Trem2 (triggering receptor expressed on myeloid cells 2) - Rat Genome Database

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Gene: Trem2 (triggering receptor expressed on myeloid cells 2) Rattus norvegicus
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Symbol: Trem2
Name: triggering receptor expressed on myeloid cells 2
RGD ID: 1309841
Description: Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including regulation of cytokine production; regulation of signal transduction; and response to bacterium. Predicted to act upstream of with a positive effect on memory and social behavior. Predicted to act upstream of or within with a positive effect on CXCL12-activated CXCR4 signaling pathway and defense response to Gram-negative bacterium. Predicted to act upstream of or within with a negative effect on pyroptotic inflammatory response. Predicted to act upstream of or within several processes, including cellular response to amyloid-beta; osteoclast differentiation; and regulation of intracellular signal transduction. Predicted to be located in plasma membrane raft. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 17. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC301227; Trem2-Mia; Trem2-Mib
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,145,215 - 20,151,797 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,144,334 - 20,151,779 (-)EnsemblGRCr8
mRatBN7.2912,647,605 - 12,654,190 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,647,259 - 12,654,170 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,160,724 - 21,167,248 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,226,948 - 26,233,472 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,616,230 - 24,622,771 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,611,541 - 14,618,076 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,611,561 - 14,618,013 (-)Ensemblrn6Rnor6.0
Rnor_5.0913,532,905 - 13,539,382 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,059,023 - 8,065,585 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera910,419,918 - 10,426,480 (-)NCBICelera
RGSC_v3.198,059,020 - 8,065,484 (-)NCBI
Cytogenetic Map9q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astaxanthin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
genistein  (EXP)
glucose  (ISO)
Harpagide  (ISO)
Jujuboside A  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
midazolam  (ISO)
minocycline  (ISO)
N-nitrosodiethylamine  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
quartz  (EXP)
quercetin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IEA,ISO)
amyloid-beta clearance by cellular catabolic process  (IEA,ISO)
apoptotic cell clearance  (ISO)
astrocyte activation  (ISO)
cell development  (IEA)
cell surface receptor signaling pathway  (IEA)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to glucose stimulus  (IMP)
cellular response to hypoxia  (IMP)
cellular response to lipid  (IEA,ISO)
cellular response to lipoprotein particle stimulus  (IEA,ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
cellular response to peptidoglycan  (ISO)
complement-mediated synapse pruning  (ISO)
CXCL12-activated CXCR4 signaling pathway  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (ISO)
dendritic cell differentiation  (IEA,ISO)
dendritic spine maintenance  (ISO)
detection of lipopolysaccharide  (ISO)
detection of lipoteichoic acid  (ISO)
detection of peptidoglycan  (ISO)
excitatory synapse pruning  (ISO)
immune response  (IEA)
import into cell  (ISO)
lipid homeostasis  (ISO)
memory  (ISO)
microglial cell activation  (ISO)
microglial cell activation involved in immune response  (ISO)
microglial cell proliferation  (ISO)
negative regulation of amyloid fibril formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of astrocyte activation  (ISO)
negative regulation of autophagic cell death  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cell activation  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of fat cell proliferation  (ISO)
negative regulation of glial cell apoptotic process  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of macrophage colony-stimulating factor signaling pathway  (IEA,ISO)
negative regulation of neuroinflammatory response  (IEA,ISO)
negative regulation of NLRP3 inflammasome complex assembly  (IEA,ISO)
negative regulation of p38MAPK cascade  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of toll-like receptor 2 signaling pathway  (ISO)
negative regulation of toll-like receptor 4 signaling pathway  (ISO)
negative regulation of triglyceride storage  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
neuroinflammatory response  (ISO)
osteoclast differentiation  (ISO)
phagocytosis  (IEA)
phagocytosis, engulfment  (ISO)
phagocytosis, recognition  (IEA,ISO)
positive regulation of amyloid-beta clearance  (IEA,ISO)
positive regulation of antigen processing and presentation of peptide antigen via MHC class II  (IEA,ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of C-C chemokine receptor CCR7 signaling pathway  (IEA,ISO)
positive regulation of calcium-mediated signaling  (IBA,IEA,ISO)
positive regulation of CAMKK-AMPK signaling cascade  (ISO)
positive regulation of CD40 signaling pathway  (IEA,ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of complement activation, classical pathway  (ISO)
positive regulation of engulfment of apoptotic cell  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IEA,ISO)
positive regulation of establishment of protein localization  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of high-density lipoprotein particle clearance  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of intracellular signal transduction  (IEA,ISO)
positive regulation of low-density lipoprotein particle clearance  (ISO)
positive regulation of macrophage fusion  (ISO)
positive regulation of microglial cell activation  (IBA,IEA,ISO)
positive regulation of microglial cell migration  (IEA,ISO)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of phagocytosis, engulfment  (IBA,IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of potassium ion transport  (ISO)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
positive regulation of protein secretion  (IEA,ISO)
positive regulation of synapse pruning  (IEA,ISO)
positive regulation of TOR signaling  (ISO)
pyroptotic inflammatory response  (ISO)
regulation of cytokine production involved in inflammatory response  (ISO)
regulation of gene expression  (ISO)
regulation of hippocampal neuron apoptotic process  (ISO)
regulation of innate immune response  (IBA,ISO)
regulation of interleukin-6 production  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of macrophage inflammatory protein 1 alpha production  (ISO)
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of plasma membrane bounded cell projection organization  (IBA,IEA,ISO)
regulation of primary metabolic process  (IEA)
regulation of resting membrane potential  (ISO)
regulation of toll-like receptor 6 signaling pathway  (ISO)
regulation of TOR signaling  (ISO)
respiratory burst after phagocytosis  (ISO)
response to axon injury  (IEA,ISO)
response to ischemia  (ISO)
semaphorin-plexin signaling pathway  (IEA,ISO)
signal transduction  (IBA)
social behavior  (IEA,ISO)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (IEA,ISO)

Cellular Component
extracellular region  (IEA)
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
plasma membrane raft  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Increased CSF Soluble TREM2 Concentration in Patients With Neurosyphilis. Li W, etal., Front Neurol. 2020 Feb 5;11:62. doi: 10.3389/fneur.2020.00062. eCollection 2020.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus. Zhang J, etal., J Neuroinflammation. 2020 Jan 3;17(1):2. doi: 10.1186/s12974-019-1688-9.
Additional References at PubMed
PMID:11602640   PMID:12847223   PMID:12925681   PMID:15728241   PMID:16418779   PMID:18957693   PMID:19079182   PMID:19155473   PMID:21841309   PMID:24990881   PMID:25631124   PMID:26949937  
PMID:27044754   PMID:27477018   PMID:27589997   PMID:27662313   PMID:27995897   PMID:28483841   PMID:28547529   PMID:28592261   PMID:28802038   PMID:28849042   PMID:28855300   PMID:28855301  
PMID:29073081   PMID:29518356   PMID:29859094   PMID:30149915   PMID:30232263   PMID:30548312   PMID:32139718   PMID:32757264   PMID:33222683   PMID:36829205   PMID:37658943   PMID:38409127  


Genomics

Comparative Map Data
Trem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,145,215 - 20,151,797 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,144,334 - 20,151,779 (-)EnsemblGRCr8
mRatBN7.2912,647,605 - 12,654,190 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,647,259 - 12,654,170 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,160,724 - 21,167,248 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,226,948 - 26,233,472 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,616,230 - 24,622,771 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,611,541 - 14,618,076 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,611,561 - 14,618,013 (-)Ensemblrn6Rnor6.0
Rnor_5.0913,532,905 - 13,539,382 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,059,023 - 8,065,585 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera910,419,918 - 10,426,480 (-)NCBICelera
RGSC_v3.198,059,020 - 8,065,484 (-)NCBI
Cytogenetic Map9q12NCBI
TREM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,158,508 - 41,163,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,158,488 - 41,163,186 (-)Ensemblhg38GRCh38
GRCh37641,126,246 - 41,130,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,234,230 - 41,238,892 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34641,234,230 - 41,238,892NCBI
Celera642,678,948 - 42,683,624 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,844,044 - 40,848,724 (-)NCBIHuRef
CHM1_1641,129,139 - 41,133,819 (-)NCBICHM1_1
T2T-CHM13v2.0640,987,077 - 40,991,685 (-)NCBIT2T-CHM13v2.0
Trem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,653,429 - 48,659,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,653,429 - 48,661,175 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381748,346,401 - 48,352,276 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,346,401 - 48,354,147 (+)Ensemblmm10GRCm38
MGSCv371748,485,726 - 48,491,598 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361747,811,968 - 47,817,840 (+)NCBIMGSCv36mm8
Celera1751,775,275 - 51,781,147 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
Trem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554377,780,679 - 7,785,697 (-)Ensembl
ChiLan1.0NW_0049554377,780,886 - 7,785,597 (-)NCBIChiLan1.0ChiLan1.0
TREM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2555,643,268 - 55,647,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1651,513,212 - 51,517,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0640,735,483 - 40,740,208 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,043,887 - 42,048,578 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,043,900 - 42,048,578 (-)EnsemblpanPan2panpan1.1
Trem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,295,126 - 45,300,504 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,659,815 - 18,663,940 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,659,725 - 18,665,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,465,324 - 36,471,516 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1736,465,921 - 36,471,509 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,763,412 - 41,767,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,965,091 - 30,999,073 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,994,357 - 30,999,087 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604441,158,611 - 41,163,469 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,643,363 - 17,648,231 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475417,643,397 - 17,649,255 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Trem2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1481,575,823 - 81,581,791 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Trem2
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000018351
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 61 155 83 82 51 86 51 6 328 180 11 133 73 90 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000018351   ⟹   ENSRNOP00000018351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,145,217 - 20,151,779 (-)Ensembl
mRatBN7.2 Ensembl912,647,608 - 12,654,170 (-)Ensembl
Rnor_6.0 Ensembl914,611,561 - 14,618,013 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093814   ⟹   ENSRNOP00000077250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,144,334 - 20,151,743 (-)Ensembl
mRatBN7.2 Ensembl912,647,259 - 12,654,170 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112464   ⟹   ENSRNOP00000087941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl912,647,887 - 12,651,892 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114012   ⟹   ENSRNOP00000086823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,145,129 - 20,151,743 (-)Ensembl
mRatBN7.2 Ensembl912,647,606 - 12,654,170 (-)Ensembl
RefSeq Acc Id: NM_001106884   ⟹   NP_001100354
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,145,217 - 20,151,779 (-)NCBI
mRatBN7.2912,647,608 - 12,654,170 (-)NCBI
Rnor_6.0914,611,561 - 14,618,013 (-)NCBI
Rnor_5.0913,532,905 - 13,539,382 (-)NCBI
RGSC_v3.498,059,023 - 8,065,585 (-)RGD
Celera910,419,918 - 10,426,480 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244425   ⟹   XP_006244487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,145,215 - 20,151,797 (-)NCBI
mRatBN7.2912,647,606 - 12,654,189 (-)NCBI
Rnor_6.0914,611,559 - 14,618,073 (-)NCBI
Rnor_5.0913,532,905 - 13,539,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266844   ⟹   XP_063122914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,145,215 - 20,151,796 (-)NCBI
RefSeq Acc Id: NP_001100354   ⟸   NM_001106884
- Peptide Label: precursor
- UniProtKB: A0A6G8MVL9 (UniProtKB/TrEMBL),   A0A6G8MV71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244487   ⟸   XM_006244425
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000018351   ⟸   ENSRNOT00000018351
Ensembl Acc Id: ENSRNOP00000086823   ⟸   ENSRNOT00000114012
Ensembl Acc Id: ENSRNOP00000077250   ⟸   ENSRNOT00000093814
Ensembl Acc Id: ENSRNOP00000087941   ⟸   ENSRNOT00000112464
RefSeq Acc Id: XP_063122914   ⟸   XM_063266844
- Peptide Label: isoform X1
Protein Domains
Immunoglobulin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZ89-F1-model_v2 AlphaFold D3ZZ89 1-228 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309841 AgrOrtholog
BioCyc Gene G2FUF-28307 BioCyc
Ensembl Genes ENSRNOG00000013578 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018351 ENTREZGENE
  ENSRNOT00000018351.7 UniProtKB/TrEMBL
  ENSRNOT00000093814.2 UniProtKB/TrEMBL
  ENSRNOT00000114012 ENTREZGENE
  ENSRNOT00000114012.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Immune_rcpt_domain UniProtKB/TrEMBL
KEGG Report rno:301227 UniProtKB/TrEMBL
NCBI Gene 301227 ENTREZGENE
PANTHER IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  TREM-LIKE TRANSCRIPT PROTEIN UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Trem2 PhenoGen
RatGTEx ENSRNOG00000013578 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A6G8MV71 ENTREZGENE, UniProtKB/TrEMBL
  A0A6G8MVL9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y9E9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A303 ENTREZGENE, UniProtKB/TrEMBL
  A6JIF4 ENTREZGENE, UniProtKB/TrEMBL
  A6JIF6_RAT UniProtKB/TrEMBL
  D3ZZ89_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Trem2  triggering receptor expressed on myeloid cells 2   Trem2_predicted  triggering receptor expressed on myeloid cells 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Trem2_predicted  triggering receptor expressed on myeloid cells 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED