Npsr1 (neuropeptide S receptor 1) - Rat Genome Database

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Gene: Npsr1 (neuropeptide S receptor 1) Rattus norvegicus
Analyze
Symbol: Npsr1
Name: neuropeptide S receptor 1
RGD ID: 1564154
Description: Predicted to enable neuropeptide receptor activity. Involved in several processes, including negative regulation of defecation; positive regulation of ERK1 and ERK2 cascade; and righting reflex. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Biomarker of morphine dependence. Human ortholog(s) of this gene implicated in asthma; inflammatory bowel disease; newborn respiratory distress syndrome; and rheumatoid arthritis. Orthologous to human NPSR1 (neuropeptide S receptor 1); INTERACTS WITH acrylamide; bisphenol A; bromobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G-protein coupled receptor 154; LOC300458; neuropeptide S receptor; RGD1564154; similar to G protein-coupled receptor 154
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8830,882,830 - 31,107,425 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl830,882,830 - 31,107,425 (+)EnsemblGRCr8
mRatBN7.2822,606,946 - 22,831,558 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl822,606,946 - 22,831,558 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx826,641,001 - 26,865,608 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0824,938,241 - 25,162,852 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0822,837,781 - 23,062,363 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0825,246,174 - 25,483,582 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl825,246,292 - 25,482,647 (+)Ensemblrn6Rnor6.0
Rnor_5.0825,328,131 - 25,514,199 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4823,736,081 - 23,970,242 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera824,184,221 - 24,410,253 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma. Acevedo N, etal., PLoS One. 2013;8(4):e60111. doi: 10.1371/journal.pone.0060111. Epub 2013 Apr 2.
2. The protective effect of farm animal exposure on childhood allergy is modified by NPSR1 polymorphisms. Bruce S, etal., J Med Genet. 2009 Mar;46(3):159-67. Epub 2008 Feb 19.
3. Effect of neuropeptide S receptor antagonists and partial agonists on palatable food consumption in the rat. Cifani C, etal., Peptides. 2011 Jan;32(1):44-50. doi: 10.1016/j.peptides.2010.10.018. Epub 2010 Oct 29.
4. Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease. D'Amato M, etal., Gastroenterology. 2007 Sep;133(3):808-17. Epub 2007 Jun 20.
5. Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis. D'Amato M, etal., PLoS One. 2010 Feb 22;5(2):e9315.
6. The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S. Fedeli A, etal., Eur J Neurosci. 2009 Oct;30(8):1594-602. doi: 10.1111/j.1460-9568.2009.06948.x. Epub 2009 Oct 12.
7. Nocturnal asthma is affected by genetic interactions between RORA and NPSR1. Gaertner VD, etal., Pediatr Pulmonol. 2019 Jun;54(6):847-857. doi: 10.1002/ppul.24292. Epub 2019 Mar 29.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain. Ghazal P, etal., Peptides. 2013 Aug;46:6-12. doi: 10.1016/j.peptides.2013.05.001. Epub 2013 May 16.
10. Comprehensive testing of positionally cloned asthma genes in two populations. Hersh CP, etal., Am J Respir Crit Care Med. 2007 Nov 1;176(9):849-57. Epub 2007 Aug 16.
11. The effects of neuropeptide S on general anesthesia in rats. Kushikata T, etal., Anesth Analg. 2011 Apr;112(4):845-9. doi: 10.1213/ANE.0b013e31820b990d. Epub 2011 Feb 2.
12. Characterization of a common susceptibility locus for asthma-related traits. Laitinen T, etal., Science. 2004 Apr 9;304(5668):300-4.
13. Nasal application of neuropeptide S inhibits arthritis pain-related behaviors through an action in the amygdala. Medina G, etal., Mol Pain. 2014 May 29;10:32. doi: 10.1186/1744-8069-10-32.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Neuropeptide S inhibits stress-stimulated faecal output in the rat. Petrella C, etal., Pharmacol Res. 2011 Nov;64(5):471-7. doi: 10.1016/j.phrs.2011.06.007. Epub 2011 Jun 17.
16. G protein-coupled receptor for asthma susceptibility associates with respiratory distress syndrome. Pulkkinen V, etal., Ann Med. 2006;38(5):357-66.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats. Ruggeri B, etal., Alcohol Clin Exp Res. 2010 Jan;34(1):90-7. doi: 10.1111/j.1530-0277.2009.01070.x. Epub 2009 Oct 23.
22. Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats. Schmoutz CD, etal., Pharmacol Biochem Behav. 2012 Dec;103(2):332-7. doi: 10.1016/j.pbb.2012.09.003. Epub 2012 Sep 12.
23. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. Thorsell A, etal., J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013.
Additional References at PubMed
PMID:15057822   PMID:15947423   PMID:16790440   PMID:17645946   PMID:20950671   PMID:24978951   PMID:26227793   PMID:29157796   PMID:32044336  


Genomics

Comparative Map Data
Npsr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8830,882,830 - 31,107,425 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl830,882,830 - 31,107,425 (+)EnsemblGRCr8
mRatBN7.2822,606,946 - 22,831,558 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl822,606,946 - 22,831,558 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx826,641,001 - 26,865,608 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0824,938,241 - 25,162,852 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0822,837,781 - 23,062,363 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0825,246,174 - 25,483,582 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl825,246,292 - 25,482,647 (+)Ensemblrn6Rnor6.0
Rnor_5.0825,328,131 - 25,514,199 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4823,736,081 - 23,970,242 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera824,184,221 - 24,410,253 (+)NCBICelera
Cytogenetic Map8q13NCBI
NPSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38734,658,218 - 34,878,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl734,658,218 - 34,878,332 (+)Ensemblhg38GRCh38
GRCh37734,697,830 - 34,917,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36734,664,422 - 34,884,469 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34734,471,136 - 34,691,184NCBI
Celera734,678,763 - 34,899,690 (+)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef734,579,047 - 34,799,739 (+)NCBIHuRef
CHM1_1734,697,921 - 34,917,510 (+)NCBICHM1_1
T2T-CHM13v2.0734,798,021 - 35,019,005 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2734,742,034 - 34,962,952 (+)NCBI
Npsr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39924,009,212 - 24,229,151 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl924,009,292 - 24,227,694 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38924,097,912 - 24,317,590 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl924,097,996 - 24,316,398 (+)Ensemblmm10GRCm38
MGSCv37923,902,462 - 24,120,842 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36923,848,425 - 24,066,805 (+)NCBIMGSCv36mm8
Celera921,355,713 - 21,573,552 (+)NCBICelera
Cytogenetic Map9A3- A4NCBI
cM Map99.99NCBI
Npsr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555601,069,651 - 1,243,111 (-)Ensembl
ChiLan1.0NW_0049555601,069,651 - 1,243,111 (-)NCBIChiLan1.0ChiLan1.0
NPSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2639,471,925 - 39,692,384 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1787,796,660 - 88,017,106 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0735,274,102 - 35,494,389 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1735,663,335 - 35,883,988 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl735,663,335 - 35,883,988 (+)EnsemblpanPan2panpan1.1
NPSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11446,465,169 - 46,610,256 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1446,466,544 - 46,609,477 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1445,908,550 - 46,051,177 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01446,406,554 - 46,549,450 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1446,406,661 - 46,549,459 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11446,514,493 - 46,657,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01446,191,033 - 46,333,686 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01446,564,692 - 46,707,288 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Npsr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511891,141,108 - 91,331,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647810,352,741 - 10,544,102 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647810,352,894 - 10,542,949 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1838,942,487 - 39,085,754 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11838,942,499 - 39,212,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21842,772,920 - 42,892,071 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPSR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12123,558,313 - 23,784,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604279,478,183 - 79,684,440 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npsr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1819,927,840 - 20,334,446 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Npsr1
2144 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:677
Count of miRNA genes:291
Interacting mature miRNAs:370
Transcripts:ENSRNOT00000021625
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 2 18 96 41 38 13 20 13 5 119 55 2 81 42 61 25 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000021625   ⟹   ENSRNOP00000021625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl830,882,830 - 31,107,425 (+)Ensembl
mRatBN7.2 Ensembl822,606,946 - 22,831,558 (+)Ensembl
Rnor_6.0 Ensembl825,246,292 - 25,482,647 (+)Ensembl
RefSeq Acc Id: NM_001106808   ⟹   NP_001100278
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8830,882,830 - 31,107,425 (+)NCBI
mRatBN7.2822,606,946 - 22,831,558 (+)NCBI
Rnor_6.0825,246,292 - 25,482,647 (+)NCBI
Rnor_5.0825,328,131 - 25,514,199 (+)NCBI
RGSC_v3.4823,736,081 - 23,970,242 (+)RGD
Celera824,184,221 - 24,410,253 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100278 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83371 (Get FASTA)   NCBI Sequence Viewer  
  EDL83372 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021625
  ENSRNOP00000021625.7
GenBank Protein P0C0L6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001100278   ⟸   NM_001106808
- UniProtKB: P0C0L6 (UniProtKB/Swiss-Prot),   A0A0H2UHN0 (UniProtKB/TrEMBL),   A6JYA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021625   ⟸   ENSRNOT00000021625
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C0L6-F1-model_v2 AlphaFold P0C0L6 1-372 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564154 AgrOrtholog
BioCyc Gene G2FUF-31350 BioCyc
Ensembl Genes ENSRNOG00000015863 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021625 ENTREZGENE
  ENSRNOT00000021625.7 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  NPS_rcpt UniProtKB/Swiss-Prot
  Vasoprsn_rcpt UniProtKB/Swiss-Prot
NCBI Gene 300458 ENTREZGENE
PANTHER NEUROPEPTIDE S RECEPTOR UniProtKB/Swiss-Prot
  PTHR24244:SF2 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Npsr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  VASOPRESSINR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015863 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A0H2UHN0 ENTREZGENE, UniProtKB/TrEMBL
  A6JYA3 ENTREZGENE, UniProtKB/TrEMBL
  NPSR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Npsr1  neuropeptide S receptor 1  RGD1564154_predicted  similar to G protein-coupled receptor 154 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564154_predicted  similar to G protein-coupled receptor 154 (predicted)  LOC300458  similar to G protein-coupled receptor 154  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC300458  similar to G protein-coupled receptor 154      Symbol and Name status set to provisional 70820 PROVISIONAL