Dtymk (deoxythymidylate kinase) - Rat Genome Database

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Gene: Dtymk (deoxythymidylate kinase) Rattus norvegicus
Analyze
Symbol: Dtymk
Name: deoxythymidylate kinase
RGD ID: 1309614
Description: Predicted to enable ATP binding activity; dTMP kinase activity; and nucleoside diphosphate kinase activity. Involved in several processes, including pyrimidine deoxyribonucleotide biosynthetic process; response to cadmium ion; and response to estrogen. Located in mitochondrial matrix. Orthologous to human DTYMK (deoxythymidylate kinase); PARTICIPATES IN pyrimidine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxythymidylate kinase (thymidylate kinase); LOC301622; thymidylate kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,762,899 - 101,771,733 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9101,762,899 - 101,774,504 (-)EnsemblGRCr8
mRatBN7.2994,315,552 - 94,324,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,315,552 - 94,324,870 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9102,751,029 - 102,759,863 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,886,508 - 107,895,248 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,242,614 - 106,251,356 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,921,565 - 100,930,399 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,921,565 - 100,930,399 (-)Ensemblrn6Rnor6.0
Rnor_5.09100,574,720 - 100,583,554 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4993,065,333 - 93,074,168 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera991,849,852 - 91,858,636 (-)NCBICelera
RGSC_v3.1993,270,105 - 93,281,003 (-)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bucladesine  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
finasteride  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
medroxyprogesterone acetate  (ISO)
methimazole  (EXP)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
nicotine  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Metabolic alterations of liver regeneration. XV. Cadmium-mediated depression of thymidine and thymidylate kinase induction in rats. Cihak A Chem Biol Interact. 1979 May;25(2-3):355-62.
2. Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver. Cummins RR and Balinsky D, Cancer Res. 1980 Apr;40(4):1235-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Relationship between 5'-nucleotidase, adenosine deaminase, AMP deaminase, ATP-(Mg2+)-ase activities and dTMP kinase activity in rat liver mitochondria. Greger J and Fabianowska K, Enzyme. 1979;24(1):54-60.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs. Rylova SN, etal., Biochem Pharmacol. 2005 Mar 15;69(6):951-60.
9. Hormonal effects on thymidine kinase and thymidylate kinase activity of estrogen-dependent tumors in the rat. Thomson MJ, etal., Cancer Res. 1973 Feb;33(2):220-5.
Additional References at PubMed
PMID:18469   PMID:8845311   PMID:12477932   PMID:34800366  


Genomics

Comparative Map Data
Dtymk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,762,899 - 101,771,733 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9101,762,899 - 101,774,504 (-)EnsemblGRCr8
mRatBN7.2994,315,552 - 94,324,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,315,552 - 94,324,870 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9102,751,029 - 102,759,863 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,886,508 - 107,895,248 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,242,614 - 106,251,356 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,921,565 - 100,930,399 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,921,565 - 100,930,399 (-)Ensemblrn6Rnor6.0
Rnor_5.09100,574,720 - 100,583,554 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4993,065,333 - 93,074,168 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera991,849,852 - 91,858,636 (-)NCBICelera
RGSC_v3.1993,270,105 - 93,281,003 (-)NCBI
Cytogenetic Map9q36NCBI
DTYMK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,675,747 - 241,686,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,675,742 - 241,686,944 (-)Ensemblhg38GRCh38
GRCh372242,615,162 - 242,626,230 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,263,830 - 242,274,900 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2236,286,957 - 236,298,151 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,370,538 - 234,381,765 (-)NCBIHuRef
CHM1_12242,621,221 - 242,632,448 (-)NCBICHM1_1
T2T-CHM13v2.02242,179,081 - 242,190,147 (-)NCBIT2T-CHM13v2.0
Dtymk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,720,298 - 93,730,246 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,720,298 - 93,729,656 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38193,792,576 - 93,802,068 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,792,576 - 93,801,934 (-)Ensemblmm10GRCm38
MGSCv37195,689,153 - 95,698,511 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36195,630,901 - 95,632,281 (-)NCBIMGSCv36mm8
Celera196,736,573 - 96,746,015 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.34NCBI
Dtymk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542155,742 - 163,759 (+)Ensembl
ChiLan1.0NW_004955542155,741 - 163,759 (+)NCBIChiLan1.0ChiLan1.0
DTYMK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,384,093 - 144,395,584 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,398,989 - 144,410,620 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,952,009 - 128,963,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,740,881 - 247,752,507 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,740,881 - 247,752,504 (-)EnsemblpanPan2panpan1.1
DTYMK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,520,307 - 51,535,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,520,581 - 51,526,069 (-)NCBIcanFam3CanFam3.1
CanFam3.1 Ensembl2551,520,581 - 51,526,069 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2551,738,743 - 51,749,088 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02551,718,398 - 51,728,728 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,718,167 - 51,729,502 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,568,255 - 51,578,566 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02551,307,418 - 51,317,739 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,584,115 - 51,594,478 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dtymk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,930,085 - 192,936,371 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936745282,199 - 289,273 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DTYMK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,248,079 - 140,255,805 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115140,248,071 - 140,255,803 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DTYMK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,722,091 - 127,733,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,721,784 - 127,733,476 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604071,588,595 - 71,600,206 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dtymk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,630,619 - 5,638,000 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248475,630,765 - 5,637,948 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dtymk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14165,706,723 - 165,715,245 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dtymk
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:139
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000025644
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025644   ⟹   ENSRNOP00000025644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,762,899 - 101,768,459 (-)Ensembl
mRatBN7.2 Ensembl994,315,552 - 94,321,112 (-)Ensembl
Rnor_6.0 Ensembl9100,921,565 - 100,930,399 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085029   ⟹   ENSRNOP00000069272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,762,996 - 101,771,597 (-)Ensembl
mRatBN7.2 Ensembl994,315,635 - 94,324,271 (-)Ensembl
Rnor_6.0 Ensembl9100,921,662 - 100,930,263 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111179   ⟹   ENSRNOP00000091716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,762,899 - 101,774,504 (-)Ensembl
mRatBN7.2 Ensembl994,315,552 - 94,324,870 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138500   ⟹   ENSRNOP00000103901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,762,899 - 101,772,155 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168625   ⟹   ENSRNOP00000104706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,762,899 - 101,774,470 (-)Ensembl
RefSeq Acc Id: NM_001106925   ⟹   NP_001100395
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,762,899 - 101,771,733 (-)NCBI
mRatBN7.2994,315,552 - 94,324,386 (-)NCBI
Rnor_6.09100,921,565 - 100,930,399 (-)NCBI
Rnor_5.09100,574,720 - 100,583,554 (-)NCBI
RGSC_v3.4993,065,333 - 93,074,168 (-)RGD
Celera991,849,852 - 91,858,636 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245519   ⟹   XP_006245581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,762,903 - 101,771,678 (-)NCBI
mRatBN7.2994,315,556 - 94,324,314 (-)NCBI
Rnor_6.09100,921,569 - 100,930,338 (-)NCBI
Rnor_5.09100,574,720 - 100,583,554 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767363   ⟹   XP_008765585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,762,903 - 101,771,678 (-)NCBI
mRatBN7.2994,315,556 - 94,324,321 (-)NCBI
Rnor_6.09100,921,569 - 100,930,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083425   ⟹   XP_038939353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,762,903 - 101,771,678 (-)NCBI
mRatBN7.2994,315,556 - 94,324,325 (-)NCBI
RefSeq Acc Id: XM_063267043   ⟹   XP_063123113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,765,206 - 101,771,678 (-)NCBI
RefSeq Acc Id: XM_063267044   ⟹   XP_063123114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,762,903 - 101,768,145 (-)NCBI
RefSeq Acc Id: XR_005488878
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,763,249 - 101,771,678 (-)NCBI
mRatBN7.2994,315,556 - 94,324,333 (-)NCBI
RefSeq Acc Id: NP_001100395   ⟸   NM_001106925
- UniProtKB: A6JR35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245581   ⟸   XM_006245519
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008765585   ⟸   XM_008767363
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000069272   ⟸   ENSRNOT00000085029
Ensembl Acc Id: ENSRNOP00000025644   ⟸   ENSRNOT00000025644
RefSeq Acc Id: XP_038939353   ⟸   XM_039083425
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000091716   ⟸   ENSRNOT00000111179
RefSeq Acc Id: XP_063123114   ⟸   XM_063267044
- Peptide Label: isoform X5
- UniProtKB: A6JR36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123113   ⟸   XM_063267043
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000104706   ⟸   ENSRNOT00000168625
Ensembl Acc Id: ENSRNOP00000103901   ⟸   ENSRNOT00000138500
Protein Domains
Thymidylate kinase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUJ5-F1-model_v2 AlphaFold D3ZUJ5 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696884
Promoter ID:EPDNEW_R7407
Type:initiation region
Name:Dtymk_1
Description:deoxythymidylate kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09100,930,299 - 100,930,359EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309614 AgrOrtholog
BioCyc Gene G2FUF-26630 BioCyc
BioCyc Pathway PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7197 [pyrimidine deoxyribonucleotide phosphorylation] BioCyc
  PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP] BioCyc
BioCyc Pathway Image PWY-7184 BioCyc
  PWY-7197 BioCyc
  PWY-7210 BioCyc
Ensembl Genes ENSRNOG00000018904 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025644.8 UniProtKB/TrEMBL
  ENSRNOT00000085029 ENTREZGENE
  ENSRNOT00000085029.3 UniProtKB/TrEMBL
  ENSRNOT00000111179.2 UniProtKB/TrEMBL
  ENSRNOT00000138500.1 UniProtKB/TrEMBL
  ENSRNOT00000168625.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9088913 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Thymidylate_kin UniProtKB/TrEMBL
  Thymidylate_kin_CS UniProtKB/TrEMBL
  Thymidylate_kin_like_dom UniProtKB/TrEMBL
KEGG Report rno:301622 UniProtKB/TrEMBL
MGC_CLONE MGC:188749 IMAGE-MGC_LOAD
NCBI Gene 301622 ENTREZGENE
PANTHER THYMIDYLATE KINASE UniProtKB/TrEMBL
  THYMIDYLATE KINASE UniProtKB/TrEMBL
Pfam Thymidylate_kin UniProtKB/TrEMBL
PhenoGen Dtymk PhenoGen
PROSITE THYMIDYLATE_KINASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018904 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6AFQ3_RAT UniProtKB/TrEMBL
  A0ABK0L3Q7_RAT UniProtKB/TrEMBL
  A0ABK0L560_RAT UniProtKB/TrEMBL
  A6JR35 ENTREZGENE, UniProtKB/TrEMBL
  A6JR36 ENTREZGENE, UniProtKB/TrEMBL
  B0K028_RAT UniProtKB/TrEMBL
  D3ZUJ5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Dtymk  deoxythymidylate kinase  Dtymk  deoxythymidylate kinase (thymidylate kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Dtymk  deoxythymidylate kinase (thymidylate kinase)  Dtymk  deoxythymidylate kinase   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dtymk  deoxythymidylate kinase   Dtymk_predicted  deoxythymidylate kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dtymk_predicted  deoxythymidylate kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED