Ppox (protoporphyrinogen oxidase) - Rat Genome Database

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Gene: Ppox (protoporphyrinogen oxidase) Rattus norvegicus
Analyze
Symbol: Ppox
Name: protoporphyrinogen oxidase
RGD ID: 1310543
Description: Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme biosynthetic process; protoporphyrinogen IX metabolic process; and response to xenobiotic stimulus. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase); PARTICIPATES IN heme biosynthetic pathway; acute intermittent porphyria pathway; erythropoietic porphyria pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC289219
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,230,111 - 86,235,028 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,230,111 - 86,234,246 (-)EnsemblGRCr8
mRatBN7.21383,697,661 - 83,701,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,664,891 - 83,701,805 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1386,203,532 - 86,207,667 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,601,739 - 87,605,874 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,833,201 - 84,837,337 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,650,094 - 89,654,998 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,650,094 - 89,654,244 (-)Ensemblrn6Rnor6.0
Rnor_5.01394,276,960 - 94,281,296 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41387,170,602 - 87,174,740 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1383,328,348 - 83,332,483 (-)NCBICelera
RGSC_v3.11387,359,527 - 87,363,605 (-)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effects of iron deficiency and chronic iron overloading on mitochondrial heme biosynthetic enzymes in rat liver. Abraham NG, etal., Biochim Biophys Acta. 1986 Mar 28;870(2):339-49.
2. Biosynthesis of heme in mammals. Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
3. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
4. The mitochondrial location of protoporphyrinogen oxidase. Deybach JC, etal., Eur J Biochem. 1985 Jun 3;149(2):431-5.
5. Mutations in the protoporphyrinogen oxidase gene in patients with variegate porphyria. Deybach JC, etal., Hum Mol Genet. 1996 Mar;5(3):407-10.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GenMAPP: Gene Map Annotator and Pathway Profiler GenMAPP
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Variegate porphyria in South Africa, 1688-1996--new developments in an old disease. Hift RJ, etal., S Afr Med J. 1997 Jun;87(6):722-31.
10. Rat liver protoporphyrinogen IX oxidase: site of synthesis and factor influencing its activity. Kolarov J, etal., Biochem Biophys Res Commun. 1983 Oct 31;116(2):383-7.
11. Herbicide-induced experimental variegate porphyria in mice: tissue porphyrinogen accumulation and response to porphyrogenic drugs. Krijt J, etal., Can J Physiol Pharmacol. 1997 Oct-Nov;75(10-11):1181-7.
12. An h.p.l.c. assay for protoporphyrinogen oxidase activity in rat liver. Li F, etal., Biochem J. 1987 May 1;243(3):863-6.
13. Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria. Lindberg RL, etal., Nat Genet. 1996 Feb;12(2):195-9.
14. A mouse model for South African (R59W) variegate porphyria: construction and initial characterization. Medlock AE, etal., Cell Mol Biol (Noisy-le-grand). 2002 Feb;48(1):71-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Variegate porphyria in Western Europe: identification of PPOX gene mutations in 104 families, extent of allelic heterogeneity, and absence of correlation between phenotype and type of mutation. Whatley SD, etal., Am J Hum Genet. 1999 Oct;65(4):984-94.
Additional References at PubMed
PMID:3346226   PMID:7713909   PMID:14651853   PMID:18614015   PMID:30361391   PMID:34800366  


Genomics

Comparative Map Data
Ppox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,230,111 - 86,235,028 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,230,111 - 86,234,246 (-)EnsemblGRCr8
mRatBN7.21383,697,661 - 83,701,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,664,891 - 83,701,805 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1386,203,532 - 86,207,667 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,601,739 - 87,605,874 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,833,201 - 84,837,337 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,650,094 - 89,654,998 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,650,094 - 89,654,244 (-)Ensemblrn6Rnor6.0
Rnor_5.01394,276,960 - 94,281,296 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41387,170,602 - 87,174,740 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1383,328,348 - 83,332,483 (-)NCBICelera
RGSC_v3.11387,359,527 - 87,363,605 (-)NCBI
Cytogenetic Map13q24NCBI
PPOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,165,728 - 161,178,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,165,837 - 161,178,013 (+)Ensemblhg38GRCh38
GRCh371161,136,216 - 161,141,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,402,818 - 159,407,634 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341157,949,266 - 157,954,085NCBI
Celera1134,203,334 - 134,208,163 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,493,123 - 132,497,952 (+)NCBIHuRef
CHM1_11162,532,431 - 162,537,260 (+)NCBICHM1_1
T2T-CHM13v2.01160,303,185 - 160,315,736 (+)NCBIT2T-CHM13v2.0
Ppox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,104,564 - 171,108,955 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,103,563 - 171,108,760 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381171,276,991 - 171,281,193 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,275,990 - 171,281,186 (-)Ensemblmm10GRCm38
MGSCv371173,207,123 - 173,211,317 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361173,113,667 - 173,117,835 (-)NCBIMGSCv36mm8
Celera1173,733,013 - 173,737,208 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.3NCBI
Ppox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,930,495 - 12,934,437 (+)Ensembl
ChiLan1.0NW_00495546812,930,387 - 12,934,437 (+)NCBIChiLan1.0ChiLan1.0
PPOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,673,982 - 88,685,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,351,824 - 88,376,257 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,578,846 - 136,590,466 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,491,667 - 140,496,506 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,491,667 - 140,502,328 (+)EnsemblpanPan2panpan1.1
PPOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,306,973 - 21,310,892 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,306,974 - 21,311,012 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3821,381,833 - 21,385,563 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03821,424,824 - 21,428,556 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,424,825 - 21,428,486 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,312,659 - 21,316,388 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,727,092 - 21,730,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,136,240 - 22,139,973 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,261,120 - 7,266,047 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903470,344 - 478,025 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936903470,317 - 474,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,284,500 - 89,288,902 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1489,277,984 - 89,288,946 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,134,711 - 97,145,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,814,571 - 2,819,384 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,814,571 - 2,818,936 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660381,861,663 - 1,867,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794212,226 - 215,931 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624794212,220 - 215,891 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppox
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11050,441,914 - 50,446,077 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppox
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:68
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000004896
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
W53272  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,703,257 - 83,703,366 (+)MAPPERmRatBN7.2
Rnor_6.01389,655,691 - 89,655,799NCBIRnor6.0
Rnor_5.01394,282,557 - 94,282,665UniSTSRnor5.0
RGSC_v3.41387,176,203 - 87,176,311UniSTSRGSC3.4
Celera1383,333,945 - 83,334,053UniSTS
Cytogenetic Map13q24UniSTS
RH129176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,701,048 - 83,701,242 (+)MAPPERmRatBN7.2
Rnor_6.01389,653,481 - 89,653,674NCBIRnor6.0
Rnor_5.01394,280,347 - 94,280,540UniSTSRnor5.0
RGSC_v3.41387,173,992 - 87,174,185UniSTSRGSC3.4
Celera1383,331,735 - 83,331,928UniSTS
RH 3.4 Map13561.3UniSTS
Cytogenetic Map13q24UniSTS
AA859700  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81386,230,195 - 86,230,585 (+)Marker Load Pipeline
mRatBN7.21383,697,746 - 83,698,136 (+)MAPPERmRatBN7.2
Rnor_6.01389,650,179 - 89,650,568NCBIRnor6.0
Rnor_5.01394,277,045 - 94,277,434UniSTSRnor5.0
RGSC_v3.41387,170,687 - 87,171,076UniSTSRGSC3.4
Celera1383,328,433 - 83,328,822UniSTS
RH 3.4 Map13552.3UniSTS
Cytogenetic Map13q24UniSTS
BF405831  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,702,405 - 83,702,559 (+)MAPPERmRatBN7.2
Rnor_6.01389,654,838 - 89,654,991NCBIRnor6.0
Rnor_5.01394,281,704 - 94,281,857UniSTSRnor5.0
RGSC_v3.41387,175,349 - 87,175,502UniSTSRGSC3.4
Celera1383,333,092 - 83,333,245UniSTS
RH 3.4 Map13568.4UniSTS
Cytogenetic Map13q24UniSTS
Ppox  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,697,781 - 83,698,111 (+)MAPPERmRatBN7.2
Rnor_6.01389,650,214 - 89,650,543NCBIRnor6.0
Rnor_5.01394,277,080 - 94,277,409UniSTSRnor5.0
RGSC_v3.41387,170,722 - 87,171,051UniSTSRGSC3.4
Celera1383,328,468 - 83,328,797UniSTS
Cytogenetic Map13q24UniSTS
G43283  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,702,692 - 83,702,832 (+)MAPPERmRatBN7.2
Rnor_6.01389,655,126 - 89,655,265NCBIRnor6.0
Rnor_5.01394,281,992 - 94,282,131UniSTSRnor5.0
RGSC_v3.41387,175,637 - 87,175,776UniSTSRGSC3.4
Celera1383,333,380 - 83,333,519UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000004896   ⟹   ENSRNOP00000004896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,230,111 - 86,234,246 (-)Ensembl
mRatBN7.2 Ensembl1383,664,891 - 83,701,805 (-)Ensembl
Rnor_6.0 Ensembl1389,650,094 - 89,654,244 (-)Ensembl
RefSeq Acc Id: NM_001105968   ⟹   NP_001099438
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,234,246 (-)NCBI
mRatBN7.21383,697,662 - 83,701,797 (-)NCBI
Rnor_6.01389,650,094 - 89,654,229 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
RGSC_v3.41387,170,602 - 87,174,740 (-)RGD
Celera1383,328,348 - 83,332,483 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250240   ⟹   XP_006250302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,235,028 (-)NCBI
mRatBN7.21383,697,661 - 83,701,998 (-)NCBI
Rnor_6.01389,650,094 - 89,654,998 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250241   ⟹   XP_006250303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,234,271 (-)NCBI
mRatBN7.21383,697,661 - 83,701,822 (-)NCBI
Rnor_6.01389,650,094 - 89,654,262 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250243   ⟹   XP_006250305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,233,841 (-)NCBI
mRatBN7.21383,697,661 - 83,701,392 (-)NCBI
Rnor_6.01389,650,094 - 89,653,824 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090506   ⟹   XP_038946434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,235,028 (-)NCBI
mRatBN7.21383,697,661 - 83,701,998 (-)NCBI
RefSeq Acc Id: XM_039090508   ⟹   XP_038946436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,233,597 (-)NCBI
mRatBN7.21383,697,661 - 83,701,148 (-)NCBI
RefSeq Acc Id: XM_039090509   ⟹   XP_038946437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,863 - 86,235,028 (-)NCBI
mRatBN7.21383,698,407 - 83,701,998 (-)NCBI
RefSeq Acc Id: XM_063272128   ⟹   XP_063128198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,233,454 (-)NCBI
RefSeq Acc Id: NP_001099438   ⟸   NM_001105968
- UniProtKB: A6JFW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250302   ⟸   XM_006250240
- Peptide Label: isoform X1
- UniProtKB: D3ZVN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250303   ⟸   XM_006250241
- Peptide Label: isoform X1
- UniProtKB: D3ZVN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250305   ⟸   XM_006250243
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000004896   ⟸   ENSRNOT00000004896
RefSeq Acc Id: XP_038946434   ⟸   XM_039090506
- Peptide Label: isoform X2
- UniProtKB: A6JFW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946436   ⟸   XM_039090508
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038946437   ⟸   XM_039090509
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063128198   ⟸   XM_063272128
- Peptide Label: isoform X4
Protein Domains
Amine oxidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVN7-F1-model_v2 AlphaFold D3ZVN7 1-477 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699000
Promoter ID:EPDNEW_R9525
Type:initiation region
Name:Ppox_1
Description:protoporphyrinogen oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,654,237 - 89,654,297EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310543 AgrOrtholog
BioCyc Gene G2FUF-17378 BioCyc
Ensembl Genes ENSRNOG00000003567 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004896 ENTREZGENE
  ENSRNOT00000004896.8 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro Amino_oxidase UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/TrEMBL
  Flavin_amine_oxidase UniProtKB/TrEMBL
  Protoporphyrinogen_oxidase UniProtKB/TrEMBL
  Zeta_carotene_desat/Oxidored UniProtKB/TrEMBL
KEGG Report rno:289219 UniProtKB/TrEMBL
NCBI Gene 289219 ENTREZGENE
PANTHER PROTOPORPHYRINOGEN OXIDASE UniProtKB/TrEMBL
  PROTOPORPHYRINOGEN OXIDASE UniProtKB/TrEMBL
Pfam Amino_oxidase UniProtKB/TrEMBL
PhenoGen Ppox PhenoGen
PRINTS AMINEOXDASEF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003567 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
UniProt A6JFW5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVN7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ppox  protoporphyrinogen oxidase   Ppox_predicted  protoporphyrinogen oxidase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ppox_predicted  protoporphyrinogen oxidase (predicted)      Symbol and Name status set to approved 70820 APPROVED