Ndp (norrin cystine knot growth factor NDP) - Rat Genome Database

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Gene: Ndp (norrin cystine knot growth factor NDP) Rattus norvegicus
Analyze
Symbol: Ndp
Name: norrin cystine knot growth factor NDP
RGD ID: 1563968
Description: Predicted to enable cytokine activity; frizzled binding activity; and protein homodimerization activity. Involved in decidualization. Predicted to be located in cell surface and extracellular space. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Norrie disease; X-linked exudative vitreoretinopathy 2; and retinopathy of prematurity. Orthologous to human NDP (norrin cystine knot growth factor NDP); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH acrylamide; bisphenol A; vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100909913; LOC363443; NDP, norrin cystine knot growth factor; Ndph; Norrie disease (pseudoglioma); Norrie disease (pseudoglioma) (human); Norrie disease homolog; Norrie disease homolog (human); norrin; norrin-like; RGD1563968; similar to NDP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: Ndp was annotated incorrectly on Rnor_6.0 (Annotation Release 105) but correctly on Rn_Celera. Annotation of Ndp on Rn_Celera is supported by synteny with human and mouse and this locus is instead annotated as LOC100909913 on Rnor_6.0. Additionally, the locus annotated as Ndp on Rnor_6.0 represents a duplicate placement of this locus and this annotation lacks support by the syntenic region in mouse and human. BLASTing Ndp NM_001108814.1 against the rat genome (Annotation Release 105) shows best hits to the locations where both Ndp and LOC100909913 are annotated on Rnor_6.0 (NC_005120.4, 100% identity at each location) and where Ndp is annotated on Rn_Celera (AC_000089.1, 100% identity). BLASTing LOC100909913 XM_003751998.3 against the rat genome (Annotation Release 105) shows best hits to the locations where both Ndp and LOC100909913 are annotated on Rnor_6.0 (NC_005120.4, 100% identity at each location) and where Ndp is annotated on Rn_Celera (AC_000089.1, 100% identity). 2-sequence BLAST of Ndp NM_001108814.1 against LOC100909913 XM_003751998.3 shows high sequence identity (100% coverage, 100% identity). 2-sequence BLAST of Ndp underlying component AC097257.7 against the LOC100909913 underlying component AABR07073515.1 (both on Rnor_6.0) shows high sequence identity (99%) across ~67 kb. [26 Mar 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X8,379,569 - 8,404,019 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX8,379,569 - 8,406,802 (+)EnsemblGRCr8
mRatBN7.2X5,796,487 - 5,820,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX5,796,487 - 5,820,934 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX5,849,552 - 5,874,029 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X9,325,362 - 9,349,843 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X5,645,547 - 5,669,996 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X6,791,090 - 6,815,586 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,791,136 - 6,815,583 (+)Ensemblrn6Rnor6.0
Rnor_6.0 EnsemblX6,273,733 - 6,281,789 (+)Ensemblrn6Rnor6.0
Rnor_5.0X7,591,522 - 7,615,969 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X17,416,946 - 17,441,393 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX6,291,036 - 6,315,505 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (ISO)
angiogenesis  (ISO)
blood vessel remodeling  (ISO)
canonical Wnt signaling pathway  (ISO)
cell population proliferation  (ISO)
cellular response to hypoxia  (ISO)
cone retinal bipolar cell differentiation  (ISO)
decidualization  (IEP)
dendrite development  (ISO)
dendritic spine development  (ISO)
endothelial cell differentiation  (ISO)
establishment of blood-brain barrier  (ISO)
establishment of blood-retinal barrier  (ISO)
exploration behavior  (ISO)
extracellular matrix-cell signaling  (IEA,ISO)
gene expression  (ISO)
glutathione metabolic process  (ISO)
glycine metabolic process  (ISO)
inflammatory response  (ISO)
intracellular protein localization  (ISO)
L-serine metabolic process  (ISO)
lens development in camera-type eye  (ISO)
microglia differentiation  (ISO)
microglial cell proliferation  (ISO)
mitotic cell cycle  (ISO)
nervous system development  (IEA)
neural retina development  (ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
Norrin signaling pathway  (IBA,IEA,ISO)
optic nerve development  (ISO)
placenta development  (ISO)
positive regulation of DNA-templated transcription  (IBA,IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein phosphorylation  (ISO)
protein targeting to lysosome  (ISO)
protein ubiquitination  (ISO)
re-entry into mitotic cell cycle  (ISO)
response to axon injury  (ISO)
response to hypoxia  (ISO)
retina blood vessel maintenance  (ISO)
retina development in camera-type eye  (ISO)
retina layer formation  (ISO)
retina morphogenesis in camera-type eye  (ISO)
retina vasculature development in camera-type eye  (ISO)
retina vasculature morphogenesis in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (ISO)
retinal ganglion cell axon guidance  (ISO)
retinal pigment epithelium development  (ISO)
retinal rod cell differentiation  (ISO)
smoothened signaling pathway  (ISO)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
tricarboxylic acid cycle  (ISO)
ubiquitin-dependent endocytosis  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Isolation of a candidate gene for Norrie disease by positional cloning. Berger W, etal., Nat Genet. 1992 Jun;1(3):199-203.
2. A mutation in the Norrie disease gene (NDP) associated with X-linked familial exudative vitreoretinopathy. Chen ZY, etal., Nat Genet. 1993 Oct;5(2):180-3.
3. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Norrin immunolocalization and its possible functions in rat endometrium during the estrus cycle and early pregnancy. Kaloglu C, etal., Dev Growth Differ. 2011 Sep;53(7):887-96. doi: 10.1111/j.1440-169X.2011.01295.x. Epub 2011 Sep 7.
6. Comparative genomics on Norrie disease gene. Katoh M and Katoh M, Int J Mol Med. 2005 May;15(5):885-9.
7. Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice. Ohlmann A, etal., J Neurosci. 2010 Jan 6;30(1):183-93. doi: 10.1523/JNEUROSCI.3210-09.2010.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Identification of missense mutations in the Norrie disease gene associated with advanced retinopathy of prematurity. Shastry BS, etal., Arch Ophthalmol. 1997 May;115(5):651-5.
Additional References at PubMed
PMID:15035989   PMID:16035034   PMID:17955262   PMID:19837032   PMID:20427659   PMID:25188337   PMID:25550365   PMID:29933759  


Genomics

Comparative Map Data
Ndp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X8,379,569 - 8,404,019 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX8,379,569 - 8,406,802 (+)EnsemblGRCr8
mRatBN7.2X5,796,487 - 5,820,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX5,796,487 - 5,820,934 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX5,849,552 - 5,874,029 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X9,325,362 - 9,349,843 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X5,645,547 - 5,669,996 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X6,791,090 - 6,815,586 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,791,136 - 6,815,583 (+)Ensemblrn6Rnor6.0
Rnor_6.0 EnsemblX6,273,733 - 6,281,789 (+)Ensemblrn6Rnor6.0
Rnor_5.0X7,591,522 - 7,615,969 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X17,416,946 - 17,441,393 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX6,291,036 - 6,315,505 (+)NCBICelera
Cytogenetic MapXq11NCBI
NDP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X43,948,776 - 43,973,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX43,948,772 - 43,973,395 (-)Ensemblhg38GRCh38
GRCh37X43,808,022 - 43,832,636 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X43,692,966 - 43,717,788 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X43,564,279 - 43,589,004NCBI
CeleraX47,947,782 - 47,972,683 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX41,537,322 - 41,562,014 (-)NCBIHuRef
CHM1_1X43,841,148 - 43,866,049 (-)NCBICHM1_1
T2T-CHM13v2.0X43,354,970 - 43,379,584 (-)NCBIT2T-CHM13v2.0
Ndp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X16,751,760 - 16,778,013 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX16,751,760 - 16,778,013 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X16,885,521 - 16,911,774 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX16,885,521 - 16,911,774 (-)Ensemblmm10GRCm38
MGSCv37X16,462,647 - 16,488,890 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X16,042,480 - 16,068,723 (-)NCBIMGSCv36mm8
CeleraX14,501,428 - 14,528,313 (-)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX12.07NCBI
Ndp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555164,218,703 - 4,244,846 (+)Ensembl
ChiLan1.0NW_0049555164,218,703 - 4,244,774 (+)NCBIChiLan1.0ChiLan1.0
NDP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X45,598,907 - 45,624,024 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X45,602,261 - 45,627,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X36,399,868 - 36,424,953 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X44,224,161 - 44,249,067 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX44,224,161 - 44,249,067 (-)EnsemblpanPan2panpan1.1
NDP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X37,949,560 - 37,975,573 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX37,950,489 - 37,975,346 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX25,177,615 - 25,203,684 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X38,037,857 - 38,063,932 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX38,037,857 - 38,063,661 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X38,078,999 - 38,105,057 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X38,061,990 - 38,088,102 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X38,157,025 - 38,183,125 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ndp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X30,239,407 - 30,264,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650210,080,145 - 10,105,328 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650210,080,169 - 10,105,155 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX39,208,119 - 39,235,758 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X39,208,115 - 39,235,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X43,540,096 - 43,551,795 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X41,122,064 - 41,148,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX41,121,874 - 41,147,567 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660766,340,796 - 6,365,938 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476211,409,727 - 11,435,811 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476211,409,837 - 11,435,709 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ndp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X5,226,608 - 5,251,034 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ndp
148 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:156
Interacting mature miRNAs:185
Transcripts:ENSRNOT00000003984, ENSRNOT00000074275
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149314046933Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat

Markers in Region
RH144057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X5,820,619 - 5,820,771 (+)MAPPERmRatBN7.2
Rnor_6.0X6,815,269 - 6,815,420NCBIRnor6.0
Rnor_6.0X6,282,443 - 6,282,594NCBIRnor6.0
Rnor_5.0X7,105,981 - 7,106,132UniSTSRnor5.0
Rnor_5.0X7,615,655 - 7,615,806UniSTSRnor5.0
RGSC_v3.4X17,441,079 - 17,441,230UniSTSRGSC3.4
CeleraX6,315,191 - 6,315,342UniSTS
Cytogenetic MapXq12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 12 69 178 77 72 32 45 32 12 278 159 11 145 60 108 40 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003984   ⟹   ENSRNOP00000003984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX8,379,569 - 8,404,016 (+)Ensembl
mRatBN7.2 EnsemblX5,796,487 - 5,820,934 (+)Ensembl
Rnor_6.0 EnsemblX6,791,136 - 6,815,583 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074275   ⟹   ENSRNOP00000064536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX6,273,733 - 6,281,789 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162701   ⟹   ENSRNOP00000112823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX8,379,569 - 8,406,802 (+)Ensembl
RefSeq Acc Id: NM_001108814   ⟹   NP_001102284
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X8,379,569 - 8,404,016 (+)NCBI
mRatBN7.2X5,796,487 - 5,820,934 (+)NCBI
Rnor_6.0X6,791,136 - 6,815,583 (+)NCBI
Rnor_5.0X7,591,522 - 7,615,969 (+)NCBI
RGSC_v3.4X17,416,946 - 17,441,393 (+)RGD
CeleraX6,291,036 - 6,315,505 (+)RGD
Sequence:
RefSeq Acc Id: XM_063280113   ⟹   XP_063136183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X8,379,585 - 8,404,019 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102284 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136183 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97666 (Get FASTA)   NCBI Sequence Viewer  
  EDL97667 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003984
  ENSRNOP00000003984.4
  ENSRNOP00000112823.1
RefSeq Acc Id: NP_001102284   ⟸   NM_001108814
- Peptide Label: precursor
- UniProtKB: D3ZEP2 (UniProtKB/TrEMBL),   A6JZW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064536   ⟸   ENSRNOT00000074275
Ensembl Acc Id: ENSRNOP00000003984   ⟸   ENSRNOT00000003984
RefSeq Acc Id: XP_063136183   ⟸   XM_063280113
- Peptide Label: isoform X1
- UniProtKB: A6JZW8 (UniProtKB/TrEMBL),   D3ZEP2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112823   ⟸   ENSRNOT00000162701
Protein Domains
CTCK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEP2-F1-model_v2 AlphaFold D3ZEP2 1-131 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563968 AgrOrtholog
BioCyc Gene G2FUF-3115 BioCyc
Ensembl Genes ENSRNOG00000002960 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046042 Ensembl
Ensembl Transcript ENSRNOT00000003984 ENTREZGENE
  ENSRNOT00000003984.7 UniProtKB/TrEMBL
  ENSRNOT00000162701.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  DAN UniProtKB/TrEMBL
  Norrie_dis UniProtKB/TrEMBL
KEGG Report rno:363443 UniProtKB/TrEMBL
NCBI Gene 363443 ENTREZGENE
PANTHER NORRIN UniProtKB/TrEMBL
  PTHR28611 UniProtKB/TrEMBL
Pfam DAN UniProtKB/TrEMBL
PhenoGen Ndp PhenoGen
PRINTS NORRIEDSEASE UniProtKB/TrEMBL
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002960 RatGTEx
  ENSRNOG00000046042 RatGTEx
SMART SM00041 UniProtKB/TrEMBL
UniProt A0ABK0M3I8_RAT UniProtKB/TrEMBL
  A6JZW8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZEP2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ndp  norrin cystine knot growth factor NDP  LOC100909913  norrin-like  Data merged from RGD:6500886 737654 PROVISIONAL
2019-04-04 Ndp  norrin cystine knot growth factor NDP  Ndp  NDP, norrin cystine knot growth factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-02 Ndp  NDP, norrin cystine knot growth factor  Ndp  Norrie disease (pseudoglioma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Ndp  Norrie disease (pseudoglioma)  Ndp  Norrie disease (pseudoglioma) (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909913  norrin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-09 Ndp  Norrie disease (pseudoglioma) (human)  Ndph  Norrie disease homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Ndph  Norrie disease homolog  Ndph_predicted  Norrie disease homolog (human) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ndph_predicted  Norrie disease homolog (human) (predicted)  RGD1563968_predicted  similar to NDP (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563968_predicted  similar to NDP (predicted)  LOC363443  similar to NDP  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363443  similar to NDP      Symbol and Name status set to provisional 70820 PROVISIONAL