Dsg1 (desmoglein 1) - Rat Genome Database

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Gene: Dsg1 (desmoglein 1) Rattus norvegicus
Analyze
Symbol: Dsg1
Name: desmoglein 1
RGD ID: 1309925
Description: Predicted to enable calcium ion binding activity and gamma-catenin binding activity. Involved in maternal process involved in female pregnancy and response to progesterone. Located in apical plasma membrane and lateral plasma membrane. Human ortholog(s) of this gene implicated in keratosis palmoplantaris striata 1. Orthologous to human DSG1 (desmoglein 1); PARTICIPATES IN Staphylococcus aureus infection pathway; INTERACTS WITH 1-naphthyl isothiocyanate; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: desmoglein 1 beta; desmoglein 1 gamma; desmoglein-1; Dsg1b; Dsg1c; LOC291755
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81811,948,098 - 11,980,455 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1811,949,488 - 11,980,451 (+)EnsemblGRCr8
mRatBN7.21811,674,687 - 11,705,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,674,402 - 11,703,443 (+)EnsemblmRatBN7.2
Rnor_6.01812,008,301 - 12,040,337 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,008,759 - 12,038,053 (+)Ensemblrn6Rnor6.0
Rnor_5.01811,807,285 - 11,838,204 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41812,127,180 - 12,156,469 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1811,690,076 - 11,721,312 (+)NCBICelera
RGSC_v3.11812,096,380 - 12,182,381 (+)NCBI
Cytogenetic Map18p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Progesterone treatment and the progress of early pregnancy reduce desmoglein 1&2 staining along the lateral plasma membrane in rat uterine epithelial cells. Preston AM, etal., Acta Histochem. 2004;106(5):345-51.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma. Rickman L, etal., Hum Mol Genet. 1999 Jun;8(6):971-6.
12. Coordinated reassembly of the basement membrane and junctional proteins during corneal epithelial wound healing. Suzuki K, etal., Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2495-500.
13. Cell-cell junctions and vascular endothelial growth factor in rat lung as affected by ischemia/reperfusion and preconditioning with inhaled nitric oxide. Waldow T, etal., J Surg Res. 2009 Nov;157(1):30-42. Epub 2008 Sep 4.
Additional References at PubMed
PMID:7983064   PMID:12093888   PMID:12631242   PMID:14673151   PMID:15775979   PMID:23376485   PMID:23979707   PMID:25931508  


Genomics

Comparative Map Data
Dsg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81811,948,098 - 11,980,455 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1811,949,488 - 11,980,451 (+)EnsemblGRCr8
mRatBN7.21811,674,687 - 11,705,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,674,402 - 11,703,443 (+)EnsemblmRatBN7.2
Rnor_6.01812,008,301 - 12,040,337 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,008,759 - 12,038,053 (+)Ensemblrn6Rnor6.0
Rnor_5.01811,807,285 - 11,838,204 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41812,127,180 - 12,156,469 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1811,690,076 - 11,721,312 (+)NCBICelera
RGSC_v3.11812,096,380 - 12,182,381 (+)NCBI
Cytogenetic Map18p12NCBI
DSG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381831,318,160 - 31,359,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1831,318,160 - 31,359,246 (+)Ensemblhg38GRCh38
GRCh371828,898,123 - 28,939,209 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361827,152,050 - 27,191,392 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341827,152,049 - 27,190,453NCBI
Celera1825,705,178 - 25,744,520 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1825,754,044 - 25,793,387 (+)NCBIHuRef
CHM1_11828,825,336 - 28,864,663 (+)NCBICHM1_1
T2T-CHM13v2.01831,508,717 - 31,549,794 (+)NCBIT2T-CHM13v2.0
Dsg1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391820,443,982 - 20,476,407 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1820,443,868 - 20,476,407 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381820,310,873 - 20,343,353 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1820,310,811 - 20,343,350 (+)Ensemblmm10GRCm38
MGSCv371820,469,374 - 20,501,854 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361820,453,821 - 20,486,363 (+)NCBIMGSCv36mm8
Celera1820,815,287 - 20,847,880 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.29NCBI
Dsg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540218,668,196 - 18,700,630 (+)Ensembl
ChiLan1.0NW_00495540218,668,717 - 18,704,329 (+)NCBIChiLan1.0ChiLan1.0
DSG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21748,717,713 - 48,753,739 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11834,410,308 - 34,446,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01824,543,061 - 24,579,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,140,132 - 28,171,831 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,078,131 - 28,175,803 (+)EnsemblpanPan2panpan1.1
DSG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1758,159,283 - 58,239,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl758,102,113 - 58,193,708 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha757,597,684 - 57,630,602 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0758,144,506 - 58,179,775 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl758,147,900 - 58,178,837 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,822,159 - 57,855,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,848,322 - 57,881,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0758,137,415 - 58,170,337 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dsg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494453,853,056 - 53,887,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366821,853,594 - 1,889,488 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366821,854,637 - 1,889,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6115,237,677 - 115,276,645 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16115,237,836 - 115,272,944 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26107,865,594 - 107,900,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DSG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11849,372,261 - 49,408,818 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1849,375,262 - 49,406,742 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605024,016,372 - 24,052,276 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dsg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247701,517,027 - 1,542,322 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247701,514,978 - 1,551,437 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dsg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11523,246,762 - 23,276,209 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dsg1
215 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:143
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000022665, ENSRNOT00000038635, ENSRNOT00000061344
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18115642423Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
RH137413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,703,221 - 11,703,416 (+)MAPPERmRatBN7.2
Rnor_6.01812,038,177 - 12,038,371NCBIRnor6.0
Rnor_5.01811,836,044 - 11,836,238UniSTSRnor5.0
RGSC_v3.41812,155,859 - 12,156,053UniSTSRGSC3.4
Celera1811,719,152 - 11,719,346UniSTS
RH 3.4 Map18133.11UniSTS
Cytogenetic Map18p12UniSTS
RH142083  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,703,889 - 11,704,109 (+)MAPPERmRatBN7.2
Rnor_6.01812,038,845 - 12,039,064NCBIRnor6.0
Rnor_5.01811,836,712 - 11,836,931UniSTSRnor5.0
RGSC_v3.41812,156,527 - 12,156,746UniSTSRGSC3.4
Celera1811,719,820 - 11,720,039UniSTS
RH 3.4 Map18133.7UniSTS
Cytogenetic Map18p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 5 17 102 74 82 53 57 53 6 195 92 10 84 31 75 29 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000022665   ⟹   ENSRNOP00000022665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1812,008,759 - 12,037,765 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000038635   ⟹   ENSRNOP00000030176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1812,008,759 - 12,038,053 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061344   ⟹   ENSRNOP00000058060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1811,949,488 - 11,980,451 (+)Ensembl
mRatBN7.2 Ensembl1811,674,402 - 11,703,443 (+)Ensembl
Rnor_6.0 Ensembl1812,008,759 - 12,038,053 (+)Ensembl
RefSeq Acc Id: XM_063277680   ⟹   XP_063133750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81811,948,098 - 11,980,455 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001419356 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133750 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058060
  ENSRNOP00000058060.2
Ensembl Acc Id: ENSRNOP00000030176   ⟸   ENSRNOT00000038635
Ensembl Acc Id: ENSRNOP00000058060   ⟸   ENSRNOT00000061344
Ensembl Acc Id: ENSRNOP00000022665   ⟸   ENSRNOT00000022665
RefSeq Acc Id: XP_063133750   ⟸   XM_063277680
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZM39-F1-model_v2 AlphaFold D3ZM39 1-1060 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309925 AgrOrtholog
BioCyc Gene G2FUF-8234 BioCyc
Ensembl Genes ENSRNOG00000016853 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061344 ENTREZGENE
  ENSRNOT00000061344.6 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-domain_protein UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/TrEMBL
  Catenin_binding_dom UniProtKB/TrEMBL
  Desmo_cadherin UniProtKB/TrEMBL
NCBI Gene 291755 ENTREZGENE
PANTHER DESMOGLEIN FAMILY MEMBER UniProtKB/TrEMBL
  DESMOGLEIN-1 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_C UniProtKB/TrEMBL
PharmGKB DSG1 RGD
PhenoGen Dsg1 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
  DESMOCADHERN UniProtKB/TrEMBL
  DESMOGLEIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016853 RatGTEx
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
UniProt D3ZM39 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-14 Dsg1  desmoglein 1  Dsg1b  desmoglein 1 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Dsg1b  desmoglein 1 beta   LOC679010  similar to Desmoglein-1 alpha precursor (Dsg1-alpha) (Desmoglein-1) (Desmosomal glycoprotein I) (DG1) (DGI)  Data merged from RGD:1593114 1643240 APPROVED
2008-04-30 Dsg1b  desmoglein 1 beta   Dsg1b_predicted  desmoglein 1 beta (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC679010  similar to Desmoglein-1 alpha precursor (Dsg1-alpha) (Desmoglein-1) (Desmosomal glycoprotein I) (DG1) (DGI)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Dsg1c_predicted  desmoglein 1 gamma (predicted)      Symbol and Name status set to approved 70820 APPROVED