Qki (QKI, KH domain containing RNA binding) - Rat Genome Database

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Gene: Qki (QKI, KH domain containing RNA binding) Rattus norvegicus
Analyze
Symbol: Qki
Name: QKI, KH domain containing RNA binding
RGD ID: 1584886
Description: Predicted to enable RNA binding activity; internal N(7)-methylguanine-containing RNA reader activity; and transcription coactivator activity. Involved in several processes, including mRNA stabilization; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of oligodendrocyte differentiation. Predicted to be active in several cellular components, including cytoplasmic stress granule; cytosol; and synapse. Orthologous to human QKI (QKI, KH domain containing RNA binding); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homolog of mouse quaking QKI (KH domain RNA binding protein); KH domain-containing RNA-binding protein QKI; LOC108348175; LOC499022; MGC188205; protein quaking; protein quaking-like; Qk; quaking; quaking homolog, KH domain RNA binding (mouse); quaking, KH domain containing RNA binding; rqkI; similar to quaking homolog, KH domain RNA binding isoform HQK-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,935,357 - 53,047,338 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl152,935,382 - 53,047,337 (+)EnsemblGRCr8
mRatBN7.2150,387,716 - 50,501,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl150,387,698 - 50,498,831 (+)EnsemblmRatBN7.2
Rnor_6.0150,983,647 - 51,050,692 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl150,828,134 - 51,052,340 (+)Ensemblrn6Rnor6.0
Rnor_5.0152,104,976 - 52,207,885 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4144,922,562 - 45,025,572 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera146,204,164 - 46,271,210 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
GSK-J4  (ISO)
haloperidol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nicotine  (ISO)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (ISO)
axon ensheathment  (ISO)
cell differentiation  (IEA)
intracellular mRNA localization  (IEA,ISO)
long-chain fatty acid biosynthetic process  (ISO)
microglia differentiation  (IEA,ISO,ISS)
mRNA processing  (IEA,IMP)
mRNA stabilization  (IEA,IMP,ISO)
mRNA transport  (IEA,ISO)
muscle cell differentiation  (ISO)
myelination  (ISO)
myofibroblast contraction  (IEA,ISO)
negative regulation of 3'-UTR-mediated mRNA stabilization  (IEA,ISO,ISS)
negative regulation of angiogenesis  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of macrophage differentiation  (ISO,ISS)
negative regulation of miRNA catabolic process  (ISO,ISS)
negative regulation of translation  (IEA,ISO,ISS)
negative regulation of type I interferon production  (ISO)
positive regulation of 3'-UTR-mediated mRNA stabilization  (ISO)
positive regulation of cholesterol biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of myelination  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of oligodendrocyte differentiation  (IEA,IMP,ISO)
regulation of astrocyte differentiation  (IEA,ISO,ISS)
regulation of epithelial to mesenchymal transition  (IEA,ISO,ISS)
regulation of macrophage differentiation  (IEA,ISO)
regulation of mRNA splicing, via spliceosome  (IBA,IEA,ISO,ISS)
regulation of primary metabolic process  (IEA)
regulation of translation  (IEA)
RNA splicing  (IEA)
spermatid development  (ISO)
spliceosome-depend formation of circular RNA  (IEA,ISO,ISS)
vascular associated smooth muscle cell differentiation  (IEA,ISO,ISS)
vasculogenesis  (ISO)

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic stress granule  (ISO)
cytosol  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
synapse  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation. Chen Y, etal., J Biol Chem. 2007 Aug 10;282(32):23553-60. Epub 2007 Jun 15.
2. The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. Doukhanine E, etal., Mol Biol Cell. 2010 Sep 1;21(17):3029-40. doi: 10.1091/mbc.E10-04-0305. Epub 2010 Jul 14.
3. Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis. Farias AS, etal., Proteomics. 2012 Aug;12(17):2656-62. doi: 10.1002/pmic.201200044.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. RNA binding protein QKI inhibits the ischemia/reperfusion-induced apoptosis in neonatal cardiomyocytes. Guo W, etal., Cell Physiol Biochem. 2011;28(4):593-602. doi: 10.1159/000335755. Epub 2011 Dec 14.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells. Zearfoss NR, etal., PLoS Genet. 2011 Jan 6;7(1):e1001269. doi: 10.1371/journal.pgen.1001269.
10. QKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte development. Zhao L, etal., Mol Biol Cell. 2006 Oct;17(10):4179-86. Epub 2006 Jul 19.
Additional References at PubMed
PMID:1150661   PMID:1373175   PMID:10506177   PMID:11178867   PMID:11892011   PMID:12477932   PMID:14169723   PMID:14706070   PMID:15057822   PMID:15148410   PMID:15568022   PMID:15632090  
PMID:16452087   PMID:19517016   PMID:22681889   PMID:22871113   PMID:23385723   PMID:25145264   PMID:28283792   PMID:34227244   PMID:36627242  


Genomics

Comparative Map Data
Qki
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,935,357 - 53,047,338 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl152,935,382 - 53,047,337 (+)EnsemblGRCr8
mRatBN7.2150,387,716 - 50,501,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl150,387,698 - 50,498,831 (+)EnsemblmRatBN7.2
Rnor_6.0150,983,647 - 51,050,692 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl150,828,134 - 51,052,340 (+)Ensemblrn6Rnor6.0
Rnor_5.0152,104,976 - 52,207,885 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4144,922,562 - 45,025,572 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera146,204,164 - 46,271,210 (+)NCBICelera
Cytogenetic Map1q11NCBI
QKI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386163,414,718 - 163,578,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6163,414,000 - 163,578,592 (+)Ensemblhg38GRCh38
GRCh376163,835,750 - 163,999,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366163,755,665 - 163,914,886 (+)NCBIBuild 36Build 36hg18NCBI36
Celera6164,606,149 - 164,729,418 (+)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6161,290,590 - 161,453,987 (+)NCBIHuRef
CHM1_16164,097,893 - 164,261,842 (+)NCBICHM1_1
T2T-CHM13v2.06164,779,884 - 164,943,697 (+)NCBIT2T-CHM13v2.0
Qki
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391710,425,480 - 10,538,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1710,421,530 - 10,538,783 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381710,206,471 - 10,319,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1710,202,601 - 10,319,854 (-)Ensemblmm10GRCm38
MGSCv371710,399,336 - 10,512,226 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361710,053,536 - 10,163,211 (-)NCBIMGSCv36mm8
Celera1710,252,038 - 10,337,960 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map177.75NCBI
Qki
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543917,925,229 - 18,079,727 (-)Ensembl
ChiLan1.0NW_00495543917,925,205 - 18,079,727 (-)NCBIChiLan1.0ChiLan1.0
QKI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25183,597,079 - 183,756,086 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16181,498,349 - 181,657,357 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06161,361,413 - 161,523,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16166,398,884 - 166,517,389 (+)NCBIPanPan1.1PanPan1.1panPan2
QKI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1151,800,294 - 51,956,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,800,309 - 51,952,714 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha152,642,145 - 52,797,414 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0151,975,526 - 52,138,964 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,977,027 - 52,136,022 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,867,832 - 52,023,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,727,887 - 51,883,146 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,356,356 - 52,511,535 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Qki
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946146,649,733 - 146,750,270 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648913,901,754 - 13,999,983 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648913,901,066 - 14,000,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QKI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14,735,514 - 4,883,392 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114,732,575 - 4,883,386 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.216,380,698 - 6,486,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
QKI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11391,045,167 - 91,206,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1391,045,209 - 91,208,471 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604062,921,663 - 63,087,940 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Qki
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478515,739,187 - 15,845,024 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478515,738,231 - 15,845,051 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Qki
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12189,028,049 - 189,136,838 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Qki
833 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:614
Count of miRNA genes:229
Interacting mature miRNAs:276
Transcripts:ENSRNOT00000023290, ENSRNOT00000023304, ENSRNOT00000035402, ENSRNOT00000071865
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
BE111947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2150,497,903 - 50,498,053 (+)MAPPERmRatBN7.2
Rnor_6.0151,057,439 - 51,057,588NCBIRnor6.0
Rnor_5.0152,333,742 - 52,333,891UniSTSRnor5.0
RGSC_v3.4145,032,319 - 45,032,468UniSTSRGSC3.4
Celera146,277,965 - 46,278,114UniSTS
RH 3.4 Map1593.4UniSTS
Cytogenetic Map1q11UniSTS
QKI  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2150,489,724 - 50,489,961 (+)MAPPERmRatBN7.2
Rnor_6.0151,049,261 - 51,049,497NCBIRnor6.0
Rnor_6.0150,930,151 - 50,930,387NCBIRnor6.0
Rnor_5.0152,206,454 - 52,206,690UniSTSRnor5.0
Rnor_5.0152,325,564 - 52,325,800UniSTSRnor5.0
RGSC_v3.4145,024,141 - 45,024,377UniSTSRGSC3.4
Celera146,269,779 - 46,270,015UniSTS
Cytogenetic Map1q11UniSTS
BF394556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2150,409,623 - 50,409,858 (+)MAPPERmRatBN7.2
Rnor_6.0150,850,065 - 50,850,299NCBIRnor6.0
Rnor_6.0150,968,974 - 50,969,208NCBIRnor6.0
Rnor_5.0152,245,277 - 52,245,511UniSTSRnor5.0
Rnor_5.0152,126,368 - 52,126,602UniSTSRnor5.0
RGSC_v3.4144,944,055 - 44,944,289UniSTSRGSC3.4
Celera146,189,690 - 46,189,924UniSTS
RH 3.4 Map1594.3UniSTS
Cytogenetic Map1q11UniSTS
Qk  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0150,828,594 - 50,828,711NCBIRnor6.0
RGSC_v3.4144,922,583 - 44,922,701UniSTSRGSC3.4
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 67 138 95 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023290   ⟹   ENSRNOP00000023290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl152,935,382 - 53,038,469 (+)Ensembl
mRatBN7.2 Ensembl150,387,698 - 50,492,371 (+)Ensembl
Rnor_6.0 Ensembl150,828,585 - 51,050,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000035402   ⟹   ENSRNOP00000034413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl152,935,740 - 53,040,784 (+)Ensembl
mRatBN7.2 Ensembl150,387,698 - 50,493,096 (+)Ensembl
Rnor_6.0 Ensembl150,828,585 - 51,052,340 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086441   ⟹   ENSRNOP00000070460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl152,935,740 - 53,047,337 (+)Ensembl
mRatBN7.2 Ensembl150,388,120 - 50,498,831 (+)Ensembl
Rnor_6.0 Ensembl150,828,585 - 50,933,516 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089149   ⟹   ENSRNOP00000069203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl152,935,738 - 53,043,710 (+)Ensembl
mRatBN7.2 Ensembl150,387,698 - 50,491,151 (+)Ensembl
Rnor_6.0 Ensembl150,828,134 - 50,931,579 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099441   ⟹   ENSRNOP00000096216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl150,387,698 - 50,497,836 (+)Ensembl
RefSeq Acc Id: NM_001115021   ⟹   NP_001108493
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,632 - 53,043,717 (+)NCBI
mRatBN7.2150,387,923 - 50,496,030 (+)NCBI
Rnor_6.0150,983,647 - 51,050,692 (+)NCBI
Rnor_5.0152,104,976 - 52,207,885 (+)NCBI
RGSC_v3.4144,922,562 - 45,025,572 (+)RGD
Celera146,204,164 - 46,271,210 (+)RGD
Sequence:
RefSeq Acc Id: NM_001414465   ⟹   NP_001401394
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,425 - 53,047,338 (+)NCBI
mRatBN7.2150,387,716 - 50,499,651 (+)NCBI
RefSeq Acc Id: XM_017589896   ⟹   XP_017445385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,357 - 53,047,338 (+)NCBI
mRatBN7.2150,387,929 - 50,501,568 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086917   ⟹   XP_038942845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,357 - 53,043,721 (+)NCBI
mRatBN7.2150,387,929 - 50,496,034 (+)NCBI
RefSeq Acc Id: XM_039086921   ⟹   XP_038942849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,475 - 53,047,338 (+)NCBI
mRatBN7.2150,387,929 - 50,501,568 (+)NCBI
RefSeq Acc Id: XM_039086927   ⟹   XP_038942855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,936,472 - 53,047,338 (+)NCBI
mRatBN7.2150,388,817 - 50,501,568 (+)NCBI
RefSeq Acc Id: XM_039086931   ⟹   XP_038942859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,936,528 - 53,047,338 (+)NCBI
mRatBN7.2150,388,817 - 50,501,568 (+)NCBI
RefSeq Acc Id: XM_039086940   ⟹   XP_038942868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,475 - 53,043,721 (+)NCBI
mRatBN7.2150,387,794 - 50,496,034 (+)NCBI
RefSeq Acc Id: XM_039086942   ⟹   XP_038942870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,475 - 53,043,721 (+)NCBI
mRatBN7.2150,387,929 - 50,496,034 (+)NCBI
RefSeq Acc Id: XM_063270765   ⟹   XP_063126835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,935,357 - 53,043,721 (+)NCBI
RefSeq Acc Id: NP_001108493   ⟸   NM_001115021
- Peptide Label: isoform 2
- UniProtKB: B0BNF5 (UniProtKB/TrEMBL),   A0A0G2JUS0 (UniProtKB/TrEMBL),   A0A8I6AP33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038942868   ⟸   XM_039086940
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942849   ⟸   XM_039086921
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_017445385   ⟸   XM_017589896
- Peptide Label: isoform X1
- UniProtKB: Q91XU1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038942870   ⟸   XM_039086942
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942845   ⟸   XM_039086917
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942855   ⟸   XM_039086927
- Peptide Label: isoform X6
- UniProtKB: Q91XU1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038942859   ⟸   XM_039086931
- Peptide Label: isoform X6
- UniProtKB: Q91XU1 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000069203   ⟸   ENSRNOT00000089149
Ensembl Acc Id: ENSRNOP00000034413   ⟸   ENSRNOT00000035402
Ensembl Acc Id: ENSRNOP00000023290   ⟸   ENSRNOT00000023290
Ensembl Acc Id: ENSRNOP00000070460   ⟸   ENSRNOT00000086441
Ensembl Acc Id: ENSRNOP00000096216   ⟸   ENSRNOT00000099441
RefSeq Acc Id: NP_001401394   ⟸   NM_001414465
- Peptide Label: isoform 1
- UniProtKB: Q91XU1 (UniProtKB/Swiss-Prot),   A0A0G2JXZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126835   ⟸   XM_063270765
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AP33 (UniProtKB/TrEMBL),   D4A2X0 (UniProtKB/TrEMBL)
Protein Domains
K Homology   KH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXZ5-F1-model_v2 AlphaFold A0A0G2JXZ5 1-340 view protein structure
AF-Q91XU1-F1-model_v2 AlphaFold Q91XU1 1-341 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584886 AgrOrtholog
BioCyc Gene G2FUF-61539 BioCyc
Ensembl Genes ENSRNOG00000048297 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023290 ENTREZGENE
  ENSRNOT00000086441 ENTREZGENE
  ENSRNOT00000089149 ENTREZGENE
Gene3D-CATH 1.20.5.4010 UniProtKB/Swiss-Prot
  3.30.1370.10 UniProtKB/Swiss-Prot
InterPro BBP-like UniProtKB/Swiss-Prot
  KH_1_KHDC4/BBP-like UniProtKB/Swiss-Prot
  KH_dom UniProtKB/Swiss-Prot
  KH_dom_type_1_sf UniProtKB/Swiss-Prot
  Quaking_NLS UniProtKB/Swiss-Prot
  STAR_dimer UniProtKB/Swiss-Prot
NCBI Gene 499022 ENTREZGENE
PANTHER PROTEIN QUAKING UniProtKB/Swiss-Prot
  PTHR11208 UniProtKB/Swiss-Prot
Pfam KH-I_KHDC4-BBP UniProtKB/Swiss-Prot
  Quaking_NLS UniProtKB/Swiss-Prot
  STAR_dimer UniProtKB/Swiss-Prot
PhenoGen Qki PhenoGen
RatGTEx ENSRNOG00000048297 RatGTEx
SMART SM00322 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot
UniProt A0A0G2JUS0 ENTREZGENE
  A0A0G2JXZ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP33 ENTREZGENE
  A0ABZ3NNK2_RAT UniProtKB/TrEMBL
  B0BNF5 ENTREZGENE, UniProtKB/TrEMBL
  D4A2X0 ENTREZGENE
  F1LMH5_RAT UniProtKB/TrEMBL
  Q91XU1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-22 Qki  QKI, KH domain containing RNA binding  Qk  quaking, KH domain containing RNA binding  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-10-22 Qk  quaking, KH domain containing RNA binding  Qk  quaking  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Qk  quaking  LOC108348175  protein quaking-like  Data merged from RGD:11514364 737654 PROVISIONAL
2016-08-02 LOC108348175  protein quaking-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-15 Qk  quaking  Qki  quaking homolog, KH domain RNA binding (mouse)  Data merged from RGD:628653 737654 APPROVED
2008-03-05 Qk  quaking  LOC499022  similar to quaking homolog, KH domain RNA binding isoform HQK-6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC499022  similar to quaking homolog, KH domain RNA binding isoform HQK-6      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Qki  quaking homolog, KH domain RNA binding (mouse)    homolog of mouse quaking QKI (KH domain RNA binding protein)  Name updated 1299863 APPROVED
2003-02-27 Qki  homolog of mouse quaking QKI (KH domain RNA binding protein)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a KH-domain 625530
gene_process mouse homolog may play a role in localization of myelin basic protein (MBP) in oligodendrocytes 625530
gene_process acts as a marker for regenerating myelinating oligodendrocytes 625530
gene_process cytoplasmic protein may facilitate movement of mRNA to myelin via cytoskeleton prior to translation 625530
gene_product member of the RNA binding protein family 625530
gene_regulation elevated levels found in subsets of actively myelinating oligodendrocytes in adult brain and reduced expression observed in mature oligodendrocytes 625530
gene_transcript three isoforms identified 625530