Dusp21 (dual specificity phosphatase 21)

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Gene: Dusp21 (dual specificity phosphatase 21) Rattus norvegicus

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Symbol:

Dusp21

Name:

dual specificity phosphatase 21

RGD ID:

1560427

Description:

Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Located in mitochondrial matrix. Orthologous to human DUSP21 (dual specificity phosphatase 21); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); benzo[a]pyrene (ortholog).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dual specificity protein phosphatase 21; LOC302867; RGD1560427; similar to Dual specificity protein phosphatase 18 (Low molecular weight dual specificity phosphatase 20)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DUSP21 (dual specificity phosphatase 21)	HGNC	Ensembl, NCBI, OMA, Treefam
Mus musculus (house mouse):	Dusp21 (dual specificity phosphatase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dusp21 (dual specificity phosphatase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DUSP21 (dual specificity phosphatase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DUSP21 (dual specificity phosphatase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dusp21 (dual specificity phosphatase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DUSP21 (dual specificity phosphatase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DUSP21 (dual specificity phosphatase 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DUSP18 (dual specificity phosphatase 18)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	DUSP21 (dual specificity phosphatase 21)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OMA\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Dusp21 (dual specificity phosphatase 21)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:153044	Alliance	DIOPT (OMA\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG15528	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C04F12.8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SDP1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	alox5ap	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	dusp18	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	7,070,910 - 7,071,766 (-)	NCBI		GRCr8
mRatBN7.2	X	4,488,021 - 4,488,877 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	4,488,021 - 4,488,877 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	4,545,937 - 4,546,793 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	8,021,728 - 8,022,584 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	4,341,978 - 4,342,834 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	4,956,699 - 4,957,555 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	4,956,699 - 4,957,529 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	5,742,742 - 5,743,598 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	16,064,183 - 16,065,039 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	5,002,187 - 5,003,043 (-)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Kabuki Syndrome 2 (ISO)

Neurodevelopmental Disorders (ISO)

osteochondrodysplasia (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

fulvestrant (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

vanadyl sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA)

flagellated sperm motility (IEA,ISO)

peptidyl-tyrosine dephosphorylation (ISO)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

axonemal A tubule inner sheath (ISO)

cytoplasm (IBA,ISO)

mitochondrial inner membrane (IEA)

mitochondrial matrix (IDA)

nucleus (ISO)

sperm flagellum (IEA,ISO)

Molecular Function

calmodulin-dependent protein phosphatase activity (IEA)

histone H2AXS140 phosphatase activity (IEA)

histone H2AXY142 phosphatase activity (IEA)

MAP kinase serine/threonine phosphatase activity (IEA)

MAP kinase tyrosine/serine/threonine phosphatase activity (IEA)

myosin phosphatase activity (IEA)

non-membrane spanning protein tyrosine phosphatase activity (IEA)

phosphoprotein phosphatase activity (ISO)

protein binding (ISO)

protein tyrosine phosphatase activity (IBA,ISO)

protein tyrosine phosphatase activity, metal-dependent (IEA)

RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.	Rardin MJ, etal., J Biol Chem. 2008 May 30;283(22):15440-50. doi: 10.1074/jbc.M709547200. Epub 2008 Apr 2.
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12408986

Genomics

Comparative Map Data

Dusp21
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	7,070,910 - 7,071,766 (-)	NCBI		GRCr8
mRatBN7.2	X	4,488,021 - 4,488,877 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	4,488,021 - 4,488,877 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	4,545,937 - 4,546,793 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	8,021,728 - 8,022,584 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	4,341,978 - 4,342,834 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	4,956,699 - 4,957,555 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	4,956,699 - 4,957,529 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	5,742,742 - 5,743,598 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	16,064,183 - 16,065,039 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	5,002,187 - 5,003,043 (-)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

DUSP21
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	44,844,021 - 44,844,888 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	44,844,021 - 44,844,888 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	44,703,267 - 44,704,134 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	44,588,194 - 44,589,078 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	44,459,503 - 44,460,386	NCBI
Celera	X	48,840,019 - 48,840,904 (+)	NCBI		Celera
Cytogenetic Map	X	p11.3	NCBI
HuRef	X	42,424,798 - 42,425,683 (+)	NCBI		HuRef
CHM1_1	X	44,735,972 - 44,736,857 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	44,250,840 - 44,251,707 (+)	NCBI		T2T-CHM13v2.0

Dusp21
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	18,012,109 - 18,012,933 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	18,012,096 - 18,012,940 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	18,145,870 - 18,146,694 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	18,145,857 - 18,146,701 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	17,722,996 - 17,723,820 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	17,302,829 - 17,303,653 (+)	NCBI		MGSCv36	mm8
Celera	X	15,731,313 - 15,732,137 (+)	NCBI		Celera
Cytogenetic Map	X	A1.2	NCBI
cM Map	X	13.44	NCBI

Dusp21
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955516	3,369,548 - 3,370,403 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUSP21
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	46,478,872 - 46,479,785 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	46,482,246 - 46,483,159 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	37,283,220 - 37,284,119 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	45,098,896 - 45,099,794 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	45,099,045 - 45,099,617 (+)	Ensembl	panpan1.1		panPan2

DUSP21
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	38,721,877 - 38,722,808 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	38,722,062 - 38,722,631 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	25,948,876 - 25,949,764 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	38,810,707 - 38,811,595 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	38,810,849 - 38,811,418 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	38,843,884 - 38,844,772 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	38,830,469 - 38,831,357 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	38,923,007 - 38,923,895 (+)	NCBI		UU_Cfam_GSD_1.0

Dusp21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	31,118,087 - 31,119,016 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936502	10,959,019 - 10,959,588 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUSP21
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	X	39,929,707 - 39,930,539 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	44,313,476 - 44,314,390 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DUSP21
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	42,026,725 - 42,040,716 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	42,027,711 - 42,028,280 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666076	7,229,657 - 7,230,845 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Dusp21
1 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	17
Count of miRNA genes:	15
Interacting mature miRNAs:	16
Transcripts:	ENSRNOT00000000173
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
70166	Bp65	Blood pressure QTL 65	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1447972	11374346	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1447972	20991088	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1623715	22646544	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
2	1	2	1	1	1	2	1	2	20	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000173 ⟹ ENSRNOP00000000173

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	4,488,021 - 4,488,877 (-)	Ensembl
Rnor_6.0 Ensembl	X	4,956,699 - 4,957,529 (-)	Ensembl

RefSeq Acc Id:

NM_001106971 ⟹ NP_001100441

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	7,070,910 - 7,071,766 (-)	NCBI
mRatBN7.2	X	4,488,021 - 4,488,877 (-)	NCBI
Rnor_6.0	X	4,956,699 - 4,957,555 (-)	NCBI
Rnor_5.0	X	5,742,742 - 5,743,598 (-)	NCBI
RGSC_v3.4	X	16,064,183 - 16,065,039 (-)	RGD
Celera	X	5,002,187 - 5,003,043 (-)	RGD

Sequence:

show sequence

GACCAATGCTTGGACCTTTCCCTTATACCTTTGCCTGAGAGCAGAAGAGCAGCTGTTTTCCCAA
AGTTGCAGAGGCTGGTGCCCAGGAACCTAATGCTGAGCTGACCTGTCACTGTGATGACAACAGC
ATCTTGTATCCTTCCGTCTCAAGCTATCCAACAGGATAACATCTATGGTCTTTCTCAAATAACT
ACCAGCCTTTTTATTAGTAACTCTGCAGTAGCTAACGACAAGCTCACCTTGTCCAACAACCACA
TCACCACGATCATCAATGCCTCTGTAGAAGTAGTGAACACATTCTTCGAAGACATTCAGTATGT
GCATGTGCCGGTGAGCGATGCTCCTAATTCTTACCTTTATGACTTTTTCGACCCCATAGCTGAT
CATATCCATGGCGTGGAAATGAGGAATGGCCGCACACTATTGCACTGTGCCGCAGGAGTGAGCC
GCTCAGCAGCCCTCTGCCTTGCCTATCTCATGAAATACCACACCATGACCCTGCTGGATGCGCA
CACATGGACCAAGTCCTGCCGCCCCATCATCCGTCCCAACAATGGCTTTTGGGAACAACTGATT
CATTATGAGTTCAAGCTGTTCAGTAGGAATACTGTTCACATGATCTACTCTCCTATGGGTCTGA
TTCCTAACATCTATGAAAAGGATGCCTATTTAATGGAACTAATGTAAGCCATCCATTTCTTCCC
CTGACTGAATCCTACATCAAGATTAAAAACAATGACCTTGGACCTCTGGTTTAAAACAAAGGGA
AAAAAGACCTTGTGGATGGGGTTGGATAGGGGAGAGAAGGGATTGGAATTTTAATTATCATATC
TTCAAATAAAGTTGAATGCAAAATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100441	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL97681	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000173.3

RefSeq Acc Id:	NP_001100441 ⟸ NM_001106971
- UniProtKB:	D3ZAQ8 (UniProtKB/TrEMBL), A6JZV4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTTASCILPSQAIQQDNIYGLSQITTSLFISNSAVANDKLTLSNNHITTIINASVEVVNTFFED IQYVHVPVSDAPNSYLYDFFDPIADHIHGVEMRNGRTLLHCAAGVSRSAALCLAYLMKYHTMTL LDAHTWTKSCRPIIRPNNGFWEQLIHYEFKLFSRNTVHMIYSPMGLIPNIYEKDAYLMELM hide sequence

Ensembl Acc Id:

ENSRNOP00000000173 ⟸ ENSRNOT00000000173

Protein Domains

Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZAQ8-F1-model_v2	AlphaFold	D3ZAQ8	1-189	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701703

Promoter ID:

EPDNEW_R12226

Type:

single initiation site

Name:

Dusp21_1

Description:

dual specificity phosphatase 21

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	4,957,531 - 4,957,591	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560427	AgrOrtholog
BioCyc Gene	G2FUF-3130	BioCyc
Ensembl Genes	ENSRNOG00000024138	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000173.7	UniProtKB/TrEMBL
Gene3D-CATH	3.90.190.10	UniProtKB/TrEMBL
InterPro	Dual-sp/Tyr_phosphatase	UniProtKB/TrEMBL
	Dual-sp_phosphatase_cat-dom	UniProtKB/TrEMBL
	Dual-sp_phosphatase_famB	UniProtKB/TrEMBL
	Dual-sp_phosphatase_subgr_cat	UniProtKB/TrEMBL
	Prot-tyrosine_phosphatase-like	UniProtKB/TrEMBL
	Tyr_Pase_AS	UniProtKB/TrEMBL
KEGG Report	rno:302867	UniProtKB/TrEMBL
NCBI Gene	302867	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN PHOSPHATASE 21	UniProtKB/TrEMBL
	DUAL SPECIFICITY PROTEIN PHOSPHATASE 21	UniProtKB/TrEMBL
Pfam	DSPc	UniProtKB/TrEMBL
PhenoGen	Dusp21	PhenoGen
PRINTS	ADSPHPHTASE	UniProtKB/TrEMBL
	ADSPHPHTASEB	UniProtKB/TrEMBL
PROSITE	TYR_PHOSPHATASE_1	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_2	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000024138	RatGTEx
SMART	DSPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52799	UniProtKB/TrEMBL
UniProt	A6JZV4	ENTREZGENE, UniProtKB/TrEMBL
	D3ZAQ8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-28	Dusp21	dual specificity phosphatase 21	RGD1560427_predicted	similar to Dual specificity protein phosphatase 18 (Low molecular weight dual specificity phosphatase 20) (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-10	RGD1560427_predicted	similar to Dual specificity protein phosphatase 18 (Low molecular weight dual specificity phosphatase 20) (predicted)			Name updated	1299863	APPROVED
2006-03-07	RGD1560427_predicted	similar to Dual specificity protein phosphatase 18 (Low molecular weight dual specificity phosphatase 20) (predicted)	LOC302867	similar to Dual specificity protein phosphatase 18 (Low molecular weight dual specificity phosphatase 20)	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC302867	similar to Dual specificity protein phosphatase 18 (Low molecular weight dual specificity phosphatase 20)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar