Nsg2 (neuronal vesicle trafficking associated 2) - Rat Genome Database

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Gene: Nsg2 (neuronal vesicle trafficking associated 2) Rattus norvegicus
Analyze
Symbol: Nsg2
Name: neuronal vesicle trafficking associated 2
RGD ID: 1563944
Description: Predicted to enable clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly; endosomal transport; and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in several cellular components, including endosome; lysosomal lumen; and trans-Golgi network membrane. Orthologous to human NSG2 (neuronal vesicle trafficking associated 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hmp19; HMP19 protein; MGC125201; neuron specific gene family member 2; neuron-specific protein family member 2; neuronal vesicle trafficking-associated protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81016,106,073 - 16,165,915 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1016,147,325 - 16,165,915 (-)EnsemblGRCr8
mRatBN7.21015,601,594 - 15,661,441 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,601,596 - 15,661,441 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1020,348,910 - 20,409,040 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,837,817 - 19,897,945 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,328,108 - 15,388,082 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,867,885 - 15,928,169 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,867,887 - 15,928,169 (-)Ensemblrn6Rnor6.0
Rnor_5.01015,762,452 - 15,822,361 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,849,138 - 15,909,029 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1015,268,255 - 15,327,784 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6. The endosomal neuronal proteins Nsg1/NEEP21 and Nsg2/P19 are itinerant, not resident proteins of dendritic endosomes. Yap CC, etal., Sci Rep. 2017 Sep 5;7(1):10481. doi: 10.1038/s41598-017-07667-x.
Additional References at PubMed
PMID:7829526  


