Bex4 (brain expressed, X-linked 4) - Rat Genome Database

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Gene: Bex4 (brain expressed, X-linked 4) Rattus norvegicus
Analyze
Symbol: Bex4
Name: brain expressed, X-linked 4
RGD ID: 1564749
Description: Predicted to enable alpha-tubulin binding activity; histone deacetylase binding activity; and molecular function inhibitor activity. Predicted to be involved in several processes, including chromosome segregation; negative regulation of protein modification process; and regulation of mitotic cell cycle. Located in cytoplasm and nucleus. Orthologous to human BEX4 (brain expressed X-linked 4); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BEX1-like 1; BEX1-like protein 1; brain expressed gene 4; brain expressed X-linked 4; brain-expressed X-linked protein 4 homolog
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Bex4-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,923,609 - 103,925,041 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX103,923,338 - 103,925,496 (+)EnsemblGRCr8
mRatBN7.2X99,131,985 - 99,133,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX99,131,942 - 99,133,531 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX101,261,412 - 101,262,844 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,772,027 - 104,773,459 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,329,078 - 102,330,510 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
RGSC_v3.4X123,442,511 - 123,443,772NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX100,010,816 - 100,012,036 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
cholestasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
genistein  (ISO)
hexadecanoic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
Rutecarpine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (ISO)
microtubule  (ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,IEA,ISO)
spindle pole  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of the Bex gene family in humans, mice, and rats. Alvarez E, etal., Gene. 2005 Aug 29;357(1):18-28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:27512957   PMID:28295929   PMID:34576008  


Genomics

Comparative Map Data
Bex4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,923,609 - 103,925,041 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX103,923,338 - 103,925,496 (+)EnsemblGRCr8
mRatBN7.2X99,131,985 - 99,133,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX99,131,942 - 99,133,531 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX101,261,412 - 101,262,844 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,772,027 - 104,773,459 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,329,078 - 102,330,510 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
RGSC_v3.4X123,442,511 - 123,443,772NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX100,010,816 - 100,012,036 (-)NCBICelera
Cytogenetic MapXq32NCBI
BEX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X103,215,092 - 103,217,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX103,215,068 - 103,217,246 (+)Ensemblhg38GRCh38
GRCh37X102,470,020 - 102,472,174 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X102,356,708 - 102,358,779 (+)NCBIBuild 36Build 36hg18NCBI36
CeleraX102,909,028 - 102,911,131 (+)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX92,133,049 - 92,135,158 (+)NCBIHuRef
CHM1_1X102,363,017 - 102,365,125 (+)NCBICHM1_1
T2T-CHM13v2.0X101,662,085 - 101,664,239 (+)NCBIT2T-CHM13v2.0
Bex4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X135,039,745 - 135,041,192 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX135,039,745 - 135,041,192 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X136,138,996 - 136,140,443 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX136,138,996 - 136,140,443 (+)Ensemblmm10GRCm38
MGSCv37X132,673,584 - 132,674,978 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X131,485,407 - 131,486,805 (+)NCBIMGSCv36mm8
CeleraX119,455,566 - 119,456,922 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.4NCBI
BEX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X102,825,645 - 102,827,754 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X102,829,250 - 102,831,364 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X92,443,028 - 92,445,129 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X102,822,210 - 102,824,294 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX102,823,255 - 102,823,617 (+)EnsemblpanPan2panpan1.1
BEX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X76,473,420 - 76,474,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX62,812,105 - 62,812,691 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X78,201,009 - 78,202,614 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1X75,679,298 - 75,679,884 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X77,371,134 - 77,371,720 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X77,132,651 - 77,133,237 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bex4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X61,679,652 - 61,681,634 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365478,000,230 - 8,001,999 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365478,000,064 - 8,002,029 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BEX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX84,147,183 - 84,149,084 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X84,147,133 - 84,148,680 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BEX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X91,119,345 - 91,121,417 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX91,119,396 - 91,120,893 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606515,978,952 - 15,981,039 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bex4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X88,129,037 - 88,130,508 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bex4
8 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
RH129207  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2374,764,149 - 74,764,642 (+)MAPPERmRatBN7.2
Rnor_6.0377,598,132 - 77,598,624NCBIRnor6.0
Rnor_5.0384,062,123 - 84,062,615UniSTSRnor5.0
RGSC_v3.4373,106,018 - 73,106,510UniSTSRGSC3.4
Celera374,021,356 - 74,021,848UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic MapXq35UniSTS
RH137119  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4X123,443,416 - 123,443,652UniSTSRGSC3.4
CeleraX100,010,936 - 100,011,172UniSTS
Cytogenetic MapXq35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 67 161 91 90 59 84 59 6 346 183 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000102634   ⟹   ENSRNOP00000086315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,923,338 - 103,925,259 (+)Ensembl
mRatBN7.2 EnsemblX99,131,942 - 99,133,531 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131180   ⟹   ENSRNOP00000099122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,923,546 - 103,925,496 (+)Ensembl
RefSeq Acc Id: NM_001037554   ⟹   NP_001032643
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,923,609 - 103,925,041 (+)NCBI
mRatBN7.2X99,131,985 - 99,133,417 (+)NCBI
RGSC_v3.4X123,442,511 - 123,443,772 (+)RGD
CeleraX100,010,816 - 100,012,036 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001032643 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI28699 (Get FASTA)   NCBI Sequence Viewer  
  AAX40675 (Get FASTA)   NCBI Sequence Viewer  
  EDL85812 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086315.1
  ENSRNOP00000099122
GenBank Protein Q3MKP9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032643   ⟸   NM_001037554
- UniProtKB: A1A5L0 (UniProtKB/Swiss-Prot),   Q3MKP9 (UniProtKB/Swiss-Prot),   A6KT26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000086315   ⟸   ENSRNOT00000102634
Ensembl Acc Id: ENSRNOP00000099122   ⟸   ENSRNOT00000131180

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3MKP9-F1-model_v2 AlphaFold Q3MKP9 1-118 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564749 AgrOrtholog
BioCyc Gene G2FUF-1635 BioCyc
Ensembl Genes ENSRNOG00000062806 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000102634.1 UniProtKB/Swiss-Prot
  ENSRNOT00000131180 ENTREZGENE
IMAGE_CLONE IMAGE:8363772 IMAGE-MGC_LOAD
InterPro BEX UniProtKB/Swiss-Prot
  TF_A-like/BEX UniProtKB/Swiss-Prot
KEGG Report rno:501624 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156479 IMAGE-MGC_LOAD
NCBI Gene 501624 ENTREZGENE
PANTHER PROTEIN BEX4 UniProtKB/Swiss-Prot
  PTHR13987 UniProtKB/Swiss-Prot
Pfam BEX UniProtKB/Swiss-Prot
PhenoGen Bex4 PhenoGen
PIRSF BEX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000062806 RatGTEx
UniProt A1A5L0 ENTREZGENE
  A6KT26 ENTREZGENE, UniProtKB/TrEMBL
  BEX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1A5L0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Bex4  brain expressed gene 4  Bex4  brain expressed X-linked 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 Bex4  brain expressed X-linked 4      Symbol and Name status set to provisional 70820 PROVISIONAL