Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Mknk1 | Rat | (-)-anisomycin | increases activity | ISO | MKNK1 (Homo sapiens) | 6480464 | Anisomycin results in increased activity of MKNK1 protein | CTD | PMID:9545260 | Mknk1 | Rat | (-)-anisomycin | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | SB 203580 inhibits the reaction [Anisomycin results in increased activity of MKNK1 protein] | CTD | PMID:9545260 | Mknk1 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Mknk1 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of MKNK1 mRNA | CTD | PMID:22206623 | Mknk1 | Rat | 17beta-estradiol | decreases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of MKNK1 mRNA | CTD | PMID:23094148 | Mknk1 | Rat | 17beta-estradiol | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Norethindrone Acetate] results in increased expression of MKNK1 mRNA | CTD | PMID:22217510 | Mknk1 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of MKNK1 mRNA | CTD | PMID:26496021 | Mknk1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Mknk1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of MKNK1 mRNA | CTD | PMID:21570461 | Mknk1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MKNK1 mRNA | CTD | PMID:33387578 | Mknk1 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Mknk1 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of MKNK1 mRNA | CTD | PMID:39298647 | Mknk1 | Rat | 4-hydroxynon-2-enal | decreases expression | ISO | Mknk1 (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of MKNK1 mRNA | CTD | PMID:19191707 | Mknk1 | Rat | 4-vinylcyclohexene dioxide | affects expression | ISO | Mknk1 (Mus musculus) | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of MKNK1 mRNA | CTD | PMID:20829426 | Mknk1 | Rat | 5-aza-2'-deoxycytidine | affects expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Decitabine affects the expression of MKNK1 mRNA | CTD | PMID:23300844 | Mknk1 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of MKNK1 mRNA | CTD | PMID:24780913 | Mknk1 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of MKNK1 mRNA | CTD | PMID:28959563 | Mknk1 | Rat | aflatoxin B1 | decreases expression | ISO | Mknk1 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of MKNK1 mRNA | CTD | PMID:19770486 | Mknk1 | Rat | antirheumatic drug | decreases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of MKNK1 mRNA | CTD | PMID:24449571 | Mknk1 | Rat | aristolochic acid A | increases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of MKNK1 mRNA; aristolochic acid I results in more ... | CTD | PMID:33212167 | Mknk1 | Rat | arsenite(3-) | increases activity | ISO | MKNK1 (Homo sapiens) | 6480464 | arsenite results in increased activity of MKNK1 protein | CTD | PMID:9545260 | Mknk1 | Rat | arsenite(3-) | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | SB 203580 inhibits the reaction [arsenite results in increased activity of MKNK1 protein] | CTD | PMID:9545260 | Mknk1 | Rat | arsenite(3-) | increases phosphorylation | ISO | MKNK1 (Homo sapiens) | 6480464 | arsenite results in increased phosphorylation of MKNK1 protein | CTD | PMID:12781867 | Mknk1 | Rat | arsenous acid | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] more ... | CTD | PMID:18299328|PMID:29042487 | Mknk1 | Rat | arsenous acid | increases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of MKNK1 mRNA | CTD | PMID:20458559 | Mknk1 | Rat | arsenous acid | increases activity | ISO | MKNK1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased activity of MKNK1 protein | CTD | PMID:29042487 | Mknk1 | Rat | arsenous acid | decreases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of MKNK1 mRNA | CTD | PMID:21461292 | Mknk1 | Rat | arsenous acid | decreases response to substance | ISO | MKNK1 (Homo sapiens) | 6480464 | MKNK1 protein results in decreased susceptibility to Arsenic Trioxide | CTD | PMID:18299328 | Mknk1 | Rat | arsenous acid | affects binding | ISO | MKNK1 (Homo sapiens) | 6480464 | Arsenic Trioxide binds to MKNK1 protein | CTD | PMID:29042487 | Mknk1 | Rat | benzo[a]pyrene | decreases expression | ISO | Mknk1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of MKNK1 mRNA | CTD | PMID:21715664 | Mknk1 | Rat | benzo[a]pyrene | affects methylation | ISO | MKNK1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of MKNK1 intron | CTD | PMID:30157460 | Mknk1 | Rat | beta-lapachone | decreases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of MKNK1 mRNA | CTD | PMID:38218311 | Mknk1 | Rat | bisphenol A | increases expression | ISO | Mknk1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of MKNK1 mRNA | CTD | PMID:26063408 | Mknk1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of MKNK1 mRNA | CTD | PMID:30816183|PMID:32528016 | Mknk1 | Rat | bisphenol A | increases methylation | ISO | Mknk1 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of MKNK1 promoter | CTD | PMID:27312807 | Mknk1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of MKNK1 mRNA | CTD | PMID:25181051 | Mknk1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of MKNK1 mRNA | CTD | PMID:26496021 | Mknk1 | Rat | cadmium dichloride | increases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of MKNK1 mRNA | CTD | PMID:38174414 | Mknk1 | Rat | CGP 52608 | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to MKNK1 gene] | CTD | PMID:28238834 | Mknk1 | Rat | choline | multiple interactions | ISO | Mknk1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Mknk1 | Rat | cisplatin | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with Quercetin] results in decreased expression of MKNK1 mRNA | CTD | PMID:27514524 | Mknk1 | Rat | cisplatin | affects expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Cisplatin affects the expression of MKNK1 mRNA | CTD | PMID:23300844 | Mknk1 | Rat | copper(II) sulfate | decreases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of MKNK1 mRNA | CTD | PMID:19549813 | Mknk1 | Rat | cyclosporin A | increases methylation | ISO | MKNK1 (Homo sapiens) | 6480464 | Cyclosporine results in increased methylation of MKNK1 promoter | CTD | PMID:27989131 | Mknk1 | Rat | cyclosporin A | decreases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of MKNK1 mRNA | CTD | PMID:27989131 | Mknk1 | Rat | D-glucitol | increases activity | ISO | MKNK1 (Homo sapiens) | 6480464 | Sorbitol results in increased activity of MKNK1 protein | CTD | PMID:9545260 | Mknk1 | Rat | diarsenic trioxide | decreases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of MKNK1 mRNA | CTD | PMID:21461292 | Mknk1 | Rat | diarsenic trioxide | increases activity | ISO | MKNK1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased activity of MKNK1 protein | CTD | PMID:29042487 | Mknk1 | Rat | diarsenic trioxide | decreases response to substance | ISO | MKNK1 (Homo sapiens) | 6480464 | MKNK1 protein results in decreased susceptibility to Arsenic Trioxide | CTD | PMID:18299328 | Mknk1 | Rat | diarsenic trioxide | increases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of MKNK1 mRNA | CTD | PMID:20458559 | Mknk1 | Rat | diarsenic trioxide | affects binding | ISO | MKNK1 (Homo sapiens) | 6480464 | Arsenic Trioxide binds to MKNK1 protein | CTD | PMID:29042487 | Mknk1 | Rat | diarsenic trioxide | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] more ... | CTD | PMID:18299328|PMID:29042487 | Mknk1 | Rat | doxorubicin | decreases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of MKNK1 mRNA | CTD | PMID:29803840 | Mknk1 | Rat | epoxiconazole | decreases expression | ISO | Mknk1 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of MKNK1 mRNA | CTD | PMID:35436446 | Mknk1 | Rat | ethanol | affects splicing | ISO | Mknk1 (Mus musculus) | 6480464 | Ethanol affects the splicing of MKNK1 mRNA | CTD | PMID:30319688 | Mknk1 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of MKNK1 mRNA | CTD | PMID:24793618 | Mknk1 | Rat | folic acid | multiple interactions | ISO | Mknk1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Mknk1 | Rat | folic acid | decreases expression | ISO | Mknk1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of MKNK1 mRNA | CTD | PMID:25629700 | Mknk1 | Rat | hydrogen peroxide | increases activity | ISO | MKNK1 (Homo sapiens) | 6480464 | Hydrogen Peroxide results in increased activity of MKNK1 protein | CTD | PMID:9545260 | Mknk1 | Rat | L-methionine | multiple interactions | ISO | Mknk1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Mknk1 | Rat | lipopolysaccharide | multiple interactions | ISO | Mknk1 (Mus musculus) | 6480464 | [SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of more ... | CTD | PMID:16431125|PMID:21291324 | Mknk1 | Rat | lipopolysaccharide | increases phosphorylation | ISO | Mknk1 (Mus musculus) | 6480464 | Lipopolysaccharides results in increased phosphorylation of MKNK1 protein | CTD | PMID:16431125 | Mknk1 | Rat | lipopolysaccharide | increases activity | ISO | Mknk1 (Mus musculus) | 6480464 | Lipopolysaccharides results in increased activity of MKNK1 protein | CTD | PMID:21291324 | Mknk1 | Rat | manganese atom | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of MKNK1 more ... | CTD | PMID:39836092 | Mknk1 | Rat | manganese(0) | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of MKNK1 more ... | CTD | PMID:39836092 | Mknk1 | Rat | manganese(II) chloride | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of MKNK1 more ... | CTD | PMID:39836092 | Mknk1 | Rat | methoxyacetic acid | affects expression | EXP | | 6480464 | methoxyacetic acid affects the expression of MKNK1 mRNA | CTD | PMID:20864626 | Mknk1 | Rat | methyl methanesulfonate | increases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of MKNK1 mRNA | CTD | PMID:23649840 | Mknk1 | Rat | N(4)-hydroxycytidine | decreases expression | ISO | Mknk1 (Mus musculus) | 6480464 | N(4)-hydroxycytidine results in decreased expression of MKNK1 mRNA | CTD | PMID:37748715 | Mknk1 | Rat | nickel dichloride | multiple interactions | ISO | Mknk1 (Mus musculus) | 6480464 | HIF1A affects the reaction [nickel chloride results in increased expression of MKNK1 mRNA] | CTD | PMID:12729255 | Mknk1 | Rat | nickel subsulfide | affects expression | ISO | Mknk1 (Mus musculus) | 6480464 | nickel subsulfide affects the expression of MKNK1 mRNA | CTD | PMID:12729255 | Mknk1 | Rat | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of MKNK1 mRNA | CTD | PMID:35737395 | Mknk1 | Rat | paracetamol | affects expression | ISO | Mknk1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of MKNK1 mRNA | CTD | PMID:17562736 | Mknk1 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of MKNK1 mRNA | CTD | PMID:33387578 | Mknk1 | Rat | paracetamol | increases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of MKNK1 mRNA | CTD | PMID:22230336 | Mknk1 | Rat | phorbol 13-acetate 12-myristate | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MKNK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits more ... | CTD | PMID:12781867|PMID:9545260 | Mknk1 | Rat | phorbol 13-acetate 12-myristate | increases phosphorylation | ISO | MKNK1 (Homo sapiens) | 6480464 | Tetradecanoylphorbol Acetate results in increased phosphorylation of MKNK1 protein | CTD | PMID:12781867 | Mknk1 | Rat | phorbol 13-acetate 12-myristate | increases activity | ISO | MKNK1 (Homo sapiens) | 6480464 | Tetradecanoylphorbol Acetate results in increased activity of MKNK1 protein | CTD | PMID:9545260 | Mknk1 | Rat | quercetin | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with Quercetin] results in decreased expression of MKNK1 mRNA | CTD | PMID:27514524 | Mknk1 | Rat | SB 203580 | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity more ... | CTD | PMID:12781867|PMID:9545260 | Mknk1 | Rat | SB 203580 | multiple interactions | ISO | Mknk1 (Mus musculus) | 6480464 | [SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of more ... | CTD | PMID:16431125 | Mknk1 | Rat | sorafenib | multiple interactions | ISO | MKNK1 (Homo sapiens) | 6480464 | sorafenib inhibits the reaction [MKNK1 protein results in increased phosphorylation of EIF4E protein] | CTD | PMID:16109713 | Mknk1 | Rat | sunitinib | increases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of MKNK1 mRNA | CTD | PMID:31533062 | Mknk1 | Rat | titanium dioxide | decreases methylation | ISO | Mknk1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of MKNK1 promoter | CTD | PMID:35295148 | Mknk1 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of MKNK1 mRNA | CTD | PMID:33387578 | Mknk1 | Rat | triphenyl phosphate | affects expression | ISO | MKNK1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of MKNK1 mRNA | CTD | PMID:37042841 | Mknk1 | Rat | trovafloxacin | decreases expression | ISO | Mknk1 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of MKNK1 mRNA | CTD | PMID:35537566 | Mknk1 | Rat | valproic acid | increases methylation | ISO | MKNK1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of MKNK1 gene | CTD | PMID:29154799 | Mknk1 | Rat | valproic acid | increases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of MKNK1 mRNA | CTD | PMID:23179753|PMID:27188386|PMID:28001369 | Mknk1 | Rat | valproic acid | affects expression | ISO | MKNK1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of MKNK1 mRNA | CTD | PMID:25979313 | Mknk1 | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of MKNK1 mRNA | CTD | PMID:23034163 | Mknk1 | Rat | vorinostat | increases expression | ISO | MKNK1 (Homo sapiens) | 6480464 | vorinostat results in increased expression of MKNK1 mRNA | CTD | PMID:22083351 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















