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Gene: Ogdhl (oxoglutarate dehydrogenase L) Rattus norvegicus

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Symbol:

Ogdhl

Name:

oxoglutarate dehydrogenase L

RGD ID:

1310916

Description:

Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome. Orthologous to human OGDHL (oxoglutarate dehydrogenase L); PARTICIPATES IN citric acid cycle pathway; lysine degradation pathway; tryptophan metabolic pathway; INTERACTS WITH acetamide; aflatoxin B1; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

2-oxoglutarate dehydrogenase complex component E1-like; 2-oxoglutarate dehydrogenase-like, mitochondrial; alpha-ketoglutarate dehydrogenase-like; LOC290566; OGDC-E1-like; oxoglutarate dehydrogenase-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OGDHL (oxoglutarate dehydrogenase L)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ogdhl (oxoglutarate dehydrogenase-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ogdhl (oxoglutarate dehydrogenase L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OGDHL (oxoglutarate dehydrogenase L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OGDHL (oxoglutarate dehydrogenase L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ogdhl (oxoglutarate dehydrogenase L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OGDHL (oxoglutarate dehydrogenase L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OGDHL (oxoglutarate dehydrogenase L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ogdhl (oxoglutarate dehydrogenase L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ogdhl (oxoglutarate dehydrogenase L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	OGDHL (oxoglutarate dehydrogenase L)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	OGDHL (oxoglutarate dehydrogenase L)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ogdhl (oxoglutarate dehydrogenase-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ogdhl (oxoglutarate dehydrogenase like)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	KGD1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG33791	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Nc73EF	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ogdh-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ogdhl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ogdhl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	7,584,666 - 7,610,705 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	7,584,657 - 7,610,698 (+)	Ensembl				GRCr8
mRatBN7.2	16	7,578,343 - 7,604,385 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	7,578,367 - 7,604,386 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	7,590,801 - 7,616,842 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	8,735,662 - 8,761,703 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	7,589,114 - 7,615,255 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	8,497,495 - 8,523,552 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	8,497,569 - 8,523,557 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	8,415,706 - 8,439,690 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	7,837,198 - 7,859,438 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	7,595,930 - 7,618,394 (-)	NCBI		Celera
RGSC_v3.1	16	7,833,526 - 7,858,972 (+)	NCBI
Cytogenetic Map	16	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congestive heart failure (ISO)

depressive disorder (ISO)

genetic disease (ISO)

Yoon-Bellen neurodevelopmental syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,6-dimethoxyphenol (ISO)

2-palmitoylglycerol (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

butanal (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dinophysistoxin 1 (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (EXP,ISO)

furan (EXP)

furfural (ISO)

gentamycin (EXP)

hydrogen sulfide (ISO)

indole-3-methanol (EXP)

ivermectin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

menadione (ISO)

methamphetamine (ISO)

N-nitrosodiethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

propanal (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

tetrachloromethane (EXP)

thapsigargin (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

2-oxoglutarate metabolic process (IDA,IEA)

glycolytic process (IEA)

tricarboxylic acid cycle (IBA,IDA,IEA)

Cellular Component

mitochondrial matrix (IEA,ISO,ISS)

mitochondrion (IBA,ISO)

oxoglutarate dehydrogenase complex (IBA)

Molecular Function

metal ion binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (IEA)

oxoglutarate dehydrogenase (succinyl-transferring) activity (IBA,IEA)

protein binding (ISO)

thiamine pyrophosphate binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

citric acid cycle pathway (IEA)

lysine degradation pathway (IEA)

tryptophan metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart.	Bunik V, etal., FEBS J. 2008 Oct;275(20):4990-5006. doi: 10.1111/j.1742-4658.2008.06632.x. Epub 2008 Sep 9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15972265	PMID:34800366

Genomics

Comparative Map Data

Ogdhl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	7,584,666 - 7,610,705 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	7,584,657 - 7,610,698 (+)	Ensembl				GRCr8
mRatBN7.2	16	7,578,343 - 7,604,385 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	7,578,367 - 7,604,386 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	7,590,801 - 7,616,842 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	8,735,662 - 8,761,703 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	7,589,114 - 7,615,255 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	8,497,495 - 8,523,552 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	8,497,569 - 8,523,557 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	8,415,706 - 8,439,690 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	7,837,198 - 7,859,438 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	7,595,930 - 7,618,394 (-)	NCBI		Celera
RGSC_v3.1	16	7,833,526 - 7,858,972 (+)	NCBI
Cytogenetic Map	16	p16	NCBI

OGDHL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	49,734,641 - 49,762,379 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	49,734,641 - 49,762,392 (-)	Ensembl			hg38	GRCh38
GRCh37	10	50,942,687 - 50,970,425 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	50,612,717 - 50,640,375 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	50,612,716 - 50,640,375	NCBI
Celera	10	44,528,687 - 44,557,024 (-)	NCBI		Celera
Cytogenetic Map	10	q11.23	NCBI
HuRef	10	45,207,521 - 45,235,123 (-)	NCBI		HuRef
CHM1_1	10	51,224,672 - 51,252,417 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	50,583,410 - 50,612,062 (-)	NCBI		T2T-CHM13v2.0

Ogdhl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	32,043,941 - 32,070,108 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	32,043,976 - 32,070,108 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	32,321,982 - 32,348,151 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	32,322,019 - 32,348,151 (+)	Ensembl			mm10	GRCm38
MGSCv37	14	33,135,205 - 33,161,006 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	31,151,028 - 31,176,829 (+)	NCBI		MGSCv36	mm8
MGSCv36	14	27,427,058 - 27,452,725 (+)	NCBI		MGSCv36	mm8
Celera	14	28,579,005 - 28,605,091 (+)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	19.4	NCBI

Ogdhl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955556	566,671 - 589,236 (+)	Ensembl
ChiLan1.0	NW_004955556	566,735 - 589,178 (+)	NCBI	ChiLan1.0	ChiLan1.0

OGDHL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	62,006,485 - 62,035,055 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	62,011,805 - 62,040,373 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	44,476,006 - 44,504,578 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

OGDHL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	1,573,653 - 1,600,264 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	1,573,793 - 1,596,285 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	1,808,847 - 1,835,446 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	1,751,094 - 1,777,697 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	1,751,095 - 1,944,541 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	1,548,295 - 1,574,894 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	1,585,699 - 1,612,290 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	1,717,299 - 1,743,900 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ogdhl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	79,370,219 - 79,396,328 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936728	573,049 - 599,948 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936728	573,079 - 599,155 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OGDHL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	90,207,442 - 90,236,369 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	90,207,439 - 90,235,500 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	98,115,771 - 98,143,943 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OGDHL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	42,070,452 - 42,099,565 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	42,074,064 - 42,099,706 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	1,814,865 - 1,844,890 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ogdhl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624928	251,907 - 273,359 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624928	250,483 - 271,633 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ogdhl
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	8,036,869 - 8,064,865 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ogdhl
237 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	331
Count of miRNA genes:	220
Interacting mature miRNAs:	255
Transcripts:	ENSRNOT00000027054
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	4234212	16278352	Rat
1549842	Bp248	Blood pressure QTL 248		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	387123	45387123	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33425095	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39568015	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4234212	53708481	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	4744222	49744222	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4234212	16278352	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	1	26734272	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26734272	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	4354822	49354822	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	387123	45387123	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4234212	49757901	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4234212	66955197	Rat
737825	Alc13	Alcohol consumption QTL 13	4.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4234212	16061395	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39568015	Rat
631524	Bp75	Blood pressure QTL 75		0.05	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	117710	8157035	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	839086	66195506	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3386790	49757901	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3386790	26128267	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	839086	66195506	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	839086	66195506	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26734272	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4234333	17730812	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	839086	52786090	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	839086	66195506	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	3301683	48301683	Rat

Markers in Region

D16Got7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	7,586,010 - 7,586,195 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	8,505,181 - 8,505,363	NCBI	Rnor6.0
Rnor_5.0	16	8,421,318 - 8,421,500	UniSTS	Rnor5.0
RGSC_v3.4	16	7,841,065 - 7,841,249	UniSTS	RGSC3.4
RGSC_v3.4	16	7,841,064 - 7,841,249	RGD	RGSC3.4
Celera	16	7,614,111 - 7,614,295	UniSTS
RGSC_v3.1	16	7,841,063 - 7,841,247	RGD
RH 3.4 Map	16	75.8	UniSTS
RH 3.4 Map	16	75.8	RGD
RH 2.0 Map	16	39.0	RGD
Cytogenetic Map	16	p16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	78	59	6	341	177	10	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001395109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027054 ⟹ ENSRNOP00000027054

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	7,584,657 - 7,610,698 (+)	Ensembl
mRatBN7.2 Ensembl	16	7,578,367 - 7,604,386 (+)	Ensembl
Rnor_6.0 Ensembl	16	8,497,569 - 8,523,557 (+)	Ensembl

RefSeq Acc Id:

NM_001395109 ⟹ NP_001382038

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	7,584,666 - 7,610,705 (+)	NCBI
mRatBN7.2	16	7,578,343 - 7,604,385 (+)	NCBI

RefSeq Acc Id:

XM_039094270 ⟹ XP_038950198

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	7,585,084 - 7,610,705 (+)	NCBI
mRatBN7.2	16	7,578,729 - 7,604,385 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001382038	(Get FASTA)	NCBI Sequence Viewer
	XP_038950198	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZQD3	(Get FASTA)	NCBI Sequence Viewer
	EDL88917	(Get FASTA)	NCBI Sequence Viewer
	EDL88918	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027054

Ensembl Acc Id:

ENSRNOP00000027054 ⟸ ENSRNOT00000027054

RefSeq Acc Id:	XP_038950198 ⟸ XM_039094270
- Peptide Label:	isoform X1
- UniProtKB:	D3ZQD3 (UniProtKB/Swiss-Prot), A0A8L2QEC5 (UniProtKB/TrEMBL), A6KFW1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001382038 ⟸ NM_001395109
- UniProtKB:	D3ZQD3 (UniProtKB/Swiss-Prot), A0A8L2QEC5 (UniProtKB/TrEMBL), A6KFW1 (UniProtKB/TrEMBL)

Protein Domains

Transketolase-like pyrimidine-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZQD3-F1-model_v2	AlphaFold	D3ZQD3	1-1010	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699942

Promoter ID:

EPDNEW_R10464

Type:

multiple initiation site

Name:

Ogdhl_1

Description:

oxoglutarate dehydrogenase-like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	8,497,529 - 8,497,589	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310916	AgrOrtholog
BioCyc Gene	G2FUF-12110	BioCyc
BioCyc Pathway	LYSINE-DEG1-PWY [L-lysine degradation XI (mammalian)]	BioCyc
	PWY-5084 [2-oxoglutarate decarboxylation to succinyl-CoA]	BioCyc
	PWY-5652 [2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA]	BioCyc
	PWY-5690 [TCA cycle II (plants and fungi)]	BioCyc
BioCyc Pathway Image	LYSINE-DEG1-PWY	BioCyc
	PWY-5084	BioCyc
	PWY-5652	BioCyc
	PWY-5690	BioCyc
Ensembl Genes	ENSRNOG00000019955	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000027054	ENTREZGENE
Gene3D-CATH	3.40.50.11610	UniProtKB/Swiss-Prot
	3.40.50.12470	UniProtKB/Swiss-Prot
	3.40.50.970	UniProtKB/Swiss-Prot
	TPP helical domain	UniProtKB/Swiss-Prot
InterPro	2-oxogl_dehyd_N	UniProtKB/Swiss-Prot
	2oxoglutarate_DH_E1	UniProtKB/Swiss-Prot
	DH_E1	UniProtKB/Swiss-Prot
	KGD_C	UniProtKB/Swiss-Prot
	KGD_C_sf	UniProtKB/Swiss-Prot
	THDP-binding	UniProtKB/Swiss-Prot
	Transketolase-like_Pyr-bd	UniProtKB/Swiss-Prot
NCBI Gene	290566	ENTREZGENE
PANTHER	2-OXOGLUTARATE DEHYDROGENASE-LIKE, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	PTHR23152	UniProtKB/Swiss-Prot
Pfam	2-oxogl_dehyd_N	UniProtKB/Swiss-Prot
	E1_dh	UniProtKB/Swiss-Prot
	OxoGdeHyase_C	UniProtKB/Swiss-Prot
	Transket_pyr	UniProtKB/Swiss-Prot
PhenoGen	Ogdhl	PhenoGen
PIRSF	Oxoglu_dh_E1	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019955	RatGTEx
SMART	Transket_pyr	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52518	UniProtKB/Swiss-Prot
UniProt	A0A8L2QEC5	ENTREZGENE, UniProtKB/TrEMBL
	A6KFW1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZQD3	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-05-22	Ogdhl	oxoglutarate dehydrogenase L	Ogdhl	oxoglutarate dehydrogenase-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ogdhl	oxoglutarate dehydrogenase-like	Ogdhl_predicted	oxoglutarate dehydrogenase-like (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ogdhl_predicted	oxoglutarate dehydrogenase-like (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

BioCyc Pathways