Stk4 (serine/threonine kinase 4) - Rat Genome Database

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Gene: Stk4 (serine/threonine kinase 4) Rattus norvegicus
Analyze
Symbol: Stk4
Name: serine/threonine kinase 4
RGD ID: 1312035
Description: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Involved in positive regulation of vascular associated smooth muscle cell apoptotic process. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human STK4 (serine/threonine kinase 4); PARTICIPATES IN mitogen activated protein kinase signaling pathway; non-small cell lung carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC311622; serine/threonine-protein kinase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,165,238 - 173,247,135 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,165,083 - 173,247,134 (+)EnsemblGRCr8
mRatBN7.23152,745,958 - 152,827,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,745,681 - 152,827,744 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3156,556,038 - 156,635,241 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,054,974 - 165,134,178 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,798,706 - 162,878,517 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,467,552 - 160,546,540 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,467,552 - 160,546,540 (+)Ensemblrn6Rnor6.0
Rnor_5.03166,652,145 - 166,731,213 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43155,014,941 - 155,095,272 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,397,134 - 151,475,844 (+)NCBICelera
RGSC_v3.13154,920,949 - 154,998,005 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
hydroxyurea  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
leptomycin B  (ISO)
Licochalcone A  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
XMU-MP-1  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
branching involved in blood vessel morphogenesis  (ISO)
canonical Wnt signaling pathway  (IEA)
cell differentiation involved in embryonic placenta development  (IEA,ISO)
cell morphogenesis  (ISO)
central nervous system development  (ISO)
endocardium development  (IEA,ISO)
epithelial cell proliferation  (IEA)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
hepatocyte apoptotic process  (IEA,ISO)
hippo signaling  (IEA,ISO)
intracellular signal transduction  (IBA,IEA,ISO)
keratinocyte differentiation  (ISO)
negative regulation of canonical Wnt signaling pathway  (IBA,IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (IEA)
negative regulation of organ growth  (IEA,ISO)
neural tube formation  (IEA,ISO)
organ growth  (IEA)
peptidyl-serine phosphorylation  (ISO)
positive regulation of apoptotic process  (IBA,IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of hippo signaling  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of substrate-dependent cell migration, cell attachment to substrate  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IMP)
primitive hemopoiesis  (IEA,ISO)
protein autophosphorylation  (ISO)
protein import into nucleus  (IEA,ISO)
protein phosphorylation  (ISO)
protein stabilization  (IEA,ISO)
protein tetramerization  (IEA)
regulation of cell differentiation involved in embryonic placenta development  (IEA,ISO)
regulation of MAPK cascade  (IBA)
signal transduction  (IEA)

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
nuclear body  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Immunohistochemical localization of apoptosome-related proteins in Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Kawamoto Y, etal., Brain Res. 2014 Jul 7;1571:39-48. doi: 10.1016/j.brainres.2014.05.007. Epub 2014 May 13.
4. MicroRNA-138 plays a role in hypoxic pulmonary vascular remodelling by targeting Mst1. Li S, etal., Biochem J. 2013 Jun 1;452(2):281-91. doi: 10.1042/BJ20120680.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8566796   PMID:8702870   PMID:9545236   PMID:11278283   PMID:11805089   PMID:12384512   PMID:12477932   PMID:15109305   PMID:15688006   PMID:16751106   PMID:16930133   PMID:17517604  
PMID:17932490   PMID:18328708   PMID:18369314   PMID:18986304   PMID:19073936   PMID:19525978   PMID:19786569   PMID:19962960   PMID:20080598   PMID:20080689   PMID:20412773   PMID:20562859  
PMID:21212262   PMID:21512132   PMID:22292086   PMID:23386615   PMID:24595170   PMID:31847471   PMID:32240614   PMID:33568044   PMID:34217161   PMID:35395037   PMID:38430683  


Genomics

Comparative Map Data
Stk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,165,238 - 173,247,135 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,165,083 - 173,247,134 (+)EnsemblGRCr8
mRatBN7.23152,745,958 - 152,827,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,745,681 - 152,827,744 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3156,556,038 - 156,635,241 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,054,974 - 165,134,178 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,798,706 - 162,878,517 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,467,552 - 160,546,540 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,467,552 - 160,546,540 (+)Ensemblrn6Rnor6.0
Rnor_5.03166,652,145 - 166,731,213 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43155,014,941 - 155,095,272 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,397,134 - 151,475,844 (+)NCBICelera
RGSC_v3.13154,920,949 - 154,998,005 (+)NCBI
Cytogenetic Map3q42NCBI
STK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382044,966,512 - 45,080,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2044,966,494 - 45,084,214 (+)Ensemblhg38GRCh38
GRCh372043,595,153 - 43,708,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,028,534 - 43,142,008 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342043,028,533 - 43,142,005NCBI
Celera2040,303,755 - 40,417,237 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,336,825 - 40,450,492 (+)NCBIHuRef
CHM1_12043,497,900 - 43,611,341 (+)NCBICHM1_1
T2T-CHM13v2.02046,702,402 - 46,815,925 (+)NCBIT2T-CHM13v2.0
Stk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,916,033 - 163,997,444 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2163,912,242 - 163,997,444 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382164,074,113 - 164,155,524 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,070,322 - 164,155,524 (+)Ensemblmm10GRCm38
MGSCv372163,899,914 - 163,981,257 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362163,765,619 - 163,846,962 (+)NCBIMGSCv36mm8
Celera2170,004,346 - 170,087,071 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.6NCBI
Stk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,308,285 - 12,399,012 (-)Ensembl
ChiLan1.0NW_00495544512,308,285 - 12,399,012 (-)NCBIChiLan1.0ChiLan1.0
STK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,699,610 - 50,812,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,692,724 - 50,806,027 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,297,157 - 41,410,487 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,389,611 - 42,503,014 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,389,615 - 42,503,014 (+)EnsemblpanPan2panpan1.1
STK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,375,630 - 32,463,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,375,189 - 32,521,042 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2432,021,037 - 32,109,251 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02433,086,419 - 33,174,685 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,086,465 - 33,231,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,347,829 - 32,432,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,462,830 - 32,551,067 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,004,538 - 33,092,881 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,233,117 - 192,331,335 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,686,087 - 7,785,025 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,686,760 - 7,784,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,387,600 - 47,475,718 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11747,387,594 - 47,475,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,912,419 - 52,932,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,737,484 - 18,844,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,742,162 - 18,844,647 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605067,388,889 - 67,493,337 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,415,177 - 9,521,051 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247909,415,172 - 9,521,103 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Stk4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15153,826,896 - 153,904,594 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:450
Count of miRNA genes:234
Interacting mature miRNAs:308
Transcripts:ENSRNOT00000066657
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
RH142266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23152,827,378 - 152,827,562 (+)MAPPERmRatBN7.2
Rnor_6.03160,546,175 - 160,546,358NCBIRnor6.0
Rnor_5.03166,730,845 - 166,731,028UniSTSRnor5.0
RGSC_v3.43155,094,907 - 155,095,090UniSTSRGSC3.4
Celera3151,475,479 - 151,475,662UniSTS
RH 3.4 Map31422.2UniSTS
Cytogenetic Map3q42UniSTS
BF388103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23152,810,385 - 152,810,583 (+)MAPPERmRatBN7.2
Rnor_6.03160,529,214 - 160,529,411NCBIRnor6.0
Rnor_5.03166,713,884 - 166,714,081UniSTSRnor5.0
RGSC_v3.43155,077,946 - 155,078,143UniSTSRGSC3.4
Celera3151,458,518 - 151,458,715UniSTS
RH 3.4 Map31422.2UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066657   ⟹   ENSRNOP00000061873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,172,900 - 173,247,134 (+)Ensembl
mRatBN7.2 Ensembl3152,753,508 - 152,827,744 (+)Ensembl
Rnor_6.0 Ensembl3160,467,552 - 160,546,540 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098768   ⟹   ENSRNOP00000076920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,176,694 - 173,247,134 (+)Ensembl
mRatBN7.2 Ensembl3152,753,173 - 152,827,744 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099516   ⟹   ENSRNOP00000078057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,165,083 - 173,247,134 (+)Ensembl
mRatBN7.2 Ensembl3152,748,585 - 152,827,744 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118925   ⟹   ENSRNOP00000084019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,167,969 - 173,247,134 (+)Ensembl
mRatBN7.2 Ensembl3152,745,681 - 152,827,744 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000172656   ⟹   ENSRNOP00000100296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,165,189 - 173,219,990 (+)Ensembl
RefSeq Acc Id: NM_001107800   ⟹   NP_001101270
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,167,992 - 173,247,132 (+)NCBI
mRatBN7.23152,748,600 - 152,827,744 (+)NCBI
Rnor_6.03160,467,552 - 160,546,540 (+)NCBI
Rnor_5.03166,652,145 - 166,731,213 (+)NCBI
RGSC_v3.43155,014,941 - 155,095,272 (+)RGD
Celera3151,397,134 - 151,475,844 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105129   ⟹   XP_038961057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,165,238 - 173,247,135 (+)NCBI
mRatBN7.23152,745,958 - 152,827,747 (+)NCBI
RefSeq Acc Id: XM_039105130   ⟹   XP_038961058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,189,153 - 173,247,135 (+)NCBI
mRatBN7.23152,769,736 - 152,827,747 (+)NCBI
RefSeq Acc Id: NP_001101270   ⟸   NM_001107800
- UniProtKB: A6JX59 (UniProtKB/TrEMBL),   A0A8I6A0F8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061873   ⟸   ENSRNOT00000066657
RefSeq Acc Id: XP_038961057   ⟸   XM_039105129
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y708 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961058   ⟸   XM_039105130
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000078057   ⟸   ENSRNOT00000099516
Ensembl Acc Id: ENSRNOP00000076920   ⟸   ENSRNOT00000098768
Ensembl Acc Id: ENSRNOP00000084019   ⟸   ENSRNOT00000118925
Ensembl Acc Id: ENSRNOP00000100296   ⟸   ENSRNOT00000172656
Protein Domains
Protein kinase   SARAH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A648-F1-model_v2 AlphaFold D4A648 1-487 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692646
Promoter ID:EPDNEW_R3169
Type:initiation region
Name:Stk4_1
Description:serine/threonine kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03160,467,560 - 160,467,620EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312035 AgrOrtholog
BioCyc Gene G2FUF-46883 BioCyc
Ensembl Genes ENSRNOG00000013529 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066657.3 UniProtKB/TrEMBL
  ENSRNOT00000098768 ENTREZGENE
  ENSRNOT00000098768.2 UniProtKB/TrEMBL
  ENSRNOT00000099516.2 UniProtKB/TrEMBL
  ENSRNOT00000118925 ENTREZGENE
  ENSRNOT00000118925.2 UniProtKB/TrEMBL
  ENSRNOT00000172656.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.4270 UniProtKB/TrEMBL
  4.10.170.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  p53_tetramer_sf UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SARAH UniProtKB/TrEMBL
  SARAH_domain UniProtKB/TrEMBL
  STE20/SPS1-PAK UniProtKB/TrEMBL
KEGG Report rno:311622 UniProtKB/TrEMBL
NCBI Gene 311622 ENTREZGENE
PANTHER STERILE20-LIKE KINASE, ISOFORM B UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/TrEMBL
Pfam Mst1_SARAH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Stk4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  SARAH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013529 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5Y708 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZJB8_RAT UniProtKB/TrEMBL
  A0A8I6A0F8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LFP0_RAT UniProtKB/TrEMBL
  A6JX59 ENTREZGENE, UniProtKB/TrEMBL
  D4A648_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Stk4  serine/threonine kinase 4   Stk4_predicted  serine/threonine kinase 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Stk4_predicted  serine/threonine kinase 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED