Alms1 (ALMS1, centrosome and basal body associated protein) - Rat Genome Database

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Pathways
Gene: Alms1 (ALMS1, centrosome and basal body associated protein) Rattus norvegicus
Analyze
Symbol: Alms1
Name: ALMS1, centrosome and basal body associated protein
RGD ID: 1311590
Description: Predicted to enable alpha-actinin binding activity. Involved in positive regulation of endocytosis. Located in centriole and ciliary basal body. Human ortholog(s) of this gene implicated in Alstrom syndrome. Orthologous to human ALMS1 (ALMS1 centrosome and basal body associated protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Alstrom syndrome 1 homolog; Alstrom syndrome protein 1; centrosome-associated protein ALMS1; LOC297408
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Alms1em1Mcwi
Genetic Models: SS-Alms1em1Mcwi-/- ; SS-Alms1em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84119,683,085 - 119,783,471 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4119,683,076 - 119,783,471 (+)EnsemblGRCr8
mRatBN7.24118,125,581 - 118,226,005 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4118,125,607 - 118,226,005 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4123,606,944 - 123,707,620 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04119,382,049 - 119,482,408 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04117,995,664 - 118,095,939 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04117,371,544 - 117,472,310 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,371,659 - 117,472,198 (+)Ensemblrn6Rnor6.0
Rnor_5.04181,947,469 - 182,048,235 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44119,846,037 - 119,946,085 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4107,106,971 - 107,206,695 (+)NCBICelera
RGSC_v3.14120,087,754 - 120,190,647 (+)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
caffeine  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
levonorgestrel  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
phenobarbital  (ISO)
quercetin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zinc protoporphyrin  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Fat aussie--a new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Arsov T, etal., Mol Endocrinol. 2006 Jul;20(7):1610-22. Epub 2006 Mar 2.
2. Alms1-disrupted mice recapitulate human Alstrom syndrome. Collin GB, etal., Hum Mol Genet. 2005 Aug 15;14(16):2323-33. Epub 2005 Jul 6.
3. Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alstrom syndrome. Collin GB, etal., Nat Genet. 2002 May;31(1):74-8. Epub 2002 Apr 8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. Hearn T, etal., Diabetes. 2005 May;54(5):1581-7.
7. Alstrom Syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity. Jagger D, etal., Hum Mol Genet. 2011 Feb 1;20(3):466-81. doi: 10.1093/hmg/ddq493. Epub 2010 Nov 11.
8. Role of Alström syndrome 1 in the regulation of blood pressure and renal function. Jaykumar AB, etal., JCI Insight. 2018 Nov 2;3(21). pii: 95076. doi: 10.1172/jci.insight.95076.
9. Novel ALMS1 mutations in Chinese patients with Alstrom syndrome. Liang X, etal., Mol Vis. 2013 Sep 7;19:1885-91. eCollection 2013.
10. Syndromic obesity and diabetes: changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alstrom syndrome. Minton JA, etal., J Clin Endocrinol Metab. 2006 Aug;91(8):3110-6. Epub 2006 May 23.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population. Patel S, etal., Diabetologia. 2006 Jun;49(6):1209-13. Epub 2006 Apr 7.
13. Molecular approach in the study of Alstrom syndrome: analysis of ten Spanish families. Pineiro-Gallego T, etal., Mol Vis. 2012;18:1794-802. Epub 2012 Jul 3.
14. Defective adaptive thermogenesis contributes to metabolic syndrome and liver steatosis in obese mice. Poekes L, etal., Clin Sci (Lond). 2017 Feb 1;131(4):285-296. doi: 10.1042/CS20160469. Epub 2016 Nov 1.
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:17206865   PMID:20844083   PMID:21399614   PMID:22693585  


Genomics

Comparative Map Data
Alms1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84119,683,085 - 119,783,471 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4119,683,076 - 119,783,471 (+)EnsemblGRCr8
mRatBN7.24118,125,581 - 118,226,005 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4118,125,607 - 118,226,005 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4123,606,944 - 123,707,620 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04119,382,049 - 119,482,408 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04117,995,664 - 118,095,939 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04117,371,544 - 117,472,310 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,371,659 - 117,472,198 (+)Ensemblrn6Rnor6.0
Rnor_5.04181,947,469 - 182,048,235 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44119,846,037 - 119,946,085 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4107,106,971 - 107,206,695 (+)NCBICelera
RGSC_v3.14120,087,754 - 120,190,647 (+)NCBI
Cytogenetic Map4q34NCBI
ALMS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38273,385,758 - 73,609,919 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl273,385,758 - 73,625,166 (+)Ensemblhg38GRCh38
GRCh37273,612,886 - 73,837,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,466,394 - 73,690,554 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34273,524,540 - 73,748,701NCBI
Celera273,463,729 - 73,687,908 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef273,348,377 - 73,572,081 (+)NCBIHuRef
CHM1_1273,543,709 - 73,767,862 (+)NCBICHM1_1
T2T-CHM13v2.0273,398,811 - 73,623,015 (+)NCBIT2T-CHM13v2.0
Alms1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,564,482 - 85,698,973 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl685,564,513 - 85,679,735 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38685,587,498 - 85,726,611 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,587,531 - 85,702,753 (+)Ensemblmm10GRCm38
MGSCv37685,537,525 - 85,652,745 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36685,553,189 - 85,668,300 (+)NCBIMGSCv36mm8
Celera687,559,405 - 87,708,447 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.48NCBI
Alms1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542412,130,607 - 12,258,522 (-)Ensembl
ChiLan1.0NW_00495542412,130,496 - 12,258,684 (-)NCBIChiLan1.0ChiLan1.0
ALMS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21252,762,287 - 52,994,559 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A52,765,040 - 52,997,312 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A73,438,657 - 73,671,313 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A74,926,650 - 75,158,734 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A74,926,650 - 75,152,139 (+)EnsemblpanPan2panpan1.1
ALMS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11749,301,397 - 49,513,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1749,301,606 - 49,513,625 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1748,945,100 - 49,160,487 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01750,163,595 - 50,379,703 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1750,163,595 - 50,336,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11749,179,726 - 49,395,827 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01749,247,116 - 49,462,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,806,151 - 50,021,717 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Alms1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629211,228,877 - 11,418,533 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649117,152,759 - 17,342,648 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALMS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,253,750 - 69,417,189 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1369,253,742 - 69,417,043 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,455,187 - 72,619,961 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALMS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,571,894 - 33,795,404 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1433,573,296 - 33,789,549 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604578,295,878 - 78,526,188 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alms1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624762128,491 - 269,006 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624762129,349 - 268,945 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Alms1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1660,507,141 - 60,608,606 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Alms1
561 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:113
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000045735
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
RH136742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,219,748 - 118,219,872 (+)MAPPERmRatBN7.2
Rnor_6.04117,466,058 - 117,466,181NCBIRnor6.0
Rnor_5.04182,041,983 - 182,042,106UniSTSRnor5.0
RGSC_v3.44119,940,698 - 119,940,821UniSTSRGSC3.4
Celera4107,200,443 - 107,200,566UniSTS
Cytogenetic Map4q34UniSTS


Genetic Models
This gene Alms1 is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000045735   ⟹   ENSRNOP00000050674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4119,683,085 - 119,783,471 (+)Ensembl
mRatBN7.2 Ensembl4118,125,607 - 118,226,005 (+)Ensembl
Rnor_6.0 Ensembl4117,371,659 - 117,472,198 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101178   ⟹   ENSRNOP00000079051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4119,683,076 - 119,783,471 (+)Ensembl
mRatBN7.2 Ensembl4118,135,247 - 118,226,005 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109581   ⟹   ENSRNOP00000076984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4119,683,085 - 119,780,030 (+)Ensembl
mRatBN7.2 Ensembl4118,125,607 - 118,222,762 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113260   ⟹   ENSRNOP00000080223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4119,683,085 - 119,783,471 (+)Ensembl
mRatBN7.2 Ensembl4118,125,607 - 118,226,005 (+)Ensembl
RefSeq Acc Id: NM_001106604   ⟹   NP_001100074
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,085 - 119,783,471 (+)NCBI
mRatBN7.24118,125,607 - 118,226,005 (+)NCBI
Rnor_6.04117,371,544 - 117,472,310 (+)NCBI
Rnor_5.04181,947,469 - 182,048,235 (+)NCBI
RGSC_v3.44119,846,037 - 119,946,085 (+)RGD
Celera4107,106,971 - 107,206,695 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107348   ⟹   XP_038963276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,136 - 119,783,462 (+)NCBI
mRatBN7.24118,125,581 - 118,226,005 (+)NCBI
RefSeq Acc Id: XM_039107349   ⟹   XP_038963277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,136 - 119,783,462 (+)NCBI
mRatBN7.24118,125,581 - 118,226,005 (+)NCBI
RefSeq Acc Id: XM_039107350   ⟹   XP_038963278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,136 - 119,783,462 (+)NCBI
mRatBN7.24118,125,581 - 118,226,005 (+)NCBI
RefSeq Acc Id: XM_039107352   ⟹   XP_038963280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,136 - 119,783,462 (+)NCBI
mRatBN7.24118,125,581 - 118,226,005 (+)NCBI
RefSeq Acc Id: XM_039107353   ⟹   XP_038963281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,136 - 119,783,462 (+)NCBI
mRatBN7.24118,125,581 - 118,226,005 (+)NCBI
RefSeq Acc Id: XM_039107354   ⟹   XP_038963282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,704,030 - 119,783,462 (+)NCBI
mRatBN7.24118,146,549 - 118,226,005 (+)NCBI
RefSeq Acc Id: XM_039107355   ⟹   XP_038963283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,136 - 119,734,435 (+)NCBI
mRatBN7.24118,125,581 - 118,176,973 (+)NCBI
RefSeq Acc Id: XM_063285805   ⟹   XP_063141875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,136 - 119,783,462 (+)NCBI
RefSeq Acc Id: XM_063285806   ⟹   XP_063141876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,136 - 119,783,462 (+)NCBI
RefSeq Acc Id: XM_063285807   ⟹   XP_063141877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,683,136 - 119,783,462 (+)NCBI
RefSeq Acc Id: NP_001100074   ⟸   NM_001106604
- UniProtKB: A0A8I5ZSK7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050674   ⟸   ENSRNOT00000045735
RefSeq Acc Id: XP_038963276   ⟸   XM_039107348
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963281   ⟸   XM_039107353
- Peptide Label: isoform X7
- UniProtKB: F1LVG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963277   ⟸   XM_039107349
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZSK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963280   ⟸   XM_039107352
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZSK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963278   ⟸   XM_039107350
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZSK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963283   ⟸   XM_039107355
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038963282   ⟸   XM_039107354
- Peptide Label: isoform X9
- UniProtKB: A0A8I6G4M9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080223   ⟸   ENSRNOT00000113260
Ensembl Acc Id: ENSRNOP00000079051   ⟸   ENSRNOT00000101178
Ensembl Acc Id: ENSRNOP00000076984   ⟸   ENSRNOT00000109581
RefSeq Acc Id: XP_063141877   ⟸   XM_063285807
- Peptide Label: isoform X8
- UniProtKB: F1LVG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141875   ⟸   XM_063285805
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZSK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141876   ⟸   XM_063285806
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZSK7 (UniProtKB/TrEMBL)
Protein Domains
ALMS motif

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693199
Promoter ID:EPDNEW_R3722
Type:multiple initiation site
Name:Alms1_1
Description:ALMS1, centrosome and basal body associated protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04117,371,626 - 117,371,686EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311590 AgrOrtholog
BioCyc Gene G2FUF-43937 BioCyc
Ensembl Genes ENSRNOG00000022343 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045735 ENTREZGENE
  ENSRNOT00000045735.7 UniProtKB/TrEMBL
  ENSRNOT00000101178 ENTREZGENE
  ENSRNOT00000101178.2 UniProtKB/TrEMBL
  ENSRNOT00000109581 ENTREZGENE
  ENSRNOT00000109581.2 UniProtKB/TrEMBL
  ENSRNOT00000113260 ENTREZGENE
  ENSRNOT00000113260.2 UniProtKB/TrEMBL
InterPro ALMS_motif UniProtKB/TrEMBL
  ALMS_repeat UniProtKB/TrEMBL
NCBI Gene 297408 ENTREZGENE
PANTHER ALMS1-RELATED UniProtKB/TrEMBL
  PTHR21553:SF22 UniProtKB/TrEMBL
Pfam ALMS_motif UniProtKB/TrEMBL
  ALMS_repeat UniProtKB/TrEMBL
PhenoGen Alms1 PhenoGen
RatGTEx ENSRNOG00000022343 RatGTEx
UniProt A0A8I5XVN1_RAT UniProtKB/TrEMBL
  A0A8I5ZSK7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G4M9 ENTREZGENE, UniProtKB/TrEMBL
  F1LVG9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-15 Alms1  Alstrom syndrome 1 homolog (human)  Alms1  Alstrom syndrome 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Alms1  Alstrom syndrome 1  Alms1_predicted  Alstrom syndrome 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Alms1_predicted  Alstrom syndrome 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED