Clk1 (CDC-like kinase 1) - Rat Genome Database

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Gene: Clk1 (CDC-like kinase 1) Rattus norvegicus
Analyze
Symbol: Clk1
Name: CDC-like kinase 1
RGD ID: 1311469
Description: Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to be active in nucleus. Orthologous to human CLK1 (CDC like kinase 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity protein kinase CLK1; LOC301434
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,441,962 - 67,453,180 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl967,441,952 - 67,451,187 (-)EnsemblGRCr8
mRatBN7.2959,947,774 - 59,959,002 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl959,947,764 - 59,957,000 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx968,441,063 - 68,452,488 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,556,993 - 73,568,418 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0971,875,067 - 71,886,492 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,296,777 - 65,308,017 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,296,778 - 65,307,995 (-)Ensemblrn6Rnor6.0
Rnor_5.0965,104,068 - 65,115,289 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4957,070,825 - 57,082,043 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera957,390,465 - 57,401,657 (-)NCBICelera
RGSC_v3.1957,217,806 - 57,229,025 (-)NCBI
Cytogenetic Map9q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
influenza  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-iodotubercidin  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
epoxiconazole  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hexaconazole  (ISO)
indirubin  (ISO)
indometacin  (ISO)
ketamine  (EXP)
leflunomide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
nickel dichloride  (EXP,ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
patulin  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium nitrate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nuclear membrane  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Biochemical characterization and localization of the dual specificity kinase CLK1. Menegay HJ, etal., J Cell Sci. 2000 Sep;113 ( Pt 18):3241-53.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. A new self-attenuated therapeutic influenza vaccine that uses host cell-restricted attenuation by artificial microRNAs. Wen K, etal., Int J Pharm. 2022 Jan 25;612:121325. doi: 10.1016/j.ijpharm.2021.121325. Epub 2021 Dec 6.
Additional References at PubMed
PMID:1825055   PMID:1986248   PMID:8889548   PMID:9307018   PMID:10480872   PMID:12477932   PMID:19168442  


Genomics

Comparative Map Data
Clk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,441,962 - 67,453,180 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl967,441,952 - 67,451,187 (-)EnsemblGRCr8
mRatBN7.2959,947,774 - 59,959,002 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl959,947,764 - 59,957,000 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx968,441,063 - 68,452,488 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,556,993 - 73,568,418 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0971,875,067 - 71,886,492 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,296,777 - 65,308,017 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,296,778 - 65,307,995 (-)Ensemblrn6Rnor6.0
Rnor_5.0965,104,068 - 65,115,289 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4957,070,825 - 57,082,043 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera957,390,465 - 57,401,657 (-)NCBICelera
RGSC_v3.1957,217,806 - 57,229,025 (-)NCBI
Cytogenetic Map9q31NCBI
CLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382200,853,009 - 200,864,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2200,853,009 - 200,864,697 (-)Ensemblhg38GRCh38
GRCh372201,717,732 - 201,729,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,425,978 - 201,437,667 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342201,543,310 - 201,554,866NCBI
Celera2195,472,364 - 195,484,097 (-)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2193,569,145 - 193,580,882 (-)NCBIHuRef
CHM1_12201,723,725 - 201,735,444 (-)NCBICHM1_1
T2T-CHM13v2.02201,336,455 - 201,348,106 (-)NCBIT2T-CHM13v2.0
Clk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,451,147 - 58,463,247 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,449,348 - 58,463,225 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38158,411,988 - 58,424,088 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,410,189 - 58,424,066 (-)Ensemblmm10GRCm38
MGSCv37158,468,832 - 58,480,932 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36158,356,546 - 58,368,550 (-)NCBIMGSCv36mm8
Celera158,930,355 - 58,942,397 (-)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.09NCBI
Clk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403656,767 - 666,463 (+)Ensembl
ChiLan1.0NW_004955403655,808 - 665,007 (+)NCBIChiLan1.0ChiLan1.0
CLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213103,478,214 - 103,489,863 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B103,493,141 - 103,504,862 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B88,108,885 - 88,120,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B206,267,364 - 206,279,129 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,267,364 - 206,278,942 (-)EnsemblpanPan2panpan1.1
CLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,054,230 - 10,065,416 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,054,237 - 10,082,759 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3710,939,413 - 10,950,595 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0379,959,636 - 9,970,824 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl379,959,640 - 9,970,975 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1379,941,131 - 9,952,316 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0379,918,982 - 9,930,163 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0379,912,864 - 9,924,054 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Clk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,200,477 - 158,208,615 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726170,458 - 179,545 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936726170,763 - 178,897 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,553,430 - 104,562,171 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115104,553,512 - 104,562,348 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215115,713,454 - 115,722,084 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,508,513 - 86,520,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040112,897,742 - 112,908,935 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624889302,124 - 311,101 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624889301,304 - 309,591 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Clk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14133,979,656 - 133,991,359 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Clk1
126 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:126
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000030934
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH128672  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2959,947,839 - 59,948,088 (+)MAPPERmRatBN7.2
Rnor_6.0965,296,843 - 65,297,091NCBIRnor6.0
Rnor_5.0965,104,134 - 65,104,382UniSTSRnor5.0
RGSC_v3.4957,070,891 - 57,071,139UniSTSRGSC3.4
Celera957,390,531 - 57,390,779UniSTS
RH 3.4 Map9482.4UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000030934   ⟹   ENSRNOP00000038335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl967,441,952 - 67,451,187 (-)Ensembl
mRatBN7.2 Ensembl959,947,764 - 59,957,000 (-)Ensembl
Rnor_6.0 Ensembl965,296,778 - 65,307,995 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105031   ⟹   ENSRNOP00000089115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl959,947,776 - 59,957,000 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105751   ⟹   ENSRNOP00000078460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl959,947,764 - 59,953,302 (-)Ensembl
RefSeq Acc Id: NM_001106913   ⟹   NP_001100383
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,441,962 - 67,453,180 (-)NCBI
mRatBN7.2959,947,774 - 59,958,993 (-)NCBI
Rnor_6.0965,296,777 - 65,307,995 (-)NCBI
Rnor_5.0965,104,068 - 65,115,289 (-)NCBI
RGSC_v3.4957,070,825 - 57,082,043 (-)RGD
Celera957,390,465 - 57,401,657 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266947   ⟹   XP_063123017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,441,962 - 67,450,566 (-)NCBI
RefSeq Acc Id: NP_001100383   ⟸   NM_001106913
- UniProtKB: D4ADG3 (UniProtKB/TrEMBL),   A6IP60 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038335   ⟸   ENSRNOT00000030934
Ensembl Acc Id: ENSRNOP00000078460   ⟸   ENSRNOT00000105751
Ensembl Acc Id: ENSRNOP00000089115   ⟸   ENSRNOT00000105031
RefSeq Acc Id: XP_063123017   ⟸   XM_063266947
- Peptide Label: isoform X1
- UniProtKB: A6IP62 (UniProtKB/TrEMBL),   A0A8I6G1T6 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADG3-F1-model_v2 AlphaFold D4ADG3 1-483 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696687
Promoter ID:EPDNEW_R7212
Type:initiation region
Name:Clk1_1
Description:CDC-like kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,307,956 - 65,308,016EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311469 AgrOrtholog
BioCyc Gene G2FUF-27451 BioCyc
Ensembl Genes ENSRNOG00000025768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030934 ENTREZGENE
  ENSRNOT00000030934.8 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121242 IMAGE-MGC_LOAD
InterPro CLK_kinases UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:301434 UniProtKB/TrEMBL
MGC_CLONE MGC:94012 IMAGE-MGC_LOAD
NCBI Gene 301434 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE CLK1 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE DOA-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PharmGKB CLK1 RGD
PhenoGen Clk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025768 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6G1T6 ENTREZGENE
  A6IP60 ENTREZGENE, UniProtKB/TrEMBL
  A6IP61_RAT UniProtKB/TrEMBL
  A6IP62 ENTREZGENE, UniProtKB/TrEMBL
  A6IP63_RAT UniProtKB/TrEMBL
  A6IP64_RAT UniProtKB/TrEMBL
  A6IP65_RAT UniProtKB/TrEMBL
  D4ADG3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Clk1  CDC-like kinase 1  Clk1_predicted  CDC-like kinase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Clk1_predicted  CDC-like kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED