Tmem67 (transmembrane protein 67) - Rat Genome Database

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Gene: Tmem67 (transmembrane protein 67) Rattus norvegicus
Analyze
Symbol: Tmem67
Name: transmembrane protein 67
RGD ID: 1586167
Description: Enables misfolded protein binding activity. Involved in several processes, including photoreceptor cell outer segment organization; positive regulation of ERAD pathway; and positive regulation of non-motile cilium assembly. Located in axoneme; cytoplasmic vesicle membrane; and endoplasmic reticulum membrane. Used to study Meckel syndrome 3; autosomal recessive polycystic kidney disease; communicating hydrocephalus; hydrocephalus; and proteinuria. Human ortholog(s) of this gene implicated in several diseases, including Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis (multiple). Orthologous to human TMEM67 (transmembrane protein 67); PARTICIPATES IN Wnt signaling, non-canonical pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313067; Meckel syndrome type 3 protein homolog; Meckelin; Mks3; similar to transmembrane protein 67; Wistar polycystic kidney; Wpk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Tmem67wpk
Genetic Models: Wpk ; Wpk +/- ; Wpk -/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8530,333,793 - 30,386,702 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl530,333,793 - 30,386,666 (-)EnsemblGRCr8
mRatBN7.2525,536,458 - 25,589,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl525,536,458 - 25,589,334 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx527,679,863 - 27,732,749 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0529,272,610 - 29,325,491 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0529,217,147 - 29,270,042 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0525,666,138 - 25,721,056 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl525,666,137 - 25,721,072 (-)Ensemblrn6Rnor6.0
Rnor_5.0530,371,964 - 30,424,943 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4526,324,625 - 26,377,531 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera524,866,083 - 24,918,920 (-)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. Abdelhamed ZA, etal., Dis Model Mech. 2015 Jun;8(6):527-41. doi: 10.1242/dmm.019083. Epub 2015 Apr 7.
2. The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndrome. Baala L, etal., Am J Hum Genet. 2007 Jan;80(1):186-94. Epub 2006 Nov 15.
3. MKS3/TMEM67 mutations are a major cause of COACH Syndrome, a Joubert Syndrome related disorder with liver involvement. Brancati F, etal., Hum Mutat. 2009 Feb;30(2):E432-42. doi: 10.1002/humu.20924.
4. Molecular diagnostics of Meckel-Gruber syndrome highlights phenotypic differences between MKS1 and MKS3. Consugar MB, etal., Hum Genet. 2007 Jun;121(5):591-9. Epub 2007 Mar 22.
5. A mouse model for Meckel syndrome type 3. Cook SA, etal., J Am Soc Nephrol. 2009 Apr;20(4):753-64. doi: 10.1681/ASN.2008040412. Epub 2009 Feb 11.
6. Mutations in 3 genes (MKS3, CC2D2A and RPGRIP1L) cause COACH syndrome (Joubert syndrome with congenital hepatic fibrosis). Doherty D, etal., J Med Genet. 2010 Jan;47(1):8-21. doi: 10.1136/jmg.2009.067249. Epub 2009 Jul 1.
7. Prospective Evaluation of Kidney Disease in Joubert Syndrome. Fleming LR, etal., Clin J Am Soc Nephrol. 2017 Dec 7;12(12):1962-1973. doi: 10.2215/CJN.05660517. Epub 2017 Nov 16.
8. Development of multiorgan pathology in the wpk rat model of polycystic kidney disease. Gattone VH, etal., Anat Rec A Discov Mol Cell Evol Biol. 2004 Apr;277(2):384-95. doi: 10.1002/ar.a.20022.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Spectrum of MKS1 and MKS3 mutations in Meckel syndrome: a genotype-phenotype correlation. Mutation in brief #960. Online. Khaddour R, etal., Hum Mutat. 2007 May;28(5):523-4.
11. Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome. Leitch CC, etal., Nat Genet. 2008 Apr;40(4):443-8. doi: 10.1038/ng.97. Epub 2008 Mar 9.
12. New rat model that phenotypically resembles autosomal recessive polycystic kidney disease. Nauta J, etal., J Am Soc Nephrol 2000 Dec;11(12):2272-84.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Hypomorphic mutations in meckelin (MKS3/TMEM67) cause nephronophthisis with liver fibrosis (NPHP11). Otto EA, etal., J Med Genet. 2009 Oct;46(10):663-70. doi: 10.1136/jmg.2009.066613. Epub 2009 Jun 8.
15. Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium. Pluznick JL, etal., PLoS One. 2011;6(5):e19694. doi: 10.1371/journal.pone.0019694. Epub 2011 May 13.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Polycystic kidney and hepatic disease with mental retardation is nephronophthisis 11 caused by MKS3/TMEM67 mutations. Seeman T, etal., Pediatr Nephrol. 2010 Nov;25(11):2375-6. doi: 10.1007/s00467-010-1591-1. Epub 2010 Jul 6.
20. Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation. Shim JW, etal., Sci Rep. 2019 Jan 31;9(1):1069. doi: 10.1038/s41598-018-37620-5.
21. The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat. Smith UM, etal., Nat Genet. 2006 Feb;38(2):191-6. Epub 2006 Jan 15.
22. Characteristics of Liver Disease in 100 Individuals With Joubert Syndrome Prospectively Evaluated at a Single Center. Strongin A, etal., J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):428-435. doi: 10.1097/MPG.0000000000001816.
23. Comprehensive genetic testing in children with a clinical diagnosis of ARPKD identifies phenocopies. Szabó T, etal., Pediatr Nephrol. 2018 Oct;33(10):1713-1721. doi: 10.1007/s00467-018-3992-5. Epub 2018 Jun 28.
24. Founder mutations and genotype-phenotype correlations in Meckel-Gruber syndrome and associated ciliopathies. Szymanska K, etal., Cilia. 2012 Oct 1;1(1):18. doi: 10.1186/2046-2530-1-18.
25. Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3. Tammachote R, etal., Hum Mol Genet. 2009 Sep 1;18(17):3311-23. doi: 10.1093/hmg/ddp272. Epub 2009 Jun 10.
26. Meckelin 3 is necessary for photoreceptor outer segment development in rat Meckel syndrome. Tiwari S, etal., PLoS One. 2013;8(3):e59306. doi: 10.1371/journal.pone.0059306. Epub 2013 Mar 13.
27. Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C. Wang M, etal., J Biol Chem. 2009 Nov 27;284(48):33377-83. doi: 10.1074/jbc.M109.034371. Epub 2009 Oct 8.
28. A missense mutation in TMEM67 causes Meckel-Gruber syndrome type 3 (MKS3): a family from China. Zhang M, etal., Int J Clin Exp Pathol. 2015 May 1;8(5):5379-86. eCollection 2015.
