Nod1 (nucleotide-binding oligomerization domain containing 1) - Rat Genome Database

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Gene: Nod1 (nucleotide-binding oligomerization domain containing 1) Rattus norvegicus
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Symbol: Nod1
Name: nucleotide-binding oligomerization domain containing 1
RGD ID: 1562269
Description: Predicted to enable several functions, including CARD domain binding activity; peptidoglycan binding activity; and protein homodimerization activity. Involved in positive regulation of apoptotic process; positive regulation of cytokine production; and positive regulation of nitric-oxide synthase activity. Predicted to be located in basolateral plasma membrane; cytosol; and phagocytic vesicle. Predicted to be part of canonical inflammasome complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1); PARTICIPATES IN NOD-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC500133; nucleotide-binding oligomerization domain-containing protein 1; RGD1562269; similar to Caspase recruitment domain protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,391,142 - 85,442,281 (-)NCBIGRCr8
mRatBN7.2484,060,871 - 84,111,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,060,880 - 84,111,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,285,035 - 89,334,440 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,060,457 - 85,109,860 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,471,807 - 83,522,335 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,123,965 - 85,175,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,123,960 - 85,174,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04149,781,209 - 149,832,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,398,809 - 83,449,207 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera478,928,394 - 78,978,728 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to muramyl dipeptide  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
detection of bacterium  (ISO)
ERK1 and ERK2 cascade  (ISO)
inflammatory response  (IEA)
innate immune response  (IEA)
intracellular signal transduction  (IBA,ISO)
JNK cascade  (ISO)
negative regulation of cellular defense response  (IEA)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (ISO)
pattern recognition receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of autophagy  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of interleukin-1 beta production  (IMP)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric-oxide synthase activity  (IMP)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of pyroptotic inflammatory response  (IEA)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of tumor necrosis factor production  (IMP,ISO)
positive regulation of xenophagy  (ISO)
response to endoplasmic reticulum stress  (ISO)
stress-activated MAPK cascade  (ISO)
xenophagy  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis? Bogefors J, etal., Allergy. 2010 Oct;65(10):1222-6. Epub 2010 Apr 7.
2. Association between exposure to farming, allergies and genetic variation in CARD4/NOD1. Eder W, etal., Allergy. 2006 Sep;61(9):1117-24.
3. NOD1 activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis. Fernandez-Velasco M, etal., PLoS One. 2012;7(9):e45260. doi: 10.1371/journal.pone.0045260. Epub 2012 Sep 18.
4. The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila. Frutuoso MS, etal., Microbes Infect. 2010 Oct;12(11):819-27. Epub 2010 Jun 2.
5. A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses. Gatheral T, etal., PLoS One. 2012;7(8):e42386. doi: 10.1371/journal.pone.0042386. Epub 2012 Aug 1.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Geddes K, etal., Infect Immun. 2010 Dec;78(12):5107-15. Epub 2010 Oct 4.
8. NOD1 variation, immunoglobulin E and asthma. Hysi P, etal., Hum Mol Genet. 2005 Apr 1;14(7):935-41. Epub 2005 Feb 17.
9. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. Opitz B, etal., J Biol Chem. 2004 Aug 27;279(35):36426-32. Epub 2004 Jun 23.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. Shimada K, etal., PLoS Pathog. 2009 Apr;5(4):e1000379. Epub 2009 Apr 10.
14. TNFalpha and IL-1beta are mediated by both TLR4 and Nod1 pathways in the cultured HAPI cells stimulated by LPS. Zheng W, etal., Biochem Biophys Res Commun. 2012 Apr 20;420(4):762-7. doi: 10.1016/j.bbrc.2012.03.068. Epub 2012 Mar 17.
Additional References at PubMed
PMID:10329646   PMID:15653568   PMID:17054981   PMID:17337451   PMID:18186648   PMID:18261938   PMID:19043560   PMID:20008287   PMID:20649597   PMID:20976174   PMID:22033934   PMID:25093298  
PMID:25502289   PMID:27169686   PMID:27747243   PMID:29303910   PMID:31649195   PMID:32888957   PMID:34774740  


Genomics

Comparative Map Data
Nod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,391,142 - 85,442,281 (-)NCBIGRCr8
mRatBN7.2484,060,871 - 84,111,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,060,880 - 84,111,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,285,035 - 89,334,440 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,060,457 - 85,109,860 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,471,807 - 83,522,335 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,123,965 - 85,175,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,123,960 - 85,174,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04149,781,209 - 149,832,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,398,809 - 83,449,207 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera478,928,394 - 78,978,728 (-)NCBICelera
Cytogenetic Map4q24NCBI
NOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38730,424,527 - 30,478,784 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl730,424,527 - 30,478,784 (-)EnsemblGRCh38hg38GRCh38
GRCh37730,464,143 - 30,518,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,430,675 - 30,484,790 (-)NCBINCBI36Build 36hg18NCBI36
Build 34730,237,389 - 30,291,505NCBI
Celera730,453,464 - 30,507,713 (-)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,346,423 - 30,400,669 (-)NCBIHuRef
CHM1_1730,464,171 - 30,518,245 (-)NCBICHM1_1
T2T-CHM13v2.0730,562,221 - 30,616,484 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2730,513,913 - 30,568,158 (-)NCBI
Nod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39654,900,927 - 54,949,655 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl654,900,934 - 54,949,597 (-)EnsemblGRCm39 Ensembl
GRCm38654,923,942 - 54,972,674 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl654,923,949 - 54,972,612 (-)EnsemblGRCm38mm10GRCm38
MGSCv37654,873,936 - 54,922,606 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36654,853,527 - 54,901,991 (-)NCBIMGSCv36mm8
Celera655,457,493 - 55,496,882 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.22NCBI
Nod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541031,681,077 - 31,725,173 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541031,681,191 - 31,725,173 (-)NCBIChiLan1.0ChiLan1.0
NOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2635,258,093 - 35,306,265 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1783,582,820 - 83,631,444 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0731,060,245 - 31,109,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1731,182,275 - 31,230,388 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,182,275 - 31,208,742 (-)Ensemblpanpan1.1panPan2
NOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,162,671 - 43,226,948 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,163,571 - 43,227,103 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1442,595,450 - 42,659,740 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01443,105,467 - 43,168,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,105,475 - 43,194,265 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,221,377 - 43,284,335 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01442,900,527 - 42,960,255 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,258,705 - 43,321,637 (-)NCBIUU_Cfam_GSD_1.0
Nod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,505,623 - 87,556,280 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364786,715,245 - 6,768,372 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364786,717,354 - 6,768,293 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,432,050 - 42,512,264 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,464,667 - 42,509,135 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,989,047 - 47,012,192 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,907,628 - 27,957,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,926,710 - 27,957,619 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604276,740,001 - 76,789,440 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624739285,689 - 341,956 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624739285,791 - 339,752 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nod1
813 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:99
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000014324
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48342841995853334Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014324   ⟹   ENSRNOP00000014324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,060,880 - 84,111,404 (-)Ensembl
Rnor_6.0 Ensembl485,123,974 - 85,174,931 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088085   ⟹   ENSRNOP00000074999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl485,123,960 - 85,174,951 (-)Ensembl
RefSeq Acc Id: NM_001109236   ⟹   NP_001102706
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,391,142 - 85,441,674 (-)NCBI
mRatBN7.2484,060,871 - 84,111,404 (-)NCBI
Rnor_6.0485,123,965 - 85,174,931 (-)NCBI
Rnor_5.04149,781,209 - 149,832,175 (-)NCBI
RGSC_v3.4483,398,809 - 83,449,207 (-)RGD
Celera478,928,394 - 78,978,728 (-)RGD
Sequence:
RefSeq Acc Id: XR_005503297
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,400,348 - 85,442,281 (-)NCBI
mRatBN7.2484,070,077 - 84,111,668 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102706 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88106 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014324.4
RefSeq Acc Id: NP_001102706   ⟸   NM_001109236
- UniProtKB: D4ADT7 (UniProtKB/TrEMBL),   A6K0W2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014324   ⟸   ENSRNOT00000014324
Ensembl Acc Id: ENSRNOP00000074999   ⟸   ENSRNOT00000088085
Protein Domains
CARD   NACHT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADT7-F1-model_v2 AlphaFold D4ADT7 1-953 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693070
Promoter ID:EPDNEW_R3594
Type:multiple initiation site
Name:Nod1_1
Description:nucleotide-binding oligomerization domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0485,174,948 - 85,175,008EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562269 AgrOrtholog
BioCyc Gene G2FUF-44750 BioCyc
Ensembl Genes ENSRNOG00000010629 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014324.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NLR UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:500133 UniProtKB/TrEMBL
NCBI Gene 500133 ENTREZGENE
PANTHER NACHT, LRR AND CARD DOMAINS-CONTAINING UniProtKB/TrEMBL
  NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
PhenoGen Nod1 PhenoGen
PROSITE CARD UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010629 RatGTEx
SMART LRR_RI UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
UniProt A6K0W2 ENTREZGENE, UniProtKB/TrEMBL
  D4ADT7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Nod1  nucleotide-binding oligomerization domain containing 1  RGD1562269_predicted  similar to Caspase recruitment domain protein 4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562269_predicted  similar to Caspase recruitment domain protein 4 (predicted)  LOC500133  similar to Caspase recruitment domain protein 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500133  similar to Caspase recruitment domain protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL