Slc6a14 (solute carrier family 6 member 14) - Rat Genome Database

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Gene: Slc6a14 (solute carrier family 6 member 14) Rattus norvegicus
Analyze
Symbol: Slc6a14
Name: solute carrier family 6 member 14
RGD ID: 1561810
Description: Predicted to enable (R)-carnitine transmembrane transporter activity; carboxylic acid transmembrane transporter activity; and neutral, basic amino acid:sodium:chloride symporter activity. Predicted to be involved in several processes, including (R)-carnitine transmembrane transport; amino acid transport; and sodium ion transmembrane transport. Located in brush border membrane. Biomarker of inflammatory bowel disease. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SLC6A14 (solute carrier family 6 member 14); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Atb0+; colonic system B0+ amino acid transporter; neutral cationic amino acid transporter B0,+; sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); solute carrier family 6 (amino acid transporter), member 14; solute carrier family 6 (neurotransmitter transporter), member 14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X117,109,063 - 117,169,522 (+)NCBIGRCr8
mRatBN7.2X112,314,643 - 112,375,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX112,314,691 - 112,375,096 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX114,364,603 - 114,388,011 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X117,855,406 - 117,878,824 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X115,411,464 - 115,434,898 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X120,624,522 - 120,647,964 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX120,624,518 - 120,649,111 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X120,768,495 - 120,791,936 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,048,993 - 12,072,434 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX111,594,607 - 111,618,057 (+)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Stimulation of expression of the intestinal glutamine transporter ATB0 in tumor-bearing rats. Choudry HA, etal., Ann Surg Oncol. 2006 Dec;13(12):1747-53. Epub 2006 Sep 28.
2. Experimental colitis: decreased Octn2 and Atb0+ expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes. D'Argenio G, etal., FASEB J. 2006 Dec;20(14):2544-6. Epub 2006 Oct 25.
3. Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. Durand E, etal., Diabetes. 2004 Sep;53(9):2483-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Stimulation of intestinal glutamine absorption in chronic metabolic acidosis. Pan M, etal., Surgery. 2004 Aug;136(2):127-34.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17575980   PMID:17960566   PMID:19190083   PMID:19199708   PMID:22561015   PMID:24823859  


Genomics

Comparative Map Data
Slc6a14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X117,109,063 - 117,169,522 (+)NCBIGRCr8
mRatBN7.2X112,314,643 - 112,375,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX112,314,691 - 112,375,096 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX114,364,603 - 114,388,011 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X117,855,406 - 117,878,824 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X115,411,464 - 115,434,898 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X120,624,522 - 120,647,964 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX120,624,518 - 120,649,111 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X120,768,495 - 120,791,936 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,048,993 - 12,072,434 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX111,594,607 - 111,618,057 (+)NCBICelera
Cytogenetic MapXq34NCBI
SLC6A14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X116,436,606 - 116,461,458 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX116,436,606 - 116,461,458 (+)EnsemblGRCh38hg38GRCh38
GRCh37X115,567,774 - 115,592,625 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X115,481,818 - 115,506,651 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X115,379,671 - 115,404,505NCBI
CeleraX115,546,148 - 115,571,020 (-)NCBICelera
Cytogenetic MapXq23ENTREZGENE
HuRefX105,105,197 - 105,131,432 (+)NCBIHuRef
CHM1_1X115,478,648 - 115,503,527 (+)NCBICHM1_1
T2T-CHM13v2.0X114,846,229 - 114,871,074 (+)NCBIT2T-CHM13v2.0
Slc6a14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X21,581,139 - 21,608,597 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX21,581,135 - 21,608,594 (+)EnsemblGRCm39 Ensembl
GRCm38X21,714,900 - 21,742,358 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX21,714,896 - 21,742,355 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X21,292,026 - 21,319,484 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,871,917 - 20,898,920 (+)NCBIMGSCv36mm8
CeleraX19,829,277 - 19,856,568 (+)NCBICelera
Cytogenetic MapXA2NCBI
cM MapX16.78NCBI
Slc6a14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555343,463,057 - 3,488,577 (-)NCBIChiLan1.0ChiLan1.0
SLC6A14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X115,845,806 - 115,872,160 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X115,849,414 - 115,875,768 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X105,496,347 - 105,521,217 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X115,912,873 - 115,937,730 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX115,912,873 - 115,939,693 (+)Ensemblpanpan1.1panPan2
SLC6A14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X88,939,176 - 88,965,093 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX88,938,727 - 88,965,101 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX75,080,566 - 75,106,099 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X90,671,014 - 90,696,543 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX90,670,706 - 90,696,701 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X88,132,087 - 88,157,616 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X89,890,465 - 89,915,987 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X89,625,200 - 89,650,727 (+)NCBIUU_Cfam_GSD_1.0
Slc6a14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X87,935,539 - 87,964,626 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647913,024,831 - 13,051,908 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX95,482,456 - 95,527,369 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X95,482,494 - 95,507,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X110,086,662 - 110,139,726 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606529,220,600 - 29,242,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc6a14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462489546,289 - 83,412 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc6a14
382 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:652
Count of miRNA genes:295
Interacting mature miRNAs:377
Transcripts:ENSRNOT00000007967
Prediction methods:Microtar, Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat

Markers in Region
RH143080  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X112,374,709 - 112,374,984 (+)MAPPERmRatBN7.2
Rnor_6.0X120,648,725 - 120,648,999NCBIRnor6.0
Rnor_5.0X120,792,697 - 120,792,971UniSTSRnor5.0
RGSC_v3.4X12,073,195 - 12,073,469UniSTSRGSC3.4
CeleraX111,618,818 - 111,619,092UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 11
Low 1 14
Below cutoff 7 18 8 13 8 6 7 9 5 18 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007967   ⟹   ENSRNOP00000007967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX112,350,518 - 112,375,096 (+)Ensembl
Rnor_6.0 EnsemblX120,624,518 - 120,649,111 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103592   ⟹   ENSRNOP00000097099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX112,351,629 - 112,375,096 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115597   ⟹   ENSRNOP00000087988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX112,314,691 - 112,375,096 (+)Ensembl
RefSeq Acc Id: NM_001037544   ⟹   NP_001032633
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X117,144,926 - 117,168,372 (+)NCBI
mRatBN7.2X112,350,499 - 112,373,949 (+)NCBI
Rnor_6.0X120,624,522 - 120,647,964 (+)NCBI
Rnor_5.0X120,768,495 - 120,791,936 (+)NCBI
RGSC_v3.4X12,048,993 - 12,072,434 (+)RGD
CeleraX111,594,607 - 111,618,057 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099573   ⟹   XP_038955501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X117,109,063 - 117,169,522 (+)NCBI
mRatBN7.2X112,314,643 - 112,375,412 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001032633 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955501 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABP52097 (Get FASTA)   NCBI Sequence Viewer  
  CAI94737 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007967
  ENSRNOP00000007967.5
  ENSRNOP00000087988
  ENSRNOP00000087988.1
  ENSRNOP00000097099.1
Reference Protein Sequences
RefSeq Acc Id: NP_001032633   ⟸   NM_001037544
- UniProtKB: Q334I2 (UniProtKB/TrEMBL),   A0A8I6GLX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007967   ⟸   ENSRNOT00000007967
RefSeq Acc Id: XP_038955501   ⟸   XM_039099573
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A5L0 (UniProtKB/TrEMBL),   A0A8I6GLX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087988   ⟸   ENSRNOT00000115597
RefSeq Acc Id: ENSRNOP00000097099   ⟸   ENSRNOT00000103592

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q334I2-F1-model_v2 AlphaFold Q334I2 1-640 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701974
Promoter ID:EPDNEW_R12498
Type:single initiation site
Name:Slc6a14_1
Description:solute carrier family 6 member 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X120,624,527 - 120,624,587EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561810 AgrOrtholog
BioCyc Gene G2FUF-1359 BioCyc
Ensembl Genes ENSRNOG00000005687 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007967 ENTREZGENE
  ENSRNOT00000007967.7 UniProtKB/TrEMBL
  ENSRNOT00000103592.1 UniProtKB/TrEMBL
  ENSRNOT00000115597.1 UniProtKB/TrEMBL
InterPro Na/ntran_symport UniProtKB/TrEMBL
  SNS_sf UniProtKB/TrEMBL
KEGG Report rno:298340 UniProtKB/TrEMBL
NCBI Gene 298340 ENTREZGENE
PANTHER Na/ntran_symport UniProtKB/TrEMBL
  SODIUM- AND CHLORIDE-DEPENDENT NEUTRAL AND BASIC AMINO ACID TRANSPORTER B(0+) UniProtKB/TrEMBL
Pfam SNF UniProtKB/TrEMBL
PhenoGen Slc6a14 PhenoGen
PRINTS NANEUSMPORT UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005687 RatGTEx
Superfamily-SCOP SSF161070 UniProtKB/TrEMBL
UniProt A0A8I6A5L0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLX0 ENTREZGENE, UniProtKB/TrEMBL
  Q334I2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc6a14  solute carrier family 6 member 14  Slc6a14  solute carrier family 6 (amino acid transporter), member 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-01-19 Slc6a14  solute carrier family 6 (amino acid transporter), member 14  Slc6a14  solute carrier family 6 (neurotransmitter transporter), member 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc6a14  solute carrier family 6 (neurotransmitter transporter), member 14    colonic system B0+ amino acid transporter  Name updated 1299863 APPROVED
2006-02-09 Slc6a14  colonic system B0+ amino acid transporter      Symbol and Name status set to provisional 70820 PROVISIONAL