenase, long-chain  Acadl  acetyl-Coenzyme A dehydrogenase, long-chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Acadl  acetyl-Coenzyme A dehydrogenase, long-chain    Acyl Coenzyme A dehydrogenase, long chain  Name updated 629478 APPROVED
2002-06-10 Acadl  Acyl Coenzyme A dehydrogenase, long chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 631718
gene_function catalyzes the alpha,beta-dehydrogenation of acyl-CoA esters 631739
gene_homology has high similarity to acyl-CoA dehydrogenase family members short chain acyl-CoA (SCAD), medium chain acyl-CoA dehydrogenase (MCAD), and isovaleryl-CoA dehydrogenase (IVD) 631718
gene_process plays a role in fatty acid metabolism 631739
gene_product member of the acyl-CoA dehydrogenase family 631718
gene_protein 430 amino acid sequence with 30 amino acid leader sequence and 400 amino acid residues in the mature protein 631718