Additional References at PubMed
PMID:15057822   PMID:17185389   PMID:21725307   PMID:22121117   PMID:25807483   PMID:26595381  


Genomics

Comparative Map Data
Tmem67
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8530,333,793 - 30,386,702 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl530,333,793 - 30,386,666 (-)EnsemblGRCr8
mRatBN7.2525,536,458 - 25,589,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl525,536,458 - 25,589,334 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx527,679,863 - 27,732,749 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0529,272,610 - 29,325,491 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0529,217,147 - 29,270,042 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0525,666,138 - 25,721,056 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl525,666,137 - 25,721,072 (-)Ensemblrn6Rnor6.0
Rnor_5.0530,371,964 - 30,424,943 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4526,324,625 - 26,377,531 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera524,866,083 - 24,918,920 (-)NCBICelera
Cytogenetic Map5q13NCBI
TMEM67
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38893,754,844 - 93,832,653 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl893,754,844 - 93,819,234 (+)Ensemblhg38GRCh38
GRCh37894,767,072 - 94,831,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36894,836,321 - 94,898,323 (+)NCBIBuild 36Build 36hg18NCBI36
Celera890,953,124 - 91,017,521 (+)NCBICelera
Cytogenetic Map8q22.1NCBI
HuRef889,974,594 - 90,039,048 (+)NCBIHuRef
CHM1_1894,807,348 - 94,871,742 (+)NCBICHM1_1
T2T-CHM13v2.0894,879,829 - 94,957,683 (+)NCBIT2T-CHM13v2.0
Tmem67
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39412,039,355 - 12,090,020 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl412,039,363 - 12,090,020 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38412,039,355 - 12,090,020 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl412,039,355 - 12,090,020 (-)Ensemblmm10GRCm38
MGSCv37411,966,502 - 12,015,104 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36411,966,792 - 12,015,104 (-)NCBIMGSCv36mm8
Celera411,852,088 - 11,951,004 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map45.56NCBI
Tmem67
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541710,097,472 - 10,138,644 (+)Ensembl
ChiLan1.0NW_00495541710,097,488 - 10,137,959 (+)NCBIChiLan1.0ChiLan1.0
TMEM67
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27111,086,261 - 111,150,985 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1886,624,847 - 86,687,985 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0890,378,623 - 90,442,904 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1892,324,402 - 92,387,437 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl892,324,402 - 92,387,437 (+)EnsemblpanPan2panpan1.1
TMEM67
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12938,655,531 - 38,715,774 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2938,654,733 - 38,720,559 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2938,817,691 - 38,877,961 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02938,859,810 - 38,920,095 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2938,859,346 - 38,915,876 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12938,873,675 - 38,933,947 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02938,868,253 - 38,928,540 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02939,309,700 - 39,370,424 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem67
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530340,860,751 - 40,904,822 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365446,887,532 - 6,932,179 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365446,887,867 - 6,931,669 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM67
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl442,879,140 - 42,931,121 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1442,878,249 - 42,931,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2446,289,107 - 46,341,896 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM67
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1888,726,783 - 88,818,111 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl888,726,837 - 88,792,049 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603952,056,457 - 52,122,252 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem67
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247631,219,827 - 1,264,071 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247631,219,779 - 1,281,297 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem67
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11131,445,491 - 131,499,534 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem67
359 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:285
