Nnt (nicotinamide nucleotide transhydrogenase) - Rat Genome Database

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Gene: Nnt (nicotinamide nucleotide transhydrogenase) Rattus norvegicus
Analyze
Symbol: Nnt
Name: nicotinamide nucleotide transhydrogenase
RGD ID: 1587346
Description: Predicted to enable NADP binding activity. Involved in several processes, including cell redox homeostasis; intracellular oxygen homeostasis; and positive regulation of hydrogen peroxide catabolic process. Predicted to be located in mitochondrial inner membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase); PARTICIPATES IN niacin metabolic pathway; nicotinamide adenine dinucleotide metabolic pathway; monoterpenoid biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC109126; NAD(P) transhydrogenase, mitochondrial; nicotinamide nucleotide transhydrogenase (mapped); Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase); Nnt_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8253,144,157 - 53,237,857 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl253,144,160 - 53,237,310 (-)EnsemblGRCr8
mRatBN7.2251,411,413 - 51,505,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl251,411,413 - 51,504,823 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx258,530,027 - 58,623,484 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0256,588,743 - 56,682,196 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0251,516,043 - 51,616,358 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0252,189,523 - 52,283,095 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl252,189,529 - 52,282,548 (-)Ensemblrn6Rnor6.0
Rnor_5.0270,553,338 - 70,644,591 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4251,496,456 - 51,589,901 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera247,067,409 - 47,159,610 (-)NCBICelera
Cytogenetic Map2q15NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucose  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
butane-2,3-dione  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
eugenol  (EXP)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
heptachlor  (EXP)
Heptachlor epoxide  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
malathion  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
mirex  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nimesulide  (EXP)
NMN zwitterion  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Houtkooper RH, etal., Endocr Rev. 2010 Apr;31(2):194-223. doi: 10.1210/er.2009-0026. Epub 2009 Dec 9.
3. Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system. Lopert P and Patel M, J Biol Chem. 2014 May 30;289(22):15611-20. doi: 10.1074/jbc.M113.533653. Epub 2014 Apr 10.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Vitamin E and vitamin C do not reduce insulin sensitivity but inhibit mitochondrial protein expression in exercising obese rats. Picklo MJ and Thyfault JP, Appl Physiol Nutr Metab. 2015 Apr;40(4):343-52. doi: 10.1139/apnm-2014-0302. Epub 2014 Dec 9.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Information Derived from GenBank Report RGD, Sept. 2003
13. Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Yin F, etal., Biochim Biophys Acta. 2012 Mar;1817(3):401-9. doi: 10.1016/j.bbabio.2011.12.004. Epub 2011 Dec 16.
Additional References at PubMed
PMID:9271681   PMID:10673423   PMID:12477932   PMID:12865426   PMID:14651853   PMID:18614015   PMID:19946888   PMID:22634753   PMID:25002582  


Genomics

Comparative Map Data
Nnt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8253,144,157 - 53,237,857 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl253,144,160 - 53,237,310 (-)EnsemblGRCr8
mRatBN7.2251,411,413 - 51,505,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl251,411,413 - 51,504,823 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx258,530,027 - 58,623,484 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0256,588,743 - 56,682,196 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0251,516,043 - 51,616,358 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0252,189,523 - 52,283,095 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl252,189,529 - 52,282,548 (-)Ensemblrn6Rnor6.0
Rnor_5.0270,553,338 - 70,644,591 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4251,496,456 - 51,589,901 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera247,067,409 - 47,159,610 (-)NCBICelera
Cytogenetic Map2q15NCBI
NNT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38543,602,675 - 43,707,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl543,602,660 - 43,707,405 (+)Ensemblhg38GRCh38
