Ubqln2 (ubiquilin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ubqln2 (ubiquilin 2) Rattus norvegicus
Analyze
Symbol: Ubqln2
Name: ubiquilin 2
RGD ID: 1563566
Description: Predicted to enable identical protein binding activity; molecular condensate scaffold activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including negative regulation of receptor-mediated endocytosis; positive regulation of ERAD pathway; and proteolysis involved in protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15. Orthologous to human UBQLN2 (ubiquilin 2); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC317396; RGD1563566; similar to Ubiquilin 2; ubiquilin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X21,228,809 - 21,232,228 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX21,229,197 - 21,232,268 (-)EnsemblGRCr8
mRatBN7.2X17,853,086 - 17,856,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX17,853,114 - 17,856,505 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX15,251,663 - 15,255,083 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X24,869,844 - 24,873,264 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X18,312,169 - 18,315,589 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X18,723,313 - 18,726,732 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX18,723,341 - 18,726,732 (-)Ensemblrn6Rnor6.0
Rnor_5.0X19,487,954 - 19,491,373 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X37,992,907 - 37,996,327 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX18,131,544 - 18,134,964 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
autophagosome  (IEA)
cytoplasm  (ISO)
cytoplasmic vesicle  (IEA)
cytosol  (IBA,ISO)
membrane  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Deng HX, etal., Nature. 2011 Aug 21. doi: 10.1038/nature10353.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
Additional References at PubMed
PMID:18199683   PMID:18307982   PMID:20529957   PMID:22871113   PMID:24215460   PMID:25388785   PMID:26514267   PMID:30409191   PMID:33919255  


Genomics

Comparative Map Data
Ubqln2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X21,228,809 - 21,232,228 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX21,229,197 - 21,232,268 (-)EnsemblGRCr8
mRatBN7.2X17,853,086 - 17,856,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX17,853,114 - 17,856,505 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX15,251,663 - 15,255,083 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X24,869,844 - 24,873,264 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X18,312,169 - 18,315,589 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X18,723,313 - 18,726,732 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX18,723,341 - 18,726,732 (-)Ensemblrn6Rnor6.0
Rnor_5.0X19,487,954 - 19,491,373 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X37,992,907 - 37,996,327 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX18,131,544 - 18,134,964 (-)NCBICelera
Cytogenetic MapXq12NCBI
UBQLN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X56,563,627 - 56,567,868 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX56,563,627 - 56,567,868 (+)Ensemblhg38GRCh38
GRCh37X56,590,060 - 56,594,301 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X56,606,797 - 56,610,102 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X56,473,092 - 56,476,398NCBI
CeleraX60,422,310 - 60,425,727 (+)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX53,642,196 - 53,645,647 (+)NCBIHuRef
CHM1_1X56,580,226 - 56,583,643 (+)NCBICHM1_1
T2T-CHM13v2.0X55,856,941 - 55,861,182 (+)NCBIT2T-CHM13v2.0
Ubqln2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X152,281,228 - 152,284,558 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX152,281,223 - 152,284,566 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X153,498,232 - 153,501,562 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,498,227 - 153,501,570 (+)Ensemblmm10GRCm38
MGSCv37X149,932,775 - 149,936,105 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X148,838,948 - 148,842,278 (+)NCBIMGSCv36mm8
CeleraX135,753,727 - 135,757,059 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Ubqln2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554753,260,503 - 3,262,380 (+)Ensembl
ChiLan1.0NW_0049554753,260,209 - 3,263,586 (+)NCBIChiLan1.0ChiLan1.0
UBQLN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X57,999,446 - 58,003,742 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X58,003,059 - 58,008,444 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X48,829,844 - 48,835,040 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X56,981,696 - 56,985,979 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX56,981,985 - 56,983,859 (+)EnsemblpanPan2panpan1.1
UBQLN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X47,860,923 - 47,864,282 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX39,057,141 - 39,060,488 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X48,117,445 - 48,120,792 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1X47,357,992 - 47,361,339 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X48,101,497 - 48,104,844 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X48,016,846 - 48,020,193 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ubqln2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X40,500,402 - 40,503,770 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936819532,037 - 533,920 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936819530,833 - 534,185 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBQLN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX48,948,389 - 48,950,263 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X48,948,062 - 48,951,392 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
UBQLN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X52,486,154 - 52,489,531 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX52,486,454 - 52,488,328 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660866,589,262 - 6,593,708 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ubqln2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249101,548,249 - 1,550,126 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249101,547,942 - 1,551,323 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ubqln2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X18,756,942 - 18,760,295 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ubqln2
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:326
Count of miRNA genes:199
Interacting mature miRNAs:231
Transcripts:ENSRNOT00000026214
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026214   ⟹   ENSRNOP00000026214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX21,229,197 - 21,232,268 (-)Ensembl
mRatBN7.2 EnsemblX17,853,114 - 17,856,505 (-)Ensembl
Rnor_6.0 EnsemblX18,723,341 - 18,726,732 (-)Ensembl
RefSeq Acc Id: NM_001108251   ⟹   NP_001101721
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X21,228,809 - 21,232,228 (-)NCBI
mRatBN7.2X17,853,086 - 17,856,505 (-)NCBI
Rnor_6.0X18,723,313 - 18,726,732 (-)NCBI
Rnor_5.0X19,487,954 - 19,491,373 (-)NCBI
RGSC_v3.4X37,992,907 - 37,996,327 (-)RGD
CeleraX18,131,544 - 18,134,964 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101721 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86363 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026214
  ENSRNOP00000026214.5
RefSeq Acc Id: NP_001101721   ⟸   NM_001108251
- UniProtKB: D4AA63 (UniProtKB/TrEMBL),   A6KL57 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026214   ⟸   ENSRNOT00000026214
Protein Domains
UBA   Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA63-F1-model_v2 AlphaFold D4AA63 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701760
Promoter ID:EPDNEW_R12283
Type:multiple initiation site
Name:Ubqln2_1
Description:ubiquilin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X18,726,686 - 18,726,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563566 AgrOrtholog
BioCyc Gene G2FUF-2834 BioCyc
Ensembl Genes ENSRNOG00000003099 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026214 ENTREZGENE
  ENSRNOT00000026214.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.260.100 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  STI1_HS-bd UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL
  UBA/transl_elong_EF1B_N_euk UniProtKB/TrEMBL
  Ubiquilin UniProtKB/TrEMBL
  Ubiquitin UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:317396 UniProtKB/TrEMBL
NCBI Gene 317396 ENTREZGENE
PANTHER PTHR10677:SF5 UniProtKB/TrEMBL
  UBIQUILIN UniProtKB/TrEMBL
Pfam UBA UniProtKB/TrEMBL
  ubiquitin UniProtKB/TrEMBL
  UBQLN1 UniProtKB/TrEMBL
PhenoGen Ubqln2 PhenoGen
PROSITE UBA UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003099 RatGTEx
SMART STI1 UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
  UBQ UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  UBA_like UniProtKB/TrEMBL
UniProt A6KL57 ENTREZGENE, UniProtKB/TrEMBL
  D4AA63 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ubqln2  ubiquilin 2   Ubqln2_predicted  ubiquilin 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ubqln2_predicted  ubiquilin 2 (predicted)  RGD1563566_predicted  similar to Ubiquilin 2 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563566_predicted  similar to Ubiquilin 2 (predicted)  LOC317396  similar to Ubiquilin 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317396  similar to Ubiquilin 2      Symbol and Name status set to provisional 70820 PROVISIONAL