Nms (neuromedin S) - Rat Genome Database

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Gene: Nms (neuromedin S) Rattus norvegicus
Analyze
Symbol: Nms
Name: neuromedin S
RGD ID: 1359122
Description: Enables G protein-coupled receptor binding activity. Acts upstream of or within locomotor rhythm and neuropeptide signaling pathway. Predicted to be located in extracellular region. Orthologous to human NMS (neuromedin S); INTERACTS WITH 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 1,2-dichloroethane (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neuromedin S precursor-related peptide/neuromedin S preproprotein; neuromedin-S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8948,665,398 - 48,676,461 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl948,665,398 - 48,676,461 (+)EnsemblGRCr8
mRatBN7.2941,169,634 - 41,180,697 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,169,634 - 41,180,697 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx949,664,032 - 49,675,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0954,786,779 - 54,797,864 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0953,070,395 - 53,081,460 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0945,605,552 - 45,616,912 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl945,605,552 - 45,616,912 (+)Ensemblrn6Rnor6.0
Rnor_5.0945,297,127 - 45,332,636 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4937,928,612 - 37,937,018 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera938,920,516 - 38,931,181 (+)NCBICelera
RGSC_v3.1937,930,025 - 37,938,432 (+)NCBI
Cytogenetic Map9q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. Mori K, etal., EMBO J 2005 Jan 26;24(2):325-35. Epub 2005 Jan 6.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15976061   PMID:17110433   PMID:17611645   PMID:17870195   PMID:17900576   PMID:18675786   PMID:26826380   PMID:28874765  


Genomics

Comparative Map Data
Nms
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8948,665,398 - 48,676,461 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl948,665,398 - 48,676,461 (+)EnsemblGRCr8
mRatBN7.2941,169,634 - 41,180,697 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,169,634 - 41,180,697 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx949,664,032 - 49,675,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0954,786,779 - 54,797,864 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0953,070,395 - 53,081,460 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0945,605,552 - 45,616,912 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl945,605,552 - 45,616,912 (+)Ensemblrn6Rnor6.0
Rnor_5.0945,297,127 - 45,332,636 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4937,928,612 - 37,937,018 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera938,920,516 - 38,931,181 (+)NCBICelera
RGSC_v3.1937,930,025 - 37,938,432 (+)NCBI
Cytogenetic Map9q22NCBI
NMS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382100,470,482 - 100,483,280 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2100,470,482 - 100,483,280 (+)Ensemblhg38GRCh38
GRCh372101,086,944 - 101,099,742 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362100,453,376 - 100,466,174 (+)NCBIBuild 36Build 36hg18NCBI36
Celera295,291,564 - 95,304,362 (+)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef294,851,668 - 94,864,466 (+)NCBIHuRef
CHM1_12101,091,283 - 101,104,081 (+)NCBICHM1_1
T2T-CHM13v2.02100,929,252 - 100,942,050 (+)NCBIT2T-CHM13v2.0
Nms
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39138,978,230 - 38,989,357 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl138,978,230 - 38,989,357 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38138,939,149 - 38,950,276 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl138,939,149 - 38,950,276 (+)Ensemblmm10GRCm38
MGSCv37138,995,994 - 39,007,121 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36138,883,695 - 38,894,824 (+)NCBIMGSCv36mm8
Celera138,728,328 - 38,739,541 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map117.31NCBI
Nms
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554706,505,345 - 6,516,957 (+)Ensembl
ChiLan1.0NW_0049554706,505,345 - 6,516,964 (+)NCBIChiLan1.0ChiLan1.0
NMS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,742,873 - 27,756,036 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A27,745,634 - 27,758,797 (-)NCBINHGRI_mPanPan1
PanPan1.12A101,451,547 - 101,464,367 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A101,451,548 - 101,462,229 (+)EnsemblpanPan2panpan1.1
NMS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11042,260,542 - 42,310,397 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1042,260,540 - 42,274,613 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1042,184,027 - 42,233,831 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01043,126,905 - 43,176,920 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1043,126,855 - 43,140,936 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11042,854,986 - 42,899,578 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01043,122,387 - 43,171,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01043,313,604 - 43,363,080 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nms
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629286,076,039 - 86,090,568 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936661479,838 - 493,365 (-)EnsemblSpeTri2.0 Ensembl
NMS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1353,747,549 - 53,763,396 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2356,336,666 - 56,352,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NMS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1144,200,756 - 4,214,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041171,818,437 - 171,830,449 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nms
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247495,331,095 - 5,342,894 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247495,294,551 - 5,342,904 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nms
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14115,139,414 - 115,150,288 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nms
78 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:45
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000059587
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
sensory system
visual system
1 1 45 3 4 1 15 1 18 16 45 24 3 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000059587   ⟹   ENSRNOP00000056345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl948,665,398 - 48,676,461 (+)Ensembl
mRatBN7.2 Ensembl941,169,634 - 41,180,697 (+)Ensembl
Rnor_6.0 Ensembl945,605,552 - 45,616,912 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149399   ⟹   ENSRNOP00000111288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl948,665,398 - 48,674,934 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157217   ⟹   ENSRNOP00000101925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl948,665,398 - 48,674,934 (+)Ensembl
RefSeq Acc Id: NM_001012233   ⟹   NP_001012233
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8948,665,398 - 48,676,461 (+)NCBI
mRatBN7.2941,169,634 - 41,180,697 (+)NCBI
Rnor_6.0945,605,552 - 45,616,912 (+)NCBI
Rnor_5.0945,297,127 - 45,332,636 (+)NCBI
RGSC_v3.4937,928,612 - 37,937,018 (+)RGD
Celera938,920,516 - 38,931,181 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012233 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD89025 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056345
  ENSRNOP00000056345.2
GenBank Protein FAA01229 (Get FASTA)   NCBI Sequence Viewer  
  Q5H8A2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012233   ⟸   NM_001012233
- Peptide Label: precursor
- UniProtKB: Q5H8A2 (UniProtKB/Swiss-Prot),   A0A250SHJ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056345   ⟸   ENSRNOT00000059587
Ensembl Acc Id: ENSRNOP00000111288   ⟸   ENSRNOT00000149399
Ensembl Acc Id: ENSRNOP00000101925   ⟸   ENSRNOT00000157217

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5H8A2-F1-model_v2 AlphaFold Q5H8A2 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359122 AgrOrtholog
BioCyc Gene G2FUF-27760 BioCyc
Ensembl Genes ENSRNOG00000038979 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000059587 ENTREZGENE
  ENSRNOT00000059587.3 UniProtKB/Swiss-Prot
InterPro Neuromedin-U_amidation-site UniProtKB/Swiss-Prot
  NmS UniProtKB/Swiss-Prot
KEGG Report rno:497196 UniProtKB/Swiss-Prot
NCBI Gene 497196 ENTREZGENE
PANTHER NEUROMEDIN-S UniProtKB/Swiss-Prot
  PTHR32414 UniProtKB/Swiss-Prot
PhenoGen Nms PhenoGen
PROSITE NMU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000038979 RatGTEx
UniProt A0A250SHJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LLQ8_RAT UniProtKB/TrEMBL
  A0ABK0M6B1_RAT UniProtKB/TrEMBL
  NMS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-02-03 Nms  neuromedin S  NMS  neuromedin S  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 NMS  neuromedin S      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction an endogenous ligand for the G protein-coupled receptor Nmur2/FM-4/TGR-1 which can also bind neuromedin U 1359746
gene_process intracerebroventricular administration activates SCN neurons and results in nonphotic type phase shifts in locomotor activity circadian rhythms 1359746
gene_regulation expression in the suprachiasmatic nuclei (SCN) of the hypothalamus shows a diurnal peak under light/dark cycling but remains constant under conditions of constant darkness 1359746