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Gene: Ttc1 (tetratricopeptide repeat domain 1) Rattus norvegicus

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Symbol:

Ttc1

Name:

tetratricopeptide repeat domain 1

RGD ID:

1359604

Description:

Predicted to enable protein-macromolecule adaptor activity. Predicted to act upstream of or within inflammatory response and positive regulation of neuroinflammatory response. Orthologous to human TTC1 (tetratricopeptide repeat domain 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC95276; tetratricopeptide repeat protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TTC1 (tetratricopeptide repeat domain 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ttc1 (tetratricopeptide repeat domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ttc1 (tetratricopeptide repeat domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TTC1 (tetratricopeptide repeat domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TTC1 (tetratricopeptide repeat domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ttc1 (tetratricopeptide repeat domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TTC1 (tetratricopeptide repeat domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TTC1 (tetratricopeptide repeat domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ttc1 (tetratricopeptide repeat domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ttc1 (tetratricopeptide repeat domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TTC1 (tetratricopeptide repeat domain 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ttc1 (tetratricopeptide repeat domain 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ttc1 (tetratricopeptide repeat domain 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ttc1 (tetratricopeptide repeat domain 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14894	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ttc-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ttc-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ttc1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	28,703,763 - 28,728,910 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	28,703,769 - 28,728,882 (-)	Ensembl				GRCr8
mRatBN7.2	10	28,202,325 - 28,227,464 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	28,202,325 - 28,227,472 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	32,961,807 - 32,986,888 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	1,500,181 - 1,525,262 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	27,932,350 - 27,957,431 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	29,342,495 - 29,367,865 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	29,342,495 - 29,367,865 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	29,182,723 - 29,208,144 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	28,836,004 - 28,860,967 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	27,691,761 - 27,716,918 (-)	NCBI		Celera
RGSC_v3.1	10	28,837,052 - 28,862,016 (-)	NCBI
Cytogenetic Map	10	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

enzyme inhibitor (ISO)

finasteride (EXP)

flutamide (EXP)

FR900359 (ISO)

hypochlorous acid (ISO)

ivermectin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methoxychlor (EXP)

nefazodone (EXP)

nitrates (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of neuroinflammatory response (ISO)

Cellular Component

cytosol (ISO)

Molecular Function

protein binding (IPI,ISO)

protein-macromolecule adaptor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity.	Ligon LA, etal., J Biol Chem. 2004 Apr 30;279(18):19201-8. Epub 2004 Feb 24.
2.	Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras.	Marty C, etal., Mol Cell Biol 2003 Jun;23(11):3847-58.
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:21525035

Genomics

Comparative Map Data

Ttc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	28,703,763 - 28,728,910 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	28,703,769 - 28,728,882 (-)	Ensembl				GRCr8
mRatBN7.2	10	28,202,325 - 28,227,464 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	28,202,325 - 28,227,472 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	32,961,807 - 32,986,888 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	1,500,181 - 1,525,262 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	27,932,350 - 27,957,431 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	29,342,495 - 29,367,865 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	29,342,495 - 29,367,865 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	29,182,723 - 29,208,144 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	28,836,004 - 28,860,967 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	27,691,761 - 27,716,918 (-)	NCBI		Celera
RGSC_v3.1	10	28,837,052 - 28,862,016 (-)	NCBI
Cytogenetic Map	10	q21	NCBI

TTC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	160,009,139 - 160,065,543 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	160,009,100 - 160,065,550 (+)	Ensembl			hg38	GRCh38
GRCh37	5	159,436,146 - 159,492,550 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	159,368,758 - 159,425,128 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	159,368,757 - 159,425,128	NCBI
Celera	5	155,467,734 - 155,524,106 (+)	NCBI		Celera
Cytogenetic Map	5	q33.3	NCBI
HuRef	5	154,530,645 - 154,586,936 (+)	NCBI		HuRef
CHM1_1	5	158,869,248 - 158,925,563 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	160,537,708 - 160,594,091 (+)	NCBI		T2T-CHM13v2.0

Ttc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	43,620,833 - 43,638,835 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	43,620,339 - 43,638,835 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	43,730,006 - 43,748,008 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	43,729,512 - 43,748,008 (-)	Ensembl			mm10	GRCm38
MGSCv37	11	43,543,508 - 43,561,475 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	43,573,429 - 43,591,396 (-)	NCBI		MGSCv36	mm8
Celera	11	48,356,243 - 48,374,211 (-)	NCBI		Celera
Cytogenetic Map	11	B1.1	NCBI
cM Map	11	25.81	NCBI

Ttc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	13,966,821 - 14,007,238 (+)	Ensembl
ChiLan1.0	NW_004955408	13,966,957 - 14,007,238 (+)	NCBI	ChiLan1.0	ChiLan1.0

TTC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	155,194,236 - 155,250,926 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	153,333,784 - 153,390,474 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	155,399,781 - 155,456,454 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	162,015,981 - 162,072,884 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	162,015,845 - 162,072,884 (+)	Ensembl			panPan2	panpan1.1

TTC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	50,603,649 - 50,650,470 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	50,603,650 - 50,650,358 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	50,497,755 - 50,544,559 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	51,038,378 - 51,085,271 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	51,038,378 - 51,084,834 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	50,846,846 - 50,893,426 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	50,969,971 - 51,016,779 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	51,490,523 - 51,537,395 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ttc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	104,993,600 - 105,042,248 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936515	3,442,950 - 3,491,596 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936515	3,442,946 - 3,491,566 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TTC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	63,455,734 - 63,523,354 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	63,458,350 - 63,515,517 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	68,949,772 - 69,028,497 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TTC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	62,375,085 - 62,431,062 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	62,375,150 - 62,430,583 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	15,177,065 - 15,233,405 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ttc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	29,452,765 - 29,502,588 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	29,443,789 - 29,502,702 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ttc1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	26,570,807 - 26,595,328 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ttc1
232 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	293
Count of miRNA genes:	182
Interacting mature miRNAs:	214
Transcripts:	ENSRNOT00000005304
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15776754	60776754	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	27443787	72443787	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5893811	50893811	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5893811	50893811	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	14653541	59653541	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24662123	73695339	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6877142	51877142	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	27023535	61843633	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35730538	Rat
7387235	Uae41	Urinary albumin excretion QTL 41	5.26	0.1874	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	1	30004247	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	19939207	64939207	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	18035782	63035782	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	922197	45922197	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	2103708	47103708	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5893811	50893811	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	16175525	61175525	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	20110614	65110614	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38832698	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21833758	61843633	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	10	23422121	32490778	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6661118	35509383	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	18035782	63035782	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	27443787	72443787	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	27443787	72443787	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	20110614	65110614	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

BI294827

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	28,225,539 - 28,225,725 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	29,365,706 - 29,365,891	NCBI	Rnor6.0
Rnor_5.0	10	29,205,934 - 29,206,119	UniSTS	Rnor5.0
RGSC_v3.4	10	28,859,077 - 28,859,262	UniSTS	RGSC3.4
Celera	10	27,714,973 - 27,715,158	UniSTS
RH 3.4 Map	10	297.4	UniSTS
Cytogenetic Map	10	q21	UniSTS

RH132376

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	28,202,436 - 28,202,646 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	29,342,607 - 29,342,816	NCBI	Rnor6.0
Rnor_5.0	10	29,182,835 - 29,183,044	UniSTS	Rnor5.0
RGSC_v3.4	10	28,836,116 - 28,836,325	UniSTS	RGSC3.4
Celera	10	27,691,873 - 27,692,082	UniSTS
RH 3.4 Map	10	296.9	UniSTS
Cytogenetic Map	10	q21	UniSTS

RH139190

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	28,202,436 - 28,202,556 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	29,342,607 - 29,342,726	NCBI	Rnor6.0
Rnor_5.0	10	29,182,835 - 29,182,954	UniSTS	Rnor5.0
RGSC_v3.4	10	28,836,116 - 28,836,235	UniSTS	RGSC3.4
Celera	10	27,691,873 - 27,691,992	UniSTS
RH 3.4 Map	10	295.1	UniSTS
Cytogenetic Map	10	q21	UniSTS

AU048871

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	28,209,012 - 28,209,335 (+)	MAPPER	mRatBN7.2
mRatBN7.2	10	28,209,012 - 28,209,173 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	29,349,183 - 29,349,341	NCBI	Rnor6.0
Rnor_6.0	10	29,349,183 - 29,349,503	NCBI	Rnor6.0
Rnor_5.0	10	29,189,411 - 29,189,569	UniSTS	Rnor5.0
Rnor_5.0	10	29,189,411 - 29,189,731	UniSTS	Rnor5.0
RGSC_v3.4	10	28,842,692 - 28,842,874	UniSTS	RGSC3.4
Celera	10	27,698,450 - 27,698,770	UniSTS
Celera	10	27,698,450 - 27,698,608	UniSTS
Cytogenetic Map	10	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC082093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005304 ⟹ ENSRNOP00000005304

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	28,703,769 - 28,728,882 (-)	Ensembl
mRatBN7.2 Ensembl	10	28,202,325 - 28,227,472 (-)	Ensembl
Rnor_6.0 Ensembl	10	29,342,495 - 29,367,865 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118530 ⟹ ENSRNOP00000090869

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	28,703,769 - 28,728,882 (-)	Ensembl
mRatBN7.2 Ensembl	10	28,202,328 - 28,227,457 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000158352 ⟹ ENSRNOP00000100596

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	28,709,000 - 28,728,882 (-)	Ensembl

RefSeq Acc Id:

NM_001005529 ⟹ NP_001005529

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	28,703,763 - 28,728,865 (-)	NCBI
mRatBN7.2	10	28,202,325 - 28,227,431 (-)	NCBI
Rnor_6.0	10	29,342,495 - 29,367,865 (-)	NCBI
Rnor_5.0	10	29,182,723 - 29,208,144 (-)	NCBI
RGSC_v3.4	10	28,836,004 - 28,860,967 (-)	RGD
Celera	10	27,691,761 - 27,716,918 (-)	RGD

Sequence:

show sequence

CGAGCGGTGGAGAGCGAAACTGGGGGTCTCGGAGACCGTCGTGGGTCTCGCGGCGCAAGACATT
TAGCCGCACCTCCCTCCCTGATCTCAGCATGGAGGGAAAGTCTGAAGACTGTAAGGTTCCAGAA
GATCTGTTCAATGGTCTGAAAGTCACAGATTCTCAAGAAACAGAGTCTGCTAGCTCCCTGGTTT
CTGATCCGAAAGATCAGCATGTCCAGAGCAAGCCACTGAAGGATGCTGAAGCCCATCCCCAGGA
AGACCATGGAGAAGAGGAATGTTTTCATGACTGTAGTGCCTCCTTTGAGGAGGAACAGCCAGGG
GCACATATGGCCGGGGACAAAGCCAGCGACGAGTCTAGTTCTGAACTGGAGGAAGAATACCTAA
TTGAACTGGAAAAAAACATGCCAGAAGAAGAGAAACAGAAAAGAAGAGAAGAGAGCGCTAAACT
AAAGGAGGAGGGGAATGAGCAGTTTAAGAGAGGAGATTATGTGGAAGCTGAGAGTTCTTACAGT
CAAGCCCTTCAGATGTGCCCGGCCTGTTTCCAGAAAGATCGATCTGTTCTGTTTTCAAATAGAG
CTGCTGCAAGGATGAAACAGGACAAGAAGGAGATGGCCATTACTGACTGCAGCAAAGCCATTCA
GTTAAATCCTACCTACATCCGTGCGATACTGCGGAGAGCTGAGTTGTATGAGAAAACAGACAAA
CTGGATGAAGCACTGGAAGATTATAAATCAATATTAGAAACAGACCCGTCAGTCCATCAAGCGA
GAGAAGCTTGTGTGAGATTACCTAAGCAAATTGAAGAACGTAATGAAAGATTAAAGGAAGAGAT
GTTAGGTAAACTAAAAGATCTTGGCAACTTGGTTCTGCGACCTTTTGGGCTCTCCACAGAAAAT
TTCCAGATCAAGCAGGATTCTTCTACTGGCTCCTATTCCATCAATTTTGTTCAAAATCCAAATA
ATAATAGATAACAAATAACAGTAGTCCTAAAGGCTGACTGGGAGGCCATGAGCGGTTCACAGCG
AGCATGCTCTGCAGGTGTTCAGTGTAAAAGCATCTTATCTAAATAGACTATGCAGTAGAACCAG
AGCCGCCCGCCTTCTTGCTCTTGTTTTATGATCAGGGTGGAATGTGCGTCCTGATGTGATGAGC
CTCATTAAGTTCCATTTTAAGGTGGTGTCTGTGCAGCTGTTGTCCCTGGTTCTGGCTGTTCTTT
GTCTGATGGAGAAGCCTGCTTGTCAAAGCTGACCTCTTGGAGCCACACAAATGTGCTAGCCACC
AAAAACCTCCCCTAACCATGTAAGCCTGTCAGTTGAGTGGTGACCATTCATACTGGACAGGGCC
CCTCCTGCTCACACTCGCTCAGATGCTGCAGGGCAGGGCTTCAGCAGGCTTTTGAGTTCCTCTG
TGTCAATAAAAACATCCCGTGACAGTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039085372 ⟹ XP_038941300

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	28,704,240 - 28,728,910 (-)	NCBI
mRatBN7.2	10	28,202,325 - 28,227,438 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001005529	(Get FASTA)	NCBI Sequence Viewer
	XP_038941300	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82093	(Get FASTA)	NCBI Sequence Viewer
	EDM04141	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005304
	ENSRNOP00000005304.3
	ENSRNOP00000090869.1
	ENSRNOP00000100596.1

RefSeq Acc Id:

NP_001005529 ⟸ NM_001005529

- UniProtKB:

Q66H09 (UniProtKB/TrEMBL), F7ER79 (UniProtKB/TrEMBL), A0A8I6AEL9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGKSEDCKVPEDLFNGLKVTDSQETESASSLVSDPKDQHVQSKPLKDAEAHPQEDHGEEECFH
DCSASFEEEQPGAHMAGDKASDESSSELEEEYLIELEKNMPEEEKQKRREESAKLKEEGNEQFK
RGDYVEAESSYSQALQMCPACFQKDRSVLFSNRAAARMKQDKKEMAITDCSKAIQLNPTYIRAI
LRRAELYEKTDKLDEALEDYKSILETDPSVHQAREACVRLPKQIEERNERLKEEMLGKLKDLGN
LVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR

hide sequence

Ensembl Acc Id:

ENSRNOP00000005304 ⟸ ENSRNOT00000005304

RefSeq Acc Id:	XP_038941300 ⟸ XM_039085372
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000090869 ⟸ ENSRNOT00000118530

Ensembl Acc Id:

ENSRNOP00000100596 ⟸ ENSRNOT00000158352

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66H09-F1-model_v2	AlphaFold	Q66H09	1-292	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697118

Promoter ID:

EPDNEW_R7642

Type:

multiple initiation site

Name:

Ttc1_1

Description:

tetratricopeptide repeat domain 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	29,367,882 - 29,367,942	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359604	AgrOrtholog
BioCyc Gene	G2FUF-25439	BioCyc
Ensembl Genes	ENSRNOG00000003980	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005304	ENTREZGENE
	ENSRNOT00000005304.7	UniProtKB/TrEMBL
	ENSRNOT00000118530.2	UniProtKB/TrEMBL
	ENSRNOT00000158352.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7134129	IMAGE-MGC_LOAD
InterPro	TPR-like_helical	UniProtKB/TrEMBL
	TPR_domain_protein	UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/TrEMBL
KEGG Report	rno:287208	UniProtKB/TrEMBL
MGC_CLONE	MGC:95276	IMAGE-MGC_LOAD
NCBI Gene	287208	ENTREZGENE
PANTHER	TETRATRICOPEPTIDE REPEAT PROTEIN 1	UniProtKB/TrEMBL
	TETRATRICOPEPTIDE REPEAT PROTEIN 1	UniProtKB/TrEMBL
Pfam	TPR_1	UniProtKB/TrEMBL
	TPR_8	UniProtKB/TrEMBL
PhenoGen	Ttc1	PhenoGen
PROSITE	TPR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003980	RatGTEx
SMART	TPR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48452	UniProtKB/TrEMBL
UniProt	A0A8I6AEL9	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LFF9_RAT	UniProtKB/TrEMBL
	F7ER79	ENTREZGENE, UniProtKB/TrEMBL
	Q66H09	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Ttc1	tetratricopeptide repeat domain 1			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Ttc1	tetratricopeptide repeat domain 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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