Genomics

Comparative Map Data
Nsg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81016,106,073 - 16,165,915 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1016,147,325 - 16,165,915 (-)EnsemblGRCr8
mRatBN7.21015,601,594 - 15,661,441 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,601,596 - 15,661,441 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1020,348,910 - 20,409,040 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,837,817 - 19,897,945 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,328,108 - 15,388,082 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,867,885 - 15,928,169 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,867,887 - 15,928,169 (-)Ensemblrn6Rnor6.0
Rnor_5.01015,762,452 - 15,822,361 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,849,138 - 15,909,029 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1015,268,255 - 15,327,784 (-)NCBICelera
Cytogenetic Map10q12NCBI
NSG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385174,045,706 - 174,109,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5174,045,706 - 174,243,501 (+)Ensemblhg38GRCh38
GRCh375173,472,709 - 173,536,182 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365173,405,330 - 173,468,788 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5169,505,599 - 169,569,066 (+)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5168,568,986 - 168,632,329 (+)NCBIHuRef
CHM1_15172,905,228 - 172,968,756 (+)NCBICHM1_1
T2T-CHM13v2.05174,586,043 - 174,649,463 (+)NCBIT2T-CHM13v2.0
Nsg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,949,678 - 32,009,211 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,950,463 - 32,009,202 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381131,999,704 - 32,059,211 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,000,463 - 32,059,202 (+)Ensemblmm10GRCm38
MGSCv371131,900,459 - 31,959,202 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361131,900,459 - 31,959,202 (+)NCBIMGSCv36mm8
Celera1134,414,704 - 34,473,795 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.72NCBI
Nsg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540826,664,537 - 26,724,949 (+)Ensembl
ChiLan1.0NW_00495540826,664,884 - 26,724,949 (+)NCBIChiLan1.0ChiLan1.0
NSG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1438,491,995 - 38,550,672 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl438,491,989 - 38,550,619 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha438,439,732 - 38,496,885 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0438,866,564 - 38,923,797 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl438,865,051 - 38,923,789 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1438,683,239 - 38,740,424 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0438,871,275 - 38,928,491 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0439,379,866 - 39,437,098 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nsg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721392,960,048 - 93,013,874 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366091,680,157 - 1,736,929 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366091,682,727 - 1,736,560 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1650,206,076 - 50,361,859 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11650,301,023 - 50,361,870 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21654,733,823 - 54,735,155 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NSG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12376,192,395 - 76,254,725 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2376,192,456 - 76,255,057 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660342,348,688 - 2,412,241 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473315,940,852 - 16,000,295 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473315,940,077 - 16,000,215 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nsg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v193,867,676 - 3,933,572 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nsg2
384 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:247
Count of miRNA genes:153
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000028069
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101576223019737486Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
D10Mco50  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81016,134,620 - 16,134,936 (+)Marker Load Pipeline
mRatBN7.21015,630,146 - 15,630,462 (+)MAPPERmRatBN7.2
Rnor_6.01015,896,922 - 15,897,237NCBIRnor6.0
Rnor_5.01015,791,178 - 15,791,493UniSTSRnor5.0
RGSC_v3.41015,878,031 - 15,878,347RGDRGSC3.4
RGSC_v3.41015,878,032 - 15,878,347UniSTSRGSC3.4
Celera1015,296,475 - 15,296,810UniSTS
RGSC_v3.11015,879,080 - 15,879,396RGD
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 89 88 57 91 57 6 350 191 11 136 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028069   ⟹   ENSRNOP00000028069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,601,596 - 15,661,441 (-)Ensembl
Rnor_6.0 Ensembl1015,867,887 - 15,928,169 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116571   ⟹   ENSRNOP00000090021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1016,147,325 - 16,165,915 (-)Ensembl
mRatBN7.2 Ensembl1015,642,851 - 15,661,441 (-)Ensembl
RefSeq Acc Id: NM_001034152   ⟹   NP_001029324
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81016,106,073 - 16,165,915 (-)NCBI
mRatBN7.21015,601,594 - 15,661,441 (-)NCBI
Rnor_6.01015,867,885 - 15,928,169 (-)NCBI
Rnor_5.01015,762,452 - 15,822,361 (-)NCBI
RGSC_v3.41015,849,138 - 15,909,029 (-)RGD
Celera1015,268,255 - 15,327,784 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001029324 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI05917 (Get FASTA)   NCBI Sequence Viewer  
  EDM04026 (Get FASTA)   NCBI Sequence Viewer  
  EDM04027 (Get FASTA)   NCBI Sequence Viewer  
  EDM04028 (Get FASTA)   NCBI Sequence Viewer  
  EDM04029 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028069.3
GenBank Protein Q3KR51 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001029324   ⟸   NM_001034152
- UniProtKB: Q3KR51 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028069   ⟸   ENSRNOT00000028069
Ensembl Acc Id: ENSRNOP00000090021   ⟸   ENSRNOT00000116571

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3KR51-F1-model_v2 AlphaFold Q3KR51 1-171 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697083
Promoter ID:EPDNEW_R7607
Type:multiple initiation site
Name:Nsg2_1
Description:neuronal vesicle trafficking associated 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,928,189 - 15,928,249EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563944 AgrOrtholog
BioCyc Gene G2FUF-25689 BioCyc
Ensembl Genes ENSRNOG00000020644 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028069.5 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7384671 IMAGE-MGC_LOAD
InterPro NSG UniProtKB/Swiss-Prot
KEGG Report rno:497878 UniProtKB/Swiss-Prot
MGC_CLONE MGC:125201 IMAGE-MGC_LOAD
NCBI Gene 497878 ENTREZGENE
PANTHER NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR28546 UniProtKB/Swiss-Prot
Pfam Calcyon UniProtKB/Swiss-Prot
PhenoGen Nsg2 PhenoGen
PIRSF Calcyon UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020644 RatGTEx
UniProt A0A8I6AD04_RAT UniProtKB/TrEMBL
  NSG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-05 Nsg2  neuronal vesicle trafficking associated 2  Hmp19  HMP19 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-29 Hmp19  HMP19 protein  Nsg2  neuron specific gene family member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Nsg2  neuron specific gene family member 2  MGC125201  HMP19 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC125201  HMP19 protein      Symbol and Name status set to provisional 70820 PROVISIONAL