Lta4h (leukotriene A4 hydrolase) - Rat Genome Database

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Gene: Lta4h (leukotriene A4 hydrolase) Rattus norvegicus
Analyze
Symbol: Lta4h
Name: leukotriene A4 hydrolase
RGD ID: 1311333
Description: Enables leukotriene-A4 hydrolase activity. Involved in several processes, including leukotriene metabolic process; response to zinc ion; and type I pneumocyte differentiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in cytosol and nucleus. Biomarker of adenocarcinoma; asthma; and squamous cell carcinoma. Orthologous to human LTA4H (leukotriene A4 hydrolase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leukotriene A-4 hydrolase; LOC299732; LTA-4 hydrolase; tripeptide aminopeptidase LTA4H
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8729,856,846 - 29,888,642 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl729,856,802 - 29,888,641 (+)EnsemblGRCr8
mRatBN7.2727,969,796 - 28,001,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl727,969,789 - 28,001,600 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx729,960,190 - 29,991,962 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,122,406 - 32,154,178 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0731,897,354 - 31,929,083 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,288,333 - 34,320,243 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,288,365 - 34,320,235 (+)Ensemblrn6Rnor6.0
Rnor_5.0734,353,476 - 34,385,291 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4730,482,213 - 30,515,062 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera725,071,700 - 25,102,147 (+)NCBICelera
RGSC_v3.1730,502,483 - 30,535,333 (+)NCBI
Cytogenetic Map7q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclohexene  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
furfural  (ISO)
glyphosate  (EXP)
imidacloprid  (EXP)
ivermectin  (ISO)
leukotriene A4  (ISO)
leukotriene B4  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methylmercury chloride  (ISO)
montelukast  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
Nutlin-3  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
picrotoxin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propane-1-thiol  (ISO)
quinoline  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung. Brock TG, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L224-32. Epub 2005 Apr 1.
2. Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin. Chen X, etal., J Natl Cancer Inst. 2003 Jul 16;95(14):1053-61.
3. Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats. Deng YM, etal., Acta Pharmacol Sin. 2005 Mar;26(3):353-8.
4. Purification and characterisation of leukotriene A4 hydrolase from rat neutrophils. Evans JF, etal., Biochim Biophys Acta. 1985 May 29;840(1):43-50.
5. Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. Fong LY, etal., Int J Cancer. 2008 Mar 1;122(5):978-89.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat. Ishizaka N, etal., FEBS Lett. 1999 Dec 10;463(1-2):155-9.
9. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
10. Comparative analysis of inflammatory gene expression levels in metabolic syndrome & coronary artery disease. Nair J, etal., Indian J Med Res. 2017 Jun;145(6):777-785. doi: 10.4103/ijmr.IJMR_1678_14.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Leukotriene synthesis is increased by transcriptional up-regulation of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene C4 synthase in asthmatic children. Zaitsu M, etal., J Asthma. 2003 Apr;40(2):147-54. doi: 10.1081/jas-120017985.
Additional References at PubMed
PMID:1544505   PMID:9774412   PMID:11675384   PMID:12477932   PMID:15078870   PMID:18804029   PMID:19056867   PMID:22658674   PMID:23533145   PMID:24701582   PMID:30745237  


Genomics

Comparative Map Data
Lta4h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8729,856,846 - 29,888,642 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl729,856,802 - 29,888,641 (+)EnsemblGRCr8
mRatBN7.2727,969,796 - 28,001,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl727,969,789 - 28,001,600 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx729,960,190 - 29,991,962 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,122,406 - 32,154,178 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0731,897,354 - 31,929,083 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,288,333 - 34,320,243 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,288,365 - 34,320,235 (+)Ensemblrn6Rnor6.0
Rnor_5.0734,353,476 - 34,385,291 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4730,482,213 - 30,515,062 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera725,071,700 - 25,102,147 (+)NCBICelera
RGSC_v3.1730,502,483 - 30,535,333 (+)NCBI
Cytogenetic Map7q13NCBI
LTA4H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381296,000,753 - 96,043,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1296,000,753 - 96,043,520 (-)Ensemblhg38GRCh38
GRCh371296,394,531 - 96,437,298 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,918,742 - 94,953,496 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341294,897,078 - 94,931,833NCBI
Celera1296,060,902 - 96,095,656 (-)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1293,456,404 - 93,499,169 (-)NCBIHuRef
CHM1_11296,359,522 - 96,402,289 (-)NCBICHM1_1
T2T-CHM13v2.01295,974,750 - 96,017,515 (-)NCBIT2T-CHM13v2.0
Lta4h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,289,258 - 93,320,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,289,273 - 93,320,737 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381093,453,396 - 93,484,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,453,411 - 93,484,875 (+)Ensemblmm10GRCm38
MGSCv371092,916,141 - 92,947,641 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361092,883,229 - 92,914,633 (+)NCBIMGSCv36mm8
Celera1095,436,799 - 95,470,679 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.42NCBI
Lta4h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540532,344,925 - 32,378,384 (-)Ensembl
ChiLan1.0NW_00495540532,345,005 - 32,377,685 (-)NCBIChiLan1.0ChiLan1.0
LTA4H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210104,071,540 - 104,106,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112104,067,930 - 104,102,827 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01293,589,758 - 93,624,529 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11296,978,203 - 97,012,427 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,978,203 - 97,012,427 (-)EnsemblpanPan2panpan1.1
LTA4H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,795,934 - 35,830,681 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,795,979 - 35,830,844 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1536,182,408 - 36,217,145 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01536,460,885 - 36,495,697 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,460,861 - 36,495,858 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,733,722 - 35,768,521 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,828,282 - 35,863,043 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01536,091,485 - 36,126,289 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lta4h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,115,386 - 24,153,026 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650712,082,068 - 12,120,091 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650712,082,373 - 12,120,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTA4H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl587,486,512 - 87,518,515 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1587,486,552 - 87,518,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2591,688,970 - 91,720,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LTA4H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11191,371,383 - 91,413,396 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1191,371,383 - 91,406,542 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037153,722,667 - 153,757,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lta4h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475011,274,664 - 11,314,581 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475011,274,506 - 11,314,683 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lta4h
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11172,502,063 - 172,533,672 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lta4h
292 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:14
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000005930
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)72154197735707405Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72092049437412865Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
BF395896  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2727,988,365 - 27,988,585 (+)MAPPERmRatBN7.2
Rnor_6.0734,306,915 - 34,307,134NCBIRnor6.0
Rnor_5.0734,371,970 - 34,372,189UniSTSRnor5.0
RGSC_v3.4730,501,835 - 30,502,054UniSTSRGSC3.4
Celera725,088,926 - 25,089,145UniSTS
RH 3.4 Map7189.3UniSTS
Cytogenetic Map7q13UniSTS
RH141007  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005930   ⟹   ENSRNOP00000005930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl729,856,802 - 29,888,641 (+)Ensembl
mRatBN7.2 Ensembl727,969,789 - 28,001,600 (+)Ensembl
Rnor_6.0 Ensembl734,288,365 - 34,320,235 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143147   ⟹   ENSRNOP00000109357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl729,860,007 - 29,888,641 (+)Ensembl
RefSeq Acc Id: NM_001030031   ⟹   NP_001025202
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8729,856,871 - 29,888,642 (+)NCBI
mRatBN7.2727,969,818 - 28,001,593 (+)NCBI
Rnor_6.0734,288,365 - 34,320,236 (+)NCBI
Rnor_5.0734,353,476 - 34,385,291 (+)NCBI
RGSC_v3.4730,482,213 - 30,515,062 (+)RGD
Celera725,071,700 - 25,102,147 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263200   ⟹   XP_063119270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8729,856,846 - 29,886,866 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001025202 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119270 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99819 (Get FASTA)   NCBI Sequence Viewer  
  EDM16913 (Get FASTA)   NCBI Sequence Viewer  
  EDM16914 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005930
  ENSRNOP00000005930.4
GenBank Protein P30349 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001025202   ⟸   NM_001030031
- UniProtKB: P30349 (UniProtKB/Swiss-Prot),   Q499P2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005930   ⟸   ENSRNOT00000005930
RefSeq Acc Id: XP_063119270   ⟸   XM_063263200
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000109357   ⟸   ENSRNOT00000143147
Protein Domains
Aminopeptidase N-like N-terminal   Peptidase M1 leukotriene A4 hydrolase/aminopeptidase   Peptidase M1 membrane alanine aminopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30349-F1-model_v2 AlphaFold P30349 1-611 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695145
Promoter ID:EPDNEW_R5670
Type:initiation region
Name:Lta4h_1
Description:leukotriene A4 hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0734,288,399 - 34,288,459EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311333 AgrOrtholog
BioCyc Gene G2FUF-34393 BioCyc
BioCyc Pathway PWY66-375 [leukotriene biosynthesis] BioCyc
  PWY66-394 [aspirin triggered resolvin E biosynthesis] BioCyc
BioCyc Pathway Image PWY66-375 BioCyc
  PWY66-394 BioCyc
Ensembl Genes ENSRNOG00000004494 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005930 ENTREZGENE
  ENSRNOT00000005930.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot
  1.25.40.320 UniProtKB/Swiss-Prot
  2.60.40.1730 UniProtKB/Swiss-Prot
  3.30.2010.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7930840 IMAGE-MGC_LOAD
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  LTA4H UniProtKB/Swiss-Prot
  LTA4H_cat UniProtKB/Swiss-Prot
  M1_LTA-4_hydro/amino_C_sf UniProtKB/Swiss-Prot
  M1_LTA4H UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_C UniProtKB/Swiss-Prot
  Peptidase_M1_dom UniProtKB/Swiss-Prot
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot
KEGG Report rno:299732 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124681 IMAGE-MGC_LOAD
NCBI Gene 299732 ENTREZGENE
PANTHER LEUKOTRIENE A-4 HYDROLASE UniProtKB/Swiss-Prot
  PTHR45726 UniProtKB/Swiss-Prot
Pfam Leuk-A4-hydro_C UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_N UniProtKB/Swiss-Prot
PharmGKB LTA4H RGD
PhenoGen Lta4h PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004494 RatGTEx
SMART Leuk-A4-hydro_C UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF48371 UniProtKB/Swiss-Prot
  SSF63737 UniProtKB/Swiss-Prot
UniProt A0ABK0LYN7_RAT UniProtKB/TrEMBL
  A6IFY4_RAT UniProtKB/TrEMBL
  A6IFY5_RAT UniProtKB/TrEMBL
  LKHA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q499P2 ENTREZGENE
UniProt Secondary Q499P2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Lta4h  leukotriene A4 hydrolase  Lta4h_predicted  leukotriene A4 hydrolase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lta4h_predicted  leukotriene A4 hydrolase (predicted)      Symbol and Name status set to approved 70820 APPROVED