Kif28 (kinesin family member 28) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Kif28 (kinesin family member 28) Rattus norvegicus
Analyze
Symbol: Kif28 (Ensembl: Kif28p)
Name: kinesin family member 28 (Ensembl:kinesin family member 28, pseudogene)
RGD ID: 1559696
Description: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in mitochondrion organization and organelle transport along microtubule. Located in mitochondrial membrane. Orthologous to human KIF28P (kinesin family member 28, pseudogene); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC682385; hypothetical protein LOC689985; Kif28p; kinesin family member 28, pseudogene; Kinesin-like protein 6; kinesin-like protein KIF28; kinesin-like protein KIF28P; kinesin-like protein KLP6; KLP6; LOC289309; RGD1559696; similar to kinesin-like protein (103.5 kD) (klp-6)
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81393,959,492 - 94,014,255 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1393,959,492 - 94,014,255 (-)EnsemblGRCr8
mRatBN7.21391,427,527 - 91,482,297 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1391,427,736 - 91,482,237 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1393,932,940 - 93,987,432 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01395,333,105 - 95,387,594 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01392,507,771 - 92,562,267 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01397,969,335 - 98,023,829 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1397,969,335 - 98,023,829 (-)Ensemblrn6Rnor6.0
Rnor_5.013102,978,586 - 103,033,388 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41395,381,484 - 95,431,892 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1390,978,902 - 91,033,474 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. KLP6: a newly identified kinesin that regulates the morphology and transport of mitochondria in neuronal cells. Tanaka K, etal., J Cell Sci. 2011 Jul 15;124(Pt 14):2457-65. doi: 10.1242/jcs.086470. Epub 2011 Jun 21.

Genomics

Comparative Map Data
Kif28
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81393,959,492 - 94,014,255 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1393,959,492 - 94,014,255 (-)EnsemblGRCr8
mRatBN7.21391,427,527 - 91,482,297 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1391,427,736 - 91,482,237 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1393,932,940 - 93,987,432 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01395,333,105 - 95,387,594 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01392,507,771 - 92,562,267 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01397,969,335 - 98,023,829 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1397,969,335 - 98,023,829 (-)Ensemblrn6Rnor6.0
Rnor_5.013102,978,586 - 103,033,388 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41395,381,484 - 95,431,892 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1390,978,902 - 91,033,474 (-)NCBICelera
Cytogenetic Map13q26NCBI
KIF28P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381246,771,878 - 246,784,760 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1246,771,837 - 246,839,611 (-)Ensemblhg38GRCh38
GRCh371246,935,180 - 246,948,062 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,001,803 - 245,014,685 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1220,227,425 - 220,242,212 (-)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1217,323,769 - 217,336,364 (-)NCBIHuRef
CHM1_11253,730,177 - 253,742,786 (-)NCBICHM1_1
T2T-CHM13v2.01246,198,268 - 246,211,248 (-)NCBIT2T-CHM13v2.0
Kif28
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,522,602 - 179,572,825 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,522,862 - 179,572,836 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381179,695,037 - 179,745,200 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,695,297 - 179,745,271 (-)Ensemblmm10GRCm38
MGSCv371181,625,428 - 181,670,214 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361181,531,972 - 181,576,758 (-)NCBIMGSCv36mm8
MGSCv361181,047,024 - 181,096,491 (-)NCBIMGSCv36mm8
Cytogenetic Map1H4NCBI
cM Map183.62NCBI
Kif28
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554069,619,952 - 9,670,472 (-)Ensembl
ChiLan1.0NW_0049554069,618,041 - 9,687,626 (-)NCBIChiLan1.0ChiLan1.0
LOC102153289
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1737,493,752 - 37,514,966 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha736,974,655 - 37,027,281 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0737,324,835 - 37,377,531 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1737,165,213 - 37,217,867 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0737,172,561 - 37,225,170 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0737,442,095 - 37,494,759 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101957045
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934450,471,854 - 50,537,906 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365264,209,391 - 4,275,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100739202
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11015,131,193 - 15,203,483 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21017,450,766 - 17,521,590 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103230917
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12583,819,809 - 83,889,842 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605586,122,344 - 86,137,874 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Kif28
397 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000075426
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
BF386780  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21391,427,590 - 91,427,740 (+)MAPPERmRatBN7.2
Rnor_6.01397,729,530 - 97,729,679NCBIRnor6.0
Rnor_6.01397,969,190 - 97,969,339NCBIRnor6.0
Rnor_5.013102,978,441 - 102,978,590UniSTSRnor5.0
Rnor_5.013102,745,464 - 102,745,613UniSTSRnor5.0
RGSC_v3.41395,377,253 - 95,377,402UniSTSRGSC3.4
Celera1390,978,757 - 90,978,906UniSTS
RH 3.4 Map13615.7UniSTS
Cytogenetic Map13q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 3 44 47 47 36 16 36 6 78 25 1 35 11 49 11 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000075426   ⟹   ENSRNOP00000064972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1393,959,492 - 94,014,255 (-)Ensembl
mRatBN7.2 Ensembl1391,427,736 - 91,482,237 (-)Ensembl
Rnor_6.0 Ensembl1397,969,335 - 98,023,829 (-)Ensembl
RefSeq Acc Id: NM_001270385   ⟹   NP_001257314
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81393,959,492 - 94,014,255 (-)NCBI
mRatBN7.21391,427,527 - 91,482,297 (-)NCBI
Rnor_6.01397,969,335 - 98,023,829 (-)NCBI
Rnor_5.013102,978,586 - 103,033,388 (-)NCBI
Celera1390,978,902 - 91,033,474 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257314 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAK54843 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064972
  ENSRNOP00000064972.1
GenBank Protein F8WLE0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001257314   ⟸   NM_001270385
- UniProtKB: F8WLE0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064972   ⟸   ENSRNOT00000075426
Protein Domains
FHA   Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F8WLE0-F1-model_v2 AlphaFold F8WLE0 1-1034 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559696 AgrOrtholog
BioCyc Gene G2FUF-17136 BioCyc
Ensembl Genes ENSRNOG00000050602 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075426 ENTREZGENE
  ENSRNOT00000075426.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.200.20 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
InterPro FHA_dom UniProtKB/Swiss-Prot
  Kinesin-like_KIF1-typ UniProtKB/Swiss-Prot
  Kinesin_motor_CS UniProtKB/Swiss-Prot
  Kinesin_motor_dom UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:289309 UniProtKB/Swiss-Prot
NCBI Gene 289309 ENTREZGENE
PANTHER STAR-RELATED LIPID TRANSFER PROTEIN 9 UniProtKB/Swiss-Prot
Pfam FHA UniProtKB/Swiss-Prot
  KIF1B UniProtKB/Swiss-Prot
  Kinesin UniProtKB/Swiss-Prot
PhenoGen Kif28 PhenoGen
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot
PROSITE KINESIN_MOTOR_1 UniProtKB/Swiss-Prot
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050602 RatGTEx
SMART KISc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt F8WLE0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-11-01 Kif28  kinesin family member 28  Kif28p  kinesin family member 28, pseudogene  Name and Symbol changed 629549 APPROVED
2014-07-29 Kif28p  kinesin family member 28, pseudogene  RGD1559696  similar to kinesin-like protein (103.5 kD) (klp-6)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 RGD1559696  similar to kinesin-like protein (103.5 kD) (klp-6)  LOC689985  hypothetical protein LOC689985  Data merged from RGD:1586316 1643240 APPROVED
2013-05-24 RGD1559696  similar to kinesin-like protein (103.5 kD) (klp-6)  LOC682385  hypothetical protein LOC682385  Data merged from RGD:1584565 1643240 APPROVED
2008-04-30 RGD1559696  similar to kinesin-like protein (103.5 kD) (klp-6)   RGD1559696_predicted  similar to kinesin-like protein (103.5 kD) (klp-6) (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC682385  hypothetical protein LOC682385      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC689985  hypothetical protein LOC689985      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1559696_predicted  similar to kinesin-like protein (103.5 kD) (klp-6) (predicted)  LOC289309  similar to kinesin-like protein (103.5 kD) (klp-6)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC289309  similar to kinesin-like protein (103.5 kD) (klp-6)      Symbol and Name status set to provisional 70820 PROVISIONAL