Pdk3 (pyruvate dehydrogenase kinase 3) - Rat Genome Database

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Gene: Pdk3 (pyruvate dehydrogenase kinase 3) Rattus norvegicus
Analyze
Symbol: Pdk3
Name: pyruvate dehydrogenase kinase 3
RGD ID: 1593276
Description: Predicted to enable ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in several processes, including cellular response to fatty acid; intracellular signal transduction; and regulation of small molecule metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Orthologous to human PDK3 (pyruvate dehydrogenase kinase 3); PARTICIPATES IN pyruvate metabolic pathway; INTERACTS WITH acetamide; acrylamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; Pdk3_mapped; pyruvate dehydrogenase kinase, isoenzyme 3; pyruvate dehydrogenase kinase, isoenzyme 3 (mapped); pyruvate dehydrogenase kinase, isozyme 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X62,480,535 - 62,547,371 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX62,480,535 - 62,547,371 (-)EnsemblGRCr8
mRatBN7.2X58,486,699 - 58,553,533 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX58,486,554 - 58,553,557 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX59,924,121 - 59,991,299 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X63,425,226 - 63,492,410 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X60,976,529 - 61,043,706 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X62,836,131 - 62,904,114 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX62,836,131 - 62,903,554 (-)Ensemblrn6Rnor6.0
Rnor_5.0X63,428,816 - 63,497,161 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X81,104,667 - 81,171,536 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX58,924,116 - 58,991,740 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R,R)-tramadol  (ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
clofibrate  (ISO)
cyclosporin A  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
indole-3-methanol  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tapentadol  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tramadol  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pyruvate dehydrogenase E1alpha phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal beta-cells. Akhmedov D, etal., Biochim Biophys Acta. 2012 Oct;1823(10):1815-24. doi: 10.1016/j.bbamcr.2012.07.005. Epub 2012 Jul 15.
2. Marked differences between two isoforms of human pyruvate dehydrogenase kinase. Baker JC, etal., J Biol Chem 2000 May 26;275(21):15773-81.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE and Hiromasa Y, Cell Mol Life Sci. 2007 Apr;64(7-8):830-49.
Additional References at PubMed
PMID:11485553   PMID:11486000   PMID:12477932   PMID:14651853   PMID:15861126   PMID:17669420   PMID:18614015   PMID:18718909   PMID:20715114   PMID:22865452   PMID:32216531  


Genomics

Comparative Map Data
Pdk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X62,480,535 - 62,547,371 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX62,480,535 - 62,547,371 (-)EnsemblGRCr8
mRatBN7.2X58,486,699 - 58,553,533 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX58,486,554 - 58,553,557 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX59,924,121 - 59,991,299 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X63,425,226 - 63,492,410 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X60,976,529 - 61,043,706 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X62,836,131 - 62,904,114 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX62,836,131 - 62,903,554 (-)Ensemblrn6Rnor6.0
Rnor_5.0X63,428,816 - 63,497,161 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X81,104,667 - 81,171,536 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX58,924,116 - 58,991,740 (-)NCBICelera
Cytogenetic MapXq22NCBI
PDK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X24,465,286 - 24,550,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX24,465,244 - 24,550,466 (+)Ensemblhg38GRCh38
GRCh37X24,483,403 - 24,568,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X24,393,475 - 24,462,463 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X24,243,210 - 24,312,199NCBI
CeleraX28,606,234 - 28,691,468 (+)NCBICelera
Cytogenetic MapXp22.11NCBI
HuRefX22,225,142 - 22,310,559 (+)NCBIHuRef
CHM1_1X24,514,817 - 24,600,156 (+)NCBICHM1_1
T2T-CHM13v2.0X24,049,577 - 24,134,762 (+)NCBIT2T-CHM13v2.0
Pdk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X92,798,923 - 92,875,756 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX92,808,213 - 92,875,807 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X93,764,616 - 93,832,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX93,764,607 - 93,832,201 (-)Ensemblmm10GRCm38
MGSCv37X91,009,955 - 91,077,434 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X90,017,335 - 90,084,814 (-)NCBIMGSCv36mm8
CeleraX80,688,439 - 80,755,738 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX41.34NCBI
Pdk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555094,809,399 - 4,878,976 (+)Ensembl
ChiLan1.0NW_0049555094,809,422 - 4,888,802 (+)NCBIChiLan1.0ChiLan1.0
PDK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X26,263,232 - 26,348,938 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X26,266,679 - 26,352,325 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X17,062,278 - 17,147,489 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X24,430,028 - 24,514,873 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX24,430,028 - 24,504,730 (+)EnsemblpanPan2panpan1.1
PDK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X19,994,383 - 20,058,979 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX19,994,393 - 20,058,485 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0X19,949,236 - 20,023,756 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX19,949,236 - 20,013,855 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X19,987,464 - 20,061,958 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X20,020,576 - 20,095,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X20,078,072 - 20,152,369 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pdk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X12,944,337 - 13,025,336 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936624142,402 - 213,528 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936624141,745 - 213,495 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX20,486,341 - 20,602,664 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X20,486,205 - 20,598,492 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X21,996,492 - 22,076,913 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X22,948,162 - 23,030,542 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX22,948,203 - 23,029,868 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605624,819,882 - 24,896,265 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624897759,367 - 833,947 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pdk3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X51,597,009 - 51,664,530 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pdk3
336 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:645
Count of miRNA genes:276
Interacting mature miRNAs:350
Transcripts:ENSRNOT00000017370
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X6103585667175160Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
DXGot133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X58,488,321 - 58,488,469 (+)MAPPERmRatBN7.2
Rnor_6.0X62,837,899 - 62,838,046NCBIRnor6.0
Rnor_5.0X63,430,584 - 63,430,731UniSTSRnor5.0
RGSC_v3.4X81,106,435 - 81,106,582UniSTSRGSC3.4
CeleraX58,925,884 - 58,926,031UniSTS
Cytogenetic MapXq22UniSTS
AI035637  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X58,487,096 - 58,487,298 (+)MAPPERmRatBN7.2
Rnor_6.0X62,836,674 - 62,836,875NCBIRnor6.0
Rnor_5.0X63,429,359 - 63,429,560UniSTSRnor5.0
RGSC_v3.4X81,105,210 - 81,105,411UniSTSRGSC3.4
CeleraX58,924,659 - 58,924,860UniSTS
Cytogenetic MapXq22UniSTS
RH128023  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X58,486,992 - 58,487,188 (+)MAPPERmRatBN7.2
Rnor_6.0X62,836,570 - 62,836,765NCBIRnor6.0
Rnor_5.0X63,429,255 - 63,429,450UniSTSRnor5.0
RGSC_v3.4X81,105,106 - 81,105,301UniSTSRGSC3.4
CeleraX58,924,555 - 58,924,750UniSTS
Cytogenetic MapXq22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017370   ⟹   ENSRNOP00000017370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX62,480,535 - 62,547,371 (-)Ensembl
mRatBN7.2 EnsemblX58,486,554 - 58,553,557 (-)Ensembl
Rnor_6.0 EnsemblX62,836,131 - 62,903,554 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076652   ⟹   ENSRNOP00000068033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX58,486,554 - 58,534,107 (-)Ensembl
Rnor_6.0 EnsemblX62,836,276 - 62,903,530 (-)Ensembl
RefSeq Acc Id: NM_001106581   ⟹   NP_001100051
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,480,535 - 62,547,371 (-)NCBI
mRatBN7.2X58,486,699 - 58,553,533 (-)NCBI
Rnor_6.0X62,836,131 - 62,903,554 (-)NCBI
Rnor_5.0X63,428,816 - 63,497,161 (-)NCBI
RGSC_v3.4X81,104,667 - 81,171,536 (-)RGD
CeleraX58,924,116 - 58,991,740 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100051 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69078 (Get FASTA)   NCBI Sequence Viewer  
  EDL96013 (Get FASTA)   NCBI Sequence Viewer  
  EDL96014 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017370
  ENSRNOP00000017370.5
RefSeq Acc Id: NP_001100051   ⟸   NM_001106581
- UniProtKB: B5DFI9 (UniProtKB/TrEMBL),   A6IPZ9 (UniProtKB/TrEMBL),   A0A096MJ84 (UniProtKB/TrEMBL),   F7EQX3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017370   ⟸   ENSRNOT00000017370
Ensembl Acc Id: ENSRNOP00000068033   ⟸   ENSRNOT00000076652
Protein Domains
Histidine kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFI9-F1-model_v2 AlphaFold B5DFI9 1-415 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701843
Promoter ID:EPDNEW_R12362
Type:multiple initiation site
Name:Pdk3_1
Description:pyruvate dehydrogenase kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X62,903,509 - 62,903,569EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593276 AgrOrtholog
BioCyc Gene G2FUF-2261 BioCyc
Ensembl Genes ENSRNOG00000012513 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017370 ENTREZGENE
  ENSRNOT00000017370.9 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.20 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
InterPro AK/P_DHK_N_sf UniProtKB/TrEMBL
  BCDHK/PDK_mit UniProtKB/TrEMBL
  BCKD/PDK UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  HATPase_dom UniProtKB/TrEMBL
  Sig_transdc_His_kinase_core UniProtKB/TrEMBL
KEGG Report rno:296849 UniProtKB/TrEMBL
NCBI Gene 296849 ENTREZGENE
PANTHER [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 3, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11947 UniProtKB/TrEMBL
Pfam BCDHK_Adom3 UniProtKB/TrEMBL
  HATPase_c UniProtKB/TrEMBL
PhenoGen Pdk3 PhenoGen
PROSITE HIS_KIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012513 RatGTEx
SMART HATPase_c UniProtKB/TrEMBL
Superfamily-SCOP ATP_bd_ATPase UniProtKB/TrEMBL
  BCDHK/PDK_N UniProtKB/TrEMBL
UniProt A0A096MJ84 ENTREZGENE
  A6IPZ9 ENTREZGENE, UniProtKB/TrEMBL
  A6IQ00_RAT UniProtKB/TrEMBL
  B5DFI9 ENTREZGENE
  F7EQX3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B5DFI9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Pdk3  pyruvate dehydrogenase kinase 3  Pdk3  pyruvate dehydrogenase kinase, isozyme 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Pdk3  pyruvate dehydrogenase kinase, isozyme 3  Pdk3  pyruvate dehydrogenase kinase, isoenzyme 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   pyruvate dehydrogenase kinase, isoenzyme 3  Pdk3  pyruvate dehydrogenase kinase, isoenzyme 3 (mapped)  Name updated 737654 APPROVED
2007-04-11 Pdk3  pyruvate dehydrogenase kinase, isoenzyme 3 (mapped)  Pdk3_mapped  pyruvate dehydrogenase kinase, isoenzyme 3 (mapped)  Data merged from RGD:3291 737654 APPROVED
2006-11-20 Pdk3  pyruvate dehydrogenase kinase, isoenzyme 3 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Pdk3_mapped  pyruvate dehydrogenase kinase, isoenzyme 3 (mapped)  Pdk3  pyruvate dehydrogenase kinase, isoenzyme 3  Symbol and Name updated 1556543 APPROVED
2002-11-06 Pdk3  pyruvate dehydrogenase kinase, isoenzyme 3    Pyruvate dehydrogenase kinase 3  Name updated 625702 APPROVED
2002-06-10 Pdk3  Pyruvate dehydrogenase kinase 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology human PDK3 binds to the lipoyl domains of the dihydrolipoyl acetyltransferase (E2) to affect phosphorylation rates of the pyruvate dehydrogenase (E1) component 1302271