Tmem135 (transmembrane protein 135) - Rat Genome Database

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Gene: Tmem135 (transmembrane protein 135) Rattus norvegicus
Analyze
Symbol: Tmem135
Name: transmembrane protein 135
RGD ID: 1309948
Description: Predicted to enable lipid transporter activity. Involved in peroxisome organization. Located in peroxisome. Orthologous to human TMEM135 (transmembrane protein 135); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC293098; peroxisomal membrane protein 52; PMP52; RGD1309948; similar to CG11737-PA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,418,929 - 152,692,405 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1152,418,930 - 152,633,717 (-)EnsemblGRCr8
mRatBN7.21143,006,343 - 143,279,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,006,344 - 143,221,171 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1150,946,627 - 151,161,989 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,123,038 - 158,338,392 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01150,996,971 - 151,212,318 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01152,886,496 - 153,096,225 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1152,886,996 - 153,096,269 (-)Ensemblrn6Rnor6.0
Rnor_5.01159,198,115 - 159,407,220 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41145,664,796 - 145,894,704 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1141,267,393 - 141,482,030 (-)NCBICelera
RGSC_v3.11145,906,168 - 145,973,110 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat liver peroxisomes after fibrate treatment. A survey using quantitative mass spectrometry. Islinger M, etal., J Biol Chem. 2007 Aug 10;282(32):23055-69. Epub 2007 May 22.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17768142   PMID:21151927   PMID:27863209  


Genomics

Comparative Map Data
Tmem135
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,418,929 - 152,692,405 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1152,418,930 - 152,633,717 (-)EnsemblGRCr8
mRatBN7.21143,006,343 - 143,279,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,006,344 - 143,221,171 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1150,946,627 - 151,161,989 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,123,038 - 158,338,392 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01150,996,971 - 151,212,318 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01152,886,496 - 153,096,225 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1152,886,996 - 153,096,269 (-)Ensemblrn6Rnor6.0
Rnor_5.01159,198,115 - 159,407,220 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41145,664,796 - 145,894,704 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1141,267,393 - 141,482,030 (-)NCBICelera
RGSC_v3.11145,906,168 - 145,973,110 (-)NCBI
Cytogenetic Map1q32NCBI
TMEM135
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381187,037,934 - 87,328,824 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1187,037,831 - 87,328,824 (+)Ensemblhg38GRCh38
GRCh371186,748,976 - 87,039,866 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361186,426,713 - 86,712,220 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1184,060,241 - 84,351,174 (+)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1183,035,028 - 83,326,329 (+)NCBIHuRef
CHM1_11186,634,959 - 86,925,799 (+)NCBICHM1_1
T2T-CHM13v2.01186,978,816 - 87,269,939 (+)NCBIT2T-CHM13v2.0
Tmem135
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39788,789,230 - 89,053,911 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl788,788,922 - 89,053,430 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38789,140,022 - 89,404,703 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl789,139,714 - 89,404,222 (-)Ensemblmm10GRCm38
MGSCv37796,288,231 - 96,487,297 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36789,014,913 - 89,213,788 (-)NCBIMGSCv36mm8
Celera786,493,805 - 86,694,402 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.32NCBI
Tmem135
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554145,810,639 - 6,017,591 (-)Ensembl
ChiLan1.0NW_0049554145,810,639 - 6,016,949 (-)NCBIChiLan1.0ChiLan1.0
TMEM135
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2987,954,391 - 88,228,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11189,006,250 - 89,280,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,089,010 - 82,360,744 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,696,632 - 85,966,778 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,696,632 - 85,966,778 (+)EnsemblpanPan2panpan1.1
