Pgd (phosphogluconate dehydrogenase) - Rat Genome Database

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Gene: Pgd (phosphogluconate dehydrogenase) Rattus norvegicus
Analyze
Symbol: Pgd
Name: phosphogluconate dehydrogenase
RGD ID: 1583832
Description: Enables several functions, including NADP binding activity; carboxylic acid binding activity; and phosphogluconate dehydrogenase (decarboxylating) activity. Involved in D-gluconate metabolic process and pentose-phosphate shunt, oxidative branch. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human PGD (phosphogluconate dehydrogenase); PARTICIPATES IN pentose phosphate pathway; pentose phosphate pathway - oxidative phase; ribose 5-phosphate isomerase deficiency pathway; INTERACTS WITH (R)-noradrenaline; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-phosphogluconate dehydrogenase, decarboxylating; 6-phosphogluconate dehydrogenase, decarboxylating-like; Cc2-27; LOC100360180; Pgd_mapped; phosphogluconate dehydrogenase (mapped)
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,865,830 - 164,882,029 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5164,865,830 - 164,882,029 (-)EnsemblGRCr8
mRatBN7.25159,582,746 - 159,598,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,561,271 - 159,742,778 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5162,299,447 - 162,315,646 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,120,366 - 164,136,488 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,076,736 - 164,092,858 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,966,128 - 165,982,327 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05169,614,705 - 169,630,921 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45166,221,292 - 166,237,485 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5157,853,711 - 157,869,910 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-noradrenaline  (EXP)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methylphenazinium methyl sulfate  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
amikacin  (EXP)
ampicillin  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astaxanthin  (EXP)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
benzylpenicillin  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cefepime  (EXP)
cefotaxime  (EXP)
chloramphenicol  (EXP)
chloroprene  (ISO)
choline  (ISO)
chrysin  (ISO)
cinnamyl alcohol  (ISO)
ciprofloxacin  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl maleate  (EXP)
digoxin  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dopamine  (EXP)
ellagic acid  (ISO)
eugenol  (ISO)
ferulic acid  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
furosemide  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
hexane  (ISO)
iron trichloride  (EXP)
isepamicin  (EXP)
isoeugenol  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methoxychlor  (EXP)
methyl salicylate  (ISO)
methylene blue  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
netilmycin  (EXP)
nickel sulfate  (ISO)
ofloxacin  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propan-2-ol  (ISO)
propiconazole  (ISO)
pyrroles  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
teicoplanin  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
trans-isoeugenol  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2',5'-ADP Sepharose 4B affinity in a single chromatography step. Adem S and Ciftci M, Protein Expr Purif. 2012 Jan;81(1):1-4. doi: 10.1016/j.pep.2011.08.031. Epub 2011 Sep 10.
2. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
3. The pentose phosphate pathway in the endoplasmic reticulum. Bublitz C and Steavenson S, J Biol Chem. 1988 Sep 15;263(26):12849-53.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Hexose-6-phosphate and 6-phosphogluconate dehydrogenases of rat liver microsomes. Involvement in NADPH and carbon dioxide generation in the luminal space of microsomal vesicles. Hino Y and Minakami S, J Biochem (Tokyo). 1982 Aug;92(2):547-57.
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Effect of Anabolic Steroid Nandrolone Decanoate on the Properties of Certain Enzymes in the Heart, Liver, and Muscle of Rats, and their Effect on Rats' Cardiac Electrophysiology. Tylicki A, etal., Horm Metab Res. 2007 Apr;39(4):268-72.
9. Significance of the 5-phosphoribosyl-1-pyrophosphate pool for cardiac purine and pyrimidine nucleotide synthesis: studies with ribose, adenine, inosine, and orotic acid in rats. Zimmer HG Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:179-87.
Additional References at PubMed
PMID:204065   PMID:1235912   PMID:3858849   PMID:7323947   PMID:8491670   PMID:9920387   PMID:12479874   PMID:15057822   PMID:15155459   PMID:16284727   PMID:19056867   PMID:19343716  
PMID:20458337   PMID:21630459   PMID:23376485   PMID:23533145   PMID:25228019  


Genomics

Comparative Map Data
Pgd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,865,830 - 164,882,029 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5164,865,830 - 164,882,029 (-)EnsemblGRCr8
mRatBN7.25159,582,746 - 159,598,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,561,271 - 159,742,778 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5162,299,447 - 162,315,646 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,120,366 - 164,136,488 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,076,736 - 164,092,858 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,966,128 - 165,982,327 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05169,614,705 - 169,630,921 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45166,221,292 - 166,237,485 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5157,853,711 - 157,869,910 (-)NCBICelera
Cytogenetic Map5q36NCBI
PGD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38110,399,064 - 10,420,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl110,398,592 - 10,420,511 (+)Ensemblhg38GRCh38
GRCh37110,459,121 - 10,480,568 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36110,381,672 - 10,402,788 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34110,393,350 - 10,414,467NCBI
Celera19,570,477 - 9,591,593 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef19,612,776 - 9,633,839 (+)NCBIHuRef
CHM1_1110,447,954 - 10,469,073 (+)NCBICHM1_1
T2T-CHM13v2.019,942,673 - 9,964,125 (+)NCBIT2T-CHM13v2.0
Pgd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,234,448 - 149,251,162 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4149,234,448 - 149,251,228 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384149,149,991 - 149,166,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,149,991 - 149,166,771 (-)Ensemblmm10GRCm38
MGSCv374148,524,094 - 148,540,816 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364147,993,785 - 148,010,507 (-)NCBIMGSCv36mm8
Celera4151,416,090 - 151,432,815 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.96NCBI
Pgd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554863,343,863 - 3,357,066 (-)Ensembl
ChiLan1.0NW_0049554863,344,705 - 3,356,906 (-)NCBIChiLan1.0ChiLan1.0
PGD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1285,393,526 - 85,408,714 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl285,393,819 - 85,408,272 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha281,995,019 - 82,010,228 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0286,128,551 - 86,143,976 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl286,128,552 - 86,143,996 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,875,909 - 82,891,117 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,878,401 - 83,893,609 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,941,328 - 84,956,541 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pgd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505833,749,594 - 33,766,445 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366234,234,837 - 4,252,467 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366234,234,869 - 4,251,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl670,675,815 - 70,692,679 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1670,675,751 - 70,692,697 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2664,608,578 - 64,625,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q22-q25NCBI
PGD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120121,359,854 - 121,380,934 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605425,275,267 - 25,297,177 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248182,261,940 - 2,274,723 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248182,261,658 - 2,274,878 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pgd
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1111,611,868 - 11,628,051 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pgd
37 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 51 67 138 95 11 50 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000077784   ⟹   ENSRNOP00000074305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5159,561,271 - 159,613,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078830   ⟹   ENSRNOP00000075214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,894,763 - 165,008,841 (-)Ensembl
mRatBN7.2 Ensembl5159,611,682 - 159,742,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079919   ⟹   ENSRNOP00000075228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,894,763 - 165,008,841 (-)Ensembl
mRatBN7.2 Ensembl5159,611,682 - 159,742,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080888   ⟹   ENSRNOP00000072431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,894,763 - 165,008,841 (-)Ensembl
mRatBN7.2 Ensembl5159,611,682 - 159,742,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086226   ⟹   ENSRNOP00000077156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,951,227 - 165,008,841 (-)Ensembl
mRatBN7.2 Ensembl5159,668,015 - 159,742,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087739   ⟹   ENSRNOP00000074322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5159,611,682 - 159,742,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089099   ⟹   ENSRNOP00000075522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,894,763 - 165,008,841 (-)Ensembl
mRatBN7.2 Ensembl5159,611,682 - 159,742,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104782   ⟹   ENSRNOP00000082532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,865,830 - 164,882,029 (-)Ensembl
mRatBN7.2 Ensembl5159,582,731 - 159,598,949 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105558   ⟹   ENSRNOP00000094551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,894,763 - 165,008,841 (-)Ensembl
mRatBN7.2 Ensembl5159,611,682 - 159,742,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117986   ⟹   ENSRNOP00000088342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5159,611,682 - 159,742,778 (-)Ensembl
RefSeq Acc Id: NM_001305435   ⟹   NP_001292364
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,865,830 - 164,882,029 (-)NCBI
mRatBN7.25159,582,746 - 159,598,945 (-)NCBI
Rnor_6.05165,966,128 - 165,982,327 (-)NCBI
Celera5157,853,711 - 157,869,910 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001292364 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81153 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082532
  ENSRNOP00000082532.1
GenBank Protein P85968 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001292364   ⟸   NM_001305435
- UniProtKB: P85968 (UniProtKB/Swiss-Prot),   A6IUA2 (UniProtKB/TrEMBL),   A6IUA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072431   ⟸   ENSRNOT00000080888
Ensembl Acc Id: ENSRNOP00000077156   ⟸   ENSRNOT00000086226
Ensembl Acc Id: ENSRNOP00000094551   ⟸   ENSRNOT00000105558
Ensembl Acc Id: ENSRNOP00000075214   ⟸   ENSRNOT00000078830
Ensembl Acc Id: ENSRNOP00000088342   ⟸   ENSRNOT00000117986
Ensembl Acc Id: ENSRNOP00000082532   ⟸   ENSRNOT00000104782
Ensembl Acc Id: ENSRNOP00000074322   ⟸   ENSRNOT00000087739
Ensembl Acc Id: ENSRNOP00000075522   ⟸   ENSRNOT00000089099
Ensembl Acc Id: ENSRNOP00000075228   ⟸   ENSRNOT00000079919
Ensembl Acc Id: ENSRNOP00000074305   ⟸   ENSRNOT00000077784
Protein Domains
6-phosphogluconate dehydrogenase C-terminal   FHA   Kinesin motor   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P85968-F1-model_v2 AlphaFold P85968 1-483 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583832 AgrOrtholog
BioCyc Gene G2FUF-39141 BioCyc
BioCyc Pathway OXIDATIVEPENT-PWY [pentose phosphate pathway (oxidative branch) I] BioCyc
BioCyc Pathway Image OXIDATIVEPENT-PWY BioCyc
Ensembl Genes ENSRNOG00000057626 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000076812 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000104782 ENTREZGENE
  ENSRNOT00000104782.1 UniProtKB/Swiss-Prot
Gene3D-CATH 6-Phosphogluconate Dehydrogenase, domain 3 UniProtKB/Swiss-Prot
  N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
InterPro 6-PGluconate_DH-like_C_sf UniProtKB/Swiss-Prot
  6PGD_dom2 UniProtKB/Swiss-Prot
  6PGDH_C UniProtKB/Swiss-Prot
  6PGDH_Gnd/GntZ UniProtKB/Swiss-Prot
  6PGDH_NADP-bd UniProtKB/Swiss-Prot
  6PGdom_BS UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Pgluconate_DH UniProtKB/Swiss-Prot
KEGG Report rno:100360180 UniProtKB/Swiss-Prot
NCBI Gene Pgd ENTREZGENE
PANTHER PTHR11811 UniProtKB/Swiss-Prot
Pfam 6PGD UniProtKB/Swiss-Prot
  NAD_binding_2 UniProtKB/Swiss-Prot
PhenoGen Pgd PhenoGen
PIRSF 6PGD UniProtKB/Swiss-Prot
PRINTS 6PGDHDRGNASE UniProtKB/Swiss-Prot
PROSITE 6PGD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000057626 RatGTEx
  ENSRNOG00000076812 RatGTEx
SMART 6PGD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48179 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
UniProt 6PGD_RAT UniProtKB/Swiss-Prot
  A0A0G2KA12_RAT UniProtKB/TrEMBL
  A0A8I6AL17_RAT UniProtKB/TrEMBL
  A6IUA2 ENTREZGENE, UniProtKB/TrEMBL
  A6IUA3 ENTREZGENE, UniProtKB/TrEMBL
  P85968 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-10 Pgd  phosphogluconate dehydrogenase  LOC100360180  6-phosphogluconate dehydrogenase, decarboxylating-like  Data merged from RGD:2322669 737654 APPROVED
2010-05-06 LOC100360180  6-phosphogluconate dehydrogenase, decarboxylating-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2007-04-13   phosphogluconate dehydrogenase  Pgd  phosphogluconate dehydrogenase (mapped)  Name updated 737654 APPROVED
2007-04-11 Pgd  phosphogluconate dehydrogenase (mapped)  Pgd_mapped  phosphogluconate dehydrogenase (mapped)  Data merged from RGD:3314 737654 APPROVED
2006-11-19 Pgd  phosphogluconate dehydrogenase (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Pgd_mapped  phosphogluconate dehydrogenase (mapped)      Symbol and Name updated 1556543 APPROVED
2003-04-09 Pgd  phosphogluconate dehydrogenase    Phosphogluconate dehydrogenase  Name updated 629478 APPROVED
2002-06-10 Pgd  Phosphogluconate dehydrogenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activity decreases with age in adipose tissue and kidney cortex but not skeletal muscle, heart or brain 1334488
gene_regulation activity increased by oestradiol in females 1334488