Angptl3 (angiopoietin-like 3) - Rat Genome Database

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Gene: Angptl3 (angiopoietin-like 3) Rattus norvegicus
Analyze
Symbol: Angptl3
Name: angiopoietin-like 3
RGD ID: 1564505
Description: Predicted to enable lipase binding activity; phospholipase inhibitor activity; and signaling receptor binding activity. Involved in response to hormone. Predicted to be located in Golgi apparatus; cell surface; and early endosome. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in familial hypobetalipoproteinemia 2. Orthologous to human ANGPTL3 (angiopoietin like 3); PARTICIPATES IN lipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiopoietin-related protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85118,818,494 - 118,825,531 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5118,818,499 - 118,826,444 (+)EnsemblGRCr8
mRatBN7.25113,703,007 - 113,710,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5113,703,012 - 113,709,957 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5116,277,032 - 116,284,068 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05118,002,370 - 118,009,406 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05118,064,903 - 118,071,939 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05117,698,590 - 117,706,729 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5117,698,764 - 117,705,808 (+)Ensemblrn6Rnor6.0
Rnor_5.05121,639,555 - 121,647,526 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45119,479,669 - 119,484,358 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5112,263,891 - 112,268,719 (+)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
allopurinol  (ISO)
amiodarone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
citric acid  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
endosulfan  (EXP)
fipronil  (EXP)
flutamide  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
rifampicin  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
tianeptine  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The lipoprotein lipase inhibitor ANGPTL3 is negatively regulated by thyroid hormone. Fugier C, etal., J Biol Chem. 2006 Apr 28;281(17):11553-9. Epub 2006 Feb 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Differential regulation and properties of angiopoietin-like proteins 3 and 4. Ge H, etal., J Lipid Res. 2005 Jul;46(7):1484-90. Epub 2005 May 1.
4. Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor. Inaba T, etal., J Biol Chem. 2003 Jun 13;278(24):21344-51. Epub 2003 Apr 1.
5. ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states. Inukai K, etal., Biochem Biophys Res Commun. 2004 May 14;317(4):1075-9.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. Ono M, etal., J Biol Chem. 2003 Oct 24;278(43):41804-9. Epub 2003 Aug 8.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11877390   PMID:12097324   PMID:12565906   PMID:12671033   PMID:17110602   PMID:19542565   PMID:23150577   PMID:23918928   PMID:33443084  


Genomics

Comparative Map Data
Angptl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85118,818,494 - 118,825,531 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5118,818,499 - 118,826,444 (+)EnsemblGRCr8
mRatBN7.25113,703,007 - 113,710,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5113,703,012 - 113,709,957 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5116,277,032 - 116,284,068 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05118,002,370 - 118,009,406 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05118,064,903 - 118,071,939 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05117,698,590 - 117,706,729 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5117,698,764 - 117,705,808 (+)Ensemblrn6Rnor6.0
Rnor_5.05121,639,555 - 121,647,526 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45119,479,669 - 119,484,358 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5112,263,891 - 112,268,719 (+)NCBICelera
Cytogenetic Map5q33NCBI
ANGPTL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,597,520 - 62,606,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,597,464 - 62,607,196 (+)Ensemblhg38GRCh38
GRCh37163,063,191 - 63,071,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,835,775 - 62,843,768 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34162,775,207 - 62,783,201NCBI
Celera161,352,392 - 61,360,385 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef161,175,226 - 61,184,044 (+)NCBIHuRef
CHM1_1163,178,532 - 63,187,341 (+)NCBICHM1_1
T2T-CHM13v2.0162,476,065 - 62,484,858 (+)NCBIT2T-CHM13v2.0
Angptl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39498,919,191 - 98,926,429 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl498,919,191 - 98,934,348 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38499,030,954 - 99,038,192 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl499,030,954 - 99,046,111 (+)Ensemblmm10GRCm38
MGSCv37498,697,646 - 98,704,879 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36498,523,006 - 98,530,045 (+)NCBIMGSCv36mm8
Celera497,401,867 - 97,409,102 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map445.6NCBI
Angptl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542327,109,962 - 27,121,276 (-)Ensembl
ChiLan1.0NW_00495542327,113,378 - 27,121,339 (-)NCBIChiLan1.0ChiLan1.0
ANGPTL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21164,233,352 - 164,254,549 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,393,857 - 163,403,865 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,855,870 - 61,863,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,670,516 - 63,679,194 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,670,516 - 63,679,194 (+)EnsemblpanPan2panpan1.1
ANGPTL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1547,524,390 - 47,532,931 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl547,525,365 - 47,532,899 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha547,585,756 - 47,594,294 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0547,709,313 - 47,717,848 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl547,709,323 - 47,717,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1547,663,840 - 47,672,380 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0547,609,996 - 47,618,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0547,872,446 - 47,880,983 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Angptl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505875,971,228 - 75,979,701 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936692286,717 - 294,822 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936692286,432 - 295,021 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPTL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6149,832,542 - 149,845,831 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16149,836,417 - 149,845,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26138,100,831 - 138,111,284 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANGPTL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12070,452,771 - 70,461,590 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2070,449,227 - 70,460,469 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603346,993,590 - 47,002,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angptl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474231,260,611 - 31,270,122 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474231,261,719 - 31,269,877 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Angptl3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1155,476,089 - 55,484,222 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Angptl3
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:69
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000011486
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1298077Bp157Blood pressure QTL 157arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5114474223121056531Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH129449  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85118,819,021 - 118,820,003 (+)Marker Load Pipeline
mRatBN7.25113,703,534 - 113,704,516 (+)MAPPERmRatBN7.2
Rnor_6.05117,699,298 - 117,700,279NCBIRnor6.0
Rnor_5.05121,640,095 - 121,641,076UniSTSRnor5.0
RGSC_v3.45119,480,182 - 119,481,163UniSTSRGSC3.4
Celera5112,264,404 - 112,265,524UniSTS
RH 3.4 Map5793.0UniSTS
Cytogenetic Map5q33UniSTS
RH135495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,703,231 - 113,703,328 (+)MAPPERmRatBN7.2
Rnor_6.05117,698,995 - 117,699,091NCBIRnor6.0
Rnor_5.05121,639,792 - 121,639,888UniSTSRnor5.0
RGSC_v3.45119,479,879 - 119,479,975UniSTSRGSC3.4
Celera5112,264,101 - 112,264,197UniSTS
Cytogenetic Map5q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 9 18 60 87 86 59 25 59 3 202 61 51 60 65 27 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000011486   ⟹   ENSRNOP00000011486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,818,499 - 118,826,444 (+)Ensembl
mRatBN7.2 Ensembl5113,703,012 - 113,709,957 (+)Ensembl
Rnor_6.0 Ensembl5117,698,764 - 117,705,808 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126427   ⟹   ENSRNOP00000111950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,818,499 - 118,826,443 (+)Ensembl
RefSeq Acc Id: NM_001025065   ⟹   NP_001020236
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,818,494 - 118,823,198 (+)NCBI
mRatBN7.25113,703,007 - 113,707,711 (+)NCBI
Rnor_6.05117,698,785 - 117,703,474 (+)NCBI
Rnor_5.05121,639,555 - 121,647,526 (+)NCBI
RGSC_v3.45119,479,669 - 119,484,358 (+)RGD
Celera5112,263,891 - 112,268,719 (+)RGD
Sequence:
RefSeq Acc Id: NM_001399252   ⟹   NP_001386181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,818,494 - 118,825,531 (+)NCBI
mRatBN7.25113,703,007 - 113,710,044 (+)NCBI
RefSeq Acc Id: NM_001399253   ⟹   NP_001386182
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,818,494 - 118,820,241 (+)NCBI
mRatBN7.25113,703,007 - 113,704,754 (+)NCBI
RefSeq Acc Id: NP_001020236   ⟸   NM_001025065
- Peptide Label: isoform 2 precursor
- UniProtKB: Q5I0L8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011486   ⟸   ENSRNOT00000011486
RefSeq Acc Id: NP_001386181   ⟸   NM_001399252
- Peptide Label: isoform 1 precursor
- UniProtKB: F7FHP0 (UniProtKB/TrEMBL),   A6JRL4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386182   ⟸   NM_001399253
- Peptide Label: isoform 3 precursor
- UniProtKB: A6JRL5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111950   ⟸   ENSRNOT00000126427
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FHP0-F1-model_v2 AlphaFold F7FHP0 1-455 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693853
Promoter ID:EPDNEW_R4378
Type:multiple initiation site
Name:Angptl3_1
Description:angiopoietin-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05117,698,775 - 117,698,835EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564505 AgrOrtholog
BioCyc Gene G2FUF-40580 BioCyc
Ensembl Genes ENSRNOG00000008638 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011486 ENTREZGENE
  ENSRNOT00000011486.8 UniProtKB/TrEMBL
  ENSRNOT00000126427.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7372069 IMAGE-MGC_LOAD
InterPro ANGPTL8 UniProtKB/TrEMBL
  Fibrinogen-like_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/TrEMBL
  Fibrinogen_C-term_domain UniProtKB/TrEMBL
KEGG Report rno:502970 UniProtKB/TrEMBL
MGC_CLONE MGC:108861 IMAGE-MGC_LOAD
NCBI Gene 502970 ENTREZGENE
PANTHER ANGIOPOIETIN-LIKE PROTEIN 8 UniProtKB/TrEMBL
  ANGIOPOIETIN-LIKE PROTEIN 8 UniProtKB/TrEMBL
  ANGIOPOIETIN-RELATED PROTEIN 3 UniProtKB/TrEMBL
  FIBRINOGEN/TENASCIN/ANGIOPOEITIN UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/TrEMBL
PhenoGen Angptl3 PhenoGen
PROSITE FIBRINOGEN_C_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008638 RatGTEx
SMART FBG UniProtKB/TrEMBL
Superfamily-SCOP Fibrinogen_a/b/g_C UniProtKB/TrEMBL
UniProt A0ABK0LLY5_RAT UniProtKB/TrEMBL
  A6JRL4 ENTREZGENE, UniProtKB/TrEMBL
  A6JRL5 ENTREZGENE, UniProtKB/TrEMBL
  F7FHP0 ENTREZGENE, UniProtKB/TrEMBL
  Q5I0L8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Angptl3  angiopoietin-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL