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Gene: Usp21 (ubiquitin specific peptidase 21) Rattus norvegicus

Analyze

Symbol:

Usp21

Name:

ubiquitin specific peptidase 21

RGD ID:

1588822

Description:

Predicted to enable cysteine-type deubiquitinase activity; deNEDDylase activity; and transcription coactivator activity. Involved in neuron projection development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human USP21 (ubiquitin specific peptidase 21); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

deubiquitinating enzyme 21; LOC688466; MGC187584; similar to Ubiquitin carboxyl-terminal hydrolase 21 (Ubiquitin thiolesterase 21) (Ubiquitin-specific processing protease 21) (Deubiquitinating enzyme 21); ubiquitin carboxyl-terminal hydrolase 21; ubiquitin thioesterase 21; ubiquitin thiolesterase 21; ubiquitin-specific protease 21; ubiquitin-specific-processing protease 21

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	USP21 (ubiquitin specific peptidase 21)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, PhylomeDB
Mus musculus (house mouse):	Usp21 (ubiquitin specific peptidase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Usp21 (ubiquitin specific peptidase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	USP21 (ubiquitin specific peptidase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	USP21 (ubiquitin specific peptidase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Usp21 (ubiquitin specific peptidase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	USP21 (ubiquitin specific peptidase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	USP21 (ubiquitin specific peptidase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Usp21 (ubiquitin specific peptidase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Usp21 (ubiquitin specific peptidase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	USP21 (ubiquitin specific peptidase 21)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Usp21 (ubiquitin specific peptidase 21)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	usp21 (ubiquitin specific peptidase 21)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Usp2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	UBP5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector)
Xenopus tropicalis (tropical clawed frog):	usp21	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,235,122 - 86,241,663 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	86,235,081 - 86,241,714 (-)	Ensembl				GRCr8
mRatBN7.2	13	83,702,672 - 83,709,215 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,702,631 - 83,708,717 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	86,208,448 - 86,214,501 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,606,655 - 87,612,708 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,838,118 - 84,844,154 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,655,016 - 89,661,150 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,655,064 - 89,661,150 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	94,281,882 - 94,288,016 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	87,175,527 - 87,181,024 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	83,333,270 - 83,339,404 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

antirheumatic drug (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

cannabidiol (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

Cuprizon (EXP)

dibutyl phthalate (EXP)

doxorubicin (ISO)

epoxiconazole (ISO)

folic acid (ISO)

gallic acid (ISO)

L-methionine (ISO)

methylazoxymethanol (ISO)

ozone (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tert-butyl hydroperoxide (ISO)

titanium dioxide (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin organization (IEA)

DNA-templated transcription (IEA)

neuron projection development (IMP)

positive regulation of DNA-templated transcription (IEA)

protein deubiquitination (IEA,ISO)

proteolysis (IEA)

transcription initiation-coupled chromatin remodeling (ISO,ISS)

Cellular Component

cytoplasm (IBA,IEA)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA)

Molecular Function

cysteine-type deubiquitinase activity (IEA,ISO,ISS)

cysteine-type peptidase activity (IEA,ISO,ISS)

deNEDDylase activity (IEA,ISO,ISS)

hydrolase activity (IEA)

metal ion binding (IEA)

peptidase activity (IEA)

protein binding (ISO)

transcription coactivator activity (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology.	Belle JI and Nijnik A, Int J Biochem Cell Biol. 2014 May;50:161-74. doi: 10.1016/j.biocel.2014.03.004. Epub 2014 Mar 16.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation
5.	Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.	Urbe S, etal., Mol Biol Cell. 2012 Mar;23(6):1095-103. doi: 10.1091/mbc.E11-08-0668. Epub 2012 Feb 1.

Additional References at PubMed

PMID:10799498	PMID:12477932	PMID:18172164	PMID:26100909

Genomics

Comparative Map Data

Usp21
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,235,122 - 86,241,663 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	86,235,081 - 86,241,714 (-)	Ensembl				GRCr8
mRatBN7.2	13	83,702,672 - 83,709,215 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,702,631 - 83,708,717 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	86,208,448 - 86,214,501 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,606,655 - 87,612,708 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,838,118 - 84,844,154 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,655,016 - 89,661,150 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,655,064 - 89,661,150 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	94,281,882 - 94,288,016 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	87,175,527 - 87,181,024 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	83,333,270 - 83,339,404 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

USP21
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	161,159,500 - 161,165,723 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	161,159,450 - 161,165,723 (+)	Ensembl			hg38	GRCh38
GRCh37	1	161,129,290 - 161,135,513 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	159,395,878 - 159,402,140 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	157,942,346 - 157,948,580	NCBI
Celera	1	134,196,407 - 134,202,669 (+)	NCBI		Celera
Cytogenetic Map	1	q23.3	NCBI
HuRef	1	132,486,196 - 132,492,458 (+)	NCBI		HuRef
CHM1_1	1	162,525,504 - 162,531,766 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	160,296,946 - 160,303,180 (+)	NCBI		T2T-CHM13v2.0

Usp21
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	171,109,523 - 171,115,534 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	171,109,519 - 171,115,564 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	171,281,949 - 171,287,961 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	171,281,945 - 171,287,991 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	173,212,080 - 173,218,092 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	173,118,624 - 173,124,623 (-)	NCBI		MGSCv36	mm8
Celera	1	173,737,971 - 173,743,991 (-)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	79.3	NCBI

Usp21
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	12,924,574 - 12,929,497 (+)	Ensembl
ChiLan1.0	NW_004955468	12,923,121 - 12,929,780 (+)	NCBI	ChiLan1.0	ChiLan1.0

USP21
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	88,686,245 - 88,692,269 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	88,376,566 - 88,382,793 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	136,571,967 - 136,578,196 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	140,484,742 - 140,491,014 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	140,484,742 - 140,491,004 (+)	Ensembl			panPan2	panpan1.1

USP21
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	21,311,859 - 21,318,414 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	21,311,859 - 21,320,106 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	21,386,438 - 21,392,779 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	21,429,424 - 21,436,065 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	21,429,424 - 21,437,732 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	21,317,263 - 21,324,003 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	21,731,698 - 21,738,410 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	22,140,841 - 22,147,481 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Usp21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	7,253,974 - 7,260,943 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936903	464,353 - 469,345 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936903	462,617 - 469,592 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

USP21
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	89,289,070 - 89,295,237 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	89,289,056 - 89,295,232 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	97,145,780 - 97,152,902 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

USP21
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	2,820,012 - 2,826,817 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	2,820,333 - 2,825,131 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	1,867,141 - 1,873,408 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Usp21
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	216,951 - 223,269 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	216,668 - 223,259 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Usp21
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	50,446,842 - 50,452,861 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Usp21
56 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	275
Count of miRNA genes:	162
Interacting mature miRNAs:	188
Transcripts:	ENSRNOT00000058390
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

W53272

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	83,703,257 - 83,703,366 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	89,655,691 - 89,655,799	NCBI	Rnor6.0
Rnor_5.0	13	94,282,557 - 94,282,665	UniSTS	Rnor5.0
RGSC_v3.4	13	87,176,203 - 87,176,311	UniSTS	RGSC3.4
Celera	13	83,333,945 - 83,334,053	UniSTS
Cytogenetic Map	13	q24	UniSTS

RH127964

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	83,709,430 - 83,709,639 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	89,661,864 - 89,662,072	NCBI	Rnor6.0
Rnor_5.0	13	94,288,730 - 94,288,938	UniSTS	Rnor5.0
RGSC_v3.4	13	87,181,738 - 87,181,946	UniSTS	RGSC3.4
Celera	13	83,340,118 - 83,340,326	UniSTS
RH 3.4 Map	13	552.5	UniSTS
Cytogenetic Map	13	q24	UniSTS

BI294933

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	83,704,593 - 83,704,761 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	89,657,027 - 89,657,194	NCBI	Rnor6.0
Rnor_5.0	13	94,283,893 - 94,284,060	UniSTS	Rnor5.0
Celera	13	83,335,281 - 83,335,448	UniSTS
RH 3.4 Map	13	564.8	UniSTS
Cytogenetic Map	13	q24	UniSTS

BF405831

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	83,702,405 - 83,702,559 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	89,654,838 - 89,654,991	NCBI	Rnor6.0
Rnor_5.0	13	94,281,704 - 94,281,857	UniSTS	Rnor5.0
RGSC_v3.4	13	87,175,349 - 87,175,502	UniSTS	RGSC3.4
Celera	13	83,333,092 - 83,333,245	UniSTS
RH 3.4 Map	13	568.4	UniSTS
Cytogenetic Map	13	q24	UniSTS

RH139112

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	13	86,242,885 - 86,243,141 (+)	Marker Load Pipeline
mRatBN7.2	13	83,710,435 - 83,710,691 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	89,662,869 - 89,663,124	NCBI	Rnor6.0
Rnor_5.0	13	94,289,735 - 94,289,990	UniSTS	Rnor5.0
RGSC_v3.4	13	87,182,743 - 87,182,998	UniSTS	RGSC3.4
Celera	13	83,341,123 - 83,341,378	UniSTS
RH 3.4 Map	13	552.3	UniSTS
Cytogenetic Map	13	q24	UniSTS

G43283

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	83,702,692 - 83,702,832 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	89,655,126 - 89,655,265	NCBI	Rnor6.0
Rnor_5.0	13	94,281,992 - 94,282,131	UniSTS	Rnor5.0
RGSC_v3.4	13	87,175,637 - 87,175,776	UniSTS	RGSC3.4
Celera	13	83,333,380 - 83,333,519	UniSTS
Cytogenetic Map	13	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000058390 ⟹ ENSRNOP00000055192

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	86,235,081 - 86,241,167 (-)	Ensembl
mRatBN7.2 Ensembl	13	83,702,681 - 83,708,717 (-)	Ensembl
Rnor_6.0 Ensembl	13	89,655,064 - 89,661,150 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100554 ⟹ ENSRNOP00000084677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	86,235,081 - 86,241,714 (-)	Ensembl
mRatBN7.2 Ensembl	13	83,702,631 - 83,708,577 (-)	Ensembl

RefSeq Acc Id:

NM_001127638 ⟹ NP_001121110

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,235,127 - 86,241,180 (-)	NCBI
mRatBN7.2	13	83,702,677 - 83,708,730 (-)	NCBI
Rnor_6.0	13	89,655,016 - 89,661,150 (-)	NCBI
Rnor_5.0	13	94,281,882 - 94,288,016 (-)	NCBI
RGSC_v3.4	13	87,175,527 - 87,181,024 (-)	RGD
Celera	13	83,333,270 - 83,339,404 (-)	RGD

Sequence:

show sequence

CCGGTGGCCGGGCGGCACCAACAAAGATGGCGGCGGCCCTTGCGGCGGGAGCAAGCTGGGCAAC
AGCTGCGGCTAAAGCTGCAGCCTGGCCTGCGGGGAGGCTGTTCGGGGGTAGGAGGGGGTGGCCC
TGAGCTGGAGCTGGACCCCGGCTGGCCTCCCCCGCCGCCTCACCGGGGGACAGGTCCAGCCTGC
GGTGCCCACAATGCCCCAGGCTTCTGAGCACCGCCTGGGCCGGACTCGAGAGCCACCTGTCAAT
GTACAGCCCCGAGTGGGAGCCAAGATACCGTTTCCTCCCCGGGCCCGCAGCAAGGAGCGCCGAA
ACCCAGTTCCTGGGCCAAACTCCATGTTACGACCTTTGCCTCCCAGGCCAGGTCCCCCAGATGA
AAGGCTCAAGAAACTGGATTTGGGTCGGGGTCGGACCTCAGGCTCTCGTCCTAGAGGTCCCCTT
CGAGCAGATCATGGGGTTCCCTTGCCTGGCTCACCACCCCCAACTGTGGCTCTGCCTCTCCCAT
CCCGGACCAACCTAACCCGATCCAAGTCTGTGAGCAGTGGGGACTTGCGTCCAATGGGGATTGC
CTTGGGAGGGCACCGTGGCACTGGCGAGCTAGGGGCTGCACTGAGCCGCCTGGCACTCCGGCCT
GAGCCACCCACTTTGAGACGTAGTACTTCTCTCCGGCGTCTTGGGGGTTTCCCTGGACCCCCTA
CCCTGCTCAGCATACGGACAGAGCCCCCTCCTTCCCATGGCTCCTTCCACATGATATCTGCCCG
GCCTTCTGAGCCTTTCTACTCTGATGACAAGATGGCTCACCACACACTGCTTCTGGGCTCTGGT
CATGTTGGCCTCCGAAATCTAGGAAATACATGCTTCCTGAACGCCGTGTTACAGTGTTTGAGCA
GCACAAGGCCTCTTCGAGACTTTTGTCTGCGAAGGGACTTCCGGCAAGAGGTGCCCGGAGGAGG
CCGAGCCCAGGAACTCACAGAAGCCTTTGCAGATGTGATTGGTGCCCTCTGGCACCCTGACTCC
TGTGAAGCTGTGAATCCTACCCGATTCCGGGCTGTCTTCCAGAAATACGTCCCTTCCTTCTCTG
GATACAGCCAGCAGGATGCCCAAGAGTTCCTGAAGCTCCTTATGGAGCGGTTGCACCTCGAAAT
CAACCGACGAGGCCGCCGGGCACCACCAATTCTGGCCAGTGGTCCAGTTCCCTCCCCACCTCGC
CGAGGAGGGGCTCTGCATGAAGAACCTGAACTGAGTGATGATGACCGAGCCAACTTAATGTGGA
AGCGCTACCTGGAGCGAGAAGACAGCAAGATTGTGGACCTGTTTGTGGGCCAGCTGAAAAGTTG
CCTCAAGTGCCAGGCCTGTGGGTATCGCTCCACGACCTTCGAGGTTTTTTGTGACCTGTCCCTG
CCCATCCCCAAGAAAGGATTTGCTGGGGGCAAAGTGTCTTTGCGGGATTGCTTCAGCCTTTTCA
CCAAGGAGGAGGAGCTAGAGTCGGAGAATGCCCCAGTATGTGACCGATGTCGGCAGAAAACACG
AAGTACCAAAAAGTTGACAGTACAAAGATTCCCCCGAATCCTCGTGCTCCATCTGAACCGATTT
TCCACCTCCCGAGGCTCCATCAAGAAAAGTTCAGTAGGTGTAGACTTCCCACTGCAGCGACTAA
GCCTAGGGGACTTTGCCAGCGACAAAGTGGGAAGCCCTGTCTACCAGCTGTATGCCCTTTGCAA
CCACTCGGGTAGTGTCCACTATGGCCACTACACAGCCCTGTGCCGGTGCCAGACTGGTTGGCAT
GTCTACAATGACTCCCGTGTCTCCCCTGTCAGTGAAAACCAGGTGGCATCCAGTGAGGGCTACG
TGCTGTTCTACCAATTGATGCAGGAACCACCTCGGTGCCTGTGACGCCATCTTGAAGCCCTGGC
ACCTGTGAAAACCTTCTCAACACCCTTAAGCCCCCAGGCTCCCCACTTACCTCACAGACGTCTA
TTTTTGTGTCTTTTTAATCGGGGAGGGGAGGAGGGTTGGTTGTAGCTCCCGTTATTTTTTTTAT
TAAGAAGTACCCTTCCACCTTGTTTTCCTGTCCCATGTACAGAAATTACCAGGCCCTTGACCAT
GTACAGCCCCCAGAACCTCTGCAATCTCACTTTTTTGTGAATAAATTTATTAAGAAAAAGTAAA
TGTAGGAAGCGCAAGGCCCTGGGTTCGGTCCCCAGCTCCGGAAAAAAAAAAAAAAGAACCAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063272618 ⟹ XP_063128688

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,235,122 - 86,240,969 (-)	NCBI

RefSeq Acc Id:

XR_010056937

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,235,122 - 86,241,663 (-)	NCBI

RefSeq Acc Id:

XR_010056938

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,235,122 - 86,239,422 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001121110	(Get FASTA)	NCBI Sequence Viewer
	XP_063128688	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66443	(Get FASTA)	NCBI Sequence Viewer
	B2GUX4	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000055192
	ENSRNOP00000084677

RefSeq Acc Id:

NP_001121110 ⟸ NM_001127638

- UniProtKB:

B2GUX4 (UniProtKB/Swiss-Prot), A0A8I6A1T1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPQASEHRLGRTREPPVNVQPRVGAKIPFPPRARSKERRNPVPGPNSMLRPLPPRPGPPDERLK
KLDLGRGRTSGSRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLTRSKSVSSGDLRPMGIALGG
HRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLLSIRTEPPPSHGSFHMISARPSE
PFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQ
ELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRR
GRRAPPILASGPVPSPPRRGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKC
QACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTK
KLTVQRFPRILVLHLNRFSTSRGSIKKSSVGVDFPLQRLSLGDFASDKVGSPVYQLYALCNHSG
SVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL

hide sequence

Ensembl Acc Id:

ENSRNOP00000055192 ⟸ ENSRNOT00000058390

Ensembl Acc Id:

ENSRNOP00000084677 ⟸ ENSRNOT00000100554

RefSeq Acc Id:	XP_063128688 ⟸ XM_063272618
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A1T1 (UniProtKB/TrEMBL)

Protein Domains

USP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GUX4-F1-model_v2	AlphaFold	B2GUX4	1-565	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699001

Promoter ID:

EPDNEW_R9526

Type:

multiple initiation site

Name:

Usp21_1

Description:

ubiquitin specific peptidase 21

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	89,661,148 - 89,661,208	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1588822	AgrOrtholog
BioCyc Gene	G2FUF-17377	BioCyc
Ensembl Genes	ENSRNOG00000038347	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000058390	ENTREZGENE
	ENSRNOT00000100554	ENTREZGENE
Gene3D-CATH	Cysteine proteinases	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:8363035	IMAGE-MGC_LOAD
InterPro	Papain-like_cys_pep_sf	UniProtKB/Swiss-Prot
	Peptidase_C19_UCH	UniProtKB/Swiss-Prot
	Ub_carboxyl-term_hydrolase	UniProtKB/Swiss-Prot
	USP_CS	UniProtKB/Swiss-Prot
	USP_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:688466	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:187584	IMAGE-MGC_LOAD
NCBI Gene	688466	ENTREZGENE
PANTHER	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE	UniProtKB/Swiss-Prot
	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21	UniProtKB/Swiss-Prot
Pfam	UCH	UniProtKB/Swiss-Prot
PhenoGen	Usp21	PhenoGen
PROSITE	USP_1	UniProtKB/Swiss-Prot
	USP_2	UniProtKB/Swiss-Prot
	USP_3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000038347	RatGTEx
Superfamily-SCOP	SSF54001	UniProtKB/Swiss-Prot
UniProt	A0A8I6A1T1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QT23_RAT	UniProtKB/TrEMBL
	B2GUX4	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-15	Usp21	ubiquitin specific peptidase 21	LOC688466	similar to Ubiquitin carboxyl-terminal hydrolase 21 (Ubiquitin thiolesterase 21) (Ubiquitin-specific processing protease 21) (Deubiquitinating enzyme 21)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC688466	similar to Ubiquitin carboxyl-terminal hydrolase 21 (Ubiquitin thiolesterase 21) (Ubiquitin-specific processing protease 21) (Deubiquitinating enzyme 21)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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