Ces1f (carboxylesterase 1F) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ces1f (carboxylesterase 1F) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ces1f
Name: carboxylesterase 1F
RGD ID: 1642419
Description: Enables retinyl-palmitate esterase activity. Involved in long-chain fatty-acyl-CoA catabolic process. Predicted to be located in cytosol. Predicted to be active in endoplasmic reticulum and lipid droplet. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: carboxyesterase ES-4; carboxylesterase ES-4; kidney microsomal carboxylesterase; liver carboxylesterase 1F; liver carboxylesterase 4; LOC100125372; LOC102550594; MGC156521; microsomal palmitoyl-CoA hydrolase; uncharacterized LOC102550594
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81929,969,633 - 29,995,119 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1929,968,473 - 29,995,117 (+)EnsemblGRCr8
mRatBN7.21913,796,623 - 13,822,113 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,796,623 - 13,912,035 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1915,499,417 - 15,531,230 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01920,694,168 - 20,725,981 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,645,869 - 23,671,270 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,081,117 - 15,126,629 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,081,158 - 15,335,002 (+)Ensemblrn6Rnor6.0
Rnor_5.01926,196,170 - 26,204,190 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41914,849,955 - 14,876,724 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1913,730,396 - 13,755,742 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
endoplasmic reticulum  (IBA,IEA)
lipid droplet  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Cloning and sequencing of rat liver carboxylesterase ES-4 (microsomal palmitoyl-CoA hydrolase). Robbi M, etal., Biochem J 1996 Feb 1;313 ( Pt 3):821-6.
5. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.
Additional References at PubMed
PMID:7961958   PMID:12477932   PMID:15632090   PMID:21937439  


Genomics

Variants

.
Variants in Ces1f
110 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
D19Mgh9  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81929,982,948 - 29,983,080 (+)Marker Load Pipeline
Rnor_6.01915,114,339 - 15,114,483NCBIRnor6.0
RGSC_v3.41914,863,830 - 14,863,962RGDRGSC3.4
RGSC_v3.41914,863,831 - 14,863,962UniSTSRGSC3.4
Celera1913,743,716 - 13,743,847UniSTS
RGSC_v3.11914,868,656 - 14,868,788RGD


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
13 6 34 34 30 18 5 18 6 105 28 5 17 46 47 12

Sequence


Ensembl Acc Id: ENSRNOT00000120868   ⟹   ENSRNOP00000098477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1929,973,994 - 29,995,117 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134854   ⟹   ENSRNOP00000111327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1929,968,473 - 29,995,117 (+)Ensembl
RefSeq Acc Id: NM_001103359   ⟹   NP_001096829
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81929,969,633 - 29,995,119 (+)NCBI
mRatBN7.21913,796,623 - 13,822,113 (+)NCBI
Rnor_6.01915,081,576 - 15,126,625 (+)NCBI
RGSC_v3.41914,849,955 - 14,876,724 (+)RGD
Celera1913,730,396 - 13,755,742 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001096829 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA64638 (Get FASTA)   NCBI Sequence Viewer  
  AAI28712 (Get FASTA)   NCBI Sequence Viewer  
  CAA57419 (Get FASTA)   NCBI Sequence Viewer  
  EDL87580 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024187.6
  ENSRNOP00000111327
GenBank Protein Q64573 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001096829   ⟸   NM_001103359
- Peptide Label: precursor
- UniProtKB: A2VCW1 (UniProtKB/Swiss-Prot),   Q62679 (UniProtKB/Swiss-Prot),   Q64573 (UniProtKB/Swiss-Prot),   A6KD46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000111327   ⟸   ENSRNOT00000134854
Ensembl Acc Id: ENSRNOP00000098477   ⟸   ENSRNOT00000120868
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64573-F1-model_v2 AlphaFold Q64573 1-561 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700966
Promoter ID:EPDNEW_R11487
Type:multiple initiation site
Name:Ces1f_2
Description:carboxylesterase 1F
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11488  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01915,081,147 - 15,081,207EPDNEW
RGD ID:13700965
Promoter ID:EPDNEW_R11488
Type:multiple initiation site
Name:Ces1f_1
Description:carboxylesterase 1F
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11487  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01915,081,581 - 15,081,641EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1642419 AgrOrtholog
BioCyc Gene G2FUF-6408 BioCyc
Ensembl Genes ENSRNOG00000015438 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000091108 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024187.7 UniProtKB/Swiss-Prot
  ENSRNOT00000134854 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368807 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Type-B_Carboxylest/Lipase UniProtKB/Swiss-Prot
KEGG Report rno:100125372 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156521 IMAGE-MGC_LOAD
NCBI Gene 100125372 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Ces1f PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
  ER_TARGET UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015438 RatGTEx
  ENSRNOG00000091108 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0ABK0L7M5_RAT UniProtKB/TrEMBL
  A0ABK0M2N6_RAT UniProtKB/TrEMBL
  A2VCW1 ENTREZGENE
  A6KD46 ENTREZGENE, UniProtKB/TrEMBL
  EST4_RAT UniProtKB/Swiss-Prot
  Q62679 ENTREZGENE
  Q64573 ENTREZGENE
UniProt Secondary A2VCW1 UniProtKB/Swiss-Prot
  Q62679 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ces1f  carboxylesterase 1F  LOC102550594  uncharacterized LOC102550594  Data merged from RGD:7715723 737654 PROVISIONAL
2013-12-18 LOC102550594  uncharacterized LOC102550594      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-11-18 Ces1f  carboxylesterase 1F  LOC100125372  carboxylesterase ES-4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-15 LOC100125372  carboxylesterase ES-4      Symbol and Name status set to provisional 70820 PROVISIONAL