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Gene: Nuak2 (NUAK family kinase 2) Rattus norvegicus

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Symbol:

Nuak2

Name:

NUAK family kinase 2

RGD ID:

1359167

Description:

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in cellular response to glucose starvation and protein phosphorylation. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

1200013b22rik; MGC93817; NUAK family SNF1-like kinase 2; NUAK family, SNF1-like kinase, 2; Snark; SNF1/AMP kinase-related kinase; SNF1/AMP-activated protein kinase; UV126

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NUAK2 (NUAK family kinase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Nuak2 (NUAK family, SNF1-like kinase, 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nuak2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NUAK2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NUAK2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nuak2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NUAK2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NUAK2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nuak2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Nuak2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Nuak2 (NUAK family, SNF1-like kinase, 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NUAK2 (NUAK family kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nuak2 (NUAK family, SNF1-like kinase, 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG43143	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG43143	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Caenorhabditis elegans (roundworm):	unc-82	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	unc-82	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	KIN4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Saccharomyces cerevisiae (baker's yeast):	FRK1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	nuak2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	nuak2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	46,305,744 - 46,322,755 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	46,305,975 - 46,322,748 (+)	Ensembl				GRCr8
mRatBN7.2	13	43,753,454 - 43,770,604 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	43,753,832 - 43,770,604 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	46,360,867 - 46,377,614 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	47,649,007 - 47,665,754 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	PNS010002779.1	3,843 - 20,310 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	49,092,306 - 49,109,055 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	49,092,306 - 49,109,050 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	54,159,277 - 54,177,744 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	45,205,573 - 45,222,322 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	44,088,713 - 44,105,461 (+)	NCBI		Celera
RGSC_v3.1	13	45,219,615 - 45,236,360 (+)	NCBI
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Anencephaly 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

DDE (ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

dibenz[a,h]anthracene (ISO)

dichloroacetic acid (ISO)

diquat (ISO)

fenamidone (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

graphite (EXP)

indole-3-methanol (EXP)

lead diacetate (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

methotrexate (ISO)

methoxychlor (EXP)

N,N-diethyl-m-toluamide (EXP)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

panobinostat (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

pirinixic acid (ISO)

poly(vinylpyrrolidone) (EXP)

potassium chromate (ISO)

propiconazole (ISO)

quercitrin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

Salinomycin (ISO)

silicon dioxide (ISO)

silver atom (EXP,ISO)

silver(0) (EXP,ISO)

sodium arsenite (ISO)

Soman (EXP)

succimer (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO,ISS)

apoptotic process (IEA)

cellular response to glucose starvation (IBA,IDA,IEA,ISO)

negative regulation of apoptotic process (IEA,ISO,ISS)

protein localization to nucleus (IEA,ISO,ISS)

protein phosphorylation (IDA,ISO)

regulation of hippo signaling (IEA,ISO,ISS)

Cellular Component

nuclear speck (ISO)

Molecular Function

ATP binding (IDA,IEA,ISO)

kinase activity (IEA)

magnesium ion binding (IDA,IEA,ISO)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IDA,IEA,ISO)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Regulation of SNARK activity in response to cellular stresses.	Lefebvre DL and Rosen CF, Biochim Biophys Acta. 2005 Jun 20;1724(1-2):71-85. Epub 2005 Apr 8.
3.	Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK.	Lefebvre DL, etal., Biochem J 2001 Apr 15;355(Pt 2):297-305.
4.	Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness.	Legembre P, etal., J Biol Chem 2004 Nov 5;279(45):46742-7. Epub 2004 Sep 3.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:14575707	PMID:14976552	PMID:15489334	PMID:19927127

Genomics

Comparative Map Data

Nuak2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	46,305,744 - 46,322,755 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	46,305,975 - 46,322,748 (+)	Ensembl				GRCr8
mRatBN7.2	13	43,753,454 - 43,770,604 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	43,753,832 - 43,770,604 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	46,360,867 - 46,377,614 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	47,649,007 - 47,665,754 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	PNS010002779.1	3,843 - 20,310 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	49,092,306 - 49,109,055 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	49,092,306 - 49,109,050 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	54,159,277 - 54,177,744 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	45,205,573 - 45,222,322 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	44,088,713 - 44,105,461 (+)	NCBI		Celera
RGSC_v3.1	13	45,219,615 - 45,236,360 (+)	NCBI
Cytogenetic Map	13	q13	NCBI

NUAK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	205,302,063 - 205,321,745 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	205,302,063 - 205,321,745 (-)	Ensembl			hg38	GRCh38
GRCh37	1	205,271,191 - 205,290,873 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	203,537,814 - 203,557,506 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	178,406,280 - 178,425,974 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	176,436,830 - 176,456,534 (-)	NCBI		HuRef
CHM1_1	1	206,694,514 - 206,714,205 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	204,566,371 - 204,586,053 (-)	NCBI		T2T-CHM13v2.0

Nuak2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	132,243,827 - 132,261,233 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	132,243,864 - 132,261,226 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	132,316,125 - 132,333,488 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	132,316,126 - 132,333,488 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	134,212,715 - 134,230,065 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	134,143,684 - 134,161,034 (+)	NCBI		MGSCv36	mm8
Celera	1	134,923,119 - 134,940,418 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	57.24	NCBI

Nuak2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	41,051,419 - 41,069,066 (-)	Ensembl
ChiLan1.0	NW_004955406	41,050,396 - 41,069,066 (-)	NCBI	ChiLan1.0	ChiLan1.0

NUAK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	44,047,631 - 44,067,821 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	44,012,907 - 44,033,088 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	180,910,956 - 180,931,147 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	185,197,675 - 185,217,264 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	185,197,678 - 185,217,264 (-)	Ensembl			panPan2	panpan1.1

NUAK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	1,797,899 - 1,816,087 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	1,798,802 - 1,816,185 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	1,891,562 - 1,909,750 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	1,794,369 - 1,812,549 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	1,795,278 - 1,812,621 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	1,790,360 - 1,808,543 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	2,181,580 - 2,199,756 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	2,381,515 - 2,399,704 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Nuak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	69,839,564 - 69,864,148 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	7,085,719 - 7,104,443 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	7,085,777 - 7,104,430 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NUAK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	65,980,041 - 66,001,764 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	65,980,035 - 66,001,665 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	72,201,232 - 72,222,949 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NUAK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	24,016,909 - 24,036,640 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	24,016,930 - 24,036,641 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	24,716,229 - 24,735,961 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nuak2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	5,850,600 - 5,869,547 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624807	5,850,857 - 5,869,284 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Nuak2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	3,513,628 - 3,529,879 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Nuak2
52 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	87
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000000039
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
6893344	Cm79	Cardiac mass QTL 79	1.5	0.04	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	46272922	51216694	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
2303032	Bp328	Blood pressure QTL 328			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	43736327	47969993	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
4145117	Mcs27	Mammary carcinoma susceptibility QTL 27		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	13	45990077	50392939	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Markers in Region

D13Hmgc64

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	43,763,752 - 43,763,948 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	49,102,205 - 49,102,400	NCBI	Rnor6.0
Rnor_5.0	13	54,170,894 - 54,171,089	UniSTS	Rnor5.0
RGSC_v3.4	13	45,215,472 - 45,215,667	UniSTS	RGSC3.4
Celera	13	44,098,614 - 44,098,806	UniSTS
Cytogenetic Map	13	q13	UniSTS

RH127904

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	43,770,170 - 43,770,390 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	49,108,622 - 49,108,841	NCBI	Rnor6.0
Rnor_5.0	13	54,177,311 - 54,177,530	UniSTS	Rnor5.0
RGSC_v3.4	13	45,221,889 - 45,222,108	UniSTS	RGSC3.4
Celera	13	44,105,028 - 44,105,247	UniSTS
Cytogenetic Map	13	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U12530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000039 ⟹ ENSRNOP00000000039

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	46,305,975 - 46,322,748 (+)	Ensembl
mRatBN7.2 Ensembl	13	43,753,832 - 43,770,604 (+)	Ensembl
Rnor_6.0 Ensembl	13	49,092,306 - 49,109,050 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109571 ⟹ ENSRNOP00000096256

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	46,305,975 - 46,322,748 (+)	Ensembl
mRatBN7.2 Ensembl	13	43,753,832 - 43,770,604 (+)	Ensembl

RefSeq Acc Id:

NM_001007617 ⟹ NP_001007618

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	46,306,006 - 46,322,755 (+)	NCBI
mRatBN7.2	13	43,753,854 - 43,770,604 (+)	NCBI
Rnor_6.0	13	49,092,306 - 49,109,055 (+)	NCBI
Rnor_5.0	13	54,159,277 - 54,177,744 (+)	NCBI
RGSC_v3.4	13	45,205,573 - 45,222,322 (+)	RGD
Celera	13	44,088,713 - 44,105,461 (+)	RGD

Sequence:

show sequence

GACCTCTGAGCCTGCGGCTCTCCGCGCGCTGCTGCTGCTGCCCGACCCCCTCCGCCTCGCCGTC
CCCGCACCATGGAGTCGGTGGCCTTACACCGGCGCGGGAACCTGGCTCCCTCGGCCTCCGCCCT
GGCCACGGAGAGCGCCCGGCCGCTGGCGGACCGGCTCATCAAGTCGCCCAAACCTCTGATGAAG
AAGCAGGCGGTGAAGCGGCACCATCACAAACACAACCTGAGGCACCGCTACGAGTTCCTGGAGA
CCCTGGGCAAGGGCACCTACGGGAAGGTGAAGAAAGCACGAGAGAGCTCGGGACGCCTGGTGGC
CATCAAGTCTATCAGGAAGGACAAAATCAAAGATGAGCAGGATCTGTTGCACATAAGGAGGGAG
ATCGAGATCATGTCTTCACTCAACCACCCCCACATCATTGCCATCCATGAAGTGTTTGAGAACA
GCAGCAAGATTGTGATTGTCATGGAGTACGCCAGCCGAGGCGATCTGTACGATTACATCAGTGA
GCGGCCACGGCTGAATGAGCGGGACGCCAGGCATTTCTTCCGACAGATCGTGTCCGCCCTGCAC
TACTGCCACCAGAACGGGATTGTTCACCGGGACCTCAAGCTGGAGAACATCCTTCTAGATGCCA
GTGGCAACATCAAGATTGCTGATTTTGGCCTCTCCAACCTGTATCACAAAGGCAAGTTCCTCCA
GACGTTCTGTGGGAGCCCTCTCTATGCCTCACCTGAGATCGTCAACGGGAAGCCCTATGTGGGC
CCAGAGGTGGACAGCTGGTCTCTGGGCGTTCTTCTGTACATCCTGGTGCATGGCACCATGCCCT
TTGACGGGCAGGATCATAAAACCCTGGTGAAACAAATCAGTAGCGGGGCTTACCGAGAGCCGTG
CAAACCGTCTGATGCCTGTGGCCTGATCCGGTGGCTGTTAATGGTGAATCCCATCCGTCGGGCC
ACTCTGGAGGATGTAGCCAGTCATTGGTGGGTCAACTGGGGTTACAGCACCCGAATTGGGGAAC
AGGAAGCTCTGCGAGAGGGTGGGCACCCTAGCGGTGACTCTGGCCGGGCCTCTATGGCGGACTG
GTTACGTCGCTCCTCCCGCCCCCTCCTGGAGAATGGAGCCAAAGTGTGTAGCTTCTTCAAGCAG
CATGTGCCGGGAGGTGGAAGCACGGGACCGGGGCTGGAGCGGCAACATTCTCTTAAGAAGTCCC
GCAAGGAGAATGACATGGCTCAGACTCTGCAGAATGACCCAGCTGAAGATACTTCCTCTCGCCC
TGGCAAGAACAGCCTCAAGCTTCCGAAAGGTATCCTCAAGAAAAAGGCCTCTCCCTCATCGGGG
GAGGTACAGGAGGGCCCTCAGGAACTCAGACCAGTGTCCAATACCCCAGGGCAGCCTGTCCCTG
CTATACCCCTGCTCCCAAGGAAGGGCATTCTTAAGAAGTCTCGGCAGCGTGAATCTGGTTACTA
CTCCTCTCCAGAGCCCAGTGAGTCTGGGGAACTCTTAGACGCAGGTGATGTGTTTGTGAGTGGG
GACCCCATGGAGCAGAAGTCTCCACAAGCTTCAGGGCGCCTCCATCGCAAGGGCATCCTCAAAC
TCAATGGCAAGTTTTCCCGCACAGCCTTAGAAGGCACTGCCCCTAGCACCTTTGGCTCCCTAGA
CCAACTGGCCTCCCCTCATCCTACAGCCCGGGCCAGCCGTCCCTCGGGAGCTGTGAGTGAGGAC
AGCATCCTGTCCTCCGAGTCCTTTGACCAATTGGACTTGCCCGAGCGGCTTCCCGAAACCCCAC
TGAGGGGCTGTGTGTCTGTGGACAACCTGAGGAGGCTTGAGCAGCCTCCCTCAGAAGGCCTAAA
ACGATGGTGGCAGGAATCCTTGGGGGATAGCTGCTTTTCTCTGACAGACTGCCAAGAGGTGACA
GCAGCCTACAGACAAGCCCTAGGAATCTGCTCGAAGCTCAGCTGAGGAGGAGAGGCAGTGCCCC
AGTGATGGGGTAGACTCTGAGAGGGGTTTGCAGAGGAACCCTGGGTAGGATTCCCCAGGGGAGT
AGAGTACATCAAGAACTCTCTCTCTGTCTTCAGCCTGATTGAACCTGGAGGCTGAGAGAAATAG
CAGAGATATGGAAAGGACTGACCTACAGAGTCCTGACTGCCAGAATGTTCAAGCGGGGCCACAG
AGACCTGAAAGTGCCTACCTCCTTTATGCTGAGTGCTACCCATGGCATCTCCCCCCTGCTCTCT
GCCAGTGTCAGGGTGTACCCACATAAGTTCCTGTTCGCATCGACCACCAGGGTTAGAACCCTGA
CATCCCTGGAAGTAATGTGGAGCAACCTCGCTTATTTAAAGAGGAAACAGCCTCTGGTTTCCAT
CTCTGCTGCTGTGCATCTCAAAGACCTAGAAAGACTCAACTGCTGTTTCACTTCATCTCAAGGG
GACCTCAGAGACCTGAGCCTTGAAGCTGTTCCTGATAACCAGACTATGATGGATATGTCTGTTT
CTCAGGCCAGCAGGACCCAGAATGTGCTGACTTATTTATTTTTGTGATTCTCACTTCTGGTTTC
TGTTTCGTTTTTTCTGTTGTTGGTTTTGTTGTTGTCGTTTGTTTCTTGTTTTTTGTTTGTTTGT
TTGTTTTTTAAAGTGAATTTTGCTGCTTTCGGTAATGTGAATGCTGTGTTCTGGGGAAAGCCAC
TGTGTCATTGAAGTGTGTGTACAGAGAAGTATTTGGCAGTGATTCCTTCTAATGGGGGGTGGCT
TTTTCAGATGTATGTCTTGAGCACTGTCTGGATTGGGTCTCCTGTCCCCTCACACCAGAGGCTG
TCCACCCTCCCTCATCTGTGGCCAAAAAAAACCTCATTAAAACCAGCAACGGCAACTGGAAAAA
AAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039090614 ⟹ XP_038946542

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	46,305,744 - 46,322,755 (+)	NCBI
mRatBN7.2	13	43,753,454 - 43,770,604 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001007618	(Get FASTA)	NCBI Sequence Viewer
	XP_038946542	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81899	(Get FASTA)	NCBI Sequence Viewer
	EDM09799	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000039
	ENSRNOP00000000039.2
GenBank Protein	Q66HE5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001007618 ⟸ NM_001007617

- UniProtKB:

Q66HE5 (UniProtKB/Swiss-Prot), A6IC48 (UniProtKB/TrEMBL), A0A8I6AQK6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESVALHRRGNLAPSASALATESARPLADRLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLG
KGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVFENSSK
IVIVMEYASRGDLYDYISERPRLNERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDASGN
IKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPFDG
QDHKTLVKQISSGAYREPCKPSDACGLIRWLLMVNPIRRATLEDVASHWWVNWGYSTRIGEQEA
LREGGHPSGDSGRASMADWLRRSSRPLLENGAKVCSFFKQHVPGGGSTGPGLERQHSLKKSRKE
NDMAQTLQNDPAEDTSSRPGKNSLKLPKGILKKKASPSSGEVQEGPQELRPVSNTPGQPVPAIP
LLPRKGILKKSRQRESGYYSSPEPSESGELLDAGDVFVSGDPMEQKSPQASGRLHRKGILKLNG
KFSRTALEGTAPSTFGSLDQLASPHPTARASRPSGAVSEDSILSSESFDQLDLPERLPETPLRG
CVSVDNLRRLEQPPSEGLKRWWQESLGDSCFSLTDCQEVTAAYRQALGICSKLS

hide sequence

Ensembl Acc Id:

ENSRNOP00000000039 ⟸ ENSRNOT00000000039

RefSeq Acc Id:	XP_038946542 ⟸ XM_039090614
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000096256 ⟸ ENSRNOT00000109571

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66HE5-F1-model_v2	AlphaFold	Q66HE5	1-630	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698812

Promoter ID:

EPDNEW_R9335

Type:

multiple initiation site

Name:

Nuak2_1

Description:

NUAK family kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	49,092,285 - 49,092,345	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359167	AgrOrtholog
BioCyc Gene	G2FUF-18321	BioCyc
Ensembl Genes	ENSRNOG00000000034	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000000039	ENTREZGENE
	ENSRNOT00000000039.4	UniProtKB/Swiss-Prot
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7110518	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
KEGG Report	rno:289419	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93817	IMAGE-MGC_LOAD
NCBI Gene	289419	ENTREZGENE
PANTHER	MAP/MICROTUBULE AFFINITY-REGULATING KINASE	UniProtKB/Swiss-Prot
	NUAK FAMILY SNF1-LIKE KINASE 1	UniProtKB/Swiss-Prot
Pfam	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Nuak2	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000034	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A8I6AQK6	ENTREZGENE, UniProtKB/TrEMBL
	A6IC48	ENTREZGENE, UniProtKB/TrEMBL
	NUAK2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-17	Nuak2	NUAK family kinase 2	Nuak2	NUAK family, SNF1-like kinase, 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Nuak2	NUAK family, SNF1-like kinase, 2	1200013b22rik	SNF1/AMP-activated protein kinase	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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