Gjc2 (gap junction protein, gamma 2) - Rat Genome Database

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Gene: Gjc2 (gap junction protein, gamma 2) Rattus norvegicus
Analyze
Symbol: Gjc2
Name: gap junction protein, gamma 2
RGD ID: 1562712
Description: Predicted to enable gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of calcium ion transmembrane transport; and positive regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including paranode region of axon; perikaryon; and proximal neuron projection. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (gap junction protein gamma 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connexin-47; Cx47; gap junction alpha-12 protein; gap junction gamma-2 protein; gap junction membrane channel protein alpha 12; gap junction protein, alpha 12; gap junction protein, alpha 12, 47kDa; Gja12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,462,203 - 44,470,924 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1044,462,054 - 44,470,340 (-)EnsemblGRCr8
mRatBN7.21043,962,642 - 43,971,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,962,642 - 43,970,467 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1048,656,460 - 48,664,272 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,146,818 - 48,154,630 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,650,415 - 43,658,227 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,526,740 - 45,535,520 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,526,745 - 45,534,570 (-)Ensemblrn6Rnor6.0
Rnor_5.01045,282,830 - 45,291,628 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41045,480,937 - 45,488,651 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1043,225,920 - 43,233,731 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GJA12 mutations in children with recessive hypomyelinating leukoencephalopathy. Bugiani M, etal., Neurology. 2006 Jul 25;67(2):273-9. Epub 2006 May 17.
2. Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells. Condorelli DF, etal., Eur J Neurosci 2003 Oct;18(7):1807-27.
3. Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model. Cui Y, etal., J Neuroinflammation. 2014 Mar 6;11:42. doi: 10.1186/1742-2094-11-42.
4. GJC2 missense mutations cause human lymphedema. Ferrell RE, etal., Am J Hum Genet. 2010 Jun 11;86(6):943-8. doi: 10.1016/j.ajhg.2010.04.010. Epub 2010 May 27.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GJA12 mutations are a rare cause of Pelizaeus-Merzbacher-like disease. Henneke M, etal., Neurology. 2008 Mar 4;70(10):748-54. Epub 2007 Dec 19.
7. Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning. Kamasawa N, etal., Neuroscience. 2005;136(1):65-86. Epub 2005 Oct 3.
8. Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes. Kleopa KA, etal., Glia. 2004 Sep;47(4):346-57.
9. Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of the ERK/Id4 pathway. Liu Z, etal., Cell Cycle. 2017 Apr 3;16(7):714-722. doi: 10.1080/15384101.2017.1295183. Epub 2017 Feb 22.
10. Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis. Markoullis K, etal., Glia. 2012 Jul;60(7):1053-66. doi: 10.1002/glia.22334. Epub 2012 Mar 27.
11. Promoter mutation is a common variant in GJC2-associated Pelizaeus-Merzbacher-like disease. Meyer E, etal., Mol Genet Metab. 2011 Dec;104(4):637-43. doi: 10.1016/j.ymgme.2011.08.032. Epub 2011 Sep 8.
12. Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat. Mukhamedshina YO, etal., Spinal Cord. 2016 May;54(5):347-59. doi: 10.1038/sc.2015.161. Epub 2015 Sep 29.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations. Orthmann-Murphy JL, etal., Brain. 2009 Feb;132(Pt 2):426-38. doi: 10.1093/brain/awn328. Epub 2008 Dec 4.
15. Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype. Ostergaard P, etal., J Med Genet. 2011 Apr;48(4):251-5. doi: 10.1136/jmg.2010.085563. Epub 2011 Jan 25.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations. Singh AK, etal., Toxicol Sci. 2011 Aug;122(2):526-38. doi: 10.1093/toxsci/kfr115. Epub 2011 May 10.
21. Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans. Tress O, etal., PLoS Genet. 2011 Jul;7(7):e1002146. doi: 10.1371/journal.pgen.1002146. Epub 2011 Jul 7.
22. Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease. Uhlenberg B, etal., Am J Hum Genet. 2004 Aug;75(2):251-60. Epub 2004 Jun 10.
Additional References at PubMed
PMID:11160382   PMID:15057822   PMID:16194882   PMID:17344063   PMID:20578039   PMID:22871113   PMID:28634078   PMID:31002152  


Genomics

Comparative Map Data
Gjc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,462,203 - 44,470,924 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1044,462,054 - 44,470,340 (-)EnsemblGRCr8
mRatBN7.21043,962,642 - 43,971,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,962,642 - 43,970,467 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1048,656,460 - 48,664,272 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,146,818 - 48,154,630 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,650,415 - 43,658,227 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,526,740 - 45,535,520 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,526,745 - 45,534,570 (-)Ensemblrn6Rnor6.0
Rnor_5.01045,282,830 - 45,291,628 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41045,480,937 - 45,488,651 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1043,225,920 - 43,233,731 (-)NCBICelera
Cytogenetic Map10q22NCBI
GJC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,149,930 - 228,159,826 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1228,149,930 - 228,159,826 (+)Ensemblhg38GRCh38
GRCh371228,337,631 - 228,347,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,404,176 - 226,414,150 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341224,644,287 - 224,654,260NCBI
Celera1201,527,795 - 201,537,768 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,852,444 - 198,862,502 (+)NCBIHuRef
CHM1_11229,609,739 - 229,619,848 (+)NCBICHM1_1
T2T-CHM13v2.01227,338,927 - 227,348,822 (+)NCBIT2T-CHM13v2.0
Gjc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,066,390 - 59,074,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,066,394 - 59,074,039 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381159,175,564 - 59,183,213 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,175,568 - 59,183,213 (-)Ensemblmm10GRCm38
MGSCv371158,989,066 - 58,996,715 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361158,991,761 - 58,999,408 (-)NCBIMGSCv36mm8
Celera1163,940,632 - 63,948,320 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.05NCBI
Gjc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955581291,537 - 294,752 (-)NCBIChiLan1.0ChiLan1.0
GJC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,446,828 - 21,456,976 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,385,126 - 21,395,272 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,551,556 - 203,561,702 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,762,974 - 208,772,229 (+)NCBIPanPan1.1PanPan1.1panPan2
GJC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114810,388 - 819,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14810,386 - 820,420 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha14332,072 - 340,760 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.014531,302 - 539,994 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.114722,120 - 730,807 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014502,958 - 511,636 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014488,819 - 497,515 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gjc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,727,408 - 87,735,276 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493686469,445 - 70,752 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493686467,608 - 71,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,258,207 - 51,267,962 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1251,257,623 - 51,267,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,844,201 - 53,854,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GJC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,568,664 - 1,579,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,569,427 - 1,570,752 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660551,449,049 - 1,451,620 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gjc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937898,876 - 905,247 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Gjc2
46 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:271
Count of miRNA genes:170
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000058362
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH129753  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21043,971,537 - 43,971,732 (+)MAPPERmRatBN7.2
Rnor_6.01045,535,641 - 45,535,835NCBIRnor6.0
Rnor_5.01045,291,726 - 45,291,920UniSTSRnor5.0
RH 3.4 Map10500.29UniSTS
Cytogenetic Map10q22UniSTS
RH143586  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21043,963,867 - 43,964,007 (+)MAPPERmRatBN7.2
Rnor_6.01045,527,971 - 45,528,110NCBIRnor6.0
Rnor_5.01045,284,056 - 45,284,195UniSTSRnor5.0
RGSC_v3.41045,481,648 - 45,481,787UniSTSRGSC3.4
Celera1043,227,132 - 43,227,271UniSTS
RH 3.4 Map10481.2UniSTS
Cytogenetic Map10q22UniSTS
RH140806  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21043,963,269 - 43,963,405 (+)MAPPERmRatBN7.2
Rnor_6.01045,527,373 - 45,527,508NCBIRnor6.0
Rnor_5.01045,283,458 - 45,283,593UniSTSRnor5.0
RGSC_v3.41045,481,050 - 45,481,185UniSTSRGSC3.4
Celera1043,226,548 - 43,226,683UniSTS
RH 3.4 Map10503.4UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 65 160 88 87 56 82 56 6 325 180 10 137 67 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000058362   ⟹   ENSRNOP00000064383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1044,462,203 - 44,470,028 (-)Ensembl
mRatBN7.2 Ensembl1043,962,642 - 43,970,467 (-)Ensembl
Rnor_6.0 Ensembl1045,526,745 - 45,534,570 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133283   ⟹   ENSRNOP00000109574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1044,462,203 - 44,464,221 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140285   ⟹   ENSRNOP00000106585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1044,462,219 - 44,465,310 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145351   ⟹   ENSRNOP00000108758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1044,462,231 - 44,466,363 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145735   ⟹   ENSRNOP00000108401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1044,462,203 - 44,466,363 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146278   ⟹   ENSRNOP00000106902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1044,462,203 - 44,465,186 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155339   ⟹   ENSRNOP00000101399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1044,462,194 - 44,464,221 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162373   ⟹   ENSRNOP00000099531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1044,462,204 - 44,464,221 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167661   ⟹   ENSRNOP00000102028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1044,462,054 - 44,470,340 (-)Ensembl
RefSeq Acc Id: NM_001100784   ⟹   NP_001094254
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,462,203 - 44,470,028 (-)NCBI
mRatBN7.21043,962,642 - 43,970,467 (-)NCBI
Rnor_6.01045,526,745 - 45,534,570 (-)NCBI
Rnor_5.01045,282,830 - 45,291,628 (-)NCBI
Celera1043,225,920 - 43,233,731 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246515   ⟹   XP_006246577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,462,203 - 44,470,924 (-)NCBI
mRatBN7.21043,962,642 - 43,971,358 (-)NCBI
Rnor_6.01045,526,740 - 45,535,520 (-)NCBI
Rnor_5.01045,282,830 - 45,291,628 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086565   ⟹   XP_038942493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,462,203 - 44,470,352 (-)NCBI
mRatBN7.21043,962,642 - 43,970,795 (-)NCBI
RefSeq Acc Id: XM_039086566   ⟹   XP_038942494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,462,203 - 44,464,207 (-)NCBI
mRatBN7.21043,962,642 - 43,964,654 (-)NCBI
RefSeq Acc Id: XM_063269613   ⟹   XP_063125683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,462,203 - 44,470,040 (-)NCBI
RefSeq Acc Id: NP_001094254   ⟸   NM_001100784
- UniProtKB: Q80XF7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246577   ⟸   XM_006246515
- Peptide Label: isoform X3
- UniProtKB: Q80XF7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064383   ⟸   ENSRNOT00000058362
RefSeq Acc Id: XP_038942493   ⟸   XM_039086565
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038942494   ⟸   XM_039086566
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063125683   ⟸   XM_063269613
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000099531   ⟸   ENSRNOT00000162373
Ensembl Acc Id: ENSRNOP00000106585   ⟸   ENSRNOT00000140285
Ensembl Acc Id: ENSRNOP00000102028   ⟸   ENSRNOT00000167661
Ensembl Acc Id: ENSRNOP00000108758   ⟸   ENSRNOT00000145351
Ensembl Acc Id: ENSRNOP00000109574   ⟸   ENSRNOT00000133283
Ensembl Acc Id: ENSRNOP00000101399   ⟸   ENSRNOT00000155339
Ensembl Acc Id: ENSRNOP00000108401   ⟸   ENSRNOT00000145735
Ensembl Acc Id: ENSRNOP00000106902   ⟸   ENSRNOT00000146278

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80XF7-F1-model_v2 AlphaFold Q80XF7 1-440 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562712 AgrOrtholog
BioCyc Gene G2FUF-24910 BioCyc
Ensembl Genes ENSRNOG00000038328 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058362 ENTREZGENE
  ENSRNOT00000058362.4 UniProtKB/Swiss-Prot
  ENSRNOT00000167661 ENTREZGENE
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot
InterPro Connexin UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
  Connexin_CS UniProtKB/Swiss-Prot
  Connexin_N UniProtKB/Swiss-Prot
  Connexin_N_sf UniProtKB/Swiss-Prot
KEGG Report rno:497913 UniProtKB/Swiss-Prot
NCBI Gene 497913 ENTREZGENE
PANTHER GAP JUNCTION GAMMA-2 PROTEIN UniProtKB/Swiss-Prot
  PTHR11984 UniProtKB/Swiss-Prot
Pfam Connexin UniProtKB/Swiss-Prot
PhenoGen Gjc2 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot
  CONNEXINS_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000038328 RatGTEx
SMART CNX UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
UniProt A0ABK0LAI8_RAT UniProtKB/TrEMBL
  CXG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-25 Gjc2  gap junction protein, gamma 2  Gja12  gap junction membrane channel protein alpha 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Gja12  gap junction membrane channel protein alpha 12  Gja12  gap junction protein, alpha 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Gja12  gap junction protein, alpha 12  Gjc2  gap junction protein, gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Gjc2  gap junction protein, gamma 2  Gja12_predicted  gap junction protein, alpha 12, 47kDa (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 Gja12_predicted  gap junction protein, alpha 12, 47kDa (predicted)  Gja12  gap junction protein, alpha 12, 47kDa  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Gja12  gap junction protein, alpha 12, 47kDa      Symbol and Name status set to provisional 70820 PROVISIONAL