Endog (endonuclease G) - Rat Genome Database

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Gene: Endog (endonuclease G) Rattus norvegicus
Analyze
Symbol: Endog
Name: endonuclease G
RGD ID: 1310763
Description: Enables DNA nuclease activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of apoptotic DNA fragmentation; and positive regulation of hydrogen peroxide-mediated programmed cell death. Located in perikaryon and perinuclear region of cytoplasm. Biomarker of brain ischemia; congestive heart failure; and muscular atrophy. Orthologous to human ENDOG (endonuclease G); PARTICIPATES IN apoptotic cell death pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endonuclease G, mitochondrial; LOC362100
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,846,935 - 33,849,531 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl333,846,885 - 33,849,573 (+)EnsemblGRCr8
mRatBN7.2313,449,113 - 13,451,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,449,086 - 13,451,932 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx316,521,074 - 16,523,700 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.031,414,746 - 1,417,374 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,359,321 - 23,361,921 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,741,833 - 8,744,414 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,741,766 - 8,744,592 (+)Ensemblrn6Rnor6.0
Rnor_5.0314,094,275 - 14,096,910 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.439,184,023 - 9,187,524 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera38,222,701 - 8,225,752 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitrophenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP,ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
Auriculasin  (ISO)
bisphenol A  (EXP,ISO)
bufalin  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
canertinib  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
casticin  (ISO)
celastrol  (ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
ethanol  (ISO)
fisetin  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
isoflavones  (ISO)
lead diacetate  (ISO)
Lupiwighteone  (ISO)
methotrexate  (ISO)
N-acetyl-L-cysteine  (ISO)
naringin  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tebufenpyrad  (ISO)
tetrachloroethene  (ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiomalic acid  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A Ca2+-induced mitochondrial permeability transition causes complete release of rat liver endonuclease G activity from its exclusive location within the mitochondrial intermembrane space. Identification of a novel endo-exonuclease activity residing within the mitochondrial matrix. Davies AM, etal., Nucleic Acids Res. 2003 Feb 15;31(4):1364-73.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress. Ishihara Y and Shimamoto N, J Biol Chem. 2006 Mar 10;281(10):6726-33. Epub 2006 Jan 4.
5. Naringenin prevents high glucose-induced mitochondria-mediated apoptosis involving AIF, Endo-G and caspases. Kapoor R, etal., Apoptosis. 2013 Jan;18(1):9-27. doi: 10.1007/s10495-012-0781-7.
6. Age-related differences in apoptosis with disuse atrophy in soleus muscle. Leeuwenburgh C, etal., Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1288-96. Epub 2005 Jan 13.
7. Mitochondrial fission controls DNA fragmentation by regulating endonuclease G. Li J, etal., Free Radic Biol Med. 2010 Aug 15;49(4):622-31. doi: 10.1016/j.freeradbiomed.2010.05.021. Epub 2010 Jun 1.
8. Intranuclear localization of apoptosis-inducing factor and endonuclease G involves in peroxynitrite-induced apoptosis of spiral ganglion neurons. Liu W, etal., Neurol Res. 2012 Dec;34(10):915-22. doi: 10.1179/1743132812Y.0000000098. Epub 2012 Sep 20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia. Nielsen M, etal., Exp Brain Res. 2008 Sep;190(1):81-9. doi: 10.1007/s00221-008-1452-3. Epub 2008 Jun 21.
11. Ovariectomy and 17beta-estradiol replacement play a role on the expression of Endonuclease-G and phosphorylated cyclic AMP response element-binding (CREB) protein in hippocampus. Pereira RT, etal., Mol Cell Endocrinol. 2014 Jan 25;382(1):227-33. doi: 10.1016/j.mce.2013.09.037. Epub 2013 Oct 9.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats. Singh BK, etal., PLoS One. 2012;7(4):e34200. doi: 10.1371/journal.pone.0034200. Epub 2012 Apr 3.
16. Response of caspase-independent apoptotic factors to high salt diet-induced heart failure. Siu PM, etal., J Mol Cell Cardiol. 2007 Mar;42(3):678-86. Epub 2007 Jan 9.
17. Protective effect of caspase inhibition on compression-induced muscle damage. Teng BT, etal., J Physiol. 2011 Jul 1;589(Pt 13):3349-69. doi: 10.1113/jphysiol.2011.209619. Epub 2011 May 3.
18. Overexpression of SOD1 in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury. Yu F, etal., J Neurotrauma. 2006 May;23(5):595-603.
19. BNIP3 upregulation and EndoG translocation in delayed neuronal death in stroke and in hypoxia. Zhang Z, etal., Stroke. 2007 May;38(5):1606-13. Epub 2007 Mar 22.
20. Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures. Zhao S, etal., J Neurosci Res. 2010 Jun;88(8):1727-37. doi: 10.1002/jnr.22338.
Additional References at PubMed
PMID:14651853   PMID:14663139   PMID:16754658   PMID:16767516   PMID:16873557   PMID:17050806   PMID:18312415   PMID:18614015   PMID:19737385   PMID:21437288   PMID:21979051  


Genomics

Comparative Map Data
Endog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,846,935 - 33,849,531 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl333,846,885 - 33,849,573 (+)EnsemblGRCr8
mRatBN7.2313,449,113 - 13,451,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,449,086 - 13,451,932 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx316,521,074 - 16,523,700 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.031,414,746 - 1,417,374 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,359,321 - 23,361,921 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,741,833 - 8,744,414 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,741,766 - 8,744,592 (+)Ensemblrn6Rnor6.0
Rnor_5.0314,094,275 - 14,096,910 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.439,184,023 - 9,187,524 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera38,222,701 - 8,225,752 (+)NCBICelera
Cytogenetic Map3p12NCBI
ENDOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,818,500 - 128,822,676 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,818,461 - 128,822,676 (+)Ensemblhg38GRCh38
GRCh379131,580,779 - 131,584,955 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,620,600 - 130,624,776 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349128,660,332 - 128,664,509NCBI
Celera9102,231,564 - 102,235,740 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9101,189,778 - 101,193,954 (+)NCBIHuRef
CHM1_19131,731,780 - 131,735,956 (+)NCBICHM1_1
T2T-CHM13v2.09141,023,301 - 141,027,477 (+)NCBIT2T-CHM13v2.0
Endog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39230,061,525 - 30,064,057 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl230,061,505 - 30,064,081 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38230,171,408 - 30,174,069 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,171,493 - 30,174,069 (+)Ensemblmm10GRCm38
MGSCv37230,027,044 - 30,029,589 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36229,993,533 - 29,996,078 (+)NCBIMGSCv36mm8
Celera229,875,396 - 29,877,941 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.29NCBI
Endog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555701,200,996 - 1,203,566 (+)Ensembl
ChiLan1.0NW_0049555701,200,461 - 1,203,566 (+)NCBIChiLan1.0ChiLan1.0
ENDOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21110,528,426 - 10,532,489 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1910,530,841 - 10,534,838 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,941,856 - 99,945,957 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,609,839 - 128,613,353 (+)NCBIPanPan1.1PanPan1.1panPan2
ENDOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,809,470 - 54,812,795 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl954,809,530 - 54,813,042 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha954,004,973 - 54,008,297 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0955,730,508 - 55,733,832 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl955,730,568 - 55,734,098 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,491,141 - 54,494,468 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0954,803,909 - 54,807,233 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0954,897,321 - 54,900,646 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Endog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947196,513,430 - 196,519,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648716,282,398 - 16,285,418 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648716,282,115 - 16,285,486 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENDOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,154,090 - 269,157,788 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11269,153,955 - 269,157,789 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,170,007 - 303,173,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ENDOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,322,828 - 9,326,833 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,322,892 - 9,326,549 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666096150,312 - 154,313 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Endog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,193,173 - 6,196,374 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247606,193,168 - 6,196,209 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Endog
