Prag1 (PEAK1 related kinase activating pseudokinase 1) - Rat Genome Database

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Gene: Prag1 (PEAK1 related kinase activating pseudokinase 1) Rattus norvegicus
Analyze
Symbol: Prag1
Name: PEAK1 related kinase activating pseudokinase 1
RGD ID: 1311793
Description: Enables identical protein binding activity. Involved in several processes, including negative regulation of neuron projection development; positive regulation of Rho protein signal transduction; and regulation of cell shape. Located in cytoplasm and focal adhesion. Orthologous to human PRAG1 (PEAK1 related, kinase-activating pseudokinase 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inactive tyrosine-protein kinase PRAG1; LOC306506; pragma of Rnd2; Pragmin; RGD1311793; similar to DNA segment, Chr 8, ERATO Doi 82, expressed; tyrosine-protein kinase SgK223
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81662,791,249 - 62,844,532 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1662,786,329 - 62,844,532 (-)EnsemblGRCr8
mRatBN7.21656,087,885 - 56,141,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1656,087,885 - 56,141,153 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1661,401,186 - 61,454,452 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01664,815,158 - 64,868,428 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01660,035,139 - 60,088,409 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01659,666,794 - 59,730,681 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1659,666,775 - 59,721,227 (-)Ensemblrn6Rnor6.0
Rnor_5.01659,345,052 - 59,397,741 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41659,780,251 - 59,833,359 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1654,144,709 - 54,196,468 (-)NCBICelera
RGSC_v3.11659,780,708 - 59,828,812 (-)NCBI
Cytogenetic Map16q12.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
alpha-Zearalanol  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
glycidol  (EXP)
GSK-J4  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
okadaic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rotenone  (ISO)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA)
focal adhesion  (IDA,IEA,ISO)
nucleus  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation. Lecointre C, etal., Structure. 2018 Feb 27. pii: S0969-2126(18)30040-6. doi: 10.1016/j.str.2018.01.017.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. Safari F, etal., Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14938-43. doi: 10.1073/pnas.1107740108. Epub 2011 Aug 22.
6. C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility. Senda Y, etal., Cancer Sci. 2016 Jul;107(7):972-80. doi: 10.1111/cas.12962. Epub 2016 Jun 13.
7. Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity. Tanaka H, etal., J Biol Chem. 2006 Apr 14;281(15):10355-64. Epub 2006 Feb 15.
Additional References at PubMed
PMID:25038227   PMID:29079850  


Genomics

Comparative Map Data
Prag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81662,791,249 - 62,844,532 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1662,786,329 - 62,844,532 (-)EnsemblGRCr8
mRatBN7.21656,087,885 - 56,141,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1656,087,885 - 56,141,153 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1661,401,186 - 61,454,452 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01664,815,158 - 64,868,428 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01660,035,139 - 60,088,409 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01659,666,794 - 59,730,681 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1659,666,775 - 59,721,227 (-)Ensemblrn6Rnor6.0
Rnor_5.01659,345,052 - 59,397,741 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41659,780,251 - 59,833,359 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1654,144,709 - 54,196,468 (-)NCBICelera
RGSC_v3.11659,780,708 - 59,828,812 (-)NCBI
Cytogenetic Map16q12.2NCBI
PRAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3888,317,736 - 8,386,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl88,317,736 - 8,387,357 (-)Ensemblhg38GRCh38
GRCh3788,175,258 - 8,243,949 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3688,212,668 - 8,276,667 (-)NCBIBuild 36Build 36hg18NCBI36
Celera87,303,570 - 7,367,558 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef87,099,920 - 7,163,897 (-)NCBIHuRef
CHM1_188,240,753 - 8,304,766 (-)NCBICHM1_1
T2T-CHM13v2.0811,357,159 - 11,425,856 (+)NCBIT2T-CHM13v2.0
Prag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39836,562,015 - 36,614,939 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl836,561,982 - 36,614,941 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38836,094,827 - 36,147,787 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl836,094,828 - 36,147,787 (+)Ensemblmm10GRCm38
MGSCv37837,157,882 - 37,210,841 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36837,563,378 - 37,616,061 (+)NCBIMGSCv36mm8
Celera838,730,743 - 38,787,704 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map822.78NCBI
Prag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554634,394,718 - 4,446,696 (-)Ensembl
ChiLan1.0NW_0049554634,397,246 - 4,446,696 (-)NCBIChiLan1.0ChiLan1.0
PRAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2724,771,690 - 24,842,864 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18798,821 - 870,444 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0810,824,887 - 10,896,058 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11636,058,527 - 36,103,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1636,053,967 - 36,103,764 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1636,509,721 - 36,568,184 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01638,083,633 - 38,142,148 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1638,096,813 - 38,142,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11636,183,300 - 36,241,596 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01636,745,966 - 36,804,272 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01636,865,728 - 36,924,087 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494343,045,601 - 43,101,519 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365732,046,036 - 2,094,040 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365732,040,965 - 2,095,377 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.117745,039 - 793,409 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1810,641,633 - 10,704,068 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl810,629,078 - 10,703,646 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605231,689,333 - 31,756,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248394,361,051 - 4,413,061 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248394,363,337 - 4,417,585 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prag1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11350,929,912 - 50,980,123 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prag1
515 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:43
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000015166
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)166241446475736480Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015166   ⟹   ENSRNOP00000015166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1662,791,249 - 62,844,532 (-)Ensembl
mRatBN7.2 Ensembl1656,087,885 - 56,141,153 (-)Ensembl
Rnor_6.0 Ensembl1659,666,775 - 59,721,227 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136340   ⟹   ENSRNOP00000100200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1662,786,329 - 62,844,532 (-)Ensembl
RefSeq Acc Id: NM_001107315   ⟹   NP_001100785
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81662,791,249 - 62,844,532 (-)NCBI
mRatBN7.21656,087,885 - 56,141,153 (-)NCBI
Rnor_6.01659,666,794 - 59,721,246 (-)NCBI
Rnor_5.01659,345,052 - 59,397,741 (-)NCBI
RGSC_v3.41659,780,251 - 59,833,359 (-)RGD
Celera1654,144,709 - 54,196,468 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094542   ⟹   XP_038950470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81662,791,254 - 62,843,329 (-)NCBI
mRatBN7.21656,087,888 - 56,139,963 (-)NCBI
RefSeq Acc Id: XM_039094543   ⟹   XP_038950471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81662,791,254 - 62,817,157 (-)NCBI
mRatBN7.21656,087,888 - 56,113,856 (-)NCBI
RefSeq Acc Id: XM_039094544   ⟹   XP_038950472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81662,791,254 - 62,817,157 (-)NCBI
mRatBN7.21656,087,888 - 56,113,857 (-)NCBI
RefSeq Acc Id: NP_001100785   ⟸   NM_001107315
- UniProtKB: D3ZMK9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015166   ⟸   ENSRNOT00000015166
RefSeq Acc Id: XP_038950470   ⟸   XM_039094542
- Peptide Label: isoform X1
- UniProtKB: D3ZMK9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038950472   ⟸   XM_039094544
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950471   ⟸   XM_039094543
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000100200   ⟸   ENSRNOT00000136340
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMK9-F1-model_v2 AlphaFold D3ZMK9 1-1368 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700130
Promoter ID:EPDNEW_R10654
Type:single initiation site
Name:Prag1_1
Description:PEAK1 related kinase activating pseudokinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01659,721,244 - 59,721,304EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311793 AgrOrtholog
BioCyc Gene G2FUF-11187 BioCyc
Ensembl Genes ENSRNOG00000011407 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015166 ENTREZGENE
  ENSRNOT00000015166.7 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MitoQC_Scaffold_Kinases UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:306506 UniProtKB/Swiss-Prot
NCBI Gene 306506 ENTREZGENE
PANTHER INACTIVE TYROSINE-PROTEIN KINASE PRAG1 UniProtKB/Swiss-Prot
  SERINE/THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Prag1 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011407 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0ABK0KYX5_RAT UniProtKB/TrEMBL
  D3ZMK9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-17 Prag1  PEAK1 related kinase activating pseudokinase 1  Pragmin  pragma of Rnd2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-15 Pragmin  pragma of Rnd2  RGD1311793  similar to DNA segment, Chr 8, ERATO Doi 82, expressed   Symbol and Name updated 1299863 APPROVED
2008-04-30 RGD1311793  similar to DNA segment, Chr 8, ERATO Doi 82, expressed   RGD1311793_predicted  similar to DNA segment, Chr 8, ERATO Doi 82, expressed (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1311793_predicted  similar to DNA segment, Chr 8, ERATO Doi 82, expressed (predicted)  LOC306506_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306506_predicted  similar to DNA segment, Chr 8, ERATO Doi 82, expressed (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL