Mnx1 (motor neuron and pancreas homeobox 1) - Rat Genome Database

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Gene: Mnx1 (motor neuron and pancreas homeobox 1) Rattus norvegicus
Analyze
Symbol: Mnx1
Name: motor neuron and pancreas homeobox 1
RGD ID: 1588091
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH bisphenol A; methimazole; paracetamol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hlxb9; homeobox gene HB9; homeobox protein HB9; LOC682076; motor neuron and pancreas homeobox protein 1; similar to Homeobox protein HB9; uncharacterized protein LOC682076
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr846,541,645 - 6,546,604 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl46,541,645 - 6,546,604 (+)EnsemblGRCr8
mRatBN7.245,866,506 - 5,871,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,866,506 - 5,871,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx410,856,173 - 10,861,140 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.046,670,400 - 6,675,367 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.045,016,546 - 5,021,513 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.042,376,350 - 2,381,308 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl42,376,958 - 2,381,271 (-)Ensemblrn6Rnor6.0
Rnor_5.042,429,079 - 2,434,037 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera44,454,706 - 4,459,663 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A regulatory network to segregate the identity of neuronal subtypes. Lee S, etal., Dev Cell. 2008 Jun;14(6):877-89. doi: 10.1016/j.devcel.2008.03.021.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10471501   PMID:10482234   PMID:11395002   PMID:17042795   PMID:18590716   PMID:23610558   PMID:24425879  


Genomics

Comparative Map Data
Mnx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr846,541,645 - 6,546,604 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl46,541,645 - 6,546,604 (+)EnsemblGRCr8
mRatBN7.245,866,506 - 5,871,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,866,506 - 5,871,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx410,856,173 - 10,861,140 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.046,670,400 - 6,675,367 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.045,016,546 - 5,021,513 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.042,376,350 - 2,381,308 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl42,376,958 - 2,381,271 (-)Ensemblrn6Rnor6.0
Rnor_5.042,429,079 - 2,434,037 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera44,454,706 - 4,459,663 (-)NCBICelera
Cytogenetic Map4q11NCBI
MNX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387157,004,854 - 157,010,663 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7156,994,051 - 157,010,663 (-)Ensemblhg38GRCh38
GRCh377156,797,548 - 156,803,357 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367156,490,308 - 156,496,108 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347156,297,022 - 156,302,701NCBI
Celera7151,224,648 - 151,230,448 (-)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7150,530,222 - 150,535,994 (-)NCBIHuRef
CHM1_17156,806,166 - 156,811,852 (-)NCBICHM1_1
T2T-CHM13v2.07158,192,588 - 158,198,404 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27156,026,905 - 156,032,706 (-)NCBI
Mnx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39529,678,821 - 29,683,468 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl529,678,032 - 29,683,468 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38529,473,823 - 29,478,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl529,473,034 - 29,478,470 (-)Ensemblmm10GRCm38
MGSCv37529,800,363 - 29,805,010 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36529,804,048 - 29,809,257 (-)NCBIMGSCv36mm8
Celera526,989,654 - 26,994,301 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.04NCBI
Mnx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495557951,862 - 74,985 (-)NCBIChiLan1.0ChiLan1.0
MNX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26193,448,513 - 193,454,336 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1745,458,777 - 45,464,600 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07148,622,701 - 148,628,532 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MNX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11619,509,038 - 19,514,378 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1619,499,582 - 19,512,836 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1620,141,662 - 20,146,919 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01621,239,737 - 21,244,998 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1621,239,740 - 21,244,998 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11619,608,498 - 19,613,752 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01620,190,938 - 20,196,192 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01620,243,410 - 20,248,673 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mnx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051181,889,985 - 1,895,254 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936797618,696 - 623,219 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MNX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl181,725,244 - 1,730,878 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1181,724,930 - 1,730,724 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2181,693,453 - 1,699,167 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MNX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121125,132,517 - 125,138,520 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21125,133,194 - 125,138,217 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607221,366,924 - 21,372,944 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mnx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248001,426,998 - 1,431,631 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248001,426,773 - 1,431,510 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mnx1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16157,459,168 - 157,464,205 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mnx1
46 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:68
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000072287
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat

Markers in Region
D4Rat143  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr846,542,801 - 6,542,917 (+)Marker Load Pipeline
mRatBN7.245,867,662 - 5,867,778 (-)MAPPERmRatBN7.2
Rnor_6.042,380,037 - 2,380,152NCBIRnor6.0
Rnor_5.042,432,766 - 2,432,881UniSTSRnor5.0
Celera44,458,393 - 4,458,506UniSTS
SHRSP x BN Map40.0RGD
SHRSP x BN Map40.0UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 27 27 23 8 14 8 6 63 34 16 6 37 15 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000072287   ⟹   ENSRNOP00000064986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl46,541,645 - 6,546,604 (+)Ensembl
mRatBN7.2 Ensembl45,866,506 - 5,871,465 (+)Ensembl
Rnor_6.0 Ensembl42,376,958 - 2,381,271 (-)Ensembl
RefSeq Acc Id: NM_001271274   ⟹   NP_001258203
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr846,541,645 - 6,546,604 (+)NCBI
mRatBN7.245,866,506 - 5,871,465 (+)NCBI
Rnor_6.042,376,350 - 2,381,308 (-)NCBI
Rnor_5.042,429,079 - 2,434,037 (-)NCBI
Celera44,454,706 - 4,459,663 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258203 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86427 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064986
  ENSRNOP00000064986.2
GenBank Protein M0R6D8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258203   ⟸   NM_001271274
- UniProtKB: M0R6D8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064986   ⟸   ENSRNOT00000072287

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R6D8-F1-model_v2 AlphaFold M0R6D8 1-402 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588091 AgrOrtholog
BioCyc Gene G2FUF-46167 BioCyc
Ensembl Genes ENSRNOG00000046959 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072287 ENTREZGENE
  ENSRNOT00000072287.2 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
  MNX1/Ceh-12 UniProtKB/Swiss-Prot
KEGG Report rno:682076 UniProtKB/Swiss-Prot
NCBI Gene 682076 ENTREZGENE
PANTHER MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN UniProtKB/Swiss-Prot
  MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Mnx1 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046959 RatGTEx
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP Homeodomain-like UniProtKB/Swiss-Prot
UniProt M0R6D8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 Mnx1  motor neuron and pancreas homeobox 1  Hlxb9  homeobox gene HB9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Hlxb9  homeobox gene HB9   Hlxb9_predicted  homeobox gene HB9 (predicted)  'predicted' is removed 2292626 APPROVED
2007-03-15 Hlxb9_predicted  homeobox gene HB9 (predicted)  LOC682076  similar to Homeobox protein HB9  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-11-19 LOC682076  similar to Homeobox protein HB9      Symbol and Name status set to provisional 70820 PROVISIONAL