Count of miRNA genes:187
Interacting mature miRNAs:212
Transcripts:ENSRNOT00000021839
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH136782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2525,536,594 - 25,536,762 (+)MAPPERmRatBN7.2
Rnor_6.0525,666,275 - 25,666,442NCBIRnor6.0
Rnor_5.0530,372,101 - 30,372,268UniSTSRnor5.0
RGSC_v3.4526,324,762 - 26,324,929UniSTSRGSC3.4
Celera524,866,220 - 24,866,387UniSTS
RH 3.4 Map5151.9UniSTS
Cytogenetic Map5q13UniSTS
RH137862  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2525,541,186 - 25,541,433 (+)MAPPERmRatBN7.2
Rnor_6.0525,670,867 - 25,671,113NCBIRnor6.0
Rnor_5.0530,376,693 - 30,376,939UniSTSRnor5.0
RGSC_v3.4526,329,354 - 26,329,600UniSTSRGSC3.4
Celera524,870,812 - 24,871,058UniSTS
RH 3.4 Map5149.7UniSTS
Cytogenetic Map5q13UniSTS
BI275220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2525,537,167 - 25,537,299 (+)MAPPERmRatBN7.2
Rnor_6.0525,666,848 - 25,666,979NCBIRnor6.0
Rnor_5.0530,372,674 - 30,372,805UniSTSRnor5.0
RGSC_v3.4526,325,335 - 26,325,466UniSTSRGSC3.4
Celera524,866,793 - 24,866,924UniSTS
RH 3.4 Map5150.2UniSTS
Cytogenetic Map5q13UniSTS


Genetic Models
This gene Tmem67 is modified in the following models/strains:
Wpk     Wpk +/-     Wpk -/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 80 59 6 343 180 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021839   ⟹   ENSRNOP00000021839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl530,333,793 - 30,386,666 (-)Ensembl
mRatBN7.2 Ensembl525,536,458 - 25,589,334 (-)Ensembl
Rnor_6.0 Ensembl525,666,137 - 25,721,072 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123779   ⟹   ENSRNOP00000107096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl530,333,793 - 30,386,666 (-)Ensembl
RefSeq Acc Id: NM_001107916   ⟹   NP_001101386
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8530,333,793 - 30,386,666 (-)NCBI
mRatBN7.2525,536,458 - 25,589,334 (-)NCBI
Rnor_6.0525,666,138 - 25,721,056 (-)NCBI
Rnor_5.0530,371,964 - 30,424,943 (-)NCBI
RGSC_v3.4526,324,625 - 26,377,531 (-)RGD
Celera524,866,083 - 24,918,920 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109808   ⟹   XP_038965736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8530,333,793 - 30,384,882 (-)NCBI
mRatBN7.2525,536,458 - 25,589,267 (-)NCBI
RefSeq Acc Id: XM_039109810   ⟹   XP_038965738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8530,357,543 - 30,386,701 (-)NCBI
mRatBN7.2525,560,101 - 25,589,378 (-)NCBI
RefSeq Acc Id: XM_039109811   ⟹   XP_038965739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8530,356,520 - 30,386,701 (-)NCBI
mRatBN7.2525,559,185 - 25,589,377 (-)NCBI
RefSeq Acc Id: XR_005504430
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8530,356,520 - 30,386,701 (-)NCBI
mRatBN7.2525,559,185 - 25,589,377 (-)NCBI
RefSeq Acc Id: XR_005504431
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8530,358,471 - 30,386,702 (-)NCBI
mRatBN7.2525,561,133 - 25,589,378 (-)NCBI
RefSeq Acc Id: NP_001101386   ⟸   NM_001107916
- Peptide Label: precursor
- UniProtKB: P0C152 (UniProtKB/Swiss-Prot),   F1M947 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021839   ⟸   ENSRNOT00000021839
RefSeq Acc Id: XP_038965736   ⟸   XM_039109808
- Peptide Label: isoform X1
- UniProtKB: A6II79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965739   ⟸   XM_039109811
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965738   ⟸   XM_039109810
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000107096   ⟸   ENSRNOT00000123779

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C152-F1-model_v2 AlphaFold P0C152 1-992 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693570
Promoter ID:EPDNEW_R4095
Type:initiation region
Name:Tmem67_1
Description:transmembrane protein 67
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0525,721,026 - 25,721,086EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586167 AgrOrtholog
BioCyc Gene G2FUF-41913 BioCyc
Ensembl Genes ENSRNOG00000016187 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021839 ENTREZGENE
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Meckelin UniProtKB/Swiss-Prot
NCBI Gene 313067 ENTREZGENE
PANTHER MECKELIN UniProtKB/Swiss-Prot
  PTHR21274 UniProtKB/Swiss-Prot
Pfam Meckelin UniProtKB/Swiss-Prot
PhenoGen Tmem67 PhenoGen
RatGTEx ENSRNOG00000016187 RatGTEx
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
UniProt A0ABK0LSX0_RAT UniProtKB/TrEMBL
  A6II79 ENTREZGENE, UniProtKB/TrEMBL
  F1M947 ENTREZGENE, UniProtKB/TrEMBL
  MKS3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Tmem67  transmembrane protein 67  LOC313067  similar to transmembrane protein 67  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC313067  similar to transmembrane protein 67      Symbol and Name status set to provisional 70820 PROVISIONAL