GRCh37543,602,777 - 43,707,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36543,638,548 - 43,741,425 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34543,639,063 - 43,741,091NCBI
Celera543,495,188 - 43,598,076 (+)NCBICelera
Cytogenetic Map5p12NCBI
HuRef543,555,411 - 43,658,307 (+)NCBIHuRef
CHM1_1543,604,210 - 43,707,124 (+)NCBICHM1_1
T2T-CHM13v2.0543,849,920 - 43,961,029 (+)NCBIT2T-CHM13v2.0
Nnt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913119,472,063 - 119,545,793 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13119,471,984 - 119,545,533 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl13119,472,064 - 119,545,488 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3813119,335,527 - 119,409,257 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13119,335,448 - 119,408,997 (-)Ensemblmm10GRCm38
GRCm38.p6 Ensembl13119,335,528 - 119,408,952 (-)Ensemblmm10GRCm38
MGSCv3713120,124,334 - 120,197,945 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613120,453,190 - 120,527,884 (-)NCBIMGSCv36mm8
Celera13123,765,363 - 123,860,935 (-)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1367.21NCBI
Nnt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544618,685,516 - 18,778,024 (-)Ensembl
ChiLan1.0NW_00495544618,685,511 - 18,778,024 (-)NCBIChiLan1.0ChiLan1.0
NNT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2466,619,709 - 66,724,900 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1564,774,508 - 64,878,384 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0566,662,249 - 66,772,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1571,719,257 - 71,823,259 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl571,719,257 - 71,823,242 (-)EnsemblpanPan2panpan1.1
NNT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1466,348,222 - 66,437,889 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl466,349,318 - 66,442,841 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha466,108,885 - 66,203,350 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0466,840,719 - 66,935,030 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl466,840,739 - 66,934,534 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1466,598,942 - 66,693,215 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0466,729,845 - 66,824,004 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0467,265,089 - 67,359,365 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nnt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213209,662,542 - 209,755,562 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648018,598,481 - 18,691,859 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648018,599,037 - 18,692,097 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NNT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1628,157,318 - 28,250,961 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11628,157,192 - 28,248,732 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21629,706,049 - 29,756,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NNT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1442,377,979 - 42,476,247 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl442,384,435 - 42,477,002 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607132,851,165 - 32,963,567 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nnt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475911,521,778 - 11,628,716 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475911,520,793 - 11,628,003 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nnt
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13177,364,721 - 177,458,712 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nnt
648 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:427
Count of miRNA genes:226
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000033627
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
D2Rat318  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8253,197,569 - 53,197,762 (+)Marker Load Pipeline
mRatBN7.2251,464,829 - 51,465,022 (+)MAPPERmRatBN7.2
Rnor_6.0252,243,066 - 52,243,258NCBIRnor6.0
Rnor_5.0270,605,933 - 70,606,125UniSTSRnor5.0
RGSC_v3.4251,551,169 - 51,551,359RGDRGSC3.4
RGSC_v3.4251,551,170 - 51,551,362UniSTSRGSC3.4
Celera247,119,907 - 47,120,100UniSTS
RGSC_v3.1251,479,402 - 51,479,592RGD
SHRSP x BN Map222.9498UniSTS
SHRSP x BN Map222.9498RGD
Cytogenetic Map2q16UniSTS
RH139449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2251,462,839 - 51,462,976 (+)MAPPERmRatBN7.2
Rnor_6.0252,241,076 - 52,241,212NCBIRnor6.0
Rnor_5.0270,603,943 - 70,604,079UniSTSRnor5.0
RGSC_v3.4251,549,180 - 51,549,316UniSTSRGSC3.4
Celera247,117,917 - 47,118,053UniSTS
RH 3.4 Map2332.1UniSTS
Cytogenetic Map2q16UniSTS
RH128163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2251,411,670 - 51,411,873 (+)MAPPERmRatBN7.2
Rnor_6.0252,189,784 - 52,189,986NCBIRnor6.0
Rnor_5.0270,553,600 - 70,553,802UniSTSRnor5.0
RGSC_v3.4251,496,714 - 51,496,916UniSTSRGSC3.4
Celera247,067,667 - 47,067,869UniSTS
RH 3.4 Map2332.9UniSTS
Cytogenetic Map2q16UniSTS
BE115925  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8253,171,072 - 53,171,230 (+)Marker Load Pipeline
mRatBN7.2251,438,332 - 51,438,490 (+)MAPPERmRatBN7.2
Rnor_6.0252,216,593 - 52,216,750NCBIRnor6.0
Rnor_5.0270,580,409 - 70,580,566UniSTSRnor5.0
RGSC_v3.4251,523,376 - 51,523,533UniSTSRGSC3.4
Celera247,094,327 - 47,094,484UniSTS
RH 3.4 Map2332.1UniSTS
Cytogenetic Map2q16UniSTS
BE117824  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2251,506,085 - 51,506,285 (+)MAPPERmRatBN7.2
Rnor_6.0252,284,053 - 52,284,252NCBIRnor6.0
Rnor_5.0270,645,578 - 70,645,777UniSTSRnor5.0
Celera247,161,109 - 47,161,308UniSTS
RH 3.4 Map2333.6UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000033627   ⟹   ENSRNOP00000029578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl253,144,160 - 53,237,310 (-)Ensembl
mRatBN7.2 Ensembl251,411,413 - 51,504,628 (-)Ensembl
Rnor_6.0 Ensembl252,189,529 - 52,282,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103489   ⟹   ENSRNOP00000085139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl253,144,160 - 53,236,044 (-)Ensembl
mRatBN7.2 Ensembl251,411,486 - 51,504,823 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107063   ⟹   ENSRNOP00000094975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl253,144,160 - 53,237,310 (-)Ensembl
mRatBN7.2 Ensembl251,411,413 - 51,504,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108201   ⟹   ENSRNOP00000090631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl253,144,160 - 53,237,310 (-)Ensembl
mRatBN7.2 Ensembl251,411,413 - 51,504,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112693   ⟹   ENSRNOP00000090109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl253,144,160 - 53,237,310 (-)Ensembl
mRatBN7.2 Ensembl251,411,413 - 51,504,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116756   ⟹   ENSRNOP00000096310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl251,411,413 - 51,504,191 (-)Ensembl
RefSeq Acc Id: NM_001013157   ⟹   NP_001013175
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,310 (-)NCBI
mRatBN7.2251,411,413 - 51,504,578 (-)NCBI
Rnor_6.0252,189,526 - 52,282,548 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
RGSC_v3.4251,496,456 - 51,589,901 (-)RGD
Celera247,067,409 - 47,159,610 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231968   ⟹   XP_006232030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,644 (-)NCBI
mRatBN7.2251,412,134 - 51,504,909 (-)NCBI
Rnor_6.0252,189,523 - 52,282,860 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231969   ⟹   XP_006232031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,635 (-)NCBI
mRatBN7.2251,412,134 - 51,504,903 (-)NCBI
Rnor_6.0252,189,523 - 52,282,860 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231970   ⟹   XP_006232032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,236,943 (-)NCBI
mRatBN7.2251,412,134 - 51,504,243 (-)NCBI
Rnor_6.0252,189,523 - 52,282,228 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231971   ⟹   XP_006232033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,140 (-)NCBI
mRatBN7.2251,412,134 - 51,504,412 (-)NCBI
Rnor_6.0252,189,523 - 52,282,348 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231972   ⟹   XP_006232034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,325 (-)NCBI
mRatBN7.2251,412,134 - 51,504,594 (-)NCBI
Rnor_6.0252,189,523 - 52,282,591 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760774   ⟹   XP_008758996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,857 (-)NCBI
mRatBN7.2251,412,134 - 51,505,125 (-)NCBI
Rnor_6.0252,189,523 - 52,283,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102256   ⟹   XP_038958184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,236,508 (-)NCBI
mRatBN7.2251,411,413 - 51,503,138 (-)NCBI
RefSeq Acc Id: XM_039102257   ⟹   XP_038958185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,235,869 (-)NCBI
mRatBN7.2251,411,419 - 51,503,143 (-)NCBI
RefSeq Acc Id: XM_063281783   ⟹   XP_063137853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,857 (-)NCBI
RefSeq Acc Id: XM_063281784   ⟹   XP_063137854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,153 (-)NCBI
RefSeq Acc Id: XM_063281785   ⟹   XP_063137855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,325 (-)NCBI
RefSeq Acc Id: NP_001013175   ⟸   NM_001013157
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232030   ⟸   XM_006231968
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232031   ⟸   XM_006231969
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232034   ⟸   XM_006231972
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232033   ⟸   XM_006231971
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232032   ⟸   XM_006231970
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758996   ⟸   XM_008760774
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029578   ⟸   ENSRNOT00000033627
RefSeq Acc Id: XP_038958184   ⟸   XM_039102256
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQG5 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958185   ⟸   XM_039102257
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A0P0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094975   ⟸   ENSRNOT00000107063
Ensembl Acc Id: ENSRNOP00000085139   ⟸   ENSRNOT00000103489
Ensembl Acc Id: ENSRNOP00000090109   ⟸   ENSRNOT00000112693
Ensembl Acc Id: ENSRNOP00000090631   ⟸   ENSRNOT00000108201
Ensembl Acc Id: ENSRNOP00000096310   ⟸   ENSRNOT00000116756
RefSeq Acc Id: XP_063137853   ⟸   XM_063281783
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AC81 (UniProtKB/TrEMBL),   A0A8I6ALS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137855   ⟸   XM_063281785
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AC81 (UniProtKB/TrEMBL),   A0A8I6ALS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137854   ⟸   XM_063281784
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AC81 (UniProtKB/TrEMBL),   A0A8I6ALS9 (UniProtKB/TrEMBL)
Protein Domains
Alanine dehydrogenase/pyridine nucleotide

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJZ3-F1-model_v2 AlphaFold Q5BJZ3 1-1086 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691156
Promoter ID:EPDNEW_R1680
Type:initiation region
Name:Nnt_1
Description:nicotinamide nucleotide transhydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0252,282,547 - 52,282,607EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587346 AgrOrtholog
BioCyc Gene G2FUF-54293 BioCyc
BioCyc Pathway NADPHOS-DEPHOS-PWY [NAD phosphorylation and dephosphorylation] BioCyc
  NADPHOS-DEPHOS-PWY-1 [NAD phosphorylation and transhydrogenation] BioCyc
BioCyc Pathway Image NADPHOS-DEPHOS-PWY BioCyc
  NADPHOS-DEPHOS-PWY-1 BioCyc
Ensembl Genes ENSRNOG00000026842 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033627 ENTREZGENE
  ENSRNOT00000033627.5 UniProtKB/TrEMBL
  ENSRNOT00000103489 ENTREZGENE
  ENSRNOT00000103489.2 UniProtKB/TrEMBL
  ENSRNOT00000107063.2 UniProtKB/TrEMBL
  ENSRNOT00000108201 ENTREZGENE
  ENSRNOT00000108201.2 UniProtKB/TrEMBL
  ENSRNOT00000112693.2 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381610 IMAGE-MGC_LOAD
InterPro Ala_DH/PNT_C UniProtKB/TrEMBL
  Ala_DH/PNT_CS1 UniProtKB/TrEMBL
  Ala_DH/PNT_CS2 UniProtKB/TrEMBL
  Ala_DH/PNT_N UniProtKB/TrEMBL
  DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  NADP_transhyd_a UniProtKB/TrEMBL
  NADP_transhyd_a_C UniProtKB/TrEMBL
  PNTB-like UniProtKB/TrEMBL
KEGG Report rno:310378 UniProtKB/TrEMBL
MGC_CLONE MGC:109126 IMAGE-MGC_LOAD
NCBI Gene 310378 ENTREZGENE
PANTHER NAD(P) TRANSHYDROGENASE UniProtKB/TrEMBL
  NAD(P) TRANSHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam AlaDh_PNT_C UniProtKB/TrEMBL
  AlaDh_PNT_N UniProtKB/TrEMBL
  DUF3814 UniProtKB/TrEMBL
  PNTB UniProtKB/TrEMBL
PhenoGen Nnt PhenoGen
PROSITE ALADH_PNT_1 UniProtKB/TrEMBL
  ALADH_PNT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026842 RatGTEx
SMART AlaDh_PNT_C UniProtKB/TrEMBL
  AlaDh_PNT_N UniProtKB/TrEMBL
Superfamily-SCOP Formate/glycerate dehydrogenase catalytic domain-like UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
  SSF52467 UniProtKB/TrEMBL
UniProt A0A8I6A0P0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AC81 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADT1_RAT UniProtKB/TrEMBL
  A0A8I6ALS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQG5 ENTREZGENE
  A6I5V3_RAT UniProtKB/TrEMBL
  Q5BJZ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   nicotinamide nucleotide transhydrogenase  Nnt  nicotinamide nucleotide transhydrogenase (mapped)  Name updated 737654 APPROVED
2007-04-11 Nnt  nicotinamide nucleotide transhydrogenase (mapped)  Nnt_mapped  nicotinamide nucleotide transhydrogenase (mapped)  Data merged from RGD:3182 737654 APPROVED
2006-11-19 Nnt  nicotinamide nucleotide transhydrogenase (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Nnt_mapped  nicotinamide nucleotide transhydrogenase (mapped)  Nnt  nicotinamide nucleotide transhydrogenase  Symbol and Name updated 1556543 APPROVED
2002-06-10 Nnt  Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology mouse Nnt exhibits NAD(P) transhydrogenase and oxidoreductase activities 704405