Ncoa4 (nuclear receptor coactivator 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ncoa4 (nuclear receptor coactivator 4) Rattus norvegicus
Analyze
Symbol: Ncoa4
Name: nuclear receptor coactivator 4
RGD ID: 1563014
Description: Predicted to enable transcription coactivator activity. Involved in response to hormone. Predicted to be located in autolysosome. Orthologous to human NCOA4 (nuclear receptor coactivator 4); PARTICIPATES IN iron homeostasis pathway; thyroid cancer pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72479
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,395,502 - 7,415,846 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl167,401,802 - 7,415,840 (+)EnsemblGRCr8
mRatBN7.2167,389,222 - 7,409,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,366,542 - 7,409,556 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl167,366,542 - 7,409,641 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx167,401,738 - 7,422,128 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,546,594 - 8,566,985 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,399,986 - 7,420,330 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,302,950 - 8,323,294 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,302,950 - 8,323,293 (+)Ensemblrn6Rnor6.0
Rnor_5.0168,219,983 - 8,240,326 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4167,642,116 - 7,662,460 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,789,196 - 7,809,198 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
25-hydroxycholesterol  (ISO)
3-methyladenine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antimony(0)  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
beryllium sulfate  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
busulfan  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
doxorubicin  (EXP,ISO)
erastin  (EXP,ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ferric ammonium citrate  (ISO)
ferrostatin-1  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycidyl methacrylate  (ISO)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
hydrogen sulfide  (ISO)
indometacin  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
penconazole  (ISO)
pifithrin-alpha hydrobromide  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
protosappanin A  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
silibinin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium sulfide (anhydrous)  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
toosendanin  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
autolysosome  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Bogdan AR, etal., Trends Biochem Sci. 2016 Mar;41(3):274-86. doi: 10.1016/j.tibs.2015.11.012. Epub 2015 Dec 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. Hu YC, etal., J Biol Chem. 2004 Aug 6;279(32):33438-46. Epub 2004 May 27.
4. Loss of androgen receptor associated protein 70 (ARA70) expression in a subset of HER2-positive breast cancers. Kollara A, etal., Breast Cancer Res Treat. 2001 Jun;67(3):245-53.
5. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
6. Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer. Li P, etal., Am J Pathol. 2002 Oct;161(4):1467-74.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome. Quezada S, etal., Fertil Steril. 2006 Apr;85(4):1017-26. Epub 2006 Mar 9.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Activation of androgen receptor-associated protein 70 (ARA70) mRNA expression in ovarian cancer. Shaw PA, etal., Gynecol Oncol. 2001 Feb;80(2):132-8.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors. Tai PJ, etal., Endocrinology. 2007 Jul;148(7):3485-95. Epub 2007 Apr 5.
Additional References at PubMed
PMID:8889548   PMID:18614015   PMID:25327288   PMID:38465865  


Genomics

Comparative Map Data
Ncoa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,395,502 - 7,415,846 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl167,401,802 - 7,415,840 (+)EnsemblGRCr8
mRatBN7.2167,389,222 - 7,409,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,366,542 - 7,409,556 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl167,366,542 - 7,409,641 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx167,401,738 - 7,422,128 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,546,594 - 8,566,985 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,399,986 - 7,420,330 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,302,950 - 8,323,294 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,302,950 - 8,323,293 (+)Ensemblrn6Rnor6.0
Rnor_5.0168,219,983 - 8,240,326 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4167,642,116 - 7,662,460 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,789,196 - 7,809,198 (-)NCBICelera
Cytogenetic Map16p16NCBI
NCOA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381046,005,088 - 46,030,623 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1046,005,085 - 46,030,669 (-)Ensemblhg38GRCh38
GRCh371051,565,199 - 51,590,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361051,242,373 - 51,260,738 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341051,242,372 - 51,260,738NCBI
Celera1042,865,707 - 42,891,332 (+)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1045,675,105 - 45,698,057 (+)NCBIHuRef
CHM1_11051,847,046 - 51,872,689 (+)NCBICHM1_1
T2T-CHM13v2.01046,885,972 - 46,911,498 (-)NCBIT2T-CHM13v2.0
Ncoa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391431,881,884 - 31,901,210 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1431,881,822 - 31,901,812 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381432,159,879 - 32,179,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,159,865 - 32,179,855 (+)Ensemblmm10GRCm38
MGSCv371432,973,078 - 32,992,549 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361430,988,901 - 31,008,372 (+)NCBIMGSCv36mm8
Celera1428,418,721 - 28,438,204 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
Ncoa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955556392,398 - 412,166 (+)Ensembl
ChiLan1.0NW_004955556392,412 - 413,643 (+)NCBIChiLan1.0ChiLan1.0
NCOA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2858,884,053 - 58,909,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11058,889,371 - 58,914,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01043,159,014 - 43,184,558 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11046,420,952 - 46,446,479 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1046,420,952 - 46,443,223 (-)EnsemblpanPan2panpan1.1
NCOA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,801,655 - 1,867,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,802,678 - 1,825,020 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha282,036,132 - 2,102,171 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0281,979,010 - 2,045,152 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,979,034 - 2,044,626 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,776,104 - 1,842,163 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,812,773 - 1,879,059 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,945,148 - 2,011,231 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ncoa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721379,174,126 - 79,199,709 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936728376,852 - 402,539 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936728376,915 - 402,539 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,505,110 - 90,531,118 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11490,505,614 - 90,531,302 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,548,146 - 98,573,846 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,813,018 - 41,836,974 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl941,826,320 - 41,837,505 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660481,522,166 - 1,546,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncoa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462492818,148 - 30,594 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249286,298 - 32,051 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ncoa4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1137,845,633 - 7,865,914 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ncoa4
155 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:113
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000026803, ENSRNOT00000066062
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16423421216278352Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16423421216278352Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421216061395Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
631524Bp75Blood pressure QTL 750.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)161177108157035Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16423433317730812Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
D12Got38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2167,396,808 - 7,396,980 (+)MAPPERmRatBN7.2
Rnor_6.0168,310,539 - 8,310,710NCBIRnor6.0
Rnor_5.0168,227,571 - 8,227,742UniSTSRnor5.0
RGSC_v3.4167,649,704 - 7,649,876RGDRGSC3.4
RGSC_v3.4167,649,705 - 7,649,876UniSTSRGSC3.4
Celera167,801,780 - 7,801,951UniSTS
RGSC_v3.1167,649,702 - 7,649,874RGD
Cytogenetic Map16p16UniSTS
RH132366  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8167,411,540 - 7,411,754 (+)Marker Load Pipeline
mRatBN7.2167,405,258 - 7,405,472 (+)MAPPERmRatBN7.2
Rnor_6.0168,318,989 - 8,319,202NCBIRnor6.0
Rnor_5.0168,236,021 - 8,236,234UniSTSRnor5.0
RGSC_v3.4167,658,155 - 7,658,368UniSTSRGSC3.4
Celera167,793,288 - 7,793,501UniSTS
RH 3.4 Map1665.3UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001034007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001034008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI031008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI112421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC160817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB758330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB806310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV119475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV795771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026803   ⟹   ENSRNOP00000026803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,406,920 - 7,415,838 (+)Ensembl
mRatBN7.2 Ensembl167,366,542 - 7,409,556 (+)Ensembl
Rnor_6.0 Ensembl168,309,239 - 8,323,293 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066062   ⟹   ENSRNOP00000061299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,401,802 - 7,415,840 (+)Ensembl
mRatBN7.2 Ensembl167,366,542 - 7,409,556 (+)Ensembl
Rnor_6.0 Ensembl168,302,950 - 8,323,293 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095475   ⟹   ENSRNOP00000085149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,398,798 - 7,409,641 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117357   ⟹   ENSRNOP00000085575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,395,642 - 7,409,556 (+)Ensembl
RefSeq Acc Id: NM_001034007   ⟹   NP_001029179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,401,791 - 7,415,846 (+)NCBI
mRatBN7.2167,395,509 - 7,409,564 (+)NCBI
Rnor_6.0168,309,239 - 8,323,294 (+)NCBI
Rnor_5.0168,219,983 - 8,240,326 (+)NCBI
RGSC_v3.4167,642,116 - 7,662,460 (+)RGD
Celera167,789,196 - 7,803,251 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001034008   ⟹   NP_001029180
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,395,502 - 7,415,846 (+)NCBI
mRatBN7.2167,389,222 - 7,409,564 (+)NCBI
Rnor_6.0168,302,950 - 8,323,294 (+)NCBI
Rnor_5.0168,219,983 - 8,240,326 (+)NCBI
RGSC_v3.4167,642,116 - 7,662,460 (+)RGD
Celera167,789,196 - 7,809,198 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252660   ⟹   XP_006252722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,401,806 - 7,415,841 (+)NCBI
mRatBN7.2167,395,590 - 7,409,564 (+)NCBI
Rnor_6.0168,309,306 - 8,323,289 (+)NCBI
Rnor_5.0168,219,983 - 8,240,326 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001029180   ⟸   NM_001034008
- UniProtKB: B1H215 (UniProtKB/TrEMBL),   A6KFW8 (UniProtKB/TrEMBL),   A0A8I6A3B1 (UniProtKB/TrEMBL),   F7FLG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029179   ⟸   NM_001034007
- UniProtKB: B1H215 (UniProtKB/TrEMBL),   A6KFW8 (UniProtKB/TrEMBL),   A0A8I6A3B1 (UniProtKB/TrEMBL),   F7FLG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252722   ⟸   XM_006252660
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1Q3 (UniProtKB/TrEMBL),   A0A8I6A3B1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026803   ⟸   ENSRNOT00000026803
Ensembl Acc Id: ENSRNOP00000061299   ⟸   ENSRNOT00000066062
Ensembl Acc Id: ENSRNOP00000085575   ⟸   ENSRNOT00000117357
Ensembl Acc Id: ENSRNOP00000085149   ⟸   ENSRNOT00000095475
Protein Domains
Nuclear receptor coactivator 4 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1H215-F1-model_v2 AlphaFold B1H215 1-622 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699938
Promoter ID:EPDNEW_R10461
Type:initiation region
Name:Ncoa4_1
Description:nuclear receptor coactivator 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10462  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0168,303,011 - 8,303,071EPDNEW
RGD ID:13699939
Promoter ID:EPDNEW_R10462
Type:single initiation site
Name:Ncoa4_2
Description:nuclear receptor coactivator 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10461  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0168,309,251 - 8,309,311EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563014 AgrOrtholog
BioCyc Gene G2FUF-12118 BioCyc
Ensembl Genes ENSRNOG00000019768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000063221 Ensembl
Ensembl Transcript ENSRNOT00000026803 ENTREZGENE
  ENSRNOT00000026803.7 UniProtKB/TrEMBL
  ENSRNOT00000066062 ENTREZGENE
  ENSRNOT00000066062.5 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7454028 IMAGE-MGC_LOAD
InterPro ARA70 UniProtKB/TrEMBL
  NCoA-4 UniProtKB/TrEMBL
KEGG Report rno:619385 UniProtKB/TrEMBL
MGC_CLONE MGC:187270 IMAGE-MGC_LOAD
NCBI Gene 619385 ENTREZGENE
PANTHER NUCLEAR RECEPTOR COACTIVATOR 4 UniProtKB/TrEMBL
  PTHR17085 UniProtKB/TrEMBL
Pfam ARA70 UniProtKB/TrEMBL
PhenoGen Ncoa4 PhenoGen
RatGTEx ENSRNOG00000019768 RatGTEx
  ENSRNOG00000063221 RatGTEx
UniProt A0A8I6A1Q3 ENTREZGENE
  A0A8I6A3B1 ENTREZGENE
  A0ABZ3NNK3_RAT UniProtKB/TrEMBL
  A6KFW8 ENTREZGENE
  B1H215 ENTREZGENE, UniProtKB/TrEMBL
  F7FLG1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6KFW8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ncoa4  nuclear receptor coactivator 4   Ncoa4_predicted  nuclear receptor coactivator 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 Ncoa4_predicted  nuclear receptor coactivator 4 (predicted)  Ncoa4  nuclear receptor coactivator 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Ncoa4  nuclear receptor coactivator 4      Symbol and Name status set to provisional 70820 PROVISIONAL