Defb2 (defensin beta 2) - Rat Genome Database

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Gene: Defb2 (defensin beta 2) Rattus norvegicus
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Symbol: Defb2
Name: defensin beta 2
RGD ID: 1566125
Description: Predicted to enable CCR6 chemokine receptor binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-defensin 2
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,934,341 - 76,948,284 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1676,934,337 - 76,948,299 (-)EnsemblGRCr8
mRatBN7.21670,231,870 - 70,245,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,231,945 - 70,245,784 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1675,505,643 - 75,519,488 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,967,619 - 78,981,581 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,217,049 - 74,231,011 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,227,468 - 75,241,303 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,227,468 - 75,241,303 (-)Ensemblrn6Rnor6.0
Rnor_5.01674,844,019 - 74,857,854 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41674,909,293 - 74,923,128 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1668,110,804 - 68,124,639 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Sepsis  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. [Effect of recombinant beta-defensin-2 peptide on apoptosis of pulmonary tissue in rats with sepsis]. Xu XY, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 Nov;35(6):600-4.
Additional References at PubMed
PMID:15970102   PMID:16033865   PMID:19155510   PMID:32411798   PMID:35322444  


Genomics

Comparative Map Data
Defb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,934,341 - 76,948,284 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1676,934,337 - 76,948,299 (-)EnsemblGRCr8
mRatBN7.21670,231,870 - 70,245,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,231,945 - 70,245,784 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1675,505,643 - 75,519,488 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,967,619 - 78,981,581 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,217,049 - 74,231,011 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,227,468 - 75,241,303 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,227,468 - 75,241,303 (-)Ensemblrn6Rnor6.0
Rnor_5.01674,844,019 - 74,857,854 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41674,909,293 - 74,923,128 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1668,110,804 - 68,124,639 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
Defb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,329,942 - 22,333,519 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,329,942 - 22,333,498 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38821,839,926 - 21,843,482 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,839,926 - 21,843,482 (+)Ensemblmm10GRCm38
MGSCv37822,950,398 - 22,953,954 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36823,305,471 - 23,309,027 (+)NCBIMGSCv36mm8
Celera823,329,911 - 23,333,489 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.45NCBI

Variants

.
Variants in Defb2
93 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:98
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000058056
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)167523528581732231Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat


Expression

RNA-SEQ Expression

mesenchyme
renal system
reproductive system
28 28 8

Sequence


Ensembl Acc Id: ENSRNOT00000058056   ⟹   ENSRNOP00000054864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1676,934,337 - 76,948,299 (-)Ensembl
mRatBN7.2 Ensembl1670,231,945 - 70,245,784 (-)Ensembl
Rnor_6.0 Ensembl1675,227,468 - 75,241,303 (-)Ensembl
RefSeq Acc Id: NM_001037507   ⟹   NP_001032596
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,934,341 - 76,948,284 (-)NCBI
mRatBN7.21670,231,870 - 70,245,817 (-)NCBI
Rnor_6.01675,227,468 - 75,241,303 (-)NCBI
Rnor_5.01674,844,019 - 74,857,854 (-)NCBI
RGSC_v3.41674,909,293 - 74,923,128 (-)RGD
Celera1668,110,804 - 68,124,639 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001032596 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51877 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054864
  ENSRNOP00000054864.1
RefSeq Acc Id: NP_001032596   ⟸   NM_001037507
- Peptide Label: precursor
- UniProtKB: Q32ZI5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054864   ⟸   ENSRNOT00000058056
Protein Domains
Beta-defensin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32ZI5-F1-model_v2 AlphaFold Q32ZI5 1-71 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566125 AgrOrtholog
BioCyc Gene G2FUF-10841 BioCyc
Ensembl Genes ENSRNOG00000038147 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058056 ENTREZGENE
  ENSRNOT00000058056.3 UniProtKB/TrEMBL
Gene3D-CATH Antimicrobial Peptide, Beta-defensin 2, Chain A UniProtKB/TrEMBL
InterPro Defensin_beta UniProtKB/TrEMBL
KEGG Report rno:641631 UniProtKB/TrEMBL
NCBI Gene 641631 ENTREZGENE
PANTHER BETA-DEFENSIN 10-RELATED UniProtKB/TrEMBL
  BETA-DEFENSIN-RELATED UniProtKB/TrEMBL
Pfam Defensin_beta UniProtKB/TrEMBL
PhenoGen Defb2 PhenoGen
RatGTEx ENSRNOG00000038147 RatGTEx
Superfamily-SCOP Defensin-like UniProtKB/TrEMBL
UniProt Q32ZI5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-11-07 Defb2  defensin beta 2    beta-defensin 2  Name updated 1299863 APPROVED
2006-02-09 Defb2  beta-defensin 2      Symbol and Name status set to provisional 70820 PROVISIONAL