TMEM135
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12112,410,128 - 12,698,099 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2112,411,826 - 12,637,912 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2112,277,258 - 12,563,500 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02112,593,573 - 12,879,856 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2112,593,925 - 12,821,104 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12112,380,331 - 12,666,379 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02112,450,533 - 12,737,862 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02112,507,120 - 12,794,080 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem135
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494773,188,375 - 73,367,066 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367361,978,110 - 2,113,451 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367361,986,361 - 2,113,455 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM135
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl920,721,991 - 21,021,130 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1920,741,085 - 21,020,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMEM135
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1178,285,287 - 78,539,607 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl178,285,376 - 78,541,905 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604347,180,292 - 47,436,970 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem135
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248452,710,354 - 2,972,290 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248452,710,422 - 2,972,260 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem135
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12111,803,718 - 111,997,301 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem135
3125 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:131
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000022578
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
D1Rat46  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81152,424,361 - 152,424,541 (+)Marker Load Pipeline
mRatBN7.21143,011,775 - 143,011,955 (+)MAPPERmRatBN7.2
Rnor_6.01152,892,412 - 152,892,591NCBIRnor6.0
Rnor_5.01159,203,548 - 159,203,727UniSTSRnor5.0
RGSC_v3.41145,670,228 - 145,670,408RGDRGSC3.4
RGSC_v3.41145,670,229 - 145,670,408UniSTSRGSC3.4
Celera1141,272,826 - 141,272,991UniSTS
RGSC_v3.11145,748,635 - 145,748,814RGD
RH 3.4 Map11116.6RGD
RH 3.4 Map11116.6UniSTS
RH 2.0 Map1730.8RGD
SHRSP x BN Map174.52RGD
FHH x ACI Map167.75RGD
Cytogenetic Map1q32UniSTS
D1Rat210  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81152,612,652 - 152,612,788 (+)Marker Load Pipeline
mRatBN7.21143,200,066 - 143,200,202 (+)MAPPERmRatBN7.2
Rnor_6.01153,076,856 - 153,076,991NCBIRnor6.0
Rnor_5.01159,388,021 - 159,388,156UniSTSRnor5.0
RGSC_v3.41145,865,237 - 145,865,373RGDRGSC3.4
RGSC_v3.41145,865,238 - 145,865,373UniSTSRGSC3.4
Celera1141,460,534 - 141,461,143UniSTS
RGSC_v3.11145,943,644 - 145,943,779RGD
RH 3.4 Map11115.4RGD
RH 3.4 Map11115.4UniSTS
RH 2.0 Map1724.9RGD
SHRSP x BN Map174.4799RGD
FHH x ACI Map167.73RGD
Cytogenetic Map1q32UniSTS
D1Got132  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,101,678 - 143,101,811 (+)MAPPERmRatBN7.2
Rnor_6.01152,981,081 - 152,981,211NCBIRnor6.0
Rnor_5.01159,292,217 - 159,292,347UniSTSRnor5.0
RGSC_v3.41145,762,928 - 145,763,058UniSTSRGSC3.4
RGSC_v3.41145,762,930 - 145,763,058RGDRGSC3.4
Celera1141,362,123 - 141,362,253UniSTS
RGSC_v3.11145,841,336 - 145,841,464RGD
RH 3.4 Map11114.0UniSTS
RH 3.4 Map11114.0RGD
RH 2.0 Map1762.0RGD
Cytogenetic Map1q32UniSTS
RH131497  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,006,679 - 143,006,880 (+)MAPPERmRatBN7.2
Rnor_6.01152,887,316 - 152,887,516NCBIRnor6.0
Rnor_5.01159,198,452 - 159,198,652UniSTSRnor5.0
RGSC_v3.41145,665,133 - 145,665,333UniSTSRGSC3.4
Celera1141,267,730 - 141,267,930UniSTS
RH 3.4 Map11122.8UniSTS
Cytogenetic Map1q32UniSTS
BF416266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,005,913 - 143,006,032 (+)MAPPERmRatBN7.2
Rnor_6.01152,886,550 - 152,886,668NCBIRnor6.0
Rnor_5.01159,197,686 - 159,197,804UniSTSRnor5.0
RGSC_v3.41145,664,367 - 145,664,485UniSTSRGSC3.4
Celera1141,266,964 - 141,267,082UniSTS
RH 3.4 Map11118.9UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 84 217 91 90 59 144 59 6 477 271 22 195 116 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000022578   ⟹   ENSRNOP00000022578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,418,930 - 152,633,717 (-)Ensembl
mRatBN7.2 Ensembl1143,006,344 - 143,221,133 (-)Ensembl
Rnor_6.0 Ensembl1152,886,996 - 153,096,269 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100447   ⟹   ENSRNOP00000080057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,418,930 - 152,633,717 (-)Ensembl
mRatBN7.2 Ensembl1143,006,344 - 143,221,133 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104794   ⟹   ENSRNOP00000082874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,418,930 - 152,633,717 (-)Ensembl
mRatBN7.2 Ensembl1143,006,344 - 143,221,133 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109760   ⟹   ENSRNOP00000094695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,418,930 - 152,633,717 (-)Ensembl
mRatBN7.2 Ensembl1143,013,551 - 143,221,171 (-)Ensembl
RefSeq Acc Id: NM_001013896   ⟹   NP_001013918
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,418,929 - 152,633,717 (-)NCBI
mRatBN7.21143,006,343 - 143,221,133 (-)NCBI
Rnor_6.01152,886,979 - 153,096,180 (-)NCBI
Rnor_5.01159,198,115 - 159,407,220 (-)NCBI
RGSC_v3.41145,664,796 - 145,894,704 (-)RGD
Celera1141,267,393 - 141,482,030 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105799   ⟹   XP_038961727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,418,966 - 152,579,077 (-)NCBI
mRatBN7.21143,006,343 - 143,166,500 (-)NCBI
RefSeq Acc Id: XM_039105807   ⟹   XP_038961735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,418,966 - 152,579,074 (-)NCBI
mRatBN7.21143,006,343 - 143,166,499 (-)NCBI
RefSeq Acc Id: XM_039105814   ⟹   XP_038961742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,418,966 - 152,692,405 (-)NCBI
mRatBN7.21143,006,343 - 143,279,824 (-)NCBI
RefSeq Acc Id: XM_039105818   ⟹   XP_038961746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,418,966 - 152,589,956 (-)NCBI
mRatBN7.21143,006,343 - 143,177,402 (-)NCBI
RefSeq Acc Id: NP_001013918   ⟸   NM_001013896
- UniProtKB: Q5U4F4 (UniProtKB/Swiss-Prot),   A6I5Z6 (UniProtKB/TrEMBL),   A0A8I6G425 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022578   ⟸   ENSRNOT00000022578
RefSeq Acc Id: XP_038961742   ⟸   XM_039105814
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038961746   ⟸   XM_039105818
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038961727   ⟸   XM_039105799
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961735   ⟸   XM_039105807
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000094695   ⟸   ENSRNOT00000109760
Ensembl Acc Id: ENSRNOP00000080057   ⟸   ENSRNOT00000100447
Ensembl Acc Id: ENSRNOP00000082874   ⟸   ENSRNOT00000104794
Protein Domains
Transmembrane protein 135 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U4F4-F1-model_v2 AlphaFold Q5U4F4 1-458 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690180
Promoter ID:EPDNEW_R705
Type:initiation region
Name:Tmem135_1
Description:transmembrane protein 135
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01153,096,218 - 153,096,278EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309948 AgrOrtholog
BioCyc Gene G2FUF-58571 BioCyc
Ensembl Genes ENSRNOG00000016815 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022578 ENTREZGENE
  ENSRNOT00000022578.6 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106476 IMAGE-MGC_LOAD
InterPro Tmem135 UniProtKB/Swiss-Prot
  TMEM135_N UniProtKB/Swiss-Prot
KEGG Report rno:293098 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105816 IMAGE-MGC_LOAD
NCBI Gene 293098 ENTREZGENE
PANTHER PTHR12459 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 135 UniProtKB/Swiss-Prot
Pfam Tim17 UniProtKB/Swiss-Prot
  TMEM135_C_rich UniProtKB/Swiss-Prot
PhenoGen Tmem135 PhenoGen
RatGTEx ENSRNOG00000016815 RatGTEx
UniProt A0A8I5ZW19_RAT UniProtKB/TrEMBL
  A0A8I6AMQ3_RAT UniProtKB/TrEMBL
  A0A8I6G425 ENTREZGENE, UniProtKB/TrEMBL
  A6I5Z6 ENTREZGENE, UniProtKB/TrEMBL
  Q5U4F4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Tmem135  transmembrane protein 135  RGD1309948  similar to CG11737-PA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309948  similar to CG11737-PA  RGD1309948_predicted  similar to CG11737-PA (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309948_predicted  similar to CG11737-PA (predicted)  LOC293098_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC293098_predicted  similar to CG11737-PA (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL