Cadm1 (cell adhesion molecule 1) - Rat Genome Database

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Gene: Cadm1 (cell adhesion molecule 1) Rattus norvegicus
Analyze
Symbol: Cadm1
Name: cell adhesion molecule 1
RGD ID: 1310999
Description: Enables cell adhesion molecule binding activity. Involved in liver development and negative regulation of ERBB4 signaling pathway. Located in dendrite and postsynaptic density. Biomarker of hepatocellular carcinoma and lung adenocarcinoma. Human ortholog(s) of this gene implicated in breast carcinoma and prostate cancer. Orthologous to human CADM1 (cell adhesion molecule 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Igsf4; Igsf4a; immunoglobulin superfamily, member 4; immunoglobulin superfamily, member 4A; LOC363058; Necl-2; nectin-like protein 2; secretory isoform of TSLC1; sgigsf; spermatogenic immunoglobulin superfamily; synaptic cell adhesion molecule; SynCAM; TSLC-1; TSLC1; tumor suppressor in lung cancer 1 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cadm1Tn(sb-T2/Bart3)2.229Mcwi
Genetic Models: F344-Cadm1Tn(sb-T2/Bart3)2.229Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8856,744,374 - 57,075,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl856,744,372 - 57,080,192 (+)EnsemblGRCr8
mRatBN7.2847,847,836 - 48,178,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl847,847,325 - 48,182,833 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx853,352,549 - 53,672,383 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0851,631,357 - 51,951,198 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0849,495,629 - 49,815,471 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0851,858,906 - 52,200,591 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl852,127,399 - 52,189,722 (+)Ensemblrn6Rnor6.0
Rnor_5.0850,460,752 - 50,796,128 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4850,765,645 - 51,108,962 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera847,421,398 - 47,739,897 (+)NCBICelera
RGSC_v3.1850,784,698 - 51,128,015 (+)NCBI
Cytogenetic Map8q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
casticin  (ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
corn oil  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fenthion  (ISO)
finasteride  (EXP)
folic acid  (ISO)
fragrance  (ISO)
fulvestrant  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
linuron  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
Nivalenol  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors. Ehrlich M, etal., Oncogene. 2006 Apr 27;25(18):2636-45.
2. SynCAMs organize synapses through heterophilic adhesion. Fogel AI, etal., J Neurosci. 2007 Nov 14;27(46):12516-30.
3. Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer. Fukuhara H, etal., Jpn J Cancer Res. 2002 Jun;93(6):605-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Heller G, etal., Breast Cancer Res Treat. 2007 Jul;103(3):283-91. Epub 2007 Jan 27.
7. SgIGSF is a novel biliary-epithelial cell adhesion molecule mediating duct/ductule development. Ito A, etal., Hepatology. 2007 Mar;45(3):684-94.
8. IGSF4 promoter methylation and expression silencing in human cervical cancer. Li J, etal., Gynecol Oncol. 2005 Jan;96(1):150-8.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Rademacher N, etal., Sci Rep. 2016 Oct 19;6:35283. doi: 10.1038/srep35283.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Reduced expression of the Tslc1 gene and its aberrant DNA methylation in rat lung tumors. Shimizu K, etal., Biochem Biophys Res Commun. 2006 Aug 18;347(1):358-62. Epub 2006 Jun 23.
15. Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. Tsujiuchi T, etal., Cancer Sci. 2007 Jul;98(7):943-8. Epub 2007 Apr 12.
16. Necl-2/CADM1 interacts with ErbB4 and regulates its activity in GABAergic neurons. Yamada A, etal., Mol Cell Neurosci. 2013 Sep;56:234-43. doi: 10.1016/j.mcn.2013.06.003. Epub 2013 Jun 11.
17. Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis. Yang YX, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1868-72.
Additional References at PubMed
PMID:12202822   PMID:12477932   PMID:12826663   PMID:15458844   PMID:15707673   PMID:15811952   PMID:16311015   PMID:17724124   PMID:18055550   PMID:19796685   PMID:19827159   PMID:20368431  
PMID:21145003   PMID:21482734   PMID:22512338   PMID:22876197   PMID:23179183   PMID:23209303   PMID:23376485   PMID:24687959   PMID:26259600   PMID:26687224   PMID:27072493   PMID:28335740  
PMID:32929607  


Genomics

Comparative Map Data
Cadm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8856,744,374 - 57,075,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl856,744,372 - 57,080,192 (+)EnsemblGRCr8
mRatBN7.2847,847,836 - 48,178,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl847,847,325 - 48,182,833 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx853,352,549 - 53,672,383 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0851,631,357 - 51,951,198 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0849,495,629 - 49,815,471 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0851,858,906 - 52,200,591 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl852,127,399 - 52,189,722 (+)Ensemblrn6Rnor6.0
Rnor_5.0850,460,752 - 50,796,128 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4850,765,645 - 51,108,962 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera847,421,398 - 47,739,897 (+)NCBICelera
RGSC_v3.1850,784,698 - 51,128,015 (+)NCBI
Cytogenetic Map8q23NCBI
CADM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811115,169,236 - 115,504,415 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11115,169,218 - 115,504,957 (-)Ensemblhg38GRCh38
GRCh3711115,039,956 - 115,375,133 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611114,549,555 - 114,880,451 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411114,550,226 - 114,880,325NCBI
Celera11112,198,721 - 112,530,558 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11110,977,380 - 111,307,896 (-)NCBIHuRef
CHM1_111114,927,793 - 115,258,644 (-)NCBICHM1_1
T2T-CHM13v2.011115,182,091 - 115,517,534 (-)NCBIT2T-CHM13v2.0
Cadm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39947,441,468 - 47,773,578 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl947,441,471 - 47,769,413 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38947,530,170 - 47,862,280 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl947,530,173 - 47,857,637 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl947,530,173 - 47,858,115 (+)Ensemblmm10GRCm38
MGSCv37947,338,435 - 47,661,468 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36947,281,347 - 47,604,379 (+)NCBIMGSCv36mm8
Celera944,821,429 - 45,143,180 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map925.83NCBI
Cadm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541216,669,099 - 17,005,014 (-)Ensembl
ChiLan1.0NW_00495541216,673,401 - 17,005,082 (-)NCBIChiLan1.0ChiLan1.0
CADM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29115,873,383 - 116,213,048 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111116,974,841 - 117,314,496 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011110,008,314 - 110,347,876 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111113,950,291 - 114,280,453 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11113,950,291 - 114,280,324 (-)EnsemblpanPan2panpan1.1
CADM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1517,865,317 - 18,190,855 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl517,864,453 - 18,194,694 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha517,790,071 - 18,115,562 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0517,811,250 - 18,138,114 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1517,950,729 - 18,276,001 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0517,853,222 - 18,178,288 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0517,896,857 - 18,222,408 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cadm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494797,639,469 - 97,962,796 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936542565,843 - 883,609 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936542569,739 - 883,738 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CADM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl942,644,431 - 42,985,017 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1942,644,487 - 42,984,934 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2947,728,189 - 47,771,865 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CADM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11106,539,262 - 106,876,397 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1106,539,136 - 106,606,637 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604319,155,896 - 19,490,046 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cadm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478410,591,824 - 10,932,981 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478410,595,876 - 10,933,024 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cadm1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1842,025,132 - 42,343,810 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cadm1
1769 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:126
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000052392
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
D8Rat63  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8856,768,641 - 56,768,744 (+)Marker Load Pipeline
mRatBN7.2847,872,069 - 47,872,172 (+)MAPPERmRatBN7.2
Rnor_6.0851,883,143 - 51,883,245NCBIRnor6.0
Rnor_5.0850,484,989 - 50,485,091UniSTSRnor5.0
RGSC_v3.4850,795,357 - 50,795,769RGDRGSC3.4
RGSC_v3.4850,795,415 - 50,795,517UniSTSRGSC3.4
Celera847,445,625 - 47,445,727UniSTS
RGSC_v3.1850,814,469 - 50,814,571RGD
RH 3.4 Map8492.4RGD
RH 3.4 Map8492.4UniSTS
SHRSP x BN Map836.96RGD
SHRSP x BN Map836.96UniSTS
FHH x ACI Map840.27RGD
Cytogenetic Map8q23UniSTS
BF402666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2848,158,092 - 48,158,326 (+)MAPPERmRatBN7.2
Rnor_6.0852,171,436 - 52,171,669NCBIRnor6.0
Rnor_5.0850,771,166 - 50,771,399UniSTSRnor5.0
RGSC_v3.4851,091,131 - 51,091,364UniSTSRGSC3.4
Celera847,722,072 - 47,722,305UniSTS
RH 3.4 Map8495.3UniSTS
Cytogenetic Map8q23UniSTS
RH126999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2848,109,311 - 48,109,534 (+)MAPPERmRatBN7.2
Rnor_6.0852,122,654 - 52,122,876NCBIRnor6.0
Rnor_5.0850,722,384 - 50,722,606UniSTSRnor5.0
Celera847,673,285 - 47,673,507UniSTS
Cytogenetic Map8q23UniSTS
RH141584  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map8469.3UniSTS
Cytogenetic Map8q23UniSTS
AW529685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2848,159,582 - 48,159,743 (+)MAPPERmRatBN7.2
Rnor_6.0852,172,925 - 52,173,085NCBIRnor6.0
Rnor_5.0850,772,655 - 50,772,815UniSTSRnor5.0
RGSC_v3.4851,092,620 - 51,092,780UniSTSRGSC3.4
Celera847,723,561 - 47,723,721UniSTS
RH 3.4 Map8469.8UniSTS
Cytogenetic Map8q23UniSTS
RH144465  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2847,846,809 - 47,846,966 (+)MAPPERmRatBN7.2
Rnor_6.0851,857,880 - 51,858,036NCBIRnor6.0
Rnor_5.0850,459,726 - 50,459,882UniSTSRnor5.0
RGSC_v3.4850,764,618 - 50,764,774UniSTSRGSC3.4
Celera847,420,372 - 47,420,528UniSTS
RH 3.4 Map8469.9UniSTS
Cytogenetic Map8q23UniSTS
AI412733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2848,156,853 - 48,157,013 (+)MAPPERmRatBN7.2
Rnor_6.0852,170,197 - 52,170,356NCBIRnor6.0
Rnor_5.0850,769,927 - 50,770,086UniSTSRnor5.0
RGSC_v3.4851,089,892 - 51,090,051UniSTSRGSC3.4
Celera847,720,833 - 47,720,992UniSTS
RH 3.4 Map8469.6UniSTS
Cytogenetic Map8q23UniSTS
RH136632  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2848,175,873 - 48,176,062 (+)MAPPERmRatBN7.2
Rnor_6.0852,189,216 - 52,189,404NCBIRnor6.0
Rnor_5.0850,788,946 - 50,789,134UniSTSRnor5.0
RGSC_v3.4851,108,911 - 51,109,099UniSTSRGSC3.4
Celera847,739,846 - 47,740,034UniSTS
Cytogenetic Map8q23UniSTS


Genetic Models
This gene Cadm1 is modified in the following models/strains:
F344-Cadm1Tn(sb-T2/Bart3)2.229Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 67 209 91 90 59 114 59 6 406 218 16 193 105 100 31 34 34

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB114443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB257090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB257091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000052392   ⟹   ENSRNOP00000041169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl856,744,372 - 57,072,929 (+)Ensembl
mRatBN7.2 Ensembl847,847,325 - 48,176,381 (+)Ensembl
Rnor_6.0 Ensembl852,127,399 - 52,189,722 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079797   ⟹   ENSRNOP00000069217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl856,744,372 - 57,072,930 (+)Ensembl
mRatBN7.2 Ensembl847,847,325 - 48,176,381 (+)Ensembl
Rnor_6.0 Ensembl852,127,632 - 52,189,699 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097876   ⟹   ENSRNOP00000092150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl856,744,372 - 57,055,969 (+)Ensembl
mRatBN7.2 Ensembl847,847,325 - 48,159,407 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102618   ⟹   ENSRNOP00000076752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl856,744,372 - 57,072,487 (+)Ensembl
mRatBN7.2 Ensembl847,847,958 - 48,182,833 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110628   ⟹   ENSRNOP00000081058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl856,744,372 - 57,072,930 (+)Ensembl
mRatBN7.2 Ensembl847,847,325 - 48,178,652 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115996   ⟹   ENSRNOP00000096807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl856,744,372 - 57,080,192 (+)Ensembl
mRatBN7.2 Ensembl847,847,325 - 48,178,652 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131971   ⟹   ENSRNOP00000100479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl856,744,372 - 57,080,192 (+)Ensembl
RefSeq Acc Id: NM_001012201   ⟹   NP_001012201
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8856,744,408 - 57,072,487 (+)NCBI
mRatBN7.2847,847,836 - 48,175,925 (+)NCBI
Rnor_6.0851,858,906 - 52,189,267 (+)NCBI
Rnor_5.0850,460,752 - 50,796,128 (+)NCBI
RGSC_v3.4850,765,645 - 51,108,962 (+)RGD
Celera847,421,398 - 47,739,897 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242944   ⟹   XP_006243006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8856,744,389 - 57,075,264 (+)NCBI
mRatBN7.2847,847,837 - 48,178,703 (+)NCBI
Rnor_6.0851,858,912 - 52,189,716 (+)NCBI
Rnor_5.0850,460,752 - 50,796,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242946   ⟹   XP_006243008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8856,744,374 - 57,075,264 (+)NCBI
mRatBN7.2847,847,837 - 48,178,703 (+)NCBI
Rnor_6.0851,858,912 - 52,189,716 (+)NCBI
Rnor_5.0850,460,752 - 50,796,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242947   ⟹   XP_006243009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8856,744,439 - 57,075,264 (+)NCBI
mRatBN7.2847,847,837 - 48,178,703 (+)NCBI
Rnor_6.0851,858,912 - 52,189,716 (+)NCBI
Rnor_5.0850,460,752 - 50,796,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242948   ⟹   XP_006243010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8856,744,431 - 57,075,264 (+)NCBI
mRatBN7.2847,847,837 - 48,178,703 (+)NCBI
Rnor_6.0851,858,912 - 52,189,716 (+)NCBI
Rnor_5.0850,460,752 - 50,796,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081722   ⟹   XP_038937650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8856,744,505 - 57,075,264 (+)NCBI
mRatBN7.2847,847,837 - 48,178,703 (+)NCBI
RefSeq Acc Id: NP_001012201   ⟸   NM_001012201
- Peptide Label: precursor
- UniProtKB: F7EYW4 (UniProtKB/Swiss-Prot),   Q0WXX6 (UniProtKB/Swiss-Prot),   Q6AYP5 (UniProtKB/TrEMBL),   A0A8I5Y709 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243006   ⟸   XM_006242944
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006243008   ⟸   XM_006242946
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006243009   ⟸   XM_006242947
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006243010   ⟸   XM_006242948
- Peptide Label: isoform X5
- Sequence:
Ensembl Acc Id: ENSRNOP00000069217   ⟸   ENSRNOT00000079797
Ensembl Acc Id: ENSRNOP00000041169   ⟸   ENSRNOT00000052392
RefSeq Acc Id: XP_038937650   ⟸   XM_039081722
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000096807   ⟸   ENSRNOT00000115996
Ensembl Acc Id: ENSRNOP00000076752   ⟸   ENSRNOT00000102618
Ensembl Acc Id: ENSRNOP00000081058   ⟸   ENSRNOT00000110628
Ensembl Acc Id: ENSRNOP00000092150   ⟸   ENSRNOT00000097876
Ensembl Acc Id: ENSRNOP00000100479   ⟸   ENSRNOT00000131971
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYP5-F1-model_v2 AlphaFold Q6AYP5 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310999 AgrOrtholog
BioCyc Gene G2FUF-30625 BioCyc
Ensembl Genes ENSRNOG00000018778 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000052392 ENTREZGENE
  ENSRNOT00000079797 ENTREZGENE
  ENSRNOT00000102618 ENTREZGENE
  ENSRNOT00000110628 ENTREZGENE
  ENSRNOT00000110628.1 UniProtKB/Swiss-Prot
  ENSRNOT00000131971 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7111523 IMAGE-MGC_LOAD
InterPro CD80_C2-set UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  Neurexin-like UniProtKB/Swiss-Prot
KEGG Report rno:363058 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93845 IMAGE-MGC_LOAD
NCBI Gene 363058 ENTREZGENE
PANTHER CELL ADHESION MOLECULE 1 UniProtKB/Swiss-Prot
  IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam C2-set_2 UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
PhenoGen Cadm1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018778 RatGTEx
SMART 4.1m UniProtKB/Swiss-Prot
  IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A0G2JUT1 ENTREZGENE, UniProtKB/TrEMBL
  A0A5H1ZRU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y709 ENTREZGENE
  A0A8I6AHK7_RAT UniProtKB/TrEMBL
  A0A8I6GLS0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L8B4_RAT UniProtKB/TrEMBL
  A6J485 ENTREZGENE, UniProtKB/TrEMBL
  A6J486 ENTREZGENE, UniProtKB/TrEMBL
  A6J487 ENTREZGENE, UniProtKB/TrEMBL
  CADM1_RAT UniProtKB/Swiss-Prot
  F7EYW4 ENTREZGENE
  Q0WXX6 ENTREZGENE
  Q6AYP5 ENTREZGENE
UniProt Secondary F7EYW4 UniProtKB/Swiss-Prot
  Q0WXX6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-01-21 Cadm1  cell adhesion molecule 1  Igsf4a  immunoglobulin superfamily, member 4A  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-12-06 Igsf4a  immunoglobulin superfamily, member 4A  Igsf4a_predicted  immunoglobulin superfamily, member 4A (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Igsf4a_predicted  immunoglobulin superfamily, member 4A (predicted)      Symbol and Name status set to approved 70820 APPROVED