30 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:77
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000021531
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH134420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,451,323 - 13,451,508 (+)MAPPERmRatBN7.2
Rnor_6.038,744,023 - 8,744,207NCBIRnor6.0
Rnor_5.0314,096,519 - 14,096,703UniSTSRnor5.0
RGSC_v3.439,187,133 - 9,187,317UniSTSRGSC3.4
Celera38,225,361 - 8,225,545UniSTS
RH 3.4 Map352.5UniSTS
Cytogenetic Map3p12UniSTS
BI278171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,451,794 - 13,451,908 (+)MAPPERmRatBN7.2
Rnor_6.038,744,494 - 8,744,607NCBIRnor6.0
Rnor_5.0314,096,990 - 14,097,103UniSTSRnor5.0
RGSC_v3.439,187,604 - 9,187,717UniSTSRGSC3.4
Celera38,225,832 - 8,225,945UniSTS
RH 3.4 Map351.81UniSTS
Cytogenetic Map3p12UniSTS
RH124237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,451,266 - 13,451,420 (+)MAPPERmRatBN7.2
Rnor_6.038,743,966 - 8,744,119NCBIRnor6.0
Rnor_5.0314,096,462 - 14,096,615UniSTSRnor5.0
RGSC_v3.439,187,076 - 9,187,229UniSTSRGSC3.4
Celera38,225,304 - 8,225,457UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 89 59 6 353 189 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021531   ⟹   ENSRNOP00000021531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl333,846,885 - 33,849,573 (+)Ensembl
mRatBN7.2 Ensembl313,449,086 - 13,451,932 (+)Ensembl
Rnor_6.0 Ensembl38,741,766 - 8,744,592 (+)Ensembl
RefSeq Acc Id: NM_001034938   ⟹   NP_001030110
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,846,935 - 33,849,531 (+)NCBI
mRatBN7.2313,449,113 - 13,451,715 (+)NCBI
Rnor_6.038,741,833 - 8,744,414 (+)NCBI
Rnor_5.0314,094,275 - 14,096,910 (+)NCBI
RGSC_v3.439,184,023 - 9,187,524 (+)RGD
Celera38,222,701 - 8,225,752 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001030110 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE44115 (Get FASTA)   NCBI Sequence Viewer  
  EDL93340 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021531
  ENSRNOP00000021531.3
RefSeq Acc Id: NP_001030110   ⟸   NM_001034938
- Peptide Label: precursor
- UniProtKB: Q3V5X8 (UniProtKB/TrEMBL),   A6JTV7 (UniProtKB/TrEMBL),   F7FQ61 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021531   ⟸   ENSRNOT00000021531
Protein Domains
DNA/RNA non-specific   ENPP1-3/EXOG-like endonuclease/phosphodiesterase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3V5X8-F1-model_v2 AlphaFold Q3V5X8 1-294 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691953
Promoter ID:EPDNEW_R2477
Type:multiple initiation site
Name:Endog_1
Description:endonuclease G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.038,741,785 - 8,741,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310763 AgrOrtholog
BioCyc Gene G2FUF-50231 BioCyc
Ensembl Genes ENSRNOG00000016033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021531 ENTREZGENE
  ENSRNOT00000021531.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.570.10 UniProtKB/TrEMBL
InterPro DNA/RNA_endonuclease_AS UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease_sf UniProtKB/TrEMBL
  Extracellular_endonuc_su_A UniProtKB/TrEMBL
  His-Me_finger_sf UniProtKB/TrEMBL
  Non-specific_endonuclease UniProtKB/TrEMBL
KEGG Report rno:362100 UniProtKB/TrEMBL
NCBI Gene 362100 ENTREZGENE
PANTHER ENDONUCLEASE G, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR13966 UniProtKB/TrEMBL
Pfam Endonuclease_NS UniProtKB/TrEMBL
PhenoGen Endog PhenoGen
PROSITE NUCLEASE_NON_SPEC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016033 RatGTEx
SMART Endonuclease_NS UniProtKB/TrEMBL
  NUC UniProtKB/TrEMBL
Superfamily-SCOP SSF54060 UniProtKB/TrEMBL
UniProt A6JTV7 ENTREZGENE, UniProtKB/TrEMBL
  F7FQ61 ENTREZGENE, UniProtKB/TrEMBL
  Q3V5X8 ENTREZGENE
UniProt Secondary Q3V5X8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Endog  endonuclease G  Endog_predicted  endonuclease G (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Endog_predicted  endonuclease G (predicted)      Symbol and Name status set to approved 70820